Iron infusions may ease POTS symptoms in small trial

NCT ID NCT07197905

Recruiting now Symptom relief Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This pilot study tests whether giving intravenous iron to people with POTS who have low iron stores can increase their blood volume and reduce symptoms like rapid heart rate upon standing. The study will enroll 12 adults aged 18-45 with confirmed POTS and low ferritin levels. Participants will receive one IV iron infusion, and researchers will measure changes in heart rate during a tilt table test.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: intravenous iron
What this could lead to: If it works, this could point toward a simple iron infusion treatment to reduce rapid heart rate and improve daily symptoms for people with POTS.
What could go wrong: This is a very small pilot study with only 12 participants, so results may not apply to everyone. It is also early-stage, so the treatment may not show clear benefit or could cause side effects like allergic reactions.

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Conditions

The condition(s) this trial relates to.

Iron Deficiencies postural orthostatic tachycardia syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POTS - POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME

Contacts and locations

Locations

Autonomic Dysfunction Center/ Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

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