SEPSIS

This study tested a new way to decide how long to give antibiotics to newborns with a serious blood infection called late-onset sepsis. Researchers wanted to see if using a blood marker called procalcitonin could safely shorten the antibiotic course compared to standard doctor-gu…

This study tested whether giving a higher dose of the common antibiotic ceftriaxone could better control severe bloodstream infections (sepsis) in adults. Researchers measured how long the drug stayed at a high enough level in the blood to effectively kill bacteria. The goal was …

This study tested whether a 90-day support program could help people recover from sepsis and prevent them from being readmitted to the hospital or dying. The program used a nurse to coordinate care, check on patients, and help manage medications and other health needs after they …

This study tested if a simple computer alert could help doctors choose the best type of IV fluid for certain patients with sepsis, a life-threatening infection. Over 2,000 adult patients were randomly assigned to either have their doctors receive the alert or follow usual care. T…

This study tested whether adding the heart medication dobutamine helps control organ damage in sepsis patients who develop weakened heart function. Researchers enrolled 136 intensive care patients with septic shock and heart weakness to receive either dobutamine or placebo alongs…

This study tested if using a heart ultrasound (echocardiogram) right away in the emergency room could help doctors better treat sepsis, a life-threatening infection. Researchers compared this personalized approach to the standard treatment guidelines. They wanted to see if the ul…

This UK study tested whether a special fluid made from a blood protein (20% albumin) works better than standard salt solutions for patients with life-threatening septic shock in intensive care. The main goal was to see if it's practical to run a larger future trial. Researchers r…

This study tested whether using frequent ultrasound scans to guide fluid treatment could improve survival for patients with severe sepsis or septic shock. 118 patients in an intensive care unit were randomly assigned to receive either this precise ultrasound-guided fluid manageme…

This study tested whether a supplement called alpha-lipoic acid could help people critically ill with sepsis. It involved 80 patients in an Egyptian hospital, who were randomly assigned to receive either the supplement or a placebo for one week. Researchers measured if it reduced…

This study tested whether giving higher doses of two common antibiotics (amikacin and gentamicin) would reach effective levels in the blood of critically ill patients with severe sepsis. Researchers enrolled 63 ICU patients to see if these increased doses achieved target concentr…

This study tested the safety and how the body processes the antibiotic cefiderocol in hospitalized children with serious bacterial infections. It involved 53 children, from 3 months to under 18 years old, who had infections like pneumonia, sepsis, or urinary tract infections. Res…

This study tested a 90-day support program for adults recovering from sepsis after hospital discharge. The program, led by nurse navigators, provided education and helped patients get recommended follow-up care. Researchers wanted to see if this program could be successfully adap…

This study tested a new, sticker-like device that continuously monitors a child's temperature. It involved 72 children, aged 2 to 4, who were in the emergency room with a fever. Researchers compared the sticker's temperature readings to those from a standard oral thermometer to s…

This study looked at whether combining measurements of a common blood protein (albumin) with other standard infection markers could better predict which sepsis patients in the surgical ICU might die. Researchers analyzed data from 30 patients to see if these new ratios gave docto…

This study tested a new blood test designed to quickly tell if a person's fever is caused by a bacterial infection or a viral one. Researchers used artificial intelligence to find specific proteins in the blood that signal the type of infection. The goal is to help doctors prescr…

This study tested a new rapid blood test for sepsis, a life-threatening infection. It involved 110 adult patients in intensive care units. The goal was to see if this new test could accurately identify the specific bacteria causing the infection in just a few hours, compared to t…

This study looked back at 950 emergency room patients to see if combining simple vital sign checklists (MEWS and qSOFA scores) with artificial intelligence could help doctors predict sepsis faster. The goal was to create a tool that alerts doctors sooner when a patient might be d…

This study looked at whether tracking changes in two simple urine test results—white blood cells and nitrites—in the days before a common kidney stone surgery could help predict which patients are at higher risk for developing a fever or serious bloodstream infection afterward. R…

This study tested a new type of blood culture vial to see if it works as well as an existing one for detecting serious bloodstream infections (sepsis). Researchers enrolled 394 patients who showed signs of a possible infection, like high fever or low blood pressure. They collecte…

