SEPSIS

This study is testing whether metformin, a common diabetes medication, is safe and practical to use for treating sudden kidney failure caused by severe bloodstream infections (sepsis). Researchers will give metformin or a placebo to 80 adult patients in intensive care with sepsis…

This study is testing whether a drug called emapalumab can help patients with severe sepsis who have a specific overactive immune response. It involves 75 adults in Greece with sepsis from infections like pneumonia, comparing two doses of the drug against a placebo. The main goal…

This study planned to test if a device called LifeFlow® could deliver emergency fluids faster and more effectively than standard methods in children with sepsis. It aimed to enroll 600 children under 19 years old in the emergency room. The main goals were to see if the device hel…

This study is testing a structured plan for delivering nutrition to patients in the intensive care unit (ICU) after major abdominal surgery or trauma. The goal is to see if this careful feeding approach, which uses a device to measure calorie needs and includes tube feeding and s…

This study is testing a new strategy to manage severe infections like sepsis. It uses rapid tests to identify the specific germ causing the infection and its antibiotic resistance much faster than standard methods. The goal is to help doctors prescribe the most effective antibiot…

This early-stage study is testing whether carefully controlled, low doses of inhaled carbon monoxide can be safely given to patients with severe lung failure caused by infections like sepsis or pneumonia. Researchers want to see if a personalized dosing method can reliably reach …

This study aims to find out which of two common types of powerful antibiotics works better as the first treatment for sepsis, a life-threatening infection, in patients with serious burns. It will compare how well patients survive and recover when given either Meropenem or Piperac…

This study is testing a new finger-clip device that measures lactate levels without needing blood draws. Lactate is a key marker that helps doctors monitor sepsis, a serious infection. Researchers are comparing the device's readings against standard blood tests in healthy volunte…

This study aims to see if an artificial intelligence (AI) system can give safe and appropriate treatment advice for serious ICU conditions like sepsis and ARDS. It involves 350 critical care doctors and nurses reviewing simulated patient cases and judging the treatment plans. The…

This research study aims to identify biological markers in blood, saliva, stool, and other body fluids that can help predict which sepsis patients are most likely to have poor outcomes. Researchers will collect samples from 200 adult patients with suspected sepsis over several ti…

This study aims to understand how a specific gene, called TRIM25, behaves in the blood cells of people with sepsis compared to those without it. Researchers will collect blood samples from about 65 hospitalized patients to see if the activity of this gene is linked to how well pa…

This study investigates whether a standard dental cleaning for gum disease can be used as a model to find better markers in the blood for detecting sepsis, a life-threatening infection. Researchers are studying 100 people with gum disease to see if bacteria released into the bloo…

This study aimed to learn more about how to monitor the heart and blood vessels in intensive care unit (ICU) patients who need medications to support their blood pressure or heart function. Researchers wanted to test a specific measurement (called Eadyn) to see if it gives useful…

This study aims to understand the relationship between sepsis (a life-threatening infection), dangerous blood clots (VTE), and a serious clotting disorder (DIC). Researchers will analyze the past medical records of 10,000 people who were in intensive care with sepsis and blood cl…

This study aims to understand how common sepsis, a life-threatening response to infection, is in intensive care units across Turkey. Researchers will collect data from 1000 adult patients to measure the number of cases and track their health outcomes for 30 days. The goal is to g…

This study aims to better understand how heart problems affect patients with severe sepsis (septic shock) in the intensive care unit. Researchers will observe 379 adult patients to see if specific measurements of heart function and blood tests can predict who is more likely to su…

This study aims to understand why some sepsis patients develop sudden confusion or delirium, a condition linked to worse survival. Researchers will measure specific proteins in the blood of 90 emergency room patients with sepsis, comparing those with and without mental changes. T…

This study is testing whether a special heart scan (MRI) can be done safely and successfully in children with cancer who have recently recovered from a severe infection called sepsis. The goal is to see if these scans can find hidden heart problems, like inflammation or weakness,…

This study aims to understand if being physically active while in the hospital helps older adults recover better after a life-threatening illness. Researchers are tracking 312 patients with conditions like sepsis to see how their activity levels relate to their physical and menta…

This study aimed to understand why sepsis, a severe body-wide infection, often damages the heart. Researchers planned to measure tiny energy-producing parts of cells (mitochondria) and markers of inflammation in the blood of sepsis patients. The goal was to see if these measureme…

This study aims to understand why patients who receive a mechanical heart pump (LVAD) often get serious infections after surgery. Researchers will look at the medical records of 120 patients to track infection rates and see how the surgery changes their immune system. The goal is…