SEPSIS

This study tested whether using ultrasound to guide fluid management in sepsis patients leads to better outcomes. Researchers enrolled 118 adults with sepsis or septic shock in the ICU. They compared ultrasound-guided fluid therapy to standard care, measuring 60-day death rates a…

This study tested a new way to choose which IV fluid to give sepsis patients in the emergency room. Using vital signs like temperature and blood pressure, an algorithm identified patients who would benefit more from balanced crystalloids than normal saline. Over 2,000 adults acro…

This study tested whether giving a medicine called noradrenaline before anesthesia can prevent dangerously low blood pressure in adults with sepsis undergoing surgery. Eighty patients participated, and researchers compared those who received the preventive infusion to those who d…

This study tested a program called STAR that helps people who survived sepsis recover better after leaving the hospital. About 3,900 adults with sepsis took part across eight hospitals. The program used a nurse to guide care for up to 90 days, focusing on physical and mental reco…

This study tested the safety and how the body processes the antibiotic cefiderocol in 53 hospitalized children aged 3 months to 18 years with serious gram-negative bacterial infections. The goal was to see if the drug is safe and to determine the right dose. The study was complet…

This study looked at whether alpha-lipoic acid, a natural antioxidant, can help critically ill patients with sepsis. 80 adults in the ICU received either the supplement or a placebo daily for seven days. Researchers measured organ function, inflammation, and recovery time to see …

This study tested whether a drug called dobutamine could help people with septic shock who also have heart muscle weakness. The trial included 136 adults in intensive care. Researchers measured how organ function changed over three days to see if the drug improved blood flow and …

This study tested whether giving very high doses of vitamin C to people with sepsis (a severe infection that can cause organ failure) could lower the chance of dying within 28 days. 234 adults in intensive care received either vitamin C or a placebo for up to 4 days. The main goa…

This study tested whether giving a concentrated protein solution (albumin) along with standard fluids is possible in patients with septic shock. 47 adults with severe infection and low blood pressure were enrolled. The main goal was to see if enough people could be recruited to r…

This study tested a new rapid test for detecting bacteria in the blood of ICU patients with sepsis. The goal was to see if the new test could identify infections faster than the standard blood culture method, which takes 48-72 hours. The study involved 110 adults in intensive car…

This study looked at whether a simple finger-prick test to measure lactate levels can help doctors identify patients with severe sepsis early, even before they are in the intensive care unit. The test is fast and easy to do at the bedside. 60 adults with signs of sepsis took part…

This study checked if a new type of blood culture bottle works as well as the current one for finding germs in the blood of people with suspected sepsis. About 394 patients gave blood samples that were placed into both the new and standard bottles. The bottles were then monitored…

This study looked at blood proteins from 394 people with high fever to see if a computer could find a pattern that tells bacterial infections apart from viral ones. The goal is to create a simple test that helps doctors choose the right treatment faster. The research is complete …

This study tested whether giving lactoferrin, a natural protein found in breast milk, could help prevent sepsis (a severe blood infection) in premature babies. The study included 180 preterm and low-birth-weight infants. Researchers gave lactoferrin to see if it would boost the b…

This study tested whether a small device called Geko, which uses mild electrical pulses to make leg muscles twitch, can prevent dangerous blood clots in critically ill adults. It compared the Geko device to standard compression boots (IPCs) in 40 ICU patients. The goal was to see…

This small pilot study tested whether manual lymphatic drainage (a gentle massage technique) is safe and practical for patients recovering from septic shock. Researchers enrolled 24 adults in the ICU to see if the procedure could be done without interfering with standard care or …

This study reviewed records of 1248 adults admitted to an intensive care unit (ICU) in 2025. Researchers wanted to see if the reason for admission (like sepsis or breathing failure) could predict who dies in the ICU, beyond what standard severity scores show. The goal is to impro…

This study looked at 130 adults who came to the emergency room with suspected sepsis. Researchers compared two scoring systems, REMS and NEWS2, to see which one better predicts how sick a patient might become, including the need for intensive care or breathing support. The goal w…

This study looked at 192 adults with septic shock in the ICU to see if a simple bedside test (capillary refill time) could predict outcomes as well as a standard blood test (lactate level). Researchers checked both measures every 6 hours for the first day and tracked how patients…

This study looked at whether a blood-filtering device called Efferon LPS removes antibiotics from the blood of people with sepsis. Sepsis is a severe infection that can lead to organ failure, and blood filters are sometimes used to help clean the blood. The goal was to measure ho…

This research study looked at anonymous medical records from nearly 56,000 past ICU patients to find patterns that could help predict three serious conditions: sepsis (a body-wide infection), ARDS (severe lung injury), and acute kidney injury. The goal was to build computer model…

This study looked at medical records from over 5,700 adults in Japan who had sepsis (blood poisoning) to learn how many also developed a serious clotting condition called DIC. Researchers collected information from hospital databases to track DIC rates and the scoring tools docto…

This completed study looked at 1,529 intensive care unit patients to see if levels of a substance called procalcitonin (PCT) in the blood could help identify bloodstream infections and the type of germ causing them. Researchers measured PCT within 24 hours of taking a blood cultu…

This study looked at 44 adults with septic shock in the intensive care unit to see how giving fluids changes blood flow in small vessels (measured by how fast nail beds refill with color after pressing) and overall organ function. Researchers tracked organ failure scores and hear…

This study tested a handheld microscope to see tiny blood vessels in people with sepsis, a life-threatening infection. Researchers wanted to learn how blood flow problems relate to organ damage. 68 adults took part to help design better future treatments.

