Could too much oxygen harm sepsis patients? new study investigates

NCT ID NCT07332637

Not yet recruiting Knowledge-focused Sponsor: Istinye University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will follow 110 adults with sepsis in the ICU to see if the amount of oxygen they receive in the first 24 hours is linked to changes in a blood marker called the uric acid/albumin ratio (UAR). The UAR may indicate oxidative stress and inflammation. Researchers will not change any treatments—they will simply observe standard care and measure UAR at admission and 24 hours later. The goal is to learn whether high oxygen exposure might cause extra stress on the body and whether UAR could be a useful early warning sign.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could show that a simple blood test (uric acid/albumin ratio) can help doctors monitor oxygen-related stress in sepsis patients, potentially guiding safer oxygen use.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly change care. It only looks at a small group of 110 patients, and results may not apply to all sepsis patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hyperoxia infectious disease with sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPEROXIA / HIGH FIO₂ EXPOSURE URIC ACID/ALBUMIN RATIO (UAR)

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