SEPSIS

This study is testing whether giving plasma (the liquid part of blood) can help protect and repair the lining of blood vessels in people with sepsis, a life-threatening infection response. Researchers will compare plasma given in different ways against a placebo fluid in 45 adult…

This study is testing if adding a drug called MEX-CD1 to dialysis fluid can safely remove excess iron from the blood of ICU patients with severe kidney failure caused by sepsis. Fourteen participants will receive two 24-hour dialysis sessions—one standard and one with the added d…

This small pilot study aims to see if adding a drug called fludrocortisone to standard treatment helps patients survive septic shock, a deadly condition where infection causes dangerously low blood pressure. The study will involve 32 critically ill patients in intensive care unit…

This study aims to find out if giving certain antibiotics over a longer 3-hour period is more effective than the standard 30-minute infusion for critically ill children with severe infections like sepsis. Researchers will compare the two methods in 110 children (ages 0-17) in int…

This study aims to find out if one common IV fluid is better than another for the initial emergency treatment of sepsis, a life-threatening infection response. Researchers will compare Ringer's lactate solution to normal saline in 88 adult patients to see which fluid leads to bet…

This study tests whether adding steroids and stronger antibiotics to standard care improves survival for HIV patients with severe sepsis in Africa. Researchers will compare different treatment combinations in 344 hospitalized adults to see which approach works best. The goal is t…

This study is testing whether curcumin, the active compound in turmeric, can help control the dangerous, body-wide inflammation that makes sepsis so deadly. It will involve 56 critically ill sepsis patients in Mexico. Half will receive curcumin and half a placebo, in addition to …

This study aims to see if starting a blood pressure medication called norepinephrine very early in treatment helps adults survive septic shock, a life-threatening condition. Researchers will compare giving the medication quickly with adjusting the dose every 15 minutes to the sta…

This study tests two different phone-based follow-up strategies to help adult sepsis patients survive the critical 90 days after leaving the hospital in Sub-Saharan Africa. Researchers will compare standard follow-up care against standard care plus automated phone check-ins to se…

This study aims to find the best way to dose the antibiotic ceftazidime for critically ill patients in the ICU with severe infections like sepsis. It will compare a standard dosing method against a new, personalized approach that adjusts the dose based on each patient's body. The…

This project tests whether using a standardized 1-hour checklist for treating sepsis can save more lives. It will compare outcomes for about 120 patients treated before and after the new protocol is introduced at a hospital's emergency and intensive care units. The goal is to get…

This trial is testing a personalized treatment plan for adults hospitalized with severe infections like sepsis. The goal is to prevent organ failure by quickly identifying and treating specific problems in the lungs, heart, liver, blood, or immune system. Researchers will compare…

This study aims to find the best way to give a common type of antibiotic to adults with severe infections (sepsis) in the intensive care unit. It will compare giving the medicine in longer, extended infusions versus the standard shorter, intermittent doses. The goal is to see whi…

This study is testing whether Racecadotril, a drug typically used for diarrhea, can help protect organs in patients with sepsis—a life-threatening body-wide infection. Researchers will give 44 sepsis patients either Racecadotril or a placebo (inactive substance) through a feeding…

This study is testing whether a daily gut bacteria supplement can help adults recover after being treated in the intensive care unit (ICU) for sepsis. Researchers want to see if the supplement is safe and if it helps restore healthy gut bacteria. They will compare the supplement …

This study aims to find the best blood filtering method to help children with severe sepsis. Sepsis is a life-threatening overreaction to infection where the body's own inflammatory chemicals damage organs. Researchers will compare three different blood purification techniques in…

This is an early safety study for a new drug called OPT101, designed for adults hospitalized with pneumonia that has led to sepsis. The main goal is to see if the drug is safe and how it moves through the body in this seriously ill group. Researchers will compare the drug to a pl…

This large international trial aims to find better, personalized treatments for sepsis, a life-threatening response to infection. It will enroll 2,000 children and adults to test multiple treatments at once, matching them to a patient's specific biological traits. The goal is to …

This study aims to see if dapagliflozin, a drug typically used for diabetes, can reduce harmful inflammation in patients with sepsis, a life-threatening body-wide infection. Researchers will give the drug or a placebo to 64 adults in the ICU and measure specific markers in the bl…

This study is testing whether intensive care unit (ICU) nurses can learn to use a specific type of bedside ultrasound, called VExUS, to reliably check for blood congestion in the veins of sepsis patients. Sepsis is a severe reaction to infection that can cause organ damage, and e…

This study is testing two new computer-generated risk scores designed to give doctors an early warning. One score predicts a patient's risk of developing sepsis in the next four hours, and the other predicts their risk of serious deterioration. The goal is to see if providing the…

This study aims to find better ways to detect kidney injury early in adults with sepsis, a life-threatening infection. Researchers will test if a special kidney ultrasound and a urine test can spot signs of kidney stress before standard blood tests show a problem. The goal is to …

This study aims to create and test a new early warning system to help doctors identify sepsis in children faster and more accurately. It will involve 40,000 children under 18 across Asia who are hospitalized with a suspected infection. The goal is to validate a scoring system and…

This study aims to create and test a computer software tool that helps doctors identify sepsis in children much earlier during an emergency room visit. The tool combines artificial intelligence with a child's electronic health records and results from a special panel of blood tes…

This study is testing a new device that sends mild electrical signals to the thigh muscles of people in the Intensive Care Unit (ICU). The goal is to see if using the device is safe and practical, and if it can help slow down the severe muscle weakness that often develops in crit…