This study tested whether a simple, quick finger-prick test to measure lactate (a marker of stress in the body) could help doctors identify sepsis earlier in patients outside the intensive care unit. It involved 60 adult patients showing signs of possible infection. The goal was …

This study tested whether giving lactoferrin, a natural protein found in breast milk, to premature babies could help prevent sepsis, a life-threatening infection. It involved 180 preterm, low-birth-weight infants who received the supplement soon after birth. The goal was to see i…

This study tested whether a small, wearable leg stimulator (called Geko) is a practical alternative to standard compression sleeves for preventing blood clots in critically ill adults. Researchers compared the two methods in 40 patients to see if the new device could be reliably …

This study tested whether giving a medication called noradrenaline before surgery could prevent a dangerous drop in blood pressure that often happens when patients with sepsis are put under anesthesia. The trial involved 80 adult patients with sepsis who needed surgery. Researche…

This small, completed pilot study tested whether a gentle massage technique called manual lymphatic drainage is safe and practical for patients recovering from septic shock. The goal was to see if stimulating the body's fluid drainage system could help reduce swelling and improve…

This study aimed to understand why sepsis patients often develop weak immune systems, making them prone to new infections in the hospital. Researchers collected blood samples from 119 people, including sepsis patients, other critically ill patients, and healthy volunteers. They a…

This study looked at whether measuring a protein called vasorin in the blood could help doctors predict which patients with septic shock might develop serious kidney injury or die. Researchers measured vasorin levels in 50 critically ill patients with septic shock to see if highe…

This research study aimed to understand why sepsis patients in intensive care become vulnerable to additional infections. Researchers measured immune system function in 50 critically ill patients, comparing those with sepsis to those without. The study collected blood and lung fl…

This study aimed to understand how a severe infection (sepsis) damages the heart. Researchers analyzed blood samples from 567 critically ill adults in the ICU to look for specific molecules linked to heart problems during sepsis. The goal was to gather knowledge about these biolo…

This study aimed to find the best way to determine how much fluid to give to critically ill patients with advanced liver disease (cirrhosis) who develop a dangerous infection causing low blood pressure. Researchers observed 350 patients to compare different measurement techniques…

This study tested a computer tool that runs in the background of hospital records to sort sepsis patients into four different groups based on their vital signs. The goal was to see if these patient groups have different health outcomes, like survival rates or need for intensive c…

This study aimed to understand how problems with blood clotting are connected to damage in the body's tiniest blood vessels during sepsis, a life-threatening infection. Researchers observed 30 adult patients with sepsis, taking daily blood tests and special images of blood vessel…

This study aimed to find better ways to predict how sepsis patients will fare. Researchers tested a new handheld microscope to measure tiny blood vessels and a blood marker related to blood vessel lining in 68 adults with sepsis. The goal was to see if these measurements could be…

This study checked if new regional guidelines for spotting and treating sepsis in pregnant and postpartum women worked. Researchers compared hospital stays and health outcomes for 52 women before and after the guidelines were introduced. The goal was to see if standardized care c…

This study aimed to see if a simple bedside check of blood flow in the skin (like pressing a fingernail) is as good as a standard blood test at predicting how patients with severe septic shock will do. Researchers followed 192 adult patients in intensive care, comparing the two m…

This study looked at 400 critically ill sepsis patients in the ICU who were also at risk for poor nutrition. Researchers wanted to see if simple blood tests and body measurements could help predict which patients were more likely to die within 28 days. The goal is to find early w…

This study looked at whether a blood test for a marker called procalcitonin (PCT) can help doctors quickly figure out what type of bacteria is causing a severe bloodstream infection in intensive care unit (ICU) patients. Researchers studied over 1,500 adult ICU patients who had a…

This study aimed to understand why some hospitalized COVID-19 patients develop serious blood clotting problems, which is a major risk factor for death. Researchers tested the blood of 175 patients using a detailed clotting analysis when they were first admitted to the hospital. T…

