SEPSIS

This study tests whether ulinastatin, a drug that reduces inflammation, can help patients with severe abdominal infections. The infection often causes the immune system to overreact, leading to organ failure and high risk of death. Researchers will give patients either a low or h…

This study tests whether fecal microbiota transplantation (FMT) can help ICU patients with sepsis. Sepsis is a life-threatening infection that can cause organ failure. The trial will give 60 adults either standard care or standard care plus FMT through a tube into the gut for thr…

This trial tests a device called Nucleocore that removes cell-free DNA (cfDNA) from the blood of people with septic shock. High cfDNA levels are linked to severe inflammation and worse outcomes. The study enrolls adults aged 18-65 with septic shock and elevated cfDNA, and measure…

This phase 3 trial tests whether adding a steroid (hydrocortisone) and a stronger mix of antibiotics to standard care can improve survival in HIV patients with sepsis in sub-Saharan Africa. The study will enroll 344 adults and measure how many are alive after 28 days. It aims to …

This study compares two blood thinners used during continuous dialysis in adults with sepsis and acute kidney injury. About 1,162 participants will receive either nafamostat mesylate or standard citrate anticoagulation. The main goal is to see which approach reduces death, ongoin…

This early-stage trial tests a drug called romiplostim in 280 sepsis patients with very low platelet counts (under 50). The drug is given as a weekly shot to try to raise platelet levels. Researchers will compare it to a standard treatment and check how well it works after 7 days…

This Phase 2 trial tests whether adding the drug nogapendekin alfa inbakicept (NAI) to standard sepsis care can improve survival in critically ill adults with sepsis and persistently low lymphocyte counts (a sign of immune suppression). About 50 participants will be randomly assi…

This study tests two drugs—fenofibrate (a cholesterol medicine) and silymarin (from milk thistle)—in 66 adults with sepsis. The goal is to see if either can reduce harmful inflammation and organ damage better than standard care alone. The trial is not yet recruiting and is in Pha…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study tests a new pre-mixed fluid that contains phosphate for patients in the ICU who need continuous kidney replacement therapy (CRRT). The standard fluid often washes out phosphate, causing muscle weakness and breathing problems. The trial will compare the new fluid to the…

Sepsis damages the protective lining of blood vessels, leading to organ failure and death. This study tests whether giving fresh frozen plasma—either as short infusions or continuously—can repair that lining better than a placebo fluid. About 45 adults with sepsis in the ICU will…

This study looks at whether giving antibiotics over 3 hours works better than the usual 30-minute drip for critically ill children (0-17 years) with severe infections. About 110 kids in intensive care will take part. The goal is to see if the longer infusion clears the infection …

This study tests whether a single dose of N-acetylcysteine (NAC), an antioxidant, can help adults with severe infections and liver dysfunction recover faster. 360 participants will receive either NAC or a placebo infusion within 24 hours of hospital admission. The main goal is to…

This study tests whether giving the sedative dexmedetomidine early to adults with septic shock can calm their overactive nervous system and improve survival. 168 participants will receive either the drug or a placebo for 48 hours, with close monitoring of heart function, inflamma…

This study will test whether a standardized set of emergency steps—including early screening, blood tests, fluids, and antibiotics—can improve survival for sepsis patients. Researchers will compare outcomes for 120 adults treated before and after the new protocol is introduced. T…

This study tests whether curcumin, the active compound in turmeric, can help regulate the overactive immune response in critically ill patients with sepsis. Fifty-six participants will receive either curcumin or a placebo alongside standard care for 10 days. Researchers will meas…

This study compares three blood purification methods in 120 children with sepsis, aged 29 days to 18 years. The goal is to see which method best reduces inflammatory chemicals and organ damage. Researchers will also check survival rates at 28 days.

