Primary orthostatic hypotension

This phase 2 trial tests whether a drug called 2-HOBA can reduce immune system overactivity in people with Long COVID who also have POTS (a condition causing rapid heart rate upon standing). The study will enroll 50 participants and randomly assign them to receive either 2-HOBA o…

This study tests a minimally invasive procedure to open narrowed veins above the heart in people with orthostatic hypotension or intolerance—conditions that cause dizziness, fainting, or fatigue when standing. 100 adults who haven't improved with standard treatments will receive …

This study tests whether diaphragmatic breathing exercises can reduce heart rate, blood pressure, and dizziness in pregnant women with Postural Orthostatic Tachycardia Syndrome (POTS). 44 pregnant women will be split into two groups: one doing breathing exercises, the other recei…

This study looks at whether eating more salt can help people with POTS, a condition that causes a fast heart rate and dizziness when standing. Researchers will compare a high-salt diet to a normal-salt diet over 3 months in 50 adults. The goal is to see if extra salt lowers heart…

This study looks at whether wearing compression garments (like tight waist-high stockings or abdominal shapewear) can help adults with POTS feel better and lower their heart rate during normal daily activities. About 30 participants will wear the garments at home and have their h…

This study looks at whether a large IV bag of saline (salt water) can improve thinking problems like brain fog in people with Long COVID or a condition called POTS. About 100 adults will receive either a full or tiny dose of saline to compare effects on reaction time and memory. …

This study looks at whether a simple device that makes you breathe in a little extra carbon dioxide (CO2) can help raise blood pressure in people with a condition called neurogenic orthostatic hypotension (nOH). People with nOH get dizzy or even faint when they stand up because t…

This study tests a new drug called CST-3056 in 12 adults with neurogenic orthostatic hypotension (a sharp drop in blood pressure when standing) caused by Parkinson's disease or pure autonomic failure. The goal is to see if the drug can improve blood pressure and reduce symptoms l…

This study looks at whether breathing air with a little extra carbon dioxide can help people with neurogenic orthostatic hypotension (NOH) — a condition where blood pressure drops sharply upon standing, causing dizziness and fainting. Researchers will test this in 80 adults (pati…

This study tests whether simple physical maneuvers like leg crossing, bending, or arm tensing can prevent fainting in children aged 6 to 18. Participants who visit the emergency department after a fainting episode will either receive standard care or learn these counterpressure m…

This study looks at whether using a CPAP machine (a device that gently blows air through a mask) can safely lower high blood pressure when lying down at night and help reduce dizziness upon standing in people with autonomic failure. About 59 adults aged 40-80 with conditions like…

This study tests whether whole-body electrical muscle stimulation (WB-EMS) can help adults with neuromuscular diseases like ALS, SMA, and muscular dystrophy exercise safely. Because these conditions weaken the nerves that control muscles, traditional exercise is often too hard. W…

This phase 2 trial tests whether pyridostigmine, a drug that affects nerve signals, can reduce symptoms of postural tachycardia syndrome (POTS) like rapid heartbeat and dizziness. Fifty adults with POTS will take either pyridostigmine or a placebo for three days. The study aims t…

This study is testing whether a small, battery-powered device worn on the ear can reduce gastrointestinal symptoms in children aged 10-18 with hypermobile Ehlers-Danlos syndrome (hEDS) and related autonomic nervous system problems. The device, called IB-Stim, delivers gentle elec…

This pilot study tests whether giving intravenous iron to people with POTS who have low iron stores can increase their blood volume and reduce symptoms like rapid heart rate upon standing. The study will enroll 12 adults aged 18-45 with confirmed POTS and low ferritin levels. Par…

This study explores whether a small accelerometer worn on the thigh can objectively measure how well treatments work for neurogenic orthostatic hypotension—a condition causing dizziness and fainting upon standing. Participants wear the device for one week on placebo and one week …

This registry will follow 500 people with inappropriate sinus tachycardia (IST) or postural orthostatic tachycardia syndrome (POTS) who have had or will have a heart ablation procedure using AtriCure devices. The goal is to collect real-world data on how safe and effective the pr…

This study aims to find how common the KIT D816V mutation is in people with suspected clonal mast cell disease. Researchers will collect blood samples from 450 participants and test them using two sensitive methods. The results may improve understanding and diagnosis of these rar…

This study follows 800 adults with synucleinopathies—diseases like Parkinson's, Lewy body dementia, and multiple system atrophy—to learn how they develop and change over time. Researchers will track symptoms, biological markers, and early signs like dizziness on standing or dream…

This study looks at whether raising carbon dioxide levels in the blood can lower heart rate and reduce symptoms in people with Postural Orthostatic Tachycardia Syndrome (POTS) when they stand up. Researchers will test different CO2 levels in 26 adults with POTS during a tilt-tabl…

This study is looking at whether people with postural tachycardia syndrome (POTS) have certain antibodies that might be causing their symptoms. Researchers will compare 125 adults with and without POTS, using small doses of two drugs to see how their bodies respond. The goal is t…

This study looks at how the heart and blood vessels communicate when blood pressure drops, like when standing up quickly. Researchers will test young and older men and women using a vacuum chamber around the legs to safely mimic low blood pressure. They will also see if squeezing…

This study looks at how the brains of young people with Postural Tachycardia Syndrome (POTS) process what they see. Researchers will use brain scans to compare brain activity in teens with POTS and healthy teens. The goal is to learn more about how different parts of the brain co…

This study looks at whether simple leg movements, like crossing legs or tensing buttock muscles, can raise blood pressure in children aged 6-18 who faint often. Researchers will measure heart and blood flow responses during these movements in 30 children. The goal is to understan…

This study looks at why some people develop a fast heart rate and dizziness months after COVID-19, a condition called post-COVID tachycardia syndrome. Researchers will measure immune markers and nerve activity in 60 participants to see if ongoing inflammation and reduced vagal ne…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at why some people develop POTS (a condition causing rapid heartbeat and dizziness) after COVID-19. Researchers think a part of the nervous system that normally fights inflammation may not work well in these patients. They will compare 150 adults with and without…

This study looks at why eating carbohydrates makes symptoms worse for people with Postural Tachycardia Syndrome (POTS), a condition that causes dizziness and rapid heartbeat upon standing. Researchers will measure blood flow changes in the abdomen after a sugary drink in 50 parti…

This study is a registry that collects information from 1,000 adults who have conditions like fainting, rapid heartbeat, or low blood pressure and have received a procedure that adjusts nerve signals to the heart. Researchers will track whether symptoms return within a year. The …

This study looks at how the brain works in 120 adolescents with POTS, a condition causing rapid heart rate and dizziness when standing. Researchers will use brain scans and questionnaires to see if a problem in the brain's threat-detection system explains symptoms. The goal is to…

This study collects blood and tissue samples from 2,000 people with or without heart rhythm problems. Researchers will analyze the samples to find genetic differences linked to arrhythmias. The goal is to better understand the causes of these conditions, not to test a new treatme…