This was a pilot study to see if it's possible to build a computer warning system for two serious conditions in very small premature babies: sepsis (a bloodstream infection) and necrotizing enterocolitis (a severe intestinal disease). Researchers reviewed past medical records fro…

This study looked at how high doses of a common medication (norepinephrine) used to treat septic shock affect the body's smallest blood vessels. Researchers monitored 30 critically ill patients to see if changes in these tiny vessels were linked to survival after 28 days. The goa…

This study aimed to understand if a blood-filtering device used to treat severe sepsis also removes important antibiotics from a patient's bloodstream. Researchers observed 30 patients with sepsis to measure how much of three common antibiotics was filtered out by the device. The…

This study looked at whether a simple score calculated from routine blood tests (called EASIX) can predict which sepsis patients are most likely to die or develop serious complications. Researchers followed 150 adult patients in intensive care who had sepsis. The goal was to see …

This study aimed to find out which of two emergency room scoring systems is better at predicting how sick patients with suspected sepsis will become. Researchers observed 130 adult patients who came to the emergency department with signs of sepsis. They compared the REMS score ag…

This study aimed to understand how specific types of immune cells, called memory CD8+ T cells, are related to how severe sepsis becomes and whether a patient survives. Researchers observed 16 adult patients in the ICU with sepsis, taking blood samples to measure these cells over …

This study looked back at medical records to see if a number calculated from a routine blood test (called the Systemic Immune-Inflammation Index or SII) could help predict which critically ill patients were more likely to die in the intensive care unit (ICU). Researchers analyzed…

This study looked at whether patients with kidney stones need to wait for a second urine test to show no infection before having surgery. Researchers followed 147 patients who had surgery after taking antibiotics for a urine infection. They checked if repeat urine tests after ant…

This study looked back at the medical records of 276 adults with sepsis in the intensive care unit (ICU). Researchers wanted to see if a score calculated from three common blood tests (the CALLY index) could help predict which patients were more likely to die within 30 days or de…

This study looked back at the medical records of 212 critically ill adults to see if three simple ratios from common blood tests could predict who was most likely to die in the hospital. Researchers calculated the ratios of lactate, CRP, and procalcitonin to albumin from tests ta…

This study aimed to understand severe infections (sepsis) that people get outside the hospital in Thailand. Researchers observed over 1,000 adult patients to test a new medical definition for sepsis and to find out what germs cause it and what factors lead to better or worse outc…

This study aimed to see if two specific markers in the blood could help doctors better understand and predict outcomes for patients with septic shock, a severe and life-threatening infection. Researchers measured these markers in 56 patients on their first and eighth day in the I…

This study looked at patients in intensive care with septic shock, a life-threatening response to infection. Researchers wanted to see if a simple bedside test—pressing on a finger to check blood flow recovery time—could predict how well a standard fluid treatment would improve t…

This study analyzed medical records from 55,940 critically ill patients to understand who is most at risk for developing three serious complications: sepsis, severe lung injury, and sudden kidney failure. Researchers used computer models to find patterns in patient data that migh…

This study looked back at the records of 1,248 adult patients in an intensive care unit (ICU) to see if the type of illness they had when admitted (like sepsis or respiratory failure) was linked to their chance of dying in the ICU. Researchers wanted to know if these diagnoses pr…

This study analyzed existing medical records from over 5,700 adults in Japan who had sepsis, a life-threatening blood infection. Researchers looked back at hospital data to understand how often sepsis leads to a dangerous blood clotting problem called DIC. The goal was to gather …

This study aimed to create a prediction tool to identify children with sepsis who are most likely to develop severe complications or die. Researchers analyzed blood samples from 185 children, looking at specific proteins and genetic markers related to the immune system. The goal …

This study aimed to better understand how sepsis, a life-threatening infection, can lead to a dangerous blood clotting disorder called DIC. Researchers observed 150 adult sepsis patients in European intensive care units, collecting their standard medical data and blood samples to…

This study aimed to see if a new scoring tool called the Phoenix Score works as well as older tools for predicting how children with sepsis will fare. Researchers observed 25 children suspected of having sepsis, comparing the Phoenix Score to other established scoring systems. Th…