Can smarter dosing of a common antibiotic prevent kidney damage in kids with sepsis?
NCT ID NCT07084129
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether using personalized dosing models for the antibiotic vancomycin can improve treatment in children with sepsis. The standard dosing approach may lead to blood levels that are too high (risking kidney injury) or too low (risking ineffective treatment). The study will enroll 20 children in intensive care and use new markers of kidney function to adjust each child's dose. The main goal is to see if this personalized approach is feasible and can keep vancomycin levels in the target range.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
vancomycin
What this could lead to
If successful, this could lead to safer, more effective vancomycin dosing for children with sepsis, reducing the risk of kidney injury.
What could go wrong
This is a very small, early-phase feasibility study with only 20 participants. It is not designed to prove that personalized dosing prevents kidney injury, only that the approach is possible.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SEPSIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact