SEPSIS

This study tests whether fenofibrate (a cholesterol drug) or silymarin (a milk thistle extract) can help adults with sepsis, a life-threatening infection that causes organ failure. About 66 patients will receive one of the two drugs, and researchers will measure changes in blood …

This study looks at whether giving antibiotics over 3 hours instead of the usual 30 minutes helps critically ill children (ages 0-17) recover faster from severe infections. About 110 children in intensive care will be randomly assigned to one of the two infusion speeds. Researche…

This study tests whether the steroid methylprednisolone can help critically ill patients with severe inflammation from sepsis or acute respiratory distress syndrome (ARDS). About 150 adults in the ICU will receive either a high or low dose of the drug or a placebo for up to 7 day…

This study tests whether tailoring sepsis treatments to each patient's specific biological traits can improve survival and reduce time on life support. About 2000 children and adults with sepsis will receive either standard care or treatments guided by their individual biomarkers…

This study compares two FDA-approved antibiotic combinations to see which one is less likely to harm the kidneys in hospitalized adults with serious infections. About 852 participants will be randomly assigned to receive either vancomycin with piperacillin/tazobactam or vancomyci…

This study tests two ways to follow up with adult patients who survived sepsis in the hospital. The goal is to see if extra support after discharge can reduce deaths within 90 days. About 1,410 adults from Uganda, Nigeria, Ghana, and Mozambique will take part. The results could h…

This study tests whether a newer blood thinner, nafamostat mesylate, works as well as the standard citrate during continuous kidney dialysis in people with sepsis-related kidney injury. About 1,162 adults will be randomly assigned to receive one of the two drugs. The main goal is…

This study tests a new pre-mixed fluid that contains phosphate for ICU patients needing continuous kidney dialysis (CRRT). Standard fluids can wash out phosphate, causing muscle weakness and breathing problems. The trial will compare the new fluid to the standard one in 220 adult…

This study looks at whether the type of IV fluid given to adults with sepsis in the emergency room affects their chance of survival within 24 hours. Researchers will compare Ringer's lactate to normal saline in 88 patients. The goal is to see if one fluid leads to better short-te…

This early-stage study tests whether adding the iron-binding drug MEX-CD1 to dialysis fluid can safely remove extra iron in adults with sepsis and acute kidney injury in the ICU. Fourteen participants will each receive two 24-hour dialysis sessions—one standard and one with the d…

This study compares different blood purification techniques to see which best reduces harmful inflammation in children with sepsis. About 120 children aged 29 days to 18 years with sepsis-related organ failure will be enrolled. The goal is to find a better way to lower inflammato…

This study tests whether giving a calming drug called dexmedetomidine early can help people with septic shock. The drug aims to calm an overactive nervous system, reduce organ damage, and improve survival. About 168 adults will receive either the drug or a placebo for 48 hours, a…

This study tests whether a new set of steps for treating sepsis can help patients get the right care faster. Researchers will compare outcomes for 120 adults treated before and after the new protocol is introduced. The goal is to give key treatments like antibiotics and fluids wi…

This study tests whether giving fresh frozen plasma (FFP) to people with sepsis can protect or repair the protective lining of blood vessels, which is often damaged during sepsis. About 45 adults in the ICU will receive either FFP (as intermittent doses or continuous infusion) or…

This early-stage trial tests whether Racecadotril, a drug used for diarrhea, can reduce organ injury in people with sepsis. About 44 adults in intensive care will receive either the drug or a placebo, plus standard sepsis treatment, for up to 4 days. The main goal is to see if or…

This study tests whether N-acetylcysteine (NAC), an antioxidant, can help adults with severe infections or sepsis who also have liver problems. 360 participants will receive either NAC or a placebo through an IV on their first day in the hospital. The goal is to see if NAC increa…

This study tests whether curcumin, a natural compound found in turmeric, can help control the overwhelming immune response in critically ill patients with sepsis. Sepsis is a life-threatening condition where the body's reaction to infection damages its own organs. The trial will …

This early-stage study tests a new drug, OPT101, in 26 adults hospitalized with community-acquired pneumonia and sepsis. The goal is to check if the drug is safe and how the body processes it. Participants receive either OPT101 or a placebo for up to 4 days, and researchers monit…

