Study seeks best fluid strategy for liver patients with sepsis

NCT ID NCT05059795

First seen Jun 26, 2026 ยท Last updated Jun 26, 2026

Summary

This study compared different methods to estimate how much fluid is needed in patients with liver cirrhosis or acute-on-chronic liver failure who also have sepsis and low blood pressure. Researchers enrolled 350 adults and looked at whether using ultrasound-guided fluid assessment or standard goal-directed therapy leads to better outcomes, like reaching a target blood pressure. The goal is to find the safest and most effective way to guide fluid treatment in this complex group of patients.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Albumin + electrolyte solution
What this could lead to
If successful, this could help doctors choose the best way to give fluids to liver disease patients with sepsis, potentially improving survival.
What could go wrong
This is a completed study comparing methods, not testing a new treatment. Results may not change practice immediately or apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Acute-On-Chronic Liver Failure cirrhosis of liver Fibrosis infectious disease with sepsis Sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • PGIMER

    Chandigarh, Chandigarh, 160012, India

  • Postgraduate Institute of Medical Education and Research

    Chandigarh, 160012, India

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