Samuel Lunenfeld Research Institute, Mount Sinai Hospital

This study aims to find the smallest effective dose of oxytocin to prevent heavy bleeding after a C-section in women who have been in labor. Oxytocin helps the uterus contract and reduce blood loss. Researchers will adjust the dose for each new participant based on how the previo…

This study compares two medications, carbetocin and oxytocin, to see which works better at preventing heavy bleeding (postpartum hemorrhage) in women at high risk who are having a planned C-section. About 160 women with risk factors like carrying twins, a large baby, or having ob…

This study tests whether giving calcium chloride along with a standard drug (carbetocin) helps the uterus tighten better after a planned C-section, reducing the risk of dangerous bleeding. About 120 women having scheduled C-sections will receive either the combo or a placebo. The…

This study tests whether adding a small dose of morphine to the spinal part of a combined spinal-epidural (CSE) can reduce sudden pain during labor. About 182 first-time mothers will receive either CSE with or without morphine. The goal is to see if morphine helps prevent pain th…

This study looks at how severe bleeding after childbirth (postpartum hemorrhage) affects a mother's recovery. Researchers will compare recovery scores from a 10-question survey between 152 women who had heavy bleeding and those who did not. The goal is to understand the physical …

This study looks at how three common blood pressure drugs (ephedrine, phenylepinephrine, and norepinephrine) affect the ability of the uterus to contract after a C-section in women with type 2 or gestational diabetes. Researchers will take small samples of uterine tissue during t…

This study uses tiny samples of uterine tissue from women having planned C-sections to test which backup drug best helps the uterus contract after carbetocin. The goal is to find the most effective treatment to prevent severe bleeding after childbirth. About 32 women will provide…

This study looks at how four different blood pressure medicines (ephedrine, phenylephrine, norepinephrine, and vasopressin) affect the contraction of uterine muscle and umbilical cord blood vessels. Researchers will test these drugs on tissue samples from 144 women having planned…

This study looks at how different calcium levels in the blood affect a drug called carbetocin, which is used to prevent severe bleeding after a C-section. Researchers will take small samples of uterine muscle from 40 women having planned C-sections and test the muscle's contracti…