New drug aims to stop deadly clots in sepsis patients
NCT ID NCT06854640
First seen Apr 03, 2026 · Last updated Jun 21, 2026 · Updated 12 times
Summary
This early study tests a new drug called BAY 3389934 in 36 hospital ICU patients with sepsis-induced coagulopathy, a condition where the body forms dangerous blood clots. The main goal is to check safety and find the right dose. Researchers will monitor side effects and blood clotting measures over 28 days.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHRU de Tours - Hôpital Bretonneau - Médecine Intensive Réanimation
NOT_YET_RECRUITINGTours, Centre-Val de Loire, 37044, France
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Canisius WIlhelmina Ziekenhuis - Intensive Care
NOT_YET_RECRUITINGNijmegen, Gelderland, 6532 SZ, Netherlands
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Centre Hospitalier Départemental Vendée - Service de réanimation polyvalente
NOT_YET_RECRUITINGLa Roche-sur-Yon, Pays de la Loire Region, 85000, France
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Centre Hospitalier Universitaire (CHU) de Liege - Domaine Universitaire du Sart Tilman - Intensive Care
NOT_YET_RECRUITINGLiège, 4000, Belgium
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Centre Hospitalier Universitaire d'Angers - Médecine Intensive Réanimation et Médecine Hyperbare
NOT_YET_RECRUITINGAngers, Pays de la Loire Region, 49100, France
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Centre Hospitalier Universitaire de Limoges Dupuytren 1 - Service de réanimation polyvalente
NOT_YET_RECRUITINGLimoges, New Aquitaine, 87042, France
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Clinique Saint-Pierre d'Ottignies - Intensive Care
RECRUITINGOttignies-Louvain-la-Neuve, 1340, Belgium
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Erasmus Medisch Centrum - Intensive Care
NOT_YET_RECRUITINGRotterdam, South Holland, 3015 GD, Netherlands
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Hopital Hotel Dieu Nantes - Service de Médecine Intensive Réanimation
NOT_YET_RECRUITINGNantes, Pays de la Loire Region, 44000, France
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Hopitaux Universitaires de Strasbourg Nouvel Hopital Civil - Service de Médecine Intensive Réanimation
RECRUITINGStrasbourg, Grand Est, 67091, France
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Hôpital Raymond-Poincaré - Service de Médecine Intensive - Réanimation, Médecine Hyperbare
NOT_YET_RECRUITINGGarches, Île-de-France Region, 92380, France
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Jeroen Bosch Ziekenhuis - Intensive Care
NOT_YET_RECRUITING's-Hertogenbosch, North Brabant, 5223 GZ, Netherlands
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Kliniken der Stadt Köln gGmbH - Krankenhaus Merheim - Lungenklinik
NOT_YET_RECRUITINGCologne, North Rhine-Westphalia, 51109, Germany
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Klinikum der Universität München AöR - Klinik für Anaesthesiologie (Campus Großhadern)
NOT_YET_RECRUITINGMünchen, 81377, Germany
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Medisch Spectrum Twente - Intensive Care
NOT_YET_RECRUITINGEnschede, Overijssel, 7512 KZ, Netherlands
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UZ Antwerpen - Intensive Care
NOT_YET_RECRUITINGEdegem, 2650, Belgium
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Universitaetsklinikum Carl Gustav Carus an der Technischen Universitaet Dresden | Medizinische Klinik I - FB Haemostaseologie
NOT_YET_RECRUITINGDresden, 01307, Germany
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Universitair Medisch Centrum St. Radboud - Intensive Care
NOT_YET_RECRUITINGNijmegen, Gelderland, 6525 GA, Netherlands
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Universite Catholique de Louvain (UCL) - Cliniques Universitaires Saint-Luc - Intensive Care
NOT_YET_RECRUITINGBrussels, 1200, Belgium
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Universitätsklinikum Leipzig AöR | Interdisziplinare Internistische Intensivmedizin
NOT_YET_RECRUITINGLeipzig, 04103, Germany
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
BAY 3389934
What this could lead to
If this works, it could point toward a new treatment to control dangerous blood clotting in sepsis patients, potentially reducing organ damage and death.
What could go wrong
This is a very early Phase 1 trial with only 36 people, focused on safety and dosing. It is too soon to know if the drug will help, and there may be side effects or no benefit.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.