Can smarter dosing of a common antibiotic prevent kidney damage in kids with sepsis?

This early-phase trial tests whether using personalized dosing models for the antibiotic vancomycin can improve treatment in children with sepsis. The standard dosing approach may lead to blood levels that are too high (risking kidney injury) or too low (risking ineffective treatment). The study will enroll 20 children in intensive care and use new markers of kidney function to adjust each child's dose. The main goal is to see if this personalized approach is feasible and can keep vancomycin levels in the target range.