Shanghai Zhongshan Hospital

This early-stage trial will test the safety of a single inhaled dose of a lab-made protein (rhKGF-2) in 24 adults with moderate-to-severe ARDS who are on a breathing machine. Participants will receive either the study drug or standard care alone, and be monitored for 28 days for …

This study looks at two ways to treat bleeding from enlarged veins in the stomach and throat caused by high blood pressure in the liver. It will compare a scope procedure with a minimally invasive X-ray-guided treatment to see which better prevents future bleeding. About 1,066 ad…

This study tests a device called AnchorMan that is placed in the heart to close a small pouch in people with atrial fibrillation who are at high risk of stroke. The goal is to see how well the heart heals around the device after 6 months. About 306 participants will be followed f…

This study looks at people with advanced liver cancer that cannot be removed by surgery at first. They will receive a combination of treatments (chemo directly into the liver, anti-angiogenic drugs, and immunotherapy) to shrink the tumors. If the tumors shrink enough or become re…

This study tests whether a blood test that detects tiny traces of cancer DNA (ctDNA) can guide treatment after gastric cancer surgery. The goal is to see if patients with no detectable cancer DNA can safely skip additional chemotherapy, avoiding harsh side effects. About 90 adult…

This study tests a new combination of drugs (SHR-1701 and famitinib) given before and after surgery for a rare type of skin cancer called mucosal melanoma. The goal is to see if this approach can help keep the cancer from coming back. About 70 adults with resectable tumors will t…

This study tests whether adding an injectable medication called treprostinil to standard oral therapy can improve heart function in people with intermediate-risk pulmonary arterial hypertension (PAH). About 32 adults will receive the drug and be monitored for 3 months, with follo…

This study tests whether giving two drugs—becotatug vedotin and pucotenlimab—before surgery can shrink advanced mouth or throat cancer. About 26 people with stage III or IVa cancer will receive the combination, then have surgery to remove any remaining tumor. The main goal is to …

This study tests a newer, gentler way to treat atrial fibrillation (AFib) using short electrical pulses instead of heat. The goal is to block abnormal heart signals in a tricky area called the mitral isthmus. Thirty adults with AFib will receive this treatment during a standard p…

This study tests whether a brain-computer interface (a device implanted in the brain) can help people with tetraplegia (paralysis of all four limbs) control a robotic hand to grasp objects. Ten participants will receive the implant and undergo rehabilitation over 9 months. The go…

This study tests a new procedure called pulsed field ablation (PFA) using the FARAPULSE™ system to treat people with a type of irregular heartbeat called paroxysmal atrial fibrillation. The goal is to use targeted electric pulses to isolate the veins that trigger the abnormal rhy…

This study tests whether a newer drug, efgartigimod, works better and is safer than standard intravenous immunoglobulin (IVIG) for people with myasthenia gravis caused by a thymoma tumor. About 64 adults who need surgery to remove the tumor will receive one of the two treatments …

This study compares surgery alone versus surgery plus heated chemotherapy (HITOC) for people with thymic tumors that have spread to the chest lining. About 202 adults aged 18-75 will be randomly assigned to one of the two groups. The goal is to see if the heated chemo helps preve…

This study tests whether adding pirfenidone, a drug used for lung and liver scarring, to standard treatment can improve blood vessel damage in people with Takayasu arteritis. The disease causes blood vessels to thicken and narrow, which standard anti-inflammatory drugs don't full…

This early-phase trial tests a new type of immunotherapy called CAR-T cells, designed to find and attack stomach cancer cells that have spread. The treatment targets two proteins, CD73 and AXL, and is given to patients whose cancer has not responded to standard treatments. The st…

This study tests a new treatment plan for people with intermediate or advanced liver cancer. It combines chemotherapy delivered directly to the liver, a procedure to block the tumor's blood supply, and two drugs (apatinib and camrelizumab) that help the immune system fight cancer…

This study tests whether surgically disrupting a nerve in the tongue can make chemoimmunotherapy work better for people with advanced tongue cancer. About 69 adults with stage cT3 or cT4 tongue cancer will receive the nerve procedure along with two cycles of drugs before their ma…

This study tests whether a national accreditation program for hospitals can improve care for people with heart failure in China. About 6,240 patients will be followed for 12 months after discharge. The goal is to see if accredited hospitals reduce hospital readmissions and deaths…