This study looked at 90 sepsis patients with low blood pressure to see if changes in vein and artery size during breathing can predict who needs more fluids. Doctors often give fluids to improve circulation, but too much can be harmful. The goal was to find a simple, non-invasive…

This study looked at 120 ICU patients to see if certain blood test results (monocyte distribution, monocyte-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio) could help doctors diagnose sepsis earlier. Researchers compared these new markers with standard tests. The goal wa…

This study examined 16 ICU patients with sepsis to see if specific memory immune cells (called Tcm and Tem) are linked to how severe the infection is and the risk of death. Researchers measured these cells in blood samples taken over 72 hours. The goal was to better understand th…

This study looked at 50 people with septic shock to see if levels of a protein called vasorin could predict how severe their kidney injury might be and their risk of dying. Researchers measured vasorin in the blood on the day of diagnosis and three days later. The goal was to fin…

This study looked at whether certain blood test ratios can predict the risk of death in critically ill adults in the ICU. Researchers analyzed medical records from 212 patients to see if these ratios are linked to survival. The goal is to help doctors quickly identify high-risk p…

This study tested a computer program that uses vital signs from the first 8 hours in the hospital to sort sepsis patients into four groups. The goal was to see if these groups have different outcomes, which could help doctors choose better treatments in the future. About 1,900 ad…

This study looked at whether using an early heart ultrasound (echocardiography) in the emergency room can help guide treatment for people with sepsis or septic shock. The goal was to see if this approach reduces organ damage compared to standard care. The study involved 312 adult…

This study tested whether a special recovery program (STAR) helps people who had sepsis stay healthier after leaving the hospital. Over 1800 adults took part. Researchers looked at whether the program reduced deaths and return hospital visits within 90 days.

This study looked at how well the body breaks down blood clots in people with sepsis, a life-threatening infection. Researchers tested 100 critically ill patients using a special blood test to find those with a 'fibrinolysis shutdown' — where clot breakdown is too slow. The goal …

This study looked at whether measuring a marker called procalcitonin in the blood can help doctors decide when to stop antibiotics in newborns with late-onset sepsis. Over 500 babies were included. The goal was to reduce antibiotic use by 30% without raising the risk of infection…

This study looked back at medical records of 250 adults admitted to the ICU with suspected sepsis. Researchers checked if common blood tests (like PCT, CRP, albumin, lactate, and white blood cell counts) could predict which patients died within 28 days. The goal was to see if the…

This study looked at 175 hospitalized COVID-19 patients to understand why they develop dangerous blood clots. Researchers measured how quickly their blood forms clots using a special test. The goal was to find links between clotting problems and survival, which could help guide f…

This study looked at 276 adults with sepsis in the intensive care unit to see if a score called the CALLY index could predict who might die within 30 days. The CALLY index uses routine blood test results to measure inflammation, nutrition, and immune health. Researchers found tha…

This study looked at 30 adults with sepsis to understand how tiny blood vessel damage and blood clotting problems are connected. Researchers used a special camera under the tongue to see small vessels and measured blood clotting. The goal was to learn more about these relationshi…

This study looked at 400 ICU patients with sepsis and nutritional risk to find out which factors predict death within 28 days. Researchers measured lab tests and physical assessments to see if they could identify high-risk patients early. The goal is to help doctors intervene soo…

This study looked at whether certain white blood cell and platelet tests can help predict early worsening in sepsis patients. Researchers followed 161 adults in the ICU, checking if these blood markers could signal a rise in organ failure, septic shock, or death within the first …

This study looked at over 30,000 adults hospitalized in Maryland to understand why some patients wait in the emergency room after being admitted (called boarding) and how that affects costs and care. Researchers analyzed existing medical records to find patterns and financial imp…

This study looked at 150 adults with sepsis to see if a score called EASIX (based on routine blood tests) could predict who would die or have serious complications within 28 days. Researchers tracked deaths, septic shock, and kidney injury. The goal was to find a simple tool to h…

This study looked at over 1,000 adults in Northeast Thailand who were hospitalized with sepsis caught outside of a hospital. Researchers tested a newer way to define sepsis severity and tracked which germs caused the infections and how patients fared after 28 days. The goal was t…

This study looked at how sepsis, a severe response to infection, affects certain immune cells called antigen-presenting cells. Researchers collected extra blood samples from 119 people, including sepsis patients, other critically ill patients, and healthy volunteers. The goal was…

