Lab study probes c-section blood pressure drugs for safer choices

NCT ID NCT04053478

Recruiting now Knowledge-focused Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study takes tissue samples from women having planned C-sections and tests four drugs (ephedrine, phenylephrine, norepinephrine, vasopressin) in a dish to see how they affect womb muscle and umbilical blood vessels. The goal is to understand which drugs might be safer for mother and baby. It involves 144 participants but is purely a lab experiment, not a treatment trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ephedrine, phenylephrine, norepinephrine, vasopressin
What this could lead to: If successful, this could help doctors choose safer blood-pressure drugs for mothers during C-sections, potentially reducing harm to the baby.
What could go wrong: This is a lab study using tissue samples, not a human trial. Results may not directly apply to real patients, and the drugs' effects in the body could differ.

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Conditions

The condition(s) this trial relates to.

diabetes insipidus hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOTENSION

Contacts and locations

Locations

Mount Sinai Hospital
RECRUITING

Toronto, Ontario, M5G1X5, Canada

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