Primary orthostatic hypotension
MONDO:0015914Primary orthostatic hypotension is a rare type of orthostatic hypotension. It is not a disease per se, but a condition caused by several disorders that affect a specific part of the autonomic nervous system, such as multiple system atrophy, young-onset Parkinson's disease, pure autonomic failure, dopamine beta-hydroxylase deficiency, familial dysautonomia, and pure autonomic failure among others. The autonomic nervous system is the part of the nervous system that regulates certain involuntary body functions such as heart rate, blood pressure, sweating, and bowel and bladder control. Orthostatic hypotension is a form of low blood pressure that happens when standing-up from sitting or lying down. Common symptoms may include dizziness, lightheadedness, generalized weakness, leg buckling, nausea, blurry vision, fatigue, and headaches. Additional symptoms can include chest pain (angina), head and neck pain (often affecting neck and shoulders with a coat hanger distribution), decline in cognitive functioning such as difficulty concentrating, temporary loss of consciousness or “blackout”. Some people with primary orthostatic hypotension may also have high blood pressure when lying down. The treatment depends upon several factors including the specific underlying cause including The treatment depends upon several factors including the specific underlying cause and may include physical counter-maneuvers like lying down, sitting down, squatting clenching buttocks, leg crossing, and support garment and medication.
Also known as: neurogenic orthostatic hypotension
74 clinical trials for this condition and its sub-types.
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Broader categories
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Could a gentle brain zap help control blood pressure?
Disease control Not yet recruitingThis pilot study tests whether a non-invasive brain stimulation technique called temporal interference can safely help regulate blood pressure. Researchers will enroll 25 adults with either mild untreated hypertension or hard-to-treat hypertension, as well as people with low bloo…
Phase: NA • Sponsor: Xuanwu Hospital, Beijing • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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New blood pressure monitor could replace needles in autonomic testing
Diagnosis Not yet recruitingThis study will test a new device that measures blood pressure and heart function continuously without needles. It will be used during standard autonomic function tests (like the Valsalva maneuver and tilt table) in 75 patients with orthostatic intolerance. The goal is to see if …
Sponsor: CNSystems Medizintechnik GmbH • Aim: Diagnosis
Last updated Jun 27, 2026 11:02 UTC
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Breathing your way to better heart health: new POTS study
Symptom relief Not yet recruitingThis study tests whether regular breathing exercises can improve symptoms of Postural Tachycardia Syndrome (POTS), a condition that causes dizziness and rapid heartbeat when standing. Twelve adults with POTS will practice breathing exercises daily for four weeks while researchers…
Phase: NA • Sponsor: Virginia Commonwealth University • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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Could a bladder drug calm POTS? new trial aims to find out
Symptom relief Not yet recruitingThis phase 2 trial tests whether mirabegron, a drug currently used for overactive bladder, can reduce symptoms of Postural Orthostatic Tachycardia Syndrome (POTS). Thirty-six adults with confirmed POTS will receive either mirabegron or a placebo. The main goal is to see if the dr…
Phase: PHASE2 • Sponsor: Cedars-Sinai Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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Could a Low-Dose drug ease POTS fatigue? new trial aims to find out
Symptom relief Not yet recruitingThis study tests whether low dose naltrexone (LDN) can reduce fatigue in people with Postural Orthostatic Tachycardia Syndrome (POTS). Eighty participants will receive either LDN or a placebo for 4 months. The goal is to see if LDN improves fatigue and quality of life.
Phase: PHASE4 • Sponsor: University of Calgary • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Ear zap might tame racing heart in POTS
Symptom relief Not yet recruitingThis pilot study tests a non-invasive ear stimulation device (aVNT) in 30 people with Postural Orthostatic Tachycardia Syndrome (POTS). The goal is to see if it can reduce rapid heart rate upon standing, improve blood flow to the brain, and ease other symptoms like brain fog and …
Phase: NA • Sponsor: University of Calgary • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Nerve block aimed at calming POTS symptoms in small stanford trial
Symptom relief Not yet recruitingThis pilot study from Stanford tests whether a stellate ganglion block (a nerve block in the neck) can reduce symptoms of Postural Tachycardia Syndrome (POTS). Twenty adults with POTS will receive either the nerve block or a sham injection. Researchers will track changes in auton…
Phase: NA • Sponsor: Stanford University • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Could a gentle ear zap tame POTS?
Symptom relief Not yet recruitingThis study tests a device that stimulates a nerve in the ear to see if it can help people with POTS, a condition that causes a racing heart and dizziness when standing. Twenty-four adults with POTS will receive both active and sham stimulation in a crossover design. The main goal…
Phase: NA • Sponsor: Aristotle University Of Thessaloniki • Aim: Symptom relief
Last updated Jun 26, 2026 15:04 UTC
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Long-Term study aims to unlock mystery of joint hypermobility and chronic illness
Knowledge-focused Not yet recruitingThis study will follow 100 health science students for at least 10 years to understand why some people with very flexible joints (hypermobility) develop chronic pain, fatigue, and other health issues while others do not. Researchers will measure balance, heart rate, and quality o…
Sponsor: Clarkson University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:01 UTC
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Could muscle loss in seniors cause tiredness and dizziness? new study investigates
Knowledge-focused Not yet recruitingThis study looks at how sarcopenia (age-related muscle loss) is connected to fatigue and orthostatic intolerance (dizziness when standing up) in people aged 65 and older. Researchers will compare 90 older adults with and without sarcopenia to see if those with muscle loss experie…
Sponsor: Ain Shams University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC