SEPSIS

This study tested whether giving the steroid dexamethasone early to people with severe sepsis is safe and helps them survive. It included 102 high-risk patients and measured deaths within 28 and 90 days. The goal was to see if this simple treatment could improve outcomes in a lif…

This study tested whether metformin, a common diabetes drug, is safe and practical to use for treating acute kidney injury caused by sepsis. Researchers gave low-dose metformin to 80 ICU patients with sepsis and kidney injury, monitoring for side effects and feasibility. The goal…

This study tested whether giving very high doses of vitamin C to people with sepsis (a severe infection that can cause organ failure) could reduce the risk of death within 28 days. 234 adults in the ICU received either vitamin C or a placebo for up to 4 days. The main goal was to…

This study tested whether a supplement called alpha-lipoic acid could help critically ill patients with sepsis. Eighty adults with sepsis were randomly assigned to receive either the supplement or a placebo daily for seven days. Researchers measured organ function, inflammation, …

This study tested a computer algorithm that uses vital signs to decide which type of IV fluid is best for sepsis patients. Over 2000 adults in emergency rooms were assigned to receive either the algorithm's recommended fluid or usual care. The goal was to see if personalized flui…

This study tested the safety and how the body processes the antibiotic cefiderocol in hospitalized children aged 3 months to 18 years with serious bacterial infections. The goal was to see if the drug is safe and how it works in the body. 53 children participated, and the study i…

This study looked at whether reducing the use of strong, broad-spectrum antibiotics in cancer patients with sepsis or septic shock is as safe as continuing them. The goal is to lower the risk of creating drug-resistant bacteria. Researchers compared a de-escalation strategy to st…

This study tested whether using ultrasound to guide fluid management could improve outcomes in 118 sepsis patients in the ICU. Doctors used ultrasound to check blood flow and heart function before deciding how much fluid to give. The goal was to see if this approach could lower d…

This completed Phase 3 trial tested whether dobutamine, a heart-strengthening drug, can reduce organ failure in 136 ICU patients with septic cardiomyopathy and low blood flow. Patients received either dobutamine or a placebo alongside standard care. The study measured changes in …

This study tested a program called STAR, where a nurse navigator helps sepsis patients for 90 days after they leave the hospital. The nurse checks medications, new health problems, and offers support by phone. Researchers wanted to see if this program lowers the chance of death o…

This study tested whether giving the drug noradrenaline before anesthesia can prevent dangerous low blood pressure in patients with sepsis undergoing surgery. Eighty adults took part, and researchers measured how many experienced a drop in blood pressure after being put to sleep.…

This study tested whether measuring a blood marker called procalcitonin (PCT) could help doctors decide when to stop antibiotics in newborns with late-onset sepsis. Over 500 newborns were included, and the goal was to reduce antibiotic use by 30% without increasing infection recu…

This study looked at whether a new blood test (NuQ H3.1) can help doctors diagnose sepsis faster in adults admitted to intensive care with signs of infection. Researchers compared 34 sepsis patients to a group of surgical patients without infection. The goal was to see if the tes…

This study tested a new rapid test (OCEAN Dx) to identify bacteria in the blood of 110 ICU patients with suspected sepsis. The goal was to see if it works as well as standard blood cultures, which take 48-72 hours. A faster result could help doctors choose the right antibiotics s…

This study tested whether combining standard infection markers (like lactate, CRP, and procalcitonin) with albumin levels could better predict death in sepsis patients in a surgical ICU. Researchers looked at 30 patients and calculated three ratios (lactate-to-albumin, CRP-to-alb…

This study tested whether a new type of blood culture vial works as well as the standard one for detecting sepsis. Researchers collected extra blood samples from 394 patients with suspected bloodstream infections and compared results between the two vials. The goal was to see if …

This study looked at whether measuring a protein called PSP in the blood can help doctors recognize sepsis earlier in ICU patients at high risk. Researchers enrolled 250 adults in China, taking daily blood samples until sepsis was diagnosed or ruled out. The goal was to see if PS…

