Morphine in spinal epidural may reduce breakthrough labor pain

NCT ID NCT06572241

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether adding a small dose of morphine to the spinal part of a combined spinal-epidural injection can reduce sudden pain during labor. Researchers will compare morphine to a placebo in 182 first-time mothers. The goal is to see if morphine helps prevent breakthrough pain and improves overall comfort.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
morphine
What this could lead to
If it works, this could provide better pain relief during labor with fewer episodes of breakthrough pain.
What could go wrong
This is a small, early-stage trial. The addition of morphine may not significantly reduce pain and could have side effects like itching or nausea.

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Conditions

The condition(s) this trial relates to.

Labor Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Mount Sinai Hospital

    RECRUITING

    Toronto, Ontario, M5G1X5, Canada

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