Propofol, ketamine, or both? major trial seeks safer emergency intubation

NCT ID NCT06733129

Recruiting now Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial is testing three approaches to rapid sequence induction (RSI) in the operating room: propofol alone, ketamine alone, or a combination of both. The goal is to find which option gives the best balance—successful intubation on the first try without causing a dangerous drop in blood pressure. About 1,200 adults at risk of stomach contents entering the lungs will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: propofol, ketamine, and a combination of ketamine and propofol
What this could lead to: If it works, this could identify the best drug or drug combination to make emergency intubation safer and more stable for patients at risk of aspiration.
What could go wrong: This is a single-center trial, and results may not apply to all hospitals or patient groups. The primary outcome is a composite measure, so success in one part may not mean overall benefit.

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Conditions

The condition(s) this trial relates to.

hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RAPID SEQUENCE INDUCTION

Contacts and locations

Locations

APHP Bicêtre
NOT_YET_RECRUITING

Le Kremlin-Bicêtre, France
APHP St-Antoine
NOT_YET_RECRUITING

Paris, France
APHP Tenon
NOT_YET_RECRUITING

Paris, France
CH Le Mans
RECRUITING

Le Mans, France
CHD Vendée
RECRUITING

La Roche-sur-Yon, France
CHRU de Brest Hôpital Cavale Blanche
RECRUITING

Brest, France
CHU Dijon
RECRUITING

Dijon, France
CHU Grenoble Alpes
NOT_YET_RECRUITING

Grenoble, France
CHU Lille Hopital Salengro
RECRUITING

Lille, France
CHU Lille Hôpital Claude Huriez
RECRUITING

Lille, France
CHU Lyon Hôpital Sud
NOT_YET_RECRUITING

Lyon, France
CHU Poitiers
RECRUITING

Poitiers, France
CHU Toulouse Hôpital Purpan
NOT_YET_RECRUITING

Toulouse, France
CHU Toulouse Hôpital Rangueil
NOT_YET_RECRUITING

Toulouse, France
Ch Louis Pasteur
NOT_YET_RECRUITING

Chartres, France
Chr Angers
RECRUITING

Angers, France
Chu Nantes
RECRUITING

Nantes, 44093, France
Chu Nantes (Laennec)
RECRUITING

Nantes, 44093, France
HCL Lyon Croix-Rousse
NOT_YET_RECRUITING

Lyon, France
Hopital Foch
RECRUITING

Suresnes, France

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