This study tests two different drug combinations given before surgery for people with a specific genetic type of stomach or gastroesophageal junction cancer (dMMR/MSI-H). The goal is to see if these combinations can completely eliminate the tumor before surgery. About 30 adults w…

This study tests whether combining an immunotherapy drug (cadonilimab) with a chemotherapy pill (capecitabine) can keep a rare, aggressive liver cancer from returning after surgery. About 75 patients with mixed liver cancer who had their tumor fully removed will receive the combo…

This study compares two treatments for people with liver cancer that cannot be removed by surgery. One group gets a standard procedure (TACE) plus a three-drug pill regimen, while the other gets TACE plus standard targeted therapy and immunotherapy. The goal is to see which combi…

This study tests whether a 7-day personalized treatment for H. pylori works as well as a 14-day one. About 290 adults who have failed previous treatment will provide a stool sample to guide drug choice. The goal is to see if the shorter course is just as effective, safer, and mor…

This study tests whether an artificial intelligence (AI) system can help doctors choose the best medications for people with heart failure. About 1,200 participants from 60 hospitals will be enrolled. Hospitals are randomly assigned to either use the AI tool or continue standard …

This study tests whether a drug called sivelestat sodium can protect organ function in people who have surgery for a life-threatening tear in the main artery from the heart (type A aortic dissection). About 236 adults will receive either the drug or a placebo through a vein for 3…

This study tests whether a pacemaker set to a faster rate (90 beats per minute) can help people with right heart failure and severe tricuspid regurgitation. Twenty-four participants with a low natural heart rate will get a special pacemaker and be followed for 6 months. The goal …

This study looks at whether adding acupuncture to standard care can reduce the chance of atrial fibrillation returning after a heart procedure called catheter ablation. About 120 adults with persistent atrial fibrillation will be split into two groups: one gets acupuncture plus u…

This study tests whether a new treatment sequence—radiation followed by a mix of drugs (bevacizumab and TAS-102)—can slow the growth of advanced colorectal cancer that has not responded to earlier treatments. About 58 adults aged 18-75 will be randomly assigned to either the new …

This study compares a new injectable medication called iGlarLixi against standard diabetes treatments for adults with type 2 diabetes whose blood sugar is not well controlled with oral pills. About 1,316 participants in China will be randomly assigned to receive either iGlarLixi …

This study is for people with stage III non-small cell lung cancer who had chemotherapy and immunotherapy before surgery, then surgery to remove the tumor, but still had cancer in their lymph nodes. Researchers want to see if adding targeted radiation to the lymph nodes after sur…

This study tests whether a specific sequence of two chemotherapy combinations, each paired with an immunotherapy drug, can shrink borderline resectable or locally advanced pancreatic cancer enough to allow surgery. About 77 adults with this type of pancreatic cancer will receive …

This study tests whether a 7-day course of antibiotics, chosen based on a stool test, can cure H. pylori infection as effectively as the standard 14-day course. About 544 adults with a first-time H. pylori infection will provide a stool sample to check for drug resistance, then r…

This study tests whether giving three drugs (pucotenlimab, lenvatinib, and temozolomide) before surgery can shrink stage IIB/III acral melanoma, a type of skin cancer on the palms, soles, or under nails. About 30 adults will receive the combination for three 3-week cycles, then h…

This study will see if an artificial intelligence program can analyze a simple electrocardiogram (ECG) to quickly diagnose a life-threatening tear in the main artery (acute type A aortic dissection) in people arriving at the emergency room with chest pain. Researchers will enroll…

This study tests four different radioactive imaging agents to see which one works best for detecting prostate cancer on PET/CT scans. Nine men with advanced prostate cancer will receive each agent and have their scans compared. The goal is to find the probe that gives the cleares…

This study tests if the MetaNeb system, a breathing therapy device, can prevent or treat early lung collapse (atelectasis) in adults after esophageal cancer surgery. About 178 participants will be randomly assigned to receive either standard care or MetaNeb therapy. The main goal…

This study tests if a drug called octreotide can prevent a common and serious complication called pancreatic fistula after part of the pancreas is removed. About 230 adults scheduled for this surgery will receive either the drug or a placebo. The goal is to see if the drug reduce…

This study tests whether giving inhaled nitric oxide during heart surgery can prevent acute kidney injury in high-risk patients. About 330 adults having planned heart surgery will receive either the gas or a placebo. Researchers will check kidney function for 90 days after surger…