This study tested a blood test that measures three proteins (ICAM1, CFHR5, and GRN) to help doctors quickly tell whether a fever is caused by bacteria or a virus. Researchers studied 394 adults with high fever and short illness duration. The goal is to improve diagnosis and reduc…

This study tested whether giving a protein called lactoferrin (found in milk) to premature babies could help prevent sepsis, a severe infection. The trial included 180 preterm infants with low birth weight, who received lactoferrin or a placebo within 72 hours of birth. The goal …

This study tested whether a small, wearable device called geko can help prevent dangerous blood clots in the legs of critically ill adults. The geko device uses mild electrical pulses to stimulate leg muscles, improving blood flow. Researchers compared it to standard compression …

This study tested a home-based digital exercise program for older adults who survived sepsis. 21 participants were assigned to either an app-guided exercise routine or standard care. The goal was to see if the program could improve physical function and be safe to use at home.

This pilot study tested whether manual lymphatic drainage, a gentle massage technique, is safe and feasible for patients recovering from septic shock. Researchers enrolled 24 adults in the ICU and compared those who received the massage plus usual care to those who received usual…

This study tested a small, wearable patch called TempShield that continuously monitors body temperature in children ages 1 to 4 in the emergency department. The goal was to see if it could detect fevers earlier than standard thermometers. 72 children participated, and the patch w…

This study looked at 91 sepsis patients in intensive care to create a computer model that predicts the right dose of the antibiotic piperacillin/tazobactam. Researchers took blood samples at different times to measure drug levels. The goal was to develop a tool that helps doctors…

This study looked at whether giving higher doses of two common antibiotics (amikacin and gentamicin) to ICU patients with severe sepsis helps achieve the right levels in the blood. Researchers enrolled 63 critically ill adults to measure if the higher doses reached target concent…

This study looks at how the adrenal glands work in people who are critically ill, such as those with sepsis. Adrenal insufficiency may affect up to 77% of ICU patients, but current tests are not reliable. Researchers will measure hormone levels in 225 participants, including heal…

This pilot study tested whether a heart MRI could be done safely and effectively in children with cancer who recently had sepsis. The goal was to see if the MRI could find hidden heart inflammation or weakness that standard tests might miss. Only 7 children took part, and the foc…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study examines whether intensive care unit (ICU) patients being treated for sepsis receive aminoglycoside antibiotics at doses that achieve the recommended peak concentration in the blood. Researchers will measure drug levels after the first and later doses in about 90 adult…

This study looked at 526 adults with sepsis who had normal blood pressure to see if a simple measure called the diastolic shock index (DSI) and a blood test for lactate could predict which patients would need medication to support their blood pressure within 6 hours. Researchers …

This study tested whether a small ultrasound patch called FloPatch can help emergency doctors predict which sepsis patients will need intensive care. The device measures how well the heart responds to fluids. Researchers followed 134 patients to see if FloPatch readings could pre…

This study followed 400 intensive care patients receiving beta-lactam antibiotics to see how often these drugs cause brain-related side effects like confusion or agitation. Researchers measured antibiotic levels in the blood and checked patients' neurological status several times…

This study looked at how the body processes an antibiotic called piperacillin in intensive care patients who are on a life-support machine (ECMO) compared to those who are not. Researchers wanted to see if ECMO changes antibiotic levels, which could affect how well the drug fight…

This study looked at whether levels of free fatty acids in the blood can help predict how sick a sepsis patient will become. Researchers measured these fats in 74 adults arriving at the emergency department with signs of infection. They then tracked whether patients were admitted…

This completed study looked at 211 people with sepsis, some of whom also had acute kidney injury. Researchers measured specific microRNAs and other markers in the blood to understand how kidney damage happens. The goal was to find new targets for diagnosis or treatment, not to te…

This study looked at how certain molecules in the body change when sepsis causes heart problems. Researchers studied 567 adults in the intensive care unit to find patterns that could explain this damage. The goal was to better understand the disease, not to test a new treatment.

