Hypotensive disorder

This trial tests an automated system called ADIVA that delivers two medications to control blood pressure during spinal anesthesia for cesarean delivery. Low blood pressure is a common side effect of spinal anesthesia and can cause problems for both mother and baby. The system ai…

This study tests whether combining two drugs, droxidopa and pyridostigmine, can improve a sudden drop in blood pressure when standing up (orthostatic hypotension) without making high blood pressure worse when lying down. The trial enrolls people with neurogenic orthostatic hypote…

This pilot study tests whether actively managing blood pressure during heart surgery in newborns can reduce dangerous low blood pressure episodes. About 130 newborns will be randomly assigned to either standard care or a new approach using a special monitor to keep blood pressure…

This study tests whether a drug called Angiotensin II can help control blood pressure during liver transplant surgery, reducing the need for other strong blood pressure medicines. It involves 50 adults with severe liver disease who are receiving a liver from a deceased donor. The…

This study tests whether giving a standard amount of IV fluid (Lactated Ringer's solution) before anesthesia can prevent low blood pressure during cystoscopy. About 100 adults having elective cystoscopy will receive the fluid bolus, and researchers will track how many experience …

This study tests whether transcutaneous spinal cord stimulation (TSCS) — a gentle electrical current applied through the skin — can help veterans with chronic spinal cord injury (SCI) better regulate blood pressure during exercise and cold exposure. Participants will receive both…

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This study tests whether taking extra salt (5 grams per day in capsules) can improve symptoms and quality of life in older adults (65+) who experience dizziness and falls due to orthostatic hypotension. The trial involves 42 participants and lasts 12 months, focusing on whether s…

This study at Mayo Clinic looks at how renin, a protein in the blood, changes when patients are on the heart-lung machine during open heart surgery. Researchers want to see if renin levels can help guide treatments for low blood pressure. The study will enroll 100 adults having e…

This study looks at whether pausing sedation each day in mechanically ventilated ICU patients can reduce the amount of blood pressure medication they need. Researchers will compare medication doses before and during these daily awakening trials. The goal is to see if this simple …

This study observes 60 adults undergoing open pancreatic surgery to see if low blood pressure during the operation is linked to higher lactate levels afterward. Lactate is a marker of how well tissues are getting oxygen. The goal is to find patterns that could help doctors adjust…

This study looks at whether an ultrasound measurement of a large vein near the heart (the inferior vena cava) can predict when a patient's blood pressure will drop dangerously during hip replacement surgery. Researchers will measure this vein's flexibility before cement is used t…

This study looks at whether low blood pressure during major noncardiac surgery harms organs like the heart and kidneys. Researchers are using a non-invasive brain monitor to see if a personalized blood pressure target can be set. 650 patients at cardiovascular risk are being obse…

This study looks at whether two simple, non-invasive tests can predict when a patient's blood pressure will drop dangerously during shoulder surgery performed in the 'beach chair' position (sitting upright). The tests are a finger sensor that measures blood flow and an ultrasound…

This study looks at 80 women having breast cancer surgery to see if using a mix of two numbing medicines (levobupivacaine and lidocaine) for a nerve block causes more changes in blood pressure and heart rate than using just one (levobupivacaine alone). The goal is to find which a…

This study is closely watching heart and lung changes in extremely low birth weight babies (under 1000 grams) during their first week of life. Researchers want to understand why some preemies develop low blood pressure and related complications. By using standard and new monitori…

This study was designed to measure estrogen and testosterone levels in men with liver cirrhosis who also have low blood pressure, compared to those with cirrhosis but normal blood pressure. The goal was to understand why low blood pressure occurs in cirrhosis. However, the study …

This study looks at how the body's automatic nervous system controls blood flow in abdominal veins and how that might lead to high blood pressure in people with Multiple System Atrophy (MSA). Researchers will measure vein responses in about 16 participants aged 40-80 who have MSA…

This study uses MRI scans to measure blood flow in the gut after drinking sugar water in people with postprandial hypotension (a drop in blood pressure after meals) and healthy volunteers. Researchers will test whether blocking a hormone called GIP changes blood flow patterns. Th…

This study checks if a non-invasive monitor (ClearSight) can predict low blood pressure during surgery as accurately as the standard method that uses a needle in the wrist. 50 adults having surgery with general anesthesia and an arterial line will be enrolled. The goal is to see …

This study looks at better ways to check fluid levels in adults with acute kidney injury (AKI). AKI is a sudden drop in kidney function that can be made worse by too little or too much fluid. Researchers will compare different assessment methods, including physical exams and bioi…

This study looks at whether giving IV fluids before surgery can prevent low blood pressure after anesthesia is started. Researchers will monitor 550 adults at risk for blood pressure drops during major non-cardiac surgery. The goal is to see if this simple step reduces the need f…

This study looks at whether drinking 16 ounces of water raises blood pressure more in the morning or the afternoon in people with orthostatic hypotension (a condition where blood pressure drops when standing). Twenty participants will drink water at two different times of day, an…

This study looks at whether drinking water raises blood pressure as much the second time if you've already had a full glass a few hours earlier. Researchers are testing 20 adults with orthostatic hypotension, a condition where blood pressure drops when standing. Participants will…