New drug aims to stop deadly clots in sepsis patients

NCT ID NCT06854640

Recruiting now Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tests a new drug called BAY 3389934 in 36 hospital ICU patients with sepsis-induced coagulopathy, a condition where the body forms dangerous blood clots. The main goal is to check safety and find the right dose. Researchers will monitor side effects and blood clotting measures over 28 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BAY 3389934
What this could lead to: If this works, it could point toward a new treatment to control dangerous blood clotting in sepsis patients, potentially reducing organ damage and death.
What could go wrong: This is a very early Phase 1 trial with only 36 people, focused on safety and dosing. It is too soon to know if the drug will help, and there may be side effects or no benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

blood coagulation disease disseminated intravascular coagulation infectious disease with sepsis Sepsis vascular hemostatic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COAGULOPATHY SEPSIS

Contacts and locations

Locations

CHRU de Tours - Hôpital Bretonneau - Médecine Intensive Réanimation
NOT_YET_RECRUITING

Tours, Centre-Val de Loire, 37044, France
Canisius WIlhelmina Ziekenhuis - Intensive Care
NOT_YET_RECRUITING

Nijmegen, Gelderland, 6532 SZ, Netherlands
Centre Hospitalier Départemental Vendée - Service de réanimation polyvalente
NOT_YET_RECRUITING

La Roche-sur-Yon, Pays de la Loire Region, 85000, France
Centre Hospitalier Universitaire (CHU) de Liege - Domaine Universitaire du Sart Tilman - Intensive Care
NOT_YET_RECRUITING

Liège, 4000, Belgium
Centre Hospitalier Universitaire d'Angers - Médecine Intensive Réanimation et Médecine Hyperbare
NOT_YET_RECRUITING

Angers, Pays de la Loire Region, 49100, France
Centre Hospitalier Universitaire de Limoges Dupuytren 1 - Service de réanimation polyvalente
RECRUITING

Limoges, New Aquitaine, 87042, France
Clinique Saint-Pierre d'Ottignies - Intensive Care
RECRUITING

Ottignies-Louvain-la-Neuve, 1340, Belgium
Erasmus Medisch Centrum - Intensive Care
NOT_YET_RECRUITING

Rotterdam, South Holland, 3015 GD, Netherlands
Hopital Hotel Dieu Nantes - Service de Médecine Intensive Réanimation
NOT_YET_RECRUITING

Nantes, Pays de la Loire Region, 44000, France
Hopitaux Universitaires de Strasbourg Nouvel Hopital Civil - Service de Médecine Intensive Réanimation
RECRUITING

Strasbourg, Grand Est, 67091, France
Hôpital Raymond-Poincaré - Service de Médecine Intensive - Réanimation, Médecine Hyperbare
NOT_YET_RECRUITING

Garches, Île-de-France Region, 92380, France
Jeroen Bosch Ziekenhuis - Intensive Care
NOT_YET_RECRUITING

's-Hertogenbosch, North Brabant, 5223 GZ, Netherlands
Kliniken der Stadt Köln gGmbH - Krankenhaus Merheim - Lungenklinik
NOT_YET_RECRUITING

Cologne, North Rhine-Westphalia, 51109, Germany
Klinikum der Universität München AöR - Klinik für Anaesthesiologie (Campus Großhadern)
NOT_YET_RECRUITING

München, Bavaria, 81377, Germany
Medisch Spectrum Twente - Intensive Care
NOT_YET_RECRUITING

Enschede, Overijssel, 7512 KZ, Netherlands
UZ Antwerpen - Intensive Care
NOT_YET_RECRUITING

Edegem, 2650, Belgium
Universitaetsklinikum Carl Gustav Carus an der Technischen Universitaet Dresden | Medizinische Klinik I - FB Haemostaseologie
RECRUITING

Dresden, Saxony, 01307, Germany
Universitair Medisch Centrum St. Radboud - Intensive Care
NOT_YET_RECRUITING

Nijmegen, Gelderland, 6525 GA, Netherlands
Universite Catholique de Louvain (UCL) - Cliniques Universitaires Saint-Luc - Intensive Care
NOT_YET_RECRUITING

Woluwe-Saint-Lambert, 1200, Belgium
Universitätsklinikum Leipzig AöR | Interdisziplinare Internistische Intensivmedizin
NOT_YET_RECRUITING

Leipzig, Saxony, 04103, Germany

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