This study tests whether adding fludrocortisone to the usual steroid treatment (hydrocortisone) can help control septic shock better. It is a small pilot trial with 32 critically ill adults in the ICU. The main goal is to see if a larger, more definitive study is possible, not ye…

This study aims to find the best way to give the antibiotic ceftazidime to patients in intensive care with serious infections. Standard dosing often fails to reach effective levels in 40-60% of patients. The researchers will test a personalized dosing plan based on each patient's…

This study tests whether adding steroids and a powerful antibiotic combination to standard care can help more people with HIV survive sepsis, a life-threatening infection. About 344 adults in sub-Saharan Africa will receive either standard treatment or the enhanced therapy. The g…

This study will test a new tool called the Sepsis ImmunoScore to see if it helps doctors diagnose sepsis more quickly and accurately. Sepsis is a life-threatening reaction to infection. The study will include 5000 adults in U.S. hospitals who are suspected of having sepsis. Resea…

This study aims to create a screening tool that uses artificial intelligence and special blood tests to help doctors find sepsis in children sooner. Sepsis is a life-threatening reaction to infection, and early treatment saves lives. The tool will be tested in emergency rooms usi…

This study tests a device that sends mild electrical pulses to the thigh muscles of people in the intensive care unit (ICU). The goal is to see if it is safe and practical to use, and whether it can help prevent muscle weakness that often happens during long ICU stays. About 50 a…

This study will follow 20,000 older adults (65+) after noncardiac surgery to see if a wearable sensor can predict serious complications like heart injury, severe bleeding, and infections. Researchers will collect continuous health data for 30 days after surgery and use machine le…

This study follows 40 adults with serious burns to collect blood, tissue, and medical data. Researchers will look for patterns that could help predict who is at higher risk for infections like sepsis. The goal is to build computer models that improve burn care and outcomes.

This study will test whether an artificial intelligence (AI) tool, similar to ChatGPT-5, can help doctors make better decisions for critically ill patients in the intensive care unit (ICU). About 1000 adults will be randomly assigned to either standard care or care where doctors …

This study looks at 50 adults with sepsis or septic shock in the ICU to see if giving beta-lactam antibiotics over a longer period (extended infusion) works better than giving them all at once (intermittent dosing). The main goal is to check survival rates at 90 days and how well…

This study follows 80 adults with serious burns to collect blood, tissue, and medical record information. Researchers will look for patterns that could help predict who is at higher risk for infections like sepsis or other complications. The goal is to use this data to build comp…

This study looks at whether simple signs of blood flow to the skin, like how fast color returns after pressing a nail, are linked to recovery in adults with sepsis in the ICU. Researchers will collect routine data and blood tests on the first day only, with no extra procedures. T…

This study looks at whether a new rapid blood test, done right at the patient's bedside, can help predict which critically ill patients are at higher risk of dying within 30 days. The test measures a substance called nucleosomes in the blood. Researchers will compare this quick t…

This study looks at how the antibiotic piperacillin-tazobactam is cleared from the body by continuous kidney replacement therapy in intensive care patients with severe infections. Researchers will measure drug levels in 24 adults to help doctors give the right dose—avoiding under…

This study will collect information from 10,000 patients across Saudi Arabia who need emergency abdominal surgery. Researchers want to see how well patients recover, what complications happen, and how care can be improved. The goal is to create national standards and a risk tool …

This study looks at whether taking a daily capsule of a friendly gut bacteria (Akkermansia muciniphila) for 56 days can help adults recover after being treated in the ICU for sepsis. The main goals are to check if the supplement is safe and if it increases helpful gut bacteria. R…

This study will test whether dapagliflozin, a diabetes medicine, can reduce inflammation in adults with sepsis. Researchers will measure changes in an inflammatory marker called IL-10 and compare it to HDL cholesterol to see which better predicts organ failure and death. The goal…

This study looks at whether a special heart ultrasound can better predict serious problems in people with sepsis. Researchers will follow 200 adults in intensive care units across four countries. They will take regular heart scans and track health for up to one year. The goal is …

