Could a daily 'Good Bacteria' capsule speed up recovery after sepsis?

NCT ID NCT07295353

Not yet recruiting Disease control Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a daily capsule of pasteurized Akkermansia muciniphila, a type of beneficial gut bacteria, can help adults recover after being treated for sepsis in the ICU. Fifty participants will take either the supplement or a placebo for 56 days. Researchers will check safety and measure changes in gut bacteria and immune markers from stool and blood samples.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pasteurized Akkermansia muciniphila (a beneficial gut bacteria) taken as a daily capsule
What this could lead to: If it works, this could point toward a simple, safe supplement to help people recover their gut health and immune function after a serious ICU stay for sepsis.
What could go wrong: This is a very early, small study (50 people) testing safety and gut bacteria changes, not whether it actually improves recovery. The supplement may have no effect or cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Critical Illness infectious disease with sepsis Sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRITICAL ILLNESS INTENSIVE CARE UNIT SURVIVORS MICROBIOME DYSBIOSIS POST INTENSIVE CARE UNIT SYNDROME SEPSIS

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