This study looked at 56 patients in a French hospital who had infections from a rare type of Klebsiella pneumoniae bacteria that can be treated with the common antibiotic amoxicillin. Researchers used genetic sequencing to understand why these bacteria are sensitive to amoxicilli…

This study looked at 567 intensive care patients to find early warning signs of severe sepsis. Researchers measured proteins in the blood, especially one called MMP-3, to see if they could predict organ damage or death. The goal was to better understand why some people get worse,…

This study examined 150 adults with sepsis in the ICU to find blood markers that signal when the condition turns into a dangerous clotting problem called DIC. Researchers collected blood samples and hospital data over up to 56 days, but did not test any new treatments. The goal i…

Sepsis is a life-threatening infection response that requires fast, coordinated care. This study tested whether an AI system could give emergency doctors near-instant feedback on how well they followed sepsis treatment guidelines. Sixty-six physicians were split into two groups: …

This study looked at 150 adults with sepsis in the ICU to see if low magnesium levels are connected to blood clotting problems. Researchers measured magnesium and clotting markers at admission and tracked outcomes like DIC and survival. The goal was to understand if magnesium cou…

This study looked at whether using a portable ultrasound machine at the patient's bedside (called POCUS) helps doctors better treat people with septic shock in the intensive care unit. Researchers compared two groups of patients: one treated before POCUS was widely used and one a…

This study explored whether measuring the activity of a gene called Acod1 in blood cells can help predict which sepsis patients are at higher risk of dying. Researchers enrolled 52 adults in the ICU and measured Acod1 levels within 48 hours of admission. The goal was to see if th…

This completed study looked at whether certain blood cell tests can predict early worsening in sepsis patients. Researchers followed 161 adults in intensive care for up to 5 days after diagnosis. They compared white blood cell profiles and platelet indices to see which better pre…

This study looked at whether ultrasound measurements of the vena cava and femoral artery can predict which sepsis patients with low blood pressure will benefit from extra fluids. 90 spontaneously breathing adults in intensive care were studied. The goal is to avoid giving too muc…

This study examined whether certain blood cell measurements—monocyte distribution and ratios of white blood cells—can help detect sepsis in intensive care patients. Researchers followed 120 adults in the ICU, comparing these new markers with standard infection tests. The goal was…

This study followed 53 ICU patients who had severe abdominal infections to understand why many become frail, weak, and disabled long after leaving the hospital. Researchers measured changes in frailty, muscle loss, and overall health over 12 months. The goal was to define the nat…

This study examined whether routine blood tests (like PCT, CRP, and lactate) can help predict the risk of death within 28 days in adults admitted to the ICU with suspected sepsis. Researchers reviewed medical records of 250 patients to find links between these biomarkers and surv…

This study looked at how well the body breaks down blood clots in people with sepsis, a life-threatening response to infection. Researchers measured a specific blood test in 100 critically ill patients to see how common clot breakdown problems are. The goal was to better understa…

This completed study looked at whether a protein called vasorin in the blood can help predict how severe kidney injury will be in people with septic shock. Researchers took blood samples from 50 intensive care patients on day 0 and day 3. The goal was to see if vasorin levels are…

This study examined whether a blood test called the Systemic Immune-Inflammation Index (SII) can predict the risk of death in critically ill patients in the intensive care unit (ICU). Researchers looked back at the records of 570 adults admitted to the ICU. They found that higher…

This study tested a computer program that sorts sepsis patients into four groups based on their vital signs in the first 8 hours. The goal was to see if these groups have different outcomes, which could help doctors choose the right treatments in the future. Over 1,900 adults too…

This study looked at 232 adult cancer patients with sepsis and low blood pressure to see if adding a type of antibiotic called aminoglycosides helps them recover faster. The main goal was to see how quickly their blood pressure returned to normal without needing strong blood pres…

This pilot study tested whether computer models could predict sepsis and necrotizing enterocolitis (NEC) in very low birth weight infants (under 1500 grams). Researchers used existing NICU data to build and test these models. The goal was to see if this approach is feasible, not …

This study looked at whether measuring immature platelets in the blood can help predict how septic shock patients will fare. Researchers followed 196 intensive care patients and checked if the immature platelet fraction at admission was linked to death or organ failure at 28 days…