This study will look at why some newborns in the intensive care unit develop anemia (low red blood cells) and how it affects their recovery. Researchers will track 40 babies to find risk factors like infections or birth complications. The goal is to better understand the problem …

This study looks at 180 adults with sepsis-related acute respiratory distress syndrome (ARDS), a severe lung condition. Researchers will collect fluid from the lungs and blood samples at three time points in the first 72 hours, along with breathing machine data. The goal is to id…

This study will compare three computer programs that try to predict sepsis, a life-threatening reaction to infection, in 1,200 adults coming to the emergency room. The programs will run silently in the background of the hospital's computer system, and doctors will not see their p…

This study follows 150 older adults (age 40+) who survived a stay in the intensive care unit (ICU) for sepsis or lung injury. Researchers will measure muscle strength and physical function at hospital discharge and again at 3, 6, 12, and 24 months. A small group will also have mu…

This study aims to create a simple, accurate tool to help doctors quickly recognize sepsis in children. Researchers will test the tool in 40,000 children under 18 with suspected infections across multiple hospitals in Asia. The goal is to improve early detection and reduce deaths…

This study looks at whether a simple calculation using heart rate and blood pressure (called the Modified Shock Index) can help predict how serious sepsis is for patients arriving at the emergency department. Researchers will follow 70 adults with sepsis to see if this score rela…

This study looks at how immune cells change in adults with severe infection in the ICU. Researchers want to see if certain immune patterns are linked to survival, organ failure, or longer hospital stays. About 200 participants will provide blood samples and allow their medical re…

This study tests whether giving a simple brochure to sepsis patients leaving the intensive care unit (ICU) is practical and helpful. Researchers will enroll 30 adults with sepsis to see if they can successfully deliver the brochure and answer questions. The goal is to learn if th…

This study looks at whether intensive care nurses can learn to use a special ultrasound method called VExUS to detect vein congestion in patients with sepsis. Sepsis can cause blood to back up in veins, leading to organ damage. The goal is to see if nurses can perform the ultraso…

This study observes 400 adults with sepsis and unstable blood pressure to see how their heart and blood vessels respond. Participants will have heart ultrasounds, blood tests, and blood flow checks within 72 hours of hospital admission. Researchers will track survival for one yea…

This study will look back at medical records of 1,600 patients with liver cirrhosis who also have sepsis, a severe infection. The goal is to understand how doctors use antimicrobial drugs and how that affects survival. The main focus is on whether patients are alive 28 days after…

This study will look at 10,000 adults in intensive care units (ICUs) around the world to find out how common infections are and how they are treated. Researchers will collect information from medical records during a single 24-hour period. No new treatments or tests will be given…

This study is a registry that will follow 760 adults hospitalized with sepsis. Researchers will collect information on how patients are treated in the hospital and what happens to them after they leave, including survival and heart-related problems. The goal is to better understa…

This study looks at 300 adults in the ICU with severe infection or sepsis. Researchers will measure natural molecules called SPMs that help the body turn off inflammation. The goal is to see how SPM levels relate to organ function and survival. No extra treatments or blood draws …

This study will collect information from 1,200 patients in the French West Indies and Guiana who receive ECMO, a machine that helps the heart and lungs work. The goal is to learn how well ECMO works and what problems may occur. No new treatments are being tested; instead, researc…

This study looks at how sepsis alters the RNA in white blood cells, which may explain why some patients have long-lasting immune problems. Researchers will follow 290 adults, including 200 with sepsis, 50 critically ill without infection, and 40 healthy controls. They will take b…

This study aims to create a predictive model that helps emergency doctors quickly identify which sepsis patients are likely to have drug-resistant infections. By analyzing data from 10,000 adults treated for sepsis or septic shock, researchers hope to improve antibiotic choices a…

This study aims to see if a new scoring system called SOFA-2 can better predict which intensive care patients are at risk of dying within 30 days. Researchers will also measure how common sepsis and septic shock are in Turkish ICUs. About 2,500 adult patients will have their rout…

This study looks at whether a simple ultrasound of the kidneys and a urine test can help doctors detect kidney injury early in people with sepsis. Researchers will follow 130 adults with sepsis to see if these tests can predict kidney problems before they become serious. The goal…