Can a tiny dose of norepinephrine prevent organ damage during emergency surgery?

NCT ID NCT07719075

Not yet recruiting Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This trial tests whether a 5-microgram or 10-microgram bolus of norepinephrine is better at quickly raising dangerously low blood pressure during emergency abdominal surgery. Low blood pressure after anesthesia is common in these surgeries and can harm organs if not treated fast. The study will enroll 136 adults undergoing emergency abdominal surgery and compare how often each dose restores normal blood pressure within two minutes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: norepinephrine given as a small bolus dose (5 or 10 micrograms) to raise blood pressure during surgery
What this could lead to: If one dose works better, it could help doctors quickly and safely treat low blood pressure during emergency surgeries, reducing the risk of organ damage.
What could go wrong: This is a small, early-stage trial comparing two doses, so it may not find a clear winner. Norepinephrine can cause side effects like rapid heart rate or high blood pressure.

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Conditions

The condition(s) this trial relates to.

hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EMERGENCY SURGERY HYPOTENSION ON INDUCTION NOREPINEPHRINE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Cairo University

Cairo, Cairo Governorate, Egypt

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