This study tests two ways to follow up with adult patients who survived sepsis in the hospital. One group gets enhanced discharge instructions, and the other gets those instructions plus automated phone calls checking on symptoms and providing health tips. The goal is to see if t…

This study looks at two methods of giving beta-lactam antibiotics to patients with sepsis or septic shock in the ICU: a slow 4-hour infusion versus a quick 30-minute infusion. Researchers will track survival at 90 days and whether the infection clears within 14 days. The goal is …

This study tests whether giving sepsis patients drugs tailored to their specific biological traits can improve survival and reduce the need for life support. It will enroll 2000 adults and children across multiple countries, using an adaptive platform to test several treatments a…

This study tests whether a daily capsule of pasteurized Akkermansia muciniphila, a type of beneficial gut bacteria, can help adults recover after being treated for sepsis in the ICU. Fifty participants will take either the supplement or a placebo for 56 days. Researchers will che…

This study tests whether adjusting beta-lactam antibiotics based on blood levels helps critically ill sepsis patients recover faster. 198 adults in the ICU will be randomly assigned to either standard dosing or dosing guided by regular blood tests. The goal is to see if personali…

This study tests whether Ringer's lactate or normal saline is better for the first fluids given to adults with sepsis in the emergency department. About 88 participants will receive one of the two fluids and be monitored for 24 hours. The main goal is to see if one fluid reduces …

This early-stage trial tests a drug called OPT101 in 26 adults hospitalized with pneumonia and sepsis. The drug is designed to reduce harmful inflammation. The main goal is to check safety and how the body processes the drug, not yet to prove it works.

This study will test a new biomarker called t6A to see if it can help doctors diagnose bacterial infections in newborn babies early. Researchers will measure t6A levels in 210 infants who need blood tests for suspected infection. The goal is to find a more accurate way to detect …

This study explores whether routine blood tests—like CBC and lactate levels—can help doctors diagnose sepsis in newborns more quickly than waiting 2-3 days for a blood culture. Researchers will enroll 80 infants in the NICU with signs of infection and compare these rapid test res…

This study will check if certain blood markers can quickly tell whether a patient has sepsis or another life-threatening condition. Researchers will measure these markers over 24 hours in emergency patients with organ dysfunction. The goal is to improve early diagnosis and guide …

This study will test a new rapid test called NuRapid-CRISPR that uses CRISPR technology to quickly find the germ causing sepsis in ICU patients. The goal is to see if using this test helps doctors choose the right antibiotics faster and reduces deaths within 28 days. About 396 ad…

This study tests a new AI tool called Sepsis ImmunoScore that helps doctors quickly identify patients at risk of sepsis. Researchers will enroll 5,000 adults in U.S. hospitals to see if the tool improves diagnosis and speeds up treatment. The goal is to reduce serious complicatio…

This study will test whether a kidney ultrasound and a urine test can predict acute kidney injury in people with sepsis. Researchers will measure kidney blood flow and specific urine markers in 130 adults shortly after sepsis diagnosis. The goal is to see if these tests can spot …

This study will test a new AI-powered screening tool that uses biomarker data to help doctors recognize sepsis earlier in children arriving at the emergency room. Over 12,000 participants, including children with suspected sepsis and controls, will be enrolled. The goal is to imp…

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This study looks at how sepsis affects the bone marrow, where immune cells are made. Researchers will compare bone marrow samples from 45 people: those with sepsis, other critically ill patients, and healthy volunteers. The goal is to understand why sepsis can weaken the immune s…

This study looks at how esmolol, a drug that slows the heart rate, affects the smallest blood vessels in people with septic shock—a severe infection that can lead to organ failure. Researchers will measure changes in blood flow under the tongue and other key pressures in the circ…

This study looks at how the sedative dexmedetomidine affects the smallest blood vessels in people with septic shock, a life-threatening condition caused by severe infection. Researchers will measure blood flow in the tongue's tiny vessels and other key blood pressure indicators b…

This pilot study will test a drug called anisodamine in 20 adults with septic shock who are on a ventilator. The goal is to see if the drug can improve blood flow in small blood vessels and help with a phenomenon called 'vascular waterfall.' This is a very early study to gather i…

