SEPSIS

This study looks at whether giving two steroids (hydrocortisone and fludrocortisone) to adults with sepsis in the ICU can reduce death or the need for machines to help them breathe, filter their blood, or keep their blood pressure up. About 1,800 participants will be randomly ass…

This early-stage study tests a new medicine called BAY 3389934 in up to 36 adults with sepsis who have blood clotting issues. The goal is to find a safe dose and see how the drug affects the body. Participants are in the ICU and will be monitored for about 28 days.

This study looks at 600 ICU patients with sepsis caused by drug-resistant bacteria. It compares giving antibiotics continuously versus intermittently, and using one antibiotic versus a combination. The goal is to see which approach lowers the chance of death within 30 days.

This study tests if giving a drug called norepinephrine early and adjusting the dose quickly can help adults with septic shock survive longer. Septic shock is a life-threatening drop in blood pressure due to infection. About 600 adults will either get the drug early or standard c…

This study tests whether a drug called fisetin can prevent sepsis from getting worse in older adults. Sepsis is a life-threatening reaction to an infection that can cause organ failure. The trial will give fisetin to 220 patients aged 65 and older who have a mild infection and ar…

This study looks at whether nurses measuring blood flow in tiny vessels (microcirculation) can help treat sepsis patients earlier in the emergency room. Sepsis is a serious infection that can quickly get worse, even when standard vital signs look normal. The study will include 55…

This study is collecting real-world data from 200 adults with sepsis or septic shock who receive ARTICE® therapy in the ICU. Researchers will track organ function, lab markers, survival, and complications to better understand how well the treatment works and who benefits most. Th…

This study tests whether a nerve block in the back (erector spinae plane block) can improve organ function in people with sepsis and acute gut injury. About 116 adults in the ICU will receive the block plus standard care or standard care alone. The goal is to see if the block red…

This early-stage study tests a drug called DNase I given through a vein to 36 ICU patients with sepsis. The main goal is to check if the drug is safe and feasible to give in this setting. Researchers will also track how patients' organ function changes over time.

This study tests if a fluid called balanced gelatin is better than standard fluids for people with sepsis (a severe infection) who need emergency abdominal surgery. Sepsis causes fluid loss, leading to low blood pressure and organ problems. The trial will compare the two fluids i…

This study tests whether a personalized treatment with Pentaglobin (a mix of antibodies) can improve recovery in people with severe abdominal infection (peritonitis) that has led to sepsis or septic shock. About 200 adults will receive either standard care or standard care plus P…

This study tests an experimental drug called YD0743 in adults with sepsis who develop severe lung failure (ARDS) and need a breathing machine. The goal is to see if the drug helps patients use the ventilator for fewer days and improves oxygen levels. About 309 ICU patients will r…

This early study tests whether draining lymph fluid from the chest can lower harmful inflammation in people with septic shock. Ten adults in the surgical ICU will have a tube placed in their thoracic duct to drain lymph for up to 7 days. The goal is to see if this approach is saf…

This study tests an experimental drug called AZD4144 in adults with sepsis who develop acute kidney injury. About 124 people in intensive care will receive either the drug or a placebo daily through an IV. The main goal is to see if the drug helps the kidneys work better compared…

This study looks at two ways to clean the blood in children with sepsis, a life-threatening infection. It compares continuous blood purification (done without stopping) to non-continuous methods. The goal is to see which approach helps more children survive 28 days after leaving …

This study tests a new blood-filtering method (DPCAS+LPE) in 192 adults with acute-on-chronic liver failure and sepsis. The goal is to see if it lowers death rates at 4 and 12 weeks compared to standard plasma exchange. Participants receive two sessions of the therapy, and resear…

This study tests whether giving a blood-pressure-raising drug (vasopressor) right away, instead of starting with IV fluids, helps adults with sepsis recover faster and leave the hospital sooner. About 1,000 participants will be randomly assigned to one of the two approaches. The …

