Shanghai Zhongshan Hospital

This study tests two blood-thinning strategies in people with severe aortic regurgitation who have had a new heart valve placed without open surgery. Participants receive either daily aspirin for a year or warfarin for six months followed by aspirin. The goal is to see which appr…

This Phase 2 trial tests whether adding LAE102 to the weight-loss drug tirzepatide can improve body composition in 60 adults with obesity. Participants receive weekly injections of either LAE102 plus tirzepatide or a placebo plus tirzepatide. The main goal is to see if the combin…

This study tests whether the diabetes drug ertugliflozin, started within 72 hours of a first heart attack, can improve heart function in people with type 2 diabetes. About 476 adults will be randomly assigned to take the drug or receive standard care. Researchers will measure cha…

This study compares two ways to guide stent placement during emergency treatment for a severe type of heart attack (STEMI). About 2,500 patients will be randomly assigned to receive either standard X-ray guidance or ultrasound guidance (IVUS) during the procedure. The goal is to …

This study tests an experimental drug (PD-1/IL-2 bispecific antibody) given before a second surgery in 30 adults whose liver cancer returned early after initial curative surgery. The goal is to see if the drug can shrink or kill more cancer cells before the operation, potentially…

This study tests whether a simple blood test that detects tiny bits of tumor DNA (ctDNA) can help doctors decide which stomach cancer patients need extra chemotherapy after surgery. About 304 people with locally advanced stomach cancer will be randomly assigned to either standard…

This study tests whether the blood thinner rivaroxaban can safely improve outcomes in people with liver cirrhosis who have both a blood clot in the portal vein and a high risk of variceal bleeding. About 175 participants will receive rivaroxaban or standard care starting 48 hours…

This trial is testing a new way to treat intermediate and advanced liver cancer. It combines two liver-directed procedures (HAIC and TACE) with two drugs (apatinib and camrelizumab) to see if this approach works better than other combinations. The study will involve 315 adults wi…

This study tests a new way to treat atrial fibrillation (AFib) using short electrical pulses instead of heat. The goal is to block abnormal heart signals in a specific area called the mitral isthmus. Thirty adults with AFib will receive this treatment during a standard procedure …

This study tests a brain-computer interface (BCI) implant in 10 people with tetraplegia (paralysis of all four limbs) from brainstem or spinal cord injury. The implant reads brain signals to control a pneumatic hand glove, helping patients grasp objects like cups or phones. The t…

This study tests whether giving two drugs together before surgery can shrink advanced mouth or throat cancers. The drugs are becotatug vedotin and pucotenlimab. About 26 people with stage III or IVa cancer will take part. The goal is to see if the cancer nearly or completely disa…

This phase 2 trial tests whether adding targeted radiation (SBRT) and an immunotherapy drug (sintilimab) to standard chemotherapy (TAS-102) and bevacizumab can help people with recurrent metastatic colorectal cancer live longer without their cancer growing. The study will enroll …

This study tests a new method to guide where a pacing lead is placed in the heart's upper chambers during cardiac resynchronization therapy for heart failure. Researchers will use a special catheter to map electrical signals and target a specific area called Bachmann's bundle. Th…

This phase II trial tests two drugs—SHR-1701 (an immunotherapy) and famitinib (which cuts off tumor blood supply)—given before surgery for resectable mucosal melanoma, a rare and aggressive skin cancer. After surgery, treatment is tailored based on how well the tumor responded. T…

This study tests whether adding acupuncture to standard care can reduce the return of irregular heartbeats in people with persistent atrial fibrillation who have already had a catheter ablation. About 120 adults aged 20 to 75 will be randomly assigned to receive either acupunctur…

This study looks at two treatments—endoscopy and a procedure called TIPS—to prevent repeat bleeding from enlarged veins in the stomach or esophagus caused by liver disease. Over 1,000 adults with this condition will be followed for a year to see which approach works better. The g…

This study tests whether giving three drugs (pucotenlimab, lenvatinib, and temozolomide) before surgery can shrink tumors in people with a specific type of skin cancer called acral melanoma, which is stage IIB or III and can be removed. About 30 adults will receive the drug combi…

This study tests whether setting a pacemaker to a faster rate (90 beats per minute) can help people with right heart failure and severe tricuspid regurgitation. Twenty-four participants with a low resting heart rate will get a special pacemaker implant and be followed for 6 month…

This study tests whether a 7-day course of antibiotics chosen by a stool test works as well as a 14-day course for people with stubborn H. pylori infections. About 290 adults who have failed previous treatment will get a stool test to find which drugs their infection resists, the…

This study tests whether a 7-day course of antibiotics, chosen based on a stool test, can clear H. pylori infection as effectively as a standard 14-day course. About 544 adults with a first-time H. pylori infection will provide a stool sample for drug-resistance testing and then …