This study will compare two common anesthesia methods—inhaled gas versus intravenous drugs—to see which one causes less lung injury after major surgery in patients with sepsis. About 480 adults with sepsis who need surgery will be randomly assigned to one of the two groups. Resea…

This study will test whether combining data from wearable sensors—measuring temperature, humidity, and sweat lactate—can predict the onset of sepsis in ICU patients. Researchers will monitor 360 adults at risk of sepsis for up to 48 hours. The goal is to use this data to train ar…

This study looks at whether measuring the fluorescence of certain white blood cells (neutrophils) can help doctors quickly identify sepsis patients at risk of severe complications like organ failure or septic shock. Researchers will analyze blood samples from 492 adults in the em…

This study will test whether a special type of heart ultrasound can better predict serious outcomes in adults with sepsis in the ICU. Researchers will compare these new measurements with standard ones in 200 patients across four countries. Participants will have regular echocardi…

This study will observe how safe and effective the antibiotic Zavicefta is when used in everyday medical practice in Japan. It includes 59 patients with sepsis (a severe blood infection) or reduced kidney function who are receiving Zavicefta for the first time. Researchers will t…

VISION-2 is a large observational study of 20,000 older adults having noncardiac surgery. Participants will wear a continuous vital signs monitor for up to 30 days after surgery. The goal is to find early warning signs of serious complications like heart injury, severe bleeding, …

This study is a registry that will follow about 760 adults hospitalized with sepsis. Researchers will track their care in the hospital and health outcomes for up to 12 months after discharge. The goal is to better understand how sepsis is managed and what happens to patients long…

This study will observe 84 critically ill children with sepsis to understand how often heart injury occurs and what predicts it. Researchers will use blood tests and heart ultrasounds to track heart function. The goal is to better identify and manage heart problems in these child…

This study will check if a simple calculation called the Modified Shock Index (heart rate divided by mean arterial pressure) can predict how serious sepsis is in 70 adults coming to the emergency department. Researchers will see if a higher index is linked to needing ICU care, br…

This study will enroll 61 adults with sepsis in the ICU to see if certain blood-based inflammatory and nutritional markers (like NLR, PLR, PNI, and SII) can predict death and disease severity more accurately than established clinical scores like SOFA and APACHE. Researchers will …

This study will look at how antimicrobial drugs are used in people with liver cirrhosis who develop severe infections (sepsis). Researchers will review medical records from 1600 patients to see which treatments work best. The goal is to find ways to reduce deaths within 28 days.

This pilot study tests whether giving sepsis survivors a simple educational brochure when they leave the intensive care unit (ICU) is feasible. Researchers will enroll 30 adults with sepsis and randomly assign them to receive either usual care or the brochure plus a chance to ask…

This observational study will look at 400 adults with sepsis and unstable blood pressure to understand how their heart and blood vessels are affected. Researchers will use ultrasound and blood tests to classify patients into different groups based on their heart and blood vessel …

This study looks at how sepsis changes the RNA in white blood cells over time. Researchers will follow 200 sepsis patients, 50 other critically ill patients, and 40 healthy people to map these changes. The goal is to understand why some people have long-term immune problems after…

This study will collect data from 10,000 patients across Saudi Arabia who undergo emergency abdominal surgery (laparotomy). Researchers will track complications and deaths within 30 and 90 days after surgery. The goal is to understand current care quality, test international risk…

This study looks at whether intensive care nurses can learn to use a special ultrasound method called VExUS to find early signs of blood buildup in the veins of sepsis patients. Sepsis can cause organ damage, and this buildup may make it worse. The study will train nurses, check …

This study will enroll 40,000 children under 18 with suspected infections across Asia to develop and validate an early recognition tool for sepsis. Researchers will test the Phoenix Sepsis Score and create a new toolkit (SORT) to help doctors identify sepsis earlier. The goal is …

