Propofol, ketamine, or both? major trial seeks safer emergency intubation
NCT ID NCT06733129
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial is testing three approaches to rapid sequence induction (RSI) in the operating room: propofol alone, ketamine alone, or a combination of both. The goal is to find which option gives the best balance—successful intubation on the first try without causing a dangerous drop in blood pressure. About 1,200 adults at risk of stomach contents entering the lungs will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
propofol, ketamine, and a combination of ketamine and propofol
What this could lead to
If it works, this could identify the best drug or drug combination to make emergency intubation safer and more stable for patients at risk of aspiration.
What could go wrong
This is a single-center trial, and results may not apply to all hospitals or patient groups. The primary outcome is a composite measure, so success in one part may not mean overall benefit.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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APHP Bicêtre
NOT_YET_RECRUITINGLe Kremlin-Bicêtre, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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APHP St-Antoine
NOT_YET_RECRUITINGParis, France
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APHP Tenon
NOT_YET_RECRUITINGParis, France
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CH Le Mans
RECRUITINGLe Mans, France
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CHD Vendée
RECRUITINGLa Roche-sur-Yon, France
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CHRU de Brest Hôpital Cavale Blanche
RECRUITINGBrest, France
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CHU Dijon
RECRUITINGDijon, France
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CHU Grenoble Alpes
NOT_YET_RECRUITINGGrenoble, France
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CHU Lille Hopital Salengro
RECRUITINGLille, France
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CHU Lille Hôpital Claude Huriez
RECRUITINGLille, France
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CHU Lyon Hôpital Sud
NOT_YET_RECRUITINGLyon, France
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CHU Poitiers
RECRUITINGPoitiers, France
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CHU Toulouse Hôpital Purpan
NOT_YET_RECRUITINGToulouse, France
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CHU Toulouse Hôpital Rangueil
NOT_YET_RECRUITINGToulouse, France
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Ch Louis Pasteur
NOT_YET_RECRUITINGChartres, France
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Contact
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Chr Angers
RECRUITINGAngers, France
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Chu Nantes
RECRUITINGNantes, 44093, France
Contact
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Chu Nantes (Laennec)
RECRUITINGNantes, 44093, France
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HCL Lyon Croix-Rousse
NOT_YET_RECRUITINGLyon, France
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Hopital Foch
RECRUITINGSuresnes, France
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