SEPSIS

This study tests a drug called emapalumab in 75 adults with sepsis, a life-threatening response to infection. The drug blocks a protein called interferon-gamma that may drive severe inflammation. Researchers want to see if it improves organ function and find the best dose. Partic…

This study looks at whether a structured nutrition plan can help ICU patients recover better after abdominal surgery. The plan includes tube feeding, oral supplements, and a device to measure exact calorie needs. About 300 adults in the ICU will take part, and their nutrition and…

This study looks at two different antibiotic treatments for sepsis in burn patients. It compares a strong antibiotic called Meropenem with another called Pipracillin/Tazobactam to see which one helps more patients survive. The study involves 400 adults aged 21-60 with burns and s…

This study aimed to see if adding two immune therapies—a drug called nogapendekin alfa inbakicept and special immune cells (iNKT cells)—to standard care could help critically ill adults with severe pneumonia, sepsis, or lung failure recover. It was designed for adults in the ICU …

This study was designed to test whether adding two experimental agents (nogapendekin alfa inbakicept and iNKT cells) to standard care could lower the risk of death within 28 days in critically ill adults with severe community-acquired pneumonia, with or without sepsis or acute re…

This study tests a new approach for treating severe infections (sepsis) in intensive care units. It uses rapid tests to quickly identify the bacteria causing the infection and their antibiotic resistance, along with a blood marker called procalcitonin. The goal is to see if this …

This study tests a new finger-clasp device, similar to a pulse oximeter, that measures lactate levels from skin fluid instead of blood. Lactate is a key marker for sepsis, a life-threatening infection. The goal is to see if the device works as well as standard blood tests in 6 he…

This early-phase study tests whether low doses of inhaled carbon monoxide can be safely given to adults with severe lung injury caused by sepsis or pneumonia. The main goal is to check safety and see if a personalized dosing formula works. Only 5 participants are enrolled, so res…

This study looks at whether esketamine, a drug related to ketamine, can safely sedate and prevent confusion (delirium) in 80 adults with sepsis who need a breathing machine. The goal is to see if it reduces time on the ventilator and improves survival. Current sedatives can cause…

This study was designed to measure how stiff the arteries are in intensive care patients receiving drugs that support the heart or blood pressure. The goal was to see how these drugs affect the interaction between the heart and blood vessels. However, the study was withdrawn befo…

This study tests whether metformin, a common diabetes medicine, is safe and practical to use for treating acute kidney injury caused by sepsis. Researchers will enroll 80 intensive care patients to monitor side effects and see if the treatment can be given successfully. This is a…

This study follows 312 older adults who were in the ICU for critical illness to see how their physical activity during the hospital stay relates to their recovery. Researchers measure disability, physical function, and cognitive function at 3 and 12 months after leaving the ICU. …

This study was designed to see if an artificial intelligence (AI) system could predict sepsis—a serious infection—in patients recovering from abdominal surgery. Participants would have worn a non-invasive device on their finger to track vital signs, and the AI would combine that …

This study aimed to see if sending supportive messages to sepsis survivors after they leave the hospital would encourage them to regularly share health information through their online patient portal. The study was withdrawn before enrolling any participants, so no results are av…

This study looks at 120 adults receiving a left ventricular assist device (LVAD), a mechanical heart pump. Researchers want to understand how often infections happen after surgery and how the immune system changes. The goal is to find risk factors that could predict who might get…

This study asks critical care doctors and advanced practice providers to review patient cases of sepsis and ARDS. They will evaluate treatment recommendations and guess whether each came from a human doctor or an artificial intelligence system. The goal is to see if AI can produc…

This study is looking for markers in blood, stool, saliva, and lung fluid that can help predict how sepsis will affect a patient. Researchers will combine these markers with standard medical information to identify patients at higher risk of death or long-term illness. The goal i…

This study looks at bacteria that enter the bloodstream during dental treatment for gum disease. Researchers want to find biological markers that could help detect sepsis earlier, which could save lives. About 100 adults with gum disease are taking part, and the goal is to improv…

This study looks at 90 adults with sepsis who develop confusion or delirium. Researchers measure specific proteins in the blood to see if they can predict brain injury and long-term outcomes. No new treatments are tested—the goal is to better understand how sepsis affects the bra…

This study was designed to explore how tiny energy-producing parts of cells, called mitochondria, might lead to heart damage in people with sepsis. Researchers planned to compare blood samples from sepsis patients and healthy volunteers. However, the study was withdrawn before an…

This study aims to find out how many adult patients in Turkish intensive care units have sepsis or septic shock, and what happens to them over the next 30 days. Researchers will collect data from ICUs across Turkey between September 2025 and January 2026. The goal is to provide b…

This study looks at how sepsis affects the heart in intensive care patients. Researchers will monitor heart function, blood markers, and patient outcomes in about 330 adults with septic shock. The goal is to find better ways to diagnose and predict heart-related complications, no…

This study uses data from 16,000 hospital patients to see if men and women, or younger and older adults, need different blood lactate thresholds to predict risk of death or serious illness. Researchers hope to improve how doctors identify high-risk patients with sepsis in the ICU…

This study looks at medical records from 10,000 people who had sepsis (blood poisoning) and blood clots in their veins (VTE) while in the ICU. Researchers want to see if a serious clotting disorder called DIC happened before the blood clots formed. No new treatments or tests are …

This study looks at whether a heart MRI can be done safely in children with cancer who have recently had sepsis, a serious infection. The goal is to find hidden heart problems early so doctors can adjust treatments. About 7 participants aged 9 to 25 will be scanned within 10 days…

This study was designed to see if a device called LifeFlow® could deliver fluids faster and more safely to children with sepsis in the emergency room compared to the usual push/pull method. It planned to include 600 children under 19 years old, but the study was withdrawn before …

This study looks at a gene called TRIM25 in blood cells of people with sepsis, a life-threatening infection response. Researchers will compare gene activity and inflammatory markers between 65 sepsis patients and non-sepsis controls. The goal is to find biological clues that coul…