This study tests whether giving the drug vasopressin earlier or later helps adults with septic shock. Researchers will use a computer tool to randomly assign 300 ICU patients to one of two timing strategies. The goal is to see if early use reduces the need for other strong blood-…

This study tests whether checking vancomycin levels after the very first dose and adjusting quickly can help infants with sepsis reach the right drug levels faster. About 40 infants under 90 days old will take part. The goal is to avoid dangerous delays in treating serious infect…

This study tests whether early use of midodrine, a pill that raises blood pressure, can help people with sepsis need less IV medicine and recover faster. About 308 adults with sepsis and low blood pressure will receive midodrine or a placebo. The goal is to see if it reduces time…

This study looks at whether a special filter called oXiris helps people with septic shock and kidney failure survive. Researchers will compare patients who got the oXiris filter with those who got standard filters during blood cleaning. The goal is to see if the oXiris filter red…

This study tests two types of blood purification filters (AN69ST and polysulphone) in 80 children with sepsis. The goal is to see which filter better reduces harmful inflammatory substances and organ damage. Children aged 29 days to 18 years with sepsis-related organ failure may …

This study tests whether a combination of gentamicin and a narrow-spectrum antibiotic works as well as a broad-spectrum antibiotic alone for treating early sepsis. About 1,900 hospitalized adults with suspected sepsis will be randomly assigned to one of the two treatments. The go…

This study tests whether giving fluids and blood pressure medicines based on each person's heart response improves care for sepsis patients. Sepsis is a life-threatening infection reaction that can cause organ failure. 188 adults in the emergency department will be randomly assig…

This study tests a computer tool called pediatric eCART that uses information from electronic health records to quickly identify hospitalized children at risk of serious problems like cardiac arrest or sepsis. Researchers will compare data from before and after the tool was put i…

This study is looking at a specific blood marker called glycosylated ferritin to see if it can help doctors better distinguish between three serious conditions: Still's disease, sepsis, and macrophage activation syndrome. These illnesses can look very similar, making diagnosis di…

This study tests whether using a device that measures blood flow in the finger (called the Peripheral Perfusion Index, or PPI) to guide fluid treatment can prevent acute skin failure in elderly patients in the intensive care unit (ICU). About 216 patients aged 65 and older with s…

This study explores whether virtual reality (VR) can help patients in the Intensive Care Unit (ICU) feel more relaxed, improve their mood, and keep their minds active. About 32 adults with serious breathing problems or sepsis will use VR for 15-45 minutes each day for up to 5 day…

This study tests a drug called ivabradine to see if it can safely lower heart rate and improve blood flow in people with sepsis, a life-threatening infection. About 172 adults in intensive care will receive either ivabradine or a placebo. The goal is to find out if controlling he…

This study looks at neutrophils, a type of white blood cell, in children with sepsis (a severe infection). Researchers want to understand how these cells change and may cause lung injury. By comparing sepsis patients to healthy controls, they hope to find clues for future treatme…

This study compares two ways of giving the antibiotic cefepime to ICU patients with sepsis or infection. The new method uses available doses but adjusts them based on the patient's kidney function. The main goal is to see how easy the new method is for doctors to use, and if it h…

This study uses an anonymous online survey to measure how much healthcare professionals in seven sub-Saharan African countries know about sepsis. About 300 doctors, nurses, and trainees will answer questions to identify knowledge gaps. The survey repeats every 12-24 months to tra…

This study observes about 1,950 patients with suspected sepsis in the emergency department. Researchers will analyze blood samples to see how well certain markers (like calprotectin) and rapid DNA tests can detect infections. The goal is to better understand sepsis and move towar…

This study looks at whether certain genetic elements, called transposable elements, can prematurely age the immune system of people with sepsis in the ICU. Researchers will take blood samples from 116 adult patients to see if these elements are linked to higher death rates or mor…

