New imaging method could replace risky heart wire test

This study tests whether a new software-based method called Angio-IMR can diagnose coronary microvascular disease (blockages in tiny heart arteries) as accurately as the current standard test that uses a pressure wire inside the artery. About 192 adults with stable chest pain or suspected heart disease will have their standard angiogram images analyzed by five different software programs under three conditions (rest, mild drug effect, and strong drug effect). The goal is to see which software and condition best matches the wire-based results, potentially offering a safer, wire-free alternative.