Can a heart drug save organs in sepsis? new trial aims to find out
NCT ID NCT04166331
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 3 trial tested whether dobutamine, a heart-strengthening drug, can reduce organ failure in 136 ICU patients with septic cardiomyopathy and low blood flow. Patients received either dobutamine or a placebo alongside standard care. The study measured changes in organ function over three days to see if the drug helps improve outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dobutamine
What this could lead to
If successful, this could provide a proven treatment to improve organ function in septic shock patients with heart problems.
What could go wrong
This is a completed Phase 3 trial, but previous similar drugs have failed or caused side effects. The benefit may be small or not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Angouleme Hospital
Angoulême, 16959, France
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Aphp - Ambroise Paré
Paris, 75010, France
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Aphp - Henri Mondor
Créteil, 94010, France
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Argenteuil Hospital
Argenteuil, 95107, France
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CH d'Haguenau
Haguenau, 67500, France
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CH de Bethune
Béthune, France
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CH de Brive
Brive-la-Gaillarde, 19100, France
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CH de Cannes
Cannes, France
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CH de Toulon
Toulon, 83000, France
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CHU Orléans - service de Réanimation
Orléans, Orleans, 47067, France
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CHU Strasbourg - service de Réanimation
Strasbourg, Strasbourg, 67000, France
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CHU Tours - Service de Réanimation
Tours, Tours, 37044, France
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Dijon university hospital
Dijon, 21033, France
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HCL
Lyon, France
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Le Mans Hospital
Le Mans, 72000, France
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Lille University Hospital
Lille, 59045, France
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Limoges University Hospital
Limoges, 87042, France
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Montpellier University Hospital
Montpellier, 34295, France
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Nice University Hospital
Nice, 06202, France
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Poitiers University Hospital
Poitiers, 86000, France
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University Hospital
Brest, 29200, France