This study tests a new ultrasound technology that can continuously monitor blood flow in the brains of sick and premature infants. Researchers will enroll 180 babies, including healthy preterm and term infants as well as those with conditions like heart defects, infections, or st…

This study looks at why many ICU patients, especially those with sepsis, develop lasting muscle weakness. Researchers will test 50 adults who were on a breathing machine for at least 7 days and have left the hospital. Participants will do exercise tests to measure heart and muscl…

This study looks at whether measuring how much the axillary vein in the armpit collapses with breathing can predict which sepsis patients need more fluids. Researchers will enroll 40 spontaneously breathing adults with sepsis and signs of circulatory failure. The goal is to find …

This study looks at whether a simple blood test can measure organ damage and immune system changes in people with sepsis. Researchers will follow 1000 patients in the ICU to see if these blood markers relate to survival and recovery. The goal is to better understand sepsis, not t…

This study looks at how the immune system reacts during and after sepsis in 400 ICU patients. Researchers will analyze blood samples to identify different immune response types, called immunotypes. The goal is to understand which responses help or harm patients, which could lead …

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious problems like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections for 28 days to see how well these e…

This study tests two new risk scores that predict a patient's chance of developing sepsis or having a sudden health decline (like cardiac arrest) within the next four hours. The scores alert hospital staff so they can check vital signs sooner. The study involves up to 150,000 adu…

This study looks at how a special kidney filter (OXIRIS membrane) affects blood clotting and immune cells in intensive care patients with septic shock. Sepsis is a severe response to infection that can cause organ failure. The study will measure markers of clotting and immune act…

This study checks how accurate and safe a new continuous glucose monitor (Syai Tag) is for patients in the intensive care unit. About 100 adults with diabetes, sepsis, or other critical illnesses will wear two small sensors on their arms. The sensor readings will be compared to s…

This study looks at how the antibiotic ceftazidime avibactam behaves in children with severe infections who are on life support. Researchers want to find the right dose by measuring drug levels in the blood. About 30 children in the ICU will take part. The goal is to improve trea…

This study is observing 4,000 adults in intensive care with ARDS, sepsis, or pneumonia to identify different types of these illnesses. Researchers will collect medical information and samples to build a biobank for future studies. The goal is to improve understanding of risk fact…

This study follows 40 adults who survived sepsis in the ICU to understand how their physical function changes after leaving the hospital. Researchers will test strength and mobility at several points, especially looking at how hospital readmissions affect recovery. The goal is to…

This study looks at whether measuring the water outside cells (extracellular water) can help doctors understand fluid status in adults with sepsis who have unstable blood pressure. Twenty participants in intensive care will get standard treatment plus a non-invasive skin measurem…

This study tests whether personalized vancomycin dosing can better protect the kidneys of children with sepsis. Vancomycin is an antibiotic that can cause kidney injury if levels get too high. Researchers will use new models that account for each child's kidney function to find t…

This study looks at a rare but dangerous infection caused by Bacillus cereus bacteria in premature newborns. Researchers will analyze the bacteria's genes and patient records from 40 babies to identify which strains are most deadly and what factors increase the risk of death. The…

This study investigates why many ICU patients develop acute kidney injury, especially after sepsis or major surgery. Researchers will measure inflammatory markers in urine, blood, and sputum from 100 participants to see if these markers are linked to kidney damage. The goal is to…

This study is developing artificial intelligence (AI) tools that can help doctors make better, personalized decisions for patients with heart disease, breast cancer, or sepsis. The goal is to make AI recommendations clear and trustworthy for doctors, while also ensuring safety. T…

This study aims to develop a new scoring system (SOFA-OBS) that better predicts death risk for pregnant and postpartum women in the intensive care unit (ICU). Researchers will collect routine data from 130 ICU patients who are pregnant or recently gave birth. The goal is to see i…

This study looks at why sepsis causes long-term immune system damage, making people more likely to get serious infections again. Researchers will follow 150 ICU patients with sepsis, analyzing their blood over 28 days. The goal is to understand the cellular changes behind this im…