This study aims to understand what happens to sepsis patients after they leave the hospital. Researchers will follow 760 adult patients in Brazil for one year after their hospital stay to track survival rates, hospital readmissions, quality of life, and cognitive function. This i…

This study aims to better understand how heart and blood vessel problems affect people with severe sepsis. Researchers will observe 400 adults hospitalized with sepsis who need medication to support their blood pressure. They will perform heart ultrasounds, blood tests, and check…

This study aims to test whether a new scoring system (SOFA-2) can better predict which ICU patients with sepsis will survive. Researchers will collect routine medical data from 2,500 adult ICU patients across Turkey to compare the new score against the old one. The study will als…

This study aims to find the best computer tool for spotting sepsis early by comparing three different prediction algorithms. The tools will run quietly in the background of hospital records for 1,200 adult patients arriving at the emergency department, without doctors or patients…

This study aims to understand what causes anemia in newborns admitted to intensive care and how it affects their health. Researchers will observe 40 infants to identify risk factors and track outcomes like hospital stay length and need for blood transfusions. The study does not t…

This study aims to create a computer model that predicts which sepsis patients have antibiotic-resistant infections. Researchers will analyze data from 10,000 adult patients with sepsis at a Buenos Aires hospital to identify patterns and risk factors. The goal is to help emergenc…

This study aims to understand why some older adults don't fully recover their strength and mobility after surviving a serious illness like sepsis or acute lung injury. Researchers will follow 150 patients aged 40+ for two years after hospital discharge, measuring their muscle str…

This study aims to understand why patients with sepsis-related severe lung failure (ARDS) have such different outcomes despite similar appearances. Researchers will closely monitor 180 patients during their first 72 hours of treatment, collecting fluid samples from their lungs an…

This study aims to learn how the body's natural inflammation-resolving molecules change in adults with severe infections in the ICU. Researchers will measure these molecules in blood already taken for routine care from about 300 patients to see if their levels can help identify p…

This study aims to see if sending supportive messages helps people recovering from sepsis share their health information from home. Researchers will compare 200 patients who get these messages to those who don't, to see who is better at providing data. The goal is to learn how to…

This large international study aims to understand and predict serious complications that can happen after non-heart surgery in older adults. It will follow 20,000 patients aged 65+ for a year, using a wearable sensor to collect health data for the first 30 days. The goal is to us…

This study aims to see if simple, non-invasive checks of blood flow to the skin (like pressing a fingernail) and routine blood tests are linked to how well adults with sepsis recover in the intensive care unit (ICU). Researchers will observe 80 patients, collecting standard clini…

This study aims to understand how sepsis (a severe body-wide infection) changes the immune system's activity over time. Researchers will track 290 ICU patients—including 200 with sepsis, 50 critically ill without infection, and 40 healthy controls—for up to one year. By analyzing…

This study aims to understand how common and serious infections are in intensive care units (ICUs) worldwide. Researchers will collect information from 10,000 adult ICU patients across the globe during a single day to see what types of infections occur, how they're treated with a…

This study aims to learn if specific patterns of immune cells in the blood can predict outcomes for adults with severe infections (like sepsis) in the ICU. Researchers will collect small blood samples from 200 participants during their ICU stay and review their medical records, w…

This study aims to understand how well current treatments work for people with liver cirrhosis who develop a life-threatening bloodstream infection called sepsis. Researchers will look back at the medical records of 1,600 patients to see which treatment approaches were linked to …

This study aims to see if a simple calculation using heart rate and blood pressure, called the Modified Shock Index, can help doctors better predict how sick a sepsis patient will become. Researchers will enroll 70 adults arriving at the emergency department with sepsis to test t…

This study aims to better understand how the body recovers from serious burns and to identify early warning signs for dangerous infections like sepsis. Researchers will follow 80 adult patients with major burns, collecting small blood samples and reviewing their medical records d…

This study aims to understand how a common antibiotic combination is removed by kidney dialysis machines in critically ill patients with severe infections. Researchers will measure drug levels in 24 intensive care patients who are on dialysis and receiving this antibiotic. The go…

This is a small pilot study to see if it's practical to test an educational brochure for adults who survived sepsis in the ICU. Researchers want to know if they can successfully recruit 30 participants and deliver the brochure as planned. The study will compare usual discharge ca…

This study aims to see if a new, quick bedside blood test can predict which critically ill patients are most likely to die within 30 days. Researchers will enroll 130 adults in the ICU with severe conditions like sepsis, shock, or major trauma. They will compare the new finger-pr…

This study creates a registry to track outcomes for patients receiving ECMO life support in the Caribbean region. It will follow 1,200 patients with severe heart or lung failure who need this advanced treatment. The main goal is to understand survival rates and complications to i…

This study is testing whether an AI assistant can help doctors make better decisions for critically ill patients in intensive care. About 1000 adult ICU patients will be randomly assigned to receive either standard care or care where doctors can see AI suggestions. Researchers wi…

This national study will collect information from 10,000 emergency abdominal surgery patients across Saudi Arabia to understand current outcomes and identify ways to improve care. Researchers will review medical records to track complications, recovery times, and survival rates a…

This study follows adults with serious burns to understand how their bodies recover and identify who might develop dangerous infections like sepsis. Researchers will collect small blood and tissue samples along with medical record information to look for patterns. The goal is to …

Norwegian guidelines for empirical antibiotic therapy in suspected community acquired sepsis recommend the combination of narrow spectrum betalactam and aminoglycoside as the first choice, but broad spectrum betalactams are considered equally appropriate, effective, and safe. How…