Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can a heart drug save organs in sepsis? new trial aims to find out

NCT ID NCT04166331

Completed Disease control Sponsor: University Hospital, Limoges Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed Phase 3 trial tested whether dobutamine, a heart-strengthening drug, can reduce organ failure in 136 ICU patients with septic cardiomyopathy and low blood flow. Patients received either dobutamine or a placebo alongside standard care. The study measured changes in organ function over three days to see if the drug helps improve outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Dobutamine
What this could lead to
If successful, this could provide a proven treatment to improve organ function in septic shock patients with heart problems.
What could go wrong
This is a completed Phase 3 trial, but previous similar drugs have failed or caused side effects. The benefit may be small or not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CARDIOMYOPATHIES are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

bacterial myocarditis cardiomyopathy infectious disease with sepsis left ventricular failure Sepsis Ventricular Dysfunction, Left

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOMYOPATHIES HYPOPERFUSION LEFT VENTRICULAR SYSTOLIC DYSFUNCTION SEPSIS

Contacts and locations

Locations

  • Angouleme Hospital

    Angoulême, 16959, France

  • Aphp - Ambroise Paré

    Paris, 75010, France

  • Aphp - Henri Mondor

    Créteil, 94010, France

  • Argenteuil Hospital

    Argenteuil, 95107, France

  • CH d'Haguenau

    Haguenau, 67500, France

  • CH de Bethune

    Béthune, France

  • CH de Brive

    Brive-la-Gaillarde, 19100, France

  • CH de Cannes

    Cannes, France

  • CH de Toulon

    Toulon, 83000, France

  • CHU Orléans - service de Réanimation

    Orléans, Orleans, 47067, France

  • CHU Strasbourg - service de Réanimation

    Strasbourg, Strasbourg, 67000, France

  • CHU Tours - Service de Réanimation

    Tours, Tours, 37044, France

  • Dijon university hospital

    Dijon, 21033, France

  • HCL

    Lyon, France

  • Le Mans Hospital

    Le Mans, 72000, France

  • Lille University Hospital

    Lille, 59045, France

  • Limoges University Hospital

    Limoges, 87042, France

  • Montpellier University Hospital

    Montpellier, 34295, France

  • Nice University Hospital

    Nice, 06202, France

  • Poitiers University Hospital

    Poitiers, 86000, France

  • University Hospital

    Brest, 29200, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.