This completed study looked at 30 adults with sepsis to understand how changes in tiny blood vessels (microcirculation) relate to blood clotting problems. Researchers used a special microscope to view blood vessels under the tongue and measured clotting factors. The goal was to s…

This study looked at whether giving a concentrated protein fluid called albumin, along with standard fluids, is possible in patients with septic shock (a life-threatening infection causing very low blood pressure). 47 adults took part to see if doctors could recruit enough patien…

This study looked at two blood markers—nCD64 and mHLA-DR—in 76 adults with septic shock, a life-threatening infection that can cause organ failure. Doctors measured these markers on day 1 and day 8 to see how the immune system changed over time. The goal was to learn whether thes…

This study examined over 1,200 adults admitted to an intensive care unit to see if the reason they were admitted (like sepsis or breathing failure) could predict their risk of dying in the ICU, beyond what standard severity scores show. Researchers looked back at medical records …

This study checked whether the energy-producing parts (mitochondria) of certain immune cells work differently in ICU patients with severe infections (sepsis) compared to those without infection. Researchers used leftover blood from routine tests to measure these changes in 36 pat…

This completed study looked at whether a regional guideline for managing sepsis (a severe infection) in pregnant and postpartum women improved outcomes. Researchers compared 52 women treated before and after the guideline was introduced in Lombardy, Italy. They measured hospital …

This study tested a program called STAR, where a nurse helps sepsis patients manage medications, new health problems, and follow-up care for 90 days after leaving the hospital. Researchers wanted to see if this support reduces deaths and hospital readmissions. Over 1,800 adults a…

This completed study looked at how common gut inflammation and leaky gut are in 80 adults with blood cancer who were in intensive care for sepsis or septic shock. Researchers measured two markers—calprotectin in stool and zonulin in blood—to better understand intestinal dysfuncti…

This study looked at whether a score called EASIX, which uses routine blood test results, can predict death and poor outcomes in people with sepsis. Researchers followed 150 adults in the intensive care unit for 28 days. The goal was to see if this score could help doctors identi…

This study looked at health records from over 5,700 adults in Japan with sepsis (blood poisoning) to see how many also developed a serious blood clotting disorder called DIC. Researchers collected information from hospital databases to track DIC rates and severity scores. The goa…

This completed study in Thailand looked at how well the latest sepsis definition (Sepsis-3) works for patients with community-acquired sepsis. Researchers collected blood and other samples from 1002 adults at a hospital in Ubon Ratchathani. They tracked who survived for 28 days a…

This study looked at anonymous medical records from over 55,000 past ICU patients to find patterns that could help predict three life-threatening conditions: sepsis (body-wide infection), ARDS (severe lung injury), and acute kidney injury. Researchers used computer models to anal…

This completed study in 44 intensive care patients with sepsis or septic shock examined how giving standard IV fluids affects capillary refill time (a simple fingertip test) and organ function. Researchers measured changes in organ failure scores and stroke volume after fluid res…

This study looked at 185 children with sepsis to find patterns in blood markers and genes that might predict serious complications or death. Researchers measured immune cells, proteins like C-reactive protein, and genetic variations. The goal was to build an algorithm that helps …

This completed study looked at 30 patients with septic shock in the ICU. Researchers wanted to see how high doses of the drug norepinephrine affect not just large blood vessels, but also tiny ones (microcirculation). They used a non-invasive light-based device to measure oxygen l…

This completed observational study at a single hospital in China enrolled 16 adults with sepsis in the ICU. Researchers measured specific memory CD8+ T cells in the blood at several time points to see if their numbers or activity relate to how severe the sepsis is or whether pati…

This study looked at whether a simple blood test score, called the CALLY index, can help predict how well adult sepsis patients will do in the intensive care unit (ICU). Researchers reviewed medical records of 276 patients to see if the CALLY index was linked to the risk of death…

This completed study analyzed data from 400 sepsis patients with nutritional risk to find factors that predict death within 28 days. Researchers looked at lab tests and physical measurements. The goal is to help doctors identify high-risk patients earlier.

