Balloon vs. stent: new trial tests which is better for Rock-Hard arteries

NCT ID NCT07277114

Recruiting now Disease control Sponsor: Shanghai Zhongshan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a drug-coated balloon works as well as a drug-eluting stent for people with severe calcium deposits in their heart arteries. After using special tools to break up the calcium, 656 participants will be randomly assigned to one of the two treatments. Researchers will track major heart problems like heart attacks or the need for repeat procedures over one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: drug-coated balloon (DCB) and drug-eluting stent (DES)
What this could lead to: If DCB works as well as DES, patients with severe calcium buildup may have a stent-free option that reduces long-term hardware in the artery.
What could go wrong: This is a mid-sized trial (656 people) testing a non-inferiority idea, so even if DCB is similar, it may not be better. Risks include artery injury, blockages, or heart events during or after the procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary atherosclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY CALCIFICATION

Contacts and locations

Locations

Zhongshan Hospital, Fudan University
RECRUITING

Shanghai, 200032, China

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