This study tests a new eye-tracking system to help ICU patients who cannot speak due to breathing tubes or injuries. Researchers will compare it to current methods like writing boards to see if it improves communication. The goal is to make it easier for patients to express their…

This study tests a special eye-tracking tool to help patients in the ICU who cannot speak or move normally. The tool lets them communicate by looking at a screen. Researchers want to see if it reduces frustration, anxiety, and time spent in the ICU. About 54 adults will use the d…

This early-stage study tests the safety of inhaling tiny particles from stem cells (called extracellular vesicles) in 24 adults with interstitial lung disease. Participants receive either the particles or a saltwater placebo by nebulizer. The goal is to see if this approach is sa…

This study tests a new way to place a pacing lead in the heart to help people with heart failure. The method uses a special catheter to map the heart's electrical signals and guide the lead to a specific area called the Bachmann bundle. The goal is to see if this approach is safe…

This study aims to see if a structured arm exercise program helps people recover better after getting a heart device (CIED) implanted. The program focuses on reducing stiffness, pain, and disability in the arm on the side of the implant. Researchers will follow 600 adults for up …

This study will look at metabolic changes in 540 high-risk patients after heart surgery to find early warning signs of kidney injury. Researchers will use advanced techniques to identify markers that predict kidney problems, helping doctors intervene sooner. The goal is to improv…

This small pilot study at Shanghai Zhongshan Hospital will test whether pressing the Tian Tu acupoint (located on the neck) can improve coughing strength in 30 adults who have had esophageal surgery. Participants will cough on their own, then after a rest period, cough while the …

This study looks at 143 older adults with severe aortic stenosis (a narrowed heart valve) to see how many also have cardiac amyloidosis (abnormal protein buildup in the heart). Researchers will compare symptoms and outcomes between those with only valve disease and those with bot…

This study is a nationwide research project in China that will use special cameras inside blood vessels to study hard, bony-like plaques called calcified nodules in heart arteries. These plaques can cause sudden heart attacks and are hard to treat. By watching 500 patients over t…

This study tests whether artificial intelligence can analyze video recordings of ICU patients to predict dangerous events like pulling out breathing tubes or becoming severely agitated. About 300 patients will have a small camera above their bed that records movements and sleep p…

This study will use ultrasound to measure how well the diaphragm moves in 35 critically ill patients. The goal is to compare different ultrasound methods to see which one gives the most consistent results, especially for the left side of the diaphragm. The findings may help docto…

This study looks at people with enlarged veins in the esophagus and stomach due to high blood pressure in the liver. Researchers will compare those who get an endoscopic procedure to those who receive other treatments like medication or surgery. The goal is to see which approach …

This study follows 320 people with pancreatic cancer to see if ongoing stress, anxiety, or poor sleep is linked to shorter survival or worse treatment response. Participants fill out simple questionnaires about their mood and sleep and give a small blood sample. The goal is to un…

This study looks at 270 people with a type of liver cancer (intrahepatic cholangiocarcinoma) that cannot be removed right away. After initial chemotherapy, doctors will use a special evaluation system (TDTP-RECIST) to decide whether to continue medication or perform surgery. The …

This study looks at how blood flow in the lungs changes depending on whether you hold your breath after breathing in or out. One hundred healthy adults will receive a small, fast injection of salt water while wearing a special belt that measures electrical signals. The goal is to…

This study looks at 377 adults with severe lung failure (ARDS) who are placed on their stomachs to help them breathe. Researchers will use computer models to predict which patients are most likely to die in the ICU. The goal is to help doctors make better treatment decisions for …

This study follows 220 adult ICU patients to track daily levels of exhaled carbon monoxide, a gas produced naturally in the body. Researchers want to see if different patterns of this gas are linked to serious outcomes like death, kidney injury, or length of hospital stay. The st…

This study looks at whether a blood test that detects tiny bits of tumor DNA (called ctDNA) can help doctors decide who needs extra chemotherapy after stomach cancer surgery. About 304 people with advanced stomach cancer will be randomly assigned to either standard care or treatm…

This study looks at a specific type of stomach cancer (dMMR/MSI-H) that often responds well to immunotherapy, but about half of patients do not benefit. Researchers will treat 15 people with immunotherapy before surgery to see who has a complete response and study why some tumors…