This study examined 150 adults with sepsis in the ICU to find blood markers that signal when a dangerous clotting problem called DIC develops. Researchers collected blood samples and hospital data over up to 56 days. No new treatments were given—only standard care. The goal was t…

This study examined whether routinely using a portable ultrasound device (POCUS) in the ICU improves outcomes for patients with septic shock. Researchers compared data from 200 patients treated before and after POCUS was introduced, looking at organ failure scores and survival ra…

This study looked at 30 sepsis patients in a surgical ICU to see if combining albumin levels with other blood markers (like CRP, procalcitonin, and lactate) could better predict who would die within 28 days. Researchers found that these ratios might help doctors identify high-ris…

This study looked at 30 intensive care patients with septic shock to see how a high dose of the drug norepinephrine (used to raise blood pressure) affects the smallest blood vessels in the body. Researchers measured oxygen levels in muscle tissue to check microcirculation and com…

This study looked at whether sepsis causes immune suppression that makes ICU patients more prone to additional infections. Researchers compared 50 patients with and without sepsis by measuring immune markers in blood and lung fluid. The goal was to better understand how sepsis af…

This study looked at 570 critically ill adults in the ICU to see if a simple blood test called the Systemic Immune-Inflammation Index (SII) could predict who might die. The SII measures inflammation and immune response from a standard blood draw. Researchers found that higher SII…

This study looked at two blood markers—neutrophil CD64 and monocyte HLA-DR—in 76 people with septic shock, a life-threatening condition. Researchers measured these markers on day 1 and day 8 to see how the immune system changes over time. The goal was to learn whether these marke…

This study looked at how high doses of the antibiotic ceftriaxone work in 20 adults with sepsis, a life-threatening infection. Researchers measured drug levels in the blood to find the best dose for killing bacteria. The goal was to improve treatment guidelines so patients get th…

This study looked at 150 adults with sepsis in the intensive care unit to see if low magnesium levels are linked to blood clotting problems. Researchers measured magnesium and clotting markers at admission and tracked outcomes like DIC (a severe clotting disorder) and survival. T…

This study looked at whether two easy-to-use checklists (MEWS and qSOFA) and other vital signs can help predict sepsis in emergency room patients. Researchers reviewed medical records of 950 people who visited the ER between 2020 and 2022. The goal was to see if these tools, comb…

This study followed 53 ICU patients who had severe abdominal infections to understand why some become frail, weak, and disabled long after leaving the hospital. Researchers measured changes in muscle loss, mobility, and overall health over 12 months. The goal was to define the na…

This study looked at 147 patients with kidney stones who had a positive urine culture before a minimally invasive surgery called mini-PCNL. All patients received antibiotics for 5-7 days, and researchers checked if a follow-up urine culture was needed to predict infections after …

This study examined 346 adults who had kidney stone surgery to see if changes in their urine test results before the operation could predict fever or serious infection afterward. Researchers tracked white blood cells and nitrite levels in urine samples taken at different times. T…

This study looked at whether giving higher doses of two common antibiotics (amikacin and gentamicin) to ICU patients with severe sepsis helps achieve the right levels in the blood. 63 patients took part. The goal was to see if the higher doses reached target concentrations, not t…

This study looked at whether a set of standard care steps (called a sepsis bundle) could improve outcomes for pregnant or postpartum women with sepsis, a severe infection. Researchers compared 52 women treated before and after the bundle was introduced in hospitals across norther…

This study explored whether measuring a gene called Acod1 in the blood can help predict which sepsis patients are at higher risk of dying. Researchers tested blood samples from 52 adults in the ICU within 24-48 hours of admission. The goal was to see if this gene test could be a …

This study tested a small wearable patch called TempShield that sticks to the chest and continuously monitors body temperature in children ages 1 to 4 in the emergency department. The goal was to see if the patch could detect fevers earlier than standard thermometers. 72 children…

This study looked at 350 adults with liver cirrhosis and sepsis-induced low blood pressure to find the best way to estimate how much fluid they need. Researchers compared different methods to guide fluid therapy, aiming to improve blood pressure and reduce complications. The goal…

This study looked at 25 children with sepsis to see if a new scoring system (Phoenix score) can predict how long they stay in the hospital or intensive care, and their risk of death. Researchers compared the Phoenix score with older scoring methods. No treatments or extra tests w…

This study looked at 567 adults with sepsis-related heart problems to find out which genes and molecules in the kallikrein-kinin system change. The goal was to better understand how sepsis damages the heart, not to test a new treatment. Researchers tracked survival and heart func…

This pilot study tested whether computer models could predict sepsis and a serious gut infection called necrotizing enterocolitis in very low birth weight infants (under 1500 grams). Researchers reviewed medical charts from 144 babies in the NICU to build and test these models. T…

This study looked at 185 children with sepsis to find patterns in blood markers and genes that might predict a bad outcome. Researchers measured immune cells, proteins like C-reactive protein, and genetic variations. The goal was to create an algorithm that helps doctors identify…