This study looks at a device called AnchorMan that is placed in the heart to seal a small pouch where clots can form. It is for people with a type of irregular heartbeat (atrial fibrillation) who are at high risk for stroke. The main goal is to see how well the device gets covere…

This study compares surgery alone to surgery plus heated chemotherapy (HITOC) for people with thymic tumors that have spread to the lining of the chest. About 202 participants will be randomly assigned to one of the two groups. The goal is to see if adding HITOC helps keep the ca…

This study tests whether an artificial intelligence (AI) system can help doctors manage medications for people with heart failure with reduced ejection fraction (HFrEF). About 1,200 participants from 60 hospitals will be assigned to either AI-guided care or standard care. The goa…

This study tests whether a national hospital accreditation program for heart failure centers can improve care and outcomes for patients hospitalized with heart failure. About 6,240 adults across multiple hospitals in China will be followed for 12 months after discharge. The progr…

This phase 2 trial tests two different drug combinations given before surgery for people with a specific type of stomach cancer (dMMR/MSI-H). Participants will receive the immunotherapy drug adebrelimab plus either chemotherapy or another immunotherapy drug (SHR-8068). The goal i…

This study looks at people with stage III non-small cell lung cancer who had chemotherapy plus immunotherapy before surgery, and still had cancer in their lymph nodes after the tumor was removed. Half will get standard immunotherapy alone after surgery, and the other half will ge…

This phase II trial tests whether surgically cutting the lingual nerve (which controls tongue sensation) can make chemoimmunotherapy work better for people with advanced tongue cancer. 69 adults with stage T3/T4 tongue cancer will receive the nerve cut along with two cycles of ti…

This early-stage trial tests a new type of cell therapy called CAR-T cells that are designed to target two proteins (CD73 and AXL) found on stomach cancer cells. The study will enroll 42 people with stage IV stomach cancer that has not responded to standard treatments. The main g…

This study tests whether adding pirfenidone, a drug used for lung and liver scarring, to standard treatment can improve blood vessel damage in people with Takayasu arteritis. About 92 adults aged 18-60 will receive either pirfenidone or a placebo for 6 months. The goal is to see …

This phase 2 trial will test a combination of immunotherapy drugs and chemotherapy given before surgery for people with a specific genetic subtype of stomach cancer (dMMR/MSI-H). The study aims to see how well this approach clears the tumor and to understand why some patients do …

This study tests whether combining a liver-directed procedure (TACE) with an oral triple-drug cocktail works better than TACE plus standard targeted therapy and immunotherapy for people with liver cancer that cannot be surgically removed. About 222 participants will be randomly a…

This study compares a new injectable medicine called iGlarLixi with standard diabetes treatments in adults with type 2 diabetes whose blood sugar is not well controlled by pills alone. About 1,300 people in China will take part. The goal is to see if iGlarLixi helps lower blood s…

This study tests whether a simple blood test that detects tiny traces of cancer DNA can guide treatment decisions after gastric cancer surgery. About 90 patients will have their blood tested after surgery, and those with no detectable cancer DNA may safely skip additional chemoth…

This study tests whether combining an immunotherapy drug (cadonilimab) with a chemotherapy pill (capecitabine) can prevent a rare mixed liver cancer from returning after surgery. About 75 adults who had their tumor completely removed but are at medium-to-high risk of recurrence w…

This study tests whether a newer drug, efgartigimod, works better than standard intravenous immunoglobulin (IVIG) for people with myasthenia gravis who also have a thymoma tumor and need surgery. About 64 adults will receive either treatment before and after their operation to se…

This study tests whether a specific sequence of two different chemotherapy combinations, each paired with an immunotherapy drug (PD-L1 antibody), can shrink borderline resectable or locally advanced pancreatic cancer enough to allow surgical removal. About 77 adults with this typ…

This study looks at 270 people with a type of liver cancer (intrahepatic cholangiocarcinoma) that cannot be removed right away. After initial chemotherapy (GOLP regimen), participants are split into three groups: one continues medication, one goes straight to surgery, and one use…

This study looks at patients with advanced liver cancer that cannot be removed by surgery at first. They receive a combination of treatments—chemotherapy directly into the liver, anti-angiogenic drugs, and immunotherapy—to shrink the tumor. If the tumor shrinks enough to become r…

This study tests whether adding an injectable medication called treprostinil to standard oral therapy can improve heart function in people with intermediate-risk pulmonary arterial hypertension (PAH). About 32 adults will receive the drug for 3 months, with heart scans and walkin…

