Two-Drug combo aims to fix standing blood pressure drop without Lying-Down spike
NCT ID NCT01370512
First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time
Summary
This study tests whether combining two drugs, droxidopa and pyridostigmine, can improve a sudden drop in blood pressure when standing up (orthostatic hypotension) without making high blood pressure worse when lying down. The trial enrolls people with neurogenic orthostatic hypotension. Participants receive either the drug combination or a placebo to compare effects on blood pressure changes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a combination of droxidopa and pyridostigmine
- What this could lead to
- If successful, this combination could offer a new way to manage orthostatic hypotension without the common side effect of worsening high blood pressure when lying down.
- What could go wrong
- This is a small, early-phase trial with only 30 participants, so results may not apply to everyone. The drugs may not work as hoped or could cause unexpected side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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