Can a natural compound help seniors survive sepsis?

NCT ID NCT05758246

Recruiting now Disease control Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether the drug fisetin can reduce organ failure in adults aged 65 and older who have sepsis (a severe response to infection). Researchers will give participants either one or two doses of fisetin or a placebo, and measure changes in heart, lung, and kidney function over a week. The goal is to see if fisetin can help prevent the progression of sepsis to more serious organ damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fisetin (a drug given by mouth)
What this could lead to: If it works, this could point toward a treatment that reduces organ damage in older patients with sepsis.
What could go wrong: This is an early phase 2 trial with only 220 participants, so results may not apply to all sepsis patients. The drug may not improve outcomes or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

infectious disease with sepsis Sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE INFECTION ORGAN FAILURE SEPSIS

Contacts and locations

Locations

HCMC
RECRUITING

Minneapolis, Minnesota, 55415, United States
M Health Fairview St. John's
RECRUITING

Maplewood, Minnesota, 55109, United States
Ridges
RECRUITING

Burnsville, Minnesota, 55337, United States
Southdale
RECRUITING

Edina, Minnesota, 55435, United States
St. John's
RECRUITING

Maplewood, Minnesota, 55109, United States
UMMC
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Florida
RECRUITING

Gainesville, Florida, 32608, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55414, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States

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