Asthma drug could shield hearts after attack, new trial hopes

NCT ID NCT07320625

Recruiting now Disease control Sponsor: Shanghai Zhongshan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether montelukast, a common asthma drug, can reduce heart damage in people having a heart attack. 512 patients with a specific type of heart attack will receive either montelukast or a placebo daily for 3 months. The goal is to see if the drug prevents the heart from becoming enlarged and weak after blood flow is restored.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Montelukast
What this could lead to: If it works, this could point toward a new, low-cost way to prevent heart failure after a heart attack by reducing injury when blood flow is restored.
What could go wrong: This is a phase 3 trial, but montelukast is being repurposed for a new use, and previous studies have been small or in animals. It may not show clear benefit in humans.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

myocardial infarction ST-elevation myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYOCARDIAL INFARCTION (MI)

Contacts and locations

Locations

Affiliated Zhongshan Hospital of Dalian University
RECRUITING

Dalian, Liaoning, China
Fujian provincial hospital
RECRUITING

Fuzhou, China
Guangdong Provincial People's Hospital
RECRUITING

Guangdong, China
Harbin Medical University Second Affiliated Hospital
RECRUITING

Ha’erbin, China
Hunan Provincial People's Hospital
RECRUITING

Hunan, China
Liaoning Provincial People's Hospital
RECRUITING

Shenyang, China
The 2nd Affiliated Hospital and Yuying Children's Hospital of WMU
RECRUITING

Wenzhou, China
The First Affiliated Hospital of the University of Science and Technology of China
RECRUITING

Hefei, China
The Second Affiliated Hospital of Dalian Medical University
RECRUITING

Dalian, China
The Second Xiangya Hospital of Central South University
RECRUITING

Hunan, China
Xiangya Hospital of Central South University
RECRUITING

Hunan, China
Zhongshan Hospital, Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 200032, China

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