This study will check if easy-to-measure signs of blood flow, like how fast color returns after pressing the skin, are linked to outcomes in 80 ICU patients with sepsis. Researchers will collect routine data and blood tests during the first day. No extra treatments or procedures …

This study follows 40 adults with serious burn injuries to collect blood, tissue samples, and medical record data. Researchers will look for patterns that could help predict who will develop sepsis or other complications. The goal is to build a computer-based 'digital twin' model…

This study follows 80 adults with serious burns to understand how their bodies respond to injury and treatment. Researchers collect blood and tissue samples and review medical records to find patterns that might predict sepsis and other complications. The goal is to build compute…

This study looks at whether a routine blood test taken before septorhinoplasty (nose surgery) can help predict how much pain a person will feel right after the operation. Researchers will check the ratio of two types of white blood cells (neutrophils and lymphocytes) and other bl…

This study will collect information from 1,200 patients in the French West Indies and Guiana who received ECMO, a machine that helps the heart and lungs. Researchers aim to track survival rates and complications to better understand how ECMO works in this region. The study does n…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…

This study looks at how immune cells change in adults with severe infection (like sepsis) in the ICU. Researchers will collect blood samples and review medical records to see if certain immune patterns are linked to survival, organ failure, or longer hospital stays. The study doe…

This study will follow 110 adults with sepsis in the ICU to see if the amount of oxygen they receive in the first 24 hours is linked to changes in a blood marker called the uric acid/albumin ratio (UAR). The UAR may indicate oxidative stress and inflammation. Researchers will not…

This study looks at whether combining two blood markers—uric acid/albumin ratio and lactate—can help predict which older adults (65+) with sepsis will develop kidney injury, need blood pressure support, or die within 28 days. Researchers will follow 80 ICU patients who do not hav…

This study compares three computer programs designed to predict sepsis, a life-threatening reaction to infection. Researchers will test these programs on 1,200 adults arriving at the emergency room, but the predictions will not be shared with doctors or patients. The goal is to f…

This study tests whether an AI model (ChatGPT-5) can help doctors make better decisions for critically ill patients in the intensive care unit (ICU). About 1000 adults admitted to the ICU will be randomly assigned to standard care or care where the AI provides diagnostic and trea…

This study will closely monitor 180 adults with sepsis-related acute respiratory distress syndrome (ARDS) who are on breathing machines. Researchers will take fluid samples from the lungs and blood at several time points to measure inflammation and injury markers. The goal is to …

This study compares two scoring systems (REDS and qSOFA) to see which better predicts death within 30 days for adults coming to the emergency room with suspected sepsis. Researchers will enroll 80 patients and track their outcomes. The goal is to find a more accurate tool to help…

This study aims to find the best way to dose the antibiotic ceftazidime for patients in intensive care with serious infections. Many ICU patients don't get enough of the drug because their bodies process it differently. The researchers will test a personalized dosing plan to keep…

This study will track blood sugar levels in 105 ICU patients with sepsis before and after they receive antibiotics. Researchers want to see if large glucose fluctuations or a 'glycemic shock index' can predict serious outcomes like kidney injury or death. The goal is to find a si…

This study will observe 64 adults with sepsis to see if dapagliflozin, a diabetes medicine, reduces inflammation and improves organ function. Researchers will measure inflammatory markers and track severity of illness and survival. The goal is to learn if this drug could be a hel…

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…

This study will look at 40 newborns admitted to a neonatal intensive care unit (NICU) to understand why some develop anemia. Researchers will track risk factors from the mother, the birth, and the baby, as well as outcomes like hospital stay length and need for blood transfusions…

This study looks at how the antibiotics piperacillin and tazobactam are cleared from the body by continuous kidney replacement therapy in intensive care patients with severe infections. Researchers will measure drug levels in 24 adults to better understand dosing needs. The goal …

Sepsis is a life-threatening reaction to infection, and choosing the right antibiotic quickly is critical. This study will analyze data from 10,000 adults treated for sepsis in an emergency department to build a predictive model that estimates the likelihood of multidrug-resistan…