This study looked at 1,529 intensive care patients with sepsis to see if a blood marker called procalcitonin (PCT) can help identify the type of bacteria causing the infection. Researchers measured PCT levels within 24 hours of a positive blood culture. The goal was to see if PCT…

This study tested a handheld microscope to look at tiny blood vessels in 68 adults with sepsis or septic shock. The goal was to understand how these vessels break down during severe infection. The findings may help doctors design better treatments in the future.

This study looked at 192 adults with septic shock to see if a simple finger-pressure test (capillary refill time) could predict outcomes as well as a standard blood test (lactate level). Researchers measured both at the same time and tracked which patients got worse or died withi…

This completed study looked at blood clotting in 175 hospitalized COVID-19 patients. Researchers used a special test to measure how quickly and strongly blood clots form, and whether a protein called thrombomodulin can slow this process. The goal was to understand why some COVID-…

This study looked at whether a blood-filtering device called Efferon LPS removes antibiotics from the blood of people with sepsis. Sepsis is a severe infection that can lead to organ failure, and doctors sometimes use filters to clean the blood. The study included 30 patients and…

This completed study looked at how a high dose of the antibiotic ceftriaxone works in 20 adults with sepsis. Researchers measured drug levels in the blood to see if the dose was strong enough to kill bacteria. The goal was to find the best dose to improve survival in sepsis patie…

This study looked at 212 critically ill adults in one ICU to see if three blood test ratios could predict death. The ratios compare lactate, CRP, and procalcitonin to albumin levels. Researchers will check if these ratios are linked to survival and find cut-off values to help doc…

This study looked at whether doing an early heart ultrasound (echocardiography) in the emergency department helps doctors manage sepsis or septic shock better. 312 adults with sepsis were randomly assigned to either get the ultrasound plus a treatment guide, or standard care. The…

This study looked at 147 kidney stone patients who had a positive urine culture before a minimally invasive surgery called mini-PCNL. Doctors gave them antibiotics and then checked if a follow-up urine culture was needed to predict infections after surgery. The goal was to see if…

This study examined 346 adults who had kidney stone surgery to see if changes in their urine white blood cells and nitrite levels before the operation could predict serious infections like fever or sepsis afterward. The goal was to find a faster, simpler way to identify high-risk…

This study looked at 25 children with suspected sepsis to compare the newer Phoenix score with older scoring systems (SIRS, pSOFA, PRISM III, PELOD). The goal was to see which score best predicts how long a child stays in the hospital or ICU, and risk of death. No treatments were…

This study looked at 130 adults with suspected sepsis in an emergency department. Researchers compared two scoring systems—REMS and NEWS2—to see which one better predicts how sick a patient will become, including need for ICU care, ventilator use, and risk of death. The goal is t…

This study looked at 50 ICU patients to see if sepsis causes immune suppression that increases the risk of ventilator-associated pneumonia. Researchers compared septic patients to non-septic ones by measuring immune markers in blood and lung fluid over five days. The goal was to …

This study looks at how certain immune cells, called antigen-presenting cells, behave in people with sepsis—a life-threatening response to infection. Researchers collected blood samples from 119 participants, including sepsis patients, other ICU patients, and healthy volunteers. …

This study tested whether two simple checklists (MEWS and qSOFA) can help predict sepsis in emergency room patients. Researchers reviewed the medical records of 950 people who visited one hospital's ER between 2020 and 2022. The goal was to see if these tools, combined with AI, c…

This completed study from Peking Union Medical College Hospital looked at 200 critically ill ICU patients with sepsis. Researchers used ultrasound to measure blood flow congestion (VExUS score) and checked if it was linked to gut injury. The goal was to see if this simple test co…

This study tested whether measuring lactate from a finger-prick (capillary blood) can help doctors identify sepsis patients who need intensive care. Researchers enrolled 60 adults with signs of sepsis outside the ICU. The goal was to see if this quick, bedside test could catch ea…

This study compared different methods to estimate how much fluid is needed in patients with liver cirrhosis or acute-on-chronic liver failure who also have sepsis and low blood pressure. Researchers enrolled 350 adults and looked at whether using ultrasound-guided fluid assessmen…