Can a heart drug tame sepsis? new trial aims to find out

NCT ID NCT05882708

Recruiting now Disease control Sponsor: Second Affiliated Hospital of Guangzhou Medical University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether ivabradine, a drug that slows heart rate without weakening the heart's pumping strength, can help people with sepsis. Sepsis is a life-threatening infection that often causes a dangerously fast heart rate. The trial will enroll 172 adults in intensive care and compare ivabradine to a placebo, measuring heart rate, blood pressure, and other heart function over 96 hours.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ivabradine
What this could lead to: If it works, this could point toward a safer way to control heart rate in sepsis patients, potentially reducing deaths.
What could go wrong: This is a mid-stage trial with only 172 participants, so results may not apply to all sepsis patients. Ivabradine may not improve survival or could cause side effects like slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

infectious disease with sepsis Sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART RATE CONTROL HEMODYNAMICS IVABRADINE SEPSIS

Contacts and locations

Locations

the Affiliated Panyu central Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, Guangdong, 510000, China
the Second Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, Guangdong, 510000, China
the Third Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, Guangdong, 510260, China

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