New trial aims to find best way to give antibiotics for sepsis
NCT ID NCT05681442
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at 600 ICU patients with hospital-acquired sepsis to see if giving antibiotics continuously or adding a second antibiotic improves survival. Patients will be randomly assigned to receive a beta-lactam antibiotic either continuously or intermittently, and some will also get an aminoglycoside antibiotic for one day or five days. The main goal is to compare 30-day death rates between the groups.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- beta-lactam antibiotics (given continuously or intermittently) and aminoglycoside antibiotics (given as a single dose or for 5 days)
- What this could lead to
- If successful, this could show that continuous antibiotic infusion or adding a second antibiotic improves survival in sepsis patients in the ICU.
- What could go wrong
- This is a Phase 4 trial, but sepsis is complex and results may not apply to all patients. The open-label design could introduce bias, and the benefit may be modest.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Anesthésie - Réanimation - Beaujon
RECRUITINGClichy, 92110, France
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Anesthésie - Réanimation - CHU Orléans
RECRUITINGOrléans, 86000, France
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Institut Mutualiste du Montsouris
RECRUITINGParis, France
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Médecine Intensive Réanimation - Hôpital Croix Rousse
RECRUITINGLyon, 69004, France
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Médecine Intensive Réanimation - Pasteur 2
RECRUITINGNice, 06100, France
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Médecine intensive - réanimation
RECRUITINGOrléans, 45000, France
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Médecine intensive - réanimation - Ambroise Paré
RECRUITINGBoulogne-Billancourt, 92100, France
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Médecine intensive - réanimation - CHU Amiens-Picardie
WITHDRAWNAmiens, 80054, France
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Médecine intensive - réanimation - CHU Bordeaux - Hôpital Pellegrin
RECRUITINGBordeaux, 33000, France
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Médecine intensive - réanimation - CHU Gabriel Montpied
RECRUITINGClermont-Ferrand, 63003, France
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Médecine intensive - réanimation - CHU Grenoble-Alpes Hôpital Michallon
RECRUITINGLa Tronche, 38700, France
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Médecine intensive - réanimation - CHU Montpellier - Hôpital Lapeyronie
RECRUITINGMontpellier, 34295, France
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Médecine intensive - réanimation - CHU Nice - Hôpital Archet
RECRUITINGNice, 06202, France
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Médecine intensive - réanimation - CHU Poitiers - Site de la Milétrie
RECRUITINGPoitiers, 86000, France
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Médecine intensive - réanimation - CHU de Strasbourg - Nouvel Hôpital Civil
RECRUITINGStrasbourg, 67091, France
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Médecine intensive - réanimation - HCL - Edouard Herriot
RECRUITINGLyon, 69437, France
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Médecine intensive - réanimation-CH St Denis - Hôpital Delafontaine
RECRUITINGSaint-Denis, 93200, France
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Médecine intensive - réanimation-Centre Hospitalier Départemental Vendée
RECRUITINGLa Roche-sur-Yon, 85000, France
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Médecine intensive et réanimation infectieuse - Bichat
RECRUITINGParis, 75018, France
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Médecine intensive et réanimation polyvalente 6 CHU de Reims - Hôpital Robert Debré
WITHDRAWNReims, 51100, France
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Réanimation Chirurgicale - Saint Eloi
RECRUITINGMontpellier, 34295, France
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Réanimation Médico Chirurgicale & USC - CH Le Mans
RECRUITINGLe Mans, 72037, France
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Réanimation chirurgicale - Bichat
RECRUITINGParis, 75018, France
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Réanimation polyvalente - CH Avignon
RECRUITINGAvignon, 84000, France
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Réanimation polyvalente - CH d'Argenteuil - Hôpital Victor Dupuy
RECRUITINGArgenteuil, 95100, France
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Réanimation polyvalente - CH de Versailles - Hôpital André Mignot
RECRUITINGLe Chesnay, 78150, France
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Réanimation polyvalente - CHR Metz-Thionville - Hôpital de Mercy
RECRUITINGMetz, 57085, France
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Réanimation polyvalente/Surveillance continue - CH Sud Essonne-Etampes
RECRUITINGÉtampes, 91150, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can we optimize antibiotic dosing for children with sepsis?
- Could starting feeds sooner shield preterm babies from infection?
- Can brain waves predict thinking problems after sepsis?
- Can tailored nutrition boost recovery in the ICU?
- Blood markers may foretell brain fog after sepsis
- A hidden clue in the fingertips: could a pulse oximeter reading forecast sepsis outcomes?