Samuel Lunenfeld Research Institute, Mount Sinai Hospital

This study tests different doses of oxytocin, a drug that helps the uterus contract after childbirth, to find the lowest effective dose for women having a C-section after labor. The goal is to prevent postpartum hemorrhage (heavy bleeding) while minimizing side effects. Forty wom…

This study tests whether giving calcium chloride along with carbetocin (a longer-acting drug to tighten the uterus) improves uterine tone after planned C-sections. The goal is to reduce the risk of postpartum hemorrhage, a leading cause of maternal death. 120 low-risk women havin…

This study tests whether carbetocin works better than oxytocin to prevent severe bleeding after a planned C-section in women with risk factors like twins, a large baby, or obesity. About 160 participants will receive one of the two drugs, and doctors will measure how many need ex…

This study tests whether adding a small dose of morphine to the spinal part of a combined spinal-epidural injection can reduce sudden pain during labor. Researchers will compare morphine to a placebo in 182 first-time mothers. The goal is to see if morphine helps prevent breakthr…

This study uses small samples of uterine tissue from 32 women having planned C-sections to test which backup drug best contracts the uterus after carbetocin has been given. The goal is to improve treatment for severe bleeding after childbirth. The research is done in the lab, not…

This study looks at how three common blood pressure medications (ephedrine, phenylepinephrine, and norepinephrine) affect the ability of the uterus to contract after a C-section in women with type 2 or gestational diabetes. Researchers will take small tissue samples from the uter…

This study takes tissue samples from women having planned C-sections and tests four drugs (ephedrine, phenylephrine, norepinephrine, vasopressin) in a dish to see how they affect womb muscle and umbilical blood vessels. The goal is to understand which drugs might be safer for mot…

This study looks at how severe bleeding after childbirth (postpartum hemorrhage) affects a woman's recovery. Researchers will compare recovery scores from a 10-question survey between 152 women who had severe bleeding and those who did not. The goal is to understand the impact on…

This lab study uses uterine tissue from 40 women having planned C-sections to see if calcium levels change how well carbetocin (a drug that helps the uterus contract) works. The goal is to find the best calcium level to improve carbetocin's effect, which could help prevent or tre…