New trial aims to find best way to give antibiotics for sepsis
NCT ID NCT05681442
First seen Nov 24, 2025 · Last updated Jun 22, 2026 · Updated 25 times
Summary
This study looks at 600 ICU patients with hospital-acquired sepsis to see if giving antibiotics continuously or adding a second antibiotic improves survival. Patients will be randomly assigned to receive a beta-lactam antibiotic either continuously or intermittently, and some will also get an aminoglycoside antibiotic for one day or five days. The main goal is to compare 30-day death rates between the groups.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Anesthésie - Réanimation - Beaujon
RECRUITINGClichy, 92110, France
Contact Email: •••••@•••••
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Anesthésie - Réanimation - CHU Orléans
RECRUITINGOrléans, 86000, France
Contact Email: •••••@•••••
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Institut Mutualiste du Montsouris
RECRUITINGParis, France
Contact Email: •••••@•••••
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Médecine Intensive Réanimation - Hôpital Croix Rousse
RECRUITINGLyon, 69004, France
Contact Email: •••••@•••••
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Médecine Intensive Réanimation - Pasteur 2
RECRUITINGNice, 06100, France
Contact Email: •••••@•••••
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Médecine intensive - réanimation
RECRUITINGOrléans, 45000, France
Contact Email: •••••@•••••
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Médecine intensive - réanimation - Ambroise Paré
RECRUITINGBoulogne-Billancourt, 92100, France
Contact Email: •••••@•••••
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Médecine intensive - réanimation - CHU Amiens-Picardie
WITHDRAWNAmiens, 80054, France
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Médecine intensive - réanimation - CHU Bordeaux - Hôpital Pellegrin
RECRUITINGBordeaux, 33000, France
Contact Email: •••••@•••••
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Médecine intensive - réanimation - CHU Gabriel Montpied
RECRUITINGClermont-Ferrand, 63003, France
Contact Email: •••••@•••••
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Médecine intensive - réanimation - CHU Grenoble-Alpes Hôpital Michallon
RECRUITINGLa Tronche, 38700, France
Contact Email: •••••@•••••
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Médecine intensive - réanimation - CHU Montpellier - Hôpital Lapeyronie
RECRUITINGMontpellier, 34295, France
Contact Email: •••••@•••••
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Médecine intensive - réanimation - CHU Nice - Hôpital Archet
RECRUITINGNice, 06202, France
Contact Email: •••••@•••••
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Médecine intensive - réanimation - CHU Poitiers - Site de la Milétrie
RECRUITINGPoitiers, 86000, France
Contact Email: •••••@•••••
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Médecine intensive - réanimation - CHU de Strasbourg - Nouvel Hôpital Civil
RECRUITINGStrasbourg, 67091, France
Contact Email: •••••@•••••
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Médecine intensive - réanimation - HCL - Edouard Herriot
RECRUITINGLyon, 69437, France
Contact Email: •••••@•••••
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Médecine intensive - réanimation-CH St Denis - Hôpital Delafontaine
RECRUITINGSaint-Denis, 93200, France
Contact Email: •••••@•••••
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Médecine intensive - réanimation-Centre Hospitalier Départemental Vendée
RECRUITINGLa Roche-sur-Yon, 85000, France
Contact Email: •••••@•••••
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Médecine intensive et réanimation infectieuse - Bichat
RECRUITINGParis, 75018, France
Contact Email: •••••@•••••
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Médecine intensive et réanimation polyvalente 6 CHU de Reims - Hôpital Robert Debré
WITHDRAWNReims, 51100, France
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Réanimation Chirurgicale - Saint Eloi
RECRUITINGMontpellier, 34295, France
Contact Email: •••••@•••••
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Réanimation Médico Chirurgicale & USC - CH Le Mans
RECRUITINGLe Mans, 72037, France
Contact Email: •••••@•••••
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Réanimation chirurgicale - Bichat
RECRUITINGParis, 75018, France
Contact Email: •••••@•••••
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Réanimation polyvalente - CH Avignon
RECRUITINGAvignon, 84000, France
Contact Email: •••••@•••••
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Réanimation polyvalente - CH d'Argenteuil - Hôpital Victor Dupuy
RECRUITINGArgenteuil, 95100, France
Contact Email: •••••@•••••
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Réanimation polyvalente - CH de Versailles - Hôpital André Mignot
RECRUITINGLe Chesnay, 78150, France
Contact Email: •••••@•••••
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Réanimation polyvalente - CHR Metz-Thionville - Hôpital de Mercy
RECRUITINGMetz, 57085, France
Contact Email: •••••@•••••
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Réanimation polyvalente/Surveillance continue - CH Sud Essonne-Etampes
RECRUITINGÉtampes, 91150, France
Contact Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
beta-lactam antibiotics (given continuously or intermittently) and aminoglycoside antibiotics (given as a single dose or for 5 days)
What this could lead to
If successful, this could show that continuous antibiotic infusion or adding a second antibiotic improves survival in sepsis patients in the ICU.
What could go wrong
This is a Phase 4 trial, but sepsis is complex and results may not apply to all patients. The open-label design could introduce bias, and the benefit may be modest.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.