This study tests whether people with serious infections can be safely monitored at home using wearable devices and a smartphone app, instead of staying in the hospital. The goal is to catch early signs of sepsis—a life-threatening reaction to infection—so doctors can step in quic…

This study looks at whether a new, simpler guideline can safely reduce the number of tests, antibiotics, and hospital stays for infants 60 days or younger who have a fever. About 2,500 babies will be observed across 11 Swedish hospitals. The goal is to see if the new approach wor…

This study looks at how the immune system goes wrong in people with sepsis or serious injuries. Researchers will measure certain immune cells in 450 adults to find patterns that lead to ongoing inflammation or immune weakness. The goal is to better understand these problems, not …

This study will test a device called PIVO that collects blood samples for cultures using an existing IV line, reducing the need for extra needle sticks. Researchers will train ER staff on the device and track how often it is used and whether it leads to fewer contaminated samples…

This study aims to find biological markers that can predict whether sepsis will progress to septic shock, a life-threatening condition. Researchers will compare epigenetic markers in blood samples from 25 male patients aged 45-75 who develop sepsis after major digestive cancer su…

This study is a large registry that collects data on how a blood-filtering device called CytoSorb is used in real-world intensive care settings. It will include up to 3,000 critically ill patients with conditions like septic shock, severe lung injury, or liver failure. The goal i…

This study aims to better understand how common enterovirus infections are in newborns in Italy, especially a dangerous type called Echovirus 11. Researchers will analyze samples from up to 1,600 babies in intensive care to track the virus and identify risk factors for severe ill…

This study looks at whether a blood test marker called Monocyte Distribution Width (MDW) can help predict serious complications and survival in older adults with hip fractures. About 100 patients aged 65 and older will have their blood tested at the hospital. Researchers will tra…

This study tests whether looking at how a blood marker (procalcitonin) changes over time is better than a single measurement for deciding when to start antibiotics in critically ill patients. About 250 adults in the ICU with a suspected infection will be randomly assigned to one …

This study looks back at medical records of 1500 adults in the ICU with sepsis and low platelet counts. Researchers want to see if giving platelet transfusions helps patients survive for 28 days. The goal is to understand if this common treatment is helpful or harmful.

This study is looking for new ways to quickly diagnose sepsis, a life-threatening reaction to infection, in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve early …

This study looks at using a computer program (machine learning) to help doctors diagnose sepsis and septic shock more quickly. Researchers will analyze data from 10,000 ICU patients to see if the algorithm can spot warning signs earlier than current methods. The goal is to speed …

This study looks at neutrophils—a type of immune cell—in the blood of children with sepsis, a severe infection that can damage organs. Researchers want to understand how these cells change and cause harm, so they can develop better treatments. About 72 children with sepsis and he…

This observational study looks at how severe trauma changes the body's blood and bone marrow, aiming to understand why some patients become immune-suppressed and develop infections like sepsis. Researchers will collect blood and bone marrow samples from 255 trauma patients and co…

This study aims to see if a program that includes guidelines, feedback, and education can reduce the use of vancomycin (a strong antibiotic) in children with suspected sepsis in intensive care units. About 52,500 children will be involved across five hospitals. The goal is to low…

This study is observing 1,000 adults in the intensive care unit (ICU) to learn more about why some people get very sick from infections or injuries. Researchers will collect blood samples and health data to find early signs that could help diagnose serious conditions like sepsis …

This study follows 300 critically ill children who had sepsis for five years after they leave the hospital. Researchers want to see how sepsis affects their growth, brain development, survival, and quality of life. The goal is to better understand the long-term impact of this ser…

This study aims to understand how long a special dialysis filter (Oxiris®) effectively removes harmful toxins from the blood of adults with severe septic shock. Researchers will observe 29 patients already receiving this filter as part of their standard ICU care, taking blood sam…