This study tests a new procedure called pulsed field ablation (PFA) using the FARAPULSE system to treat people with paroxysmal atrial fibrillation, a type of irregular heartbeat. Researchers will enroll 200 Chinese patients to see if the procedure can safely isolate the veins tha…

This study tests whether a drug called sivelestat sodium can reduce organ damage in people who have emergency surgery for a torn aorta (type A aortic dissection). About 236 patients will receive either the drug or a placebo for 3 days after surgery. The main goal is to see if the…

This study looks at whether an AI tool can help radiologists (doctors who read chest CT scans) write their reports faster without sacrificing quality. About 75 radiologists from several hospitals will use the AI as part of their normal work. Researchers will compare report time a…

This study will enroll 10,000 adults with chest pain at five hospitals to see if an artificial intelligence model can detect acute type A aortic dissection from a standard ECG. The AI's predictions will be compared to the gold-standard CT scan. If accurate, this could give doctor…

This study tests three new radioactive imaging agents against a standard one for PET/CT scans in 9 men with advanced prostate cancer. The goal is to see which agent best highlights cancer lesions in the body. It is an early-stage imaging study, not a treatment trial.

This study tests whether giving inhaled nitric oxide during heart surgery can prevent acute kidney injury (AKI) in high-risk patients. AKI is a common and serious complication after heart surgery with no approved prevention. The trial will include 330 adults undergoing elective h…

This study tests whether a drug called octreotide microspheres can prevent pancreatic fistula, a common and serious leak that can happen after part of the pancreas is removed. About 230 adults scheduled for this surgery will receive either the drug or a placebo. The goal is to se…

This study tests whether an eye-tracking communication tool can help conscious ICU patients who cannot speak due to breathing tubes or injuries. Forty participants will use the device for two days, and researchers will compare their communication ease to standard methods like wri…

This early study tests whether inhaling tiny particles from stem cells (called extracellular vesicles) is safe and might help people with interstitial lung disease, a condition that scars the lungs and makes breathing hard. About 24 adults will receive either the treatment or a s…

This study will test a structured exercise program for the arm on the side where a heart device (like a pacemaker) was implanted. The goal is to see if it safely improves arm movement, reduces pain and stiffness, and boosts quality of life. About 600 adults who need or already ha…

This study tests a special eye-tracking device to help patients in the ICU who cannot speak or move normally. The device lets them communicate by looking at a screen. Researchers want to see if it reduces frustration, anxiety, and time spent in the ICU. About 54 adults will use t…

This study tests whether the MetaNeb system, a device that delivers breathing treatments, can prevent or treat lung collapse (atelectasis) in 178 adults recovering from esophageal cancer surgery. Participants will be randomly assigned to receive either MetaNeb therapy or standard…

Some people have memory, attention, or thinking speed issues after leaving the ICU. This study explores whether a simple eye-tracking test can help identify these problems early. Adult patients who recently left the ICU will take a cognitive test and an eye-tracking test. The goa…

This study looks at whether a tumor's DNA repair status (MMR) changes how well the presence of cancer cells in lymph vessels predicts spread to lymph nodes in stomach cancer. Researchers will review medical records of 3,000 patients who had surgery. The goal is to improve risk as…

This study involves 35 critically ill adults to see if different ultrasound methods give consistent measurements of left diaphragm movement. Researchers will compare standard and modified positions to find the most reliable technique. The goal is to improve how doctors assess dia…

This study looks at how certain metabolic changes in the body might help predict kidney injury after heart surgery. Researchers will study 540 high-risk patients to find patterns that could warn doctors early. The goal is to improve patient safety and outcomes by catching kidney …

This small pilot study will test whether pressing the Tian Tu acupoint (a spot on the neck) can help patients cough more effectively after esophageal surgery. Thirty adults who have had the surgery will be asked to cough on their own, then after a rest, cough while the acupoint i…

This study will measure exhaled carbon monoxide daily in 220 ICU patients to see if changes in this gas are linked to survival and recovery. It is purely observational, meaning no treatment is given. The goal is to learn whether this simple breath test can help doctors predict co…

This study looks at 377 adults with severe lung failure (ARDS) who were treated with prone positioning (lying face down to help breathing). Researchers will use computer models to predict which patients are at highest risk of dying in the ICU. The goal is to help doctors make bet…

This study will observe 143 older adults with severe aortic stenosis who are scheduled for a minimally invasive valve replacement procedure called TAVR. Researchers want to find out how many also have cardiac amyloidosis, a condition where abnormal proteins build up in the heart.…

This study tests whether artificial intelligence can analyze video recordings of ICU patients to predict dangerous events like pulling out breathing tubes or becoming severely agitated. About 300 patients will have a small camera above their bed that records movements and sleep p…

This study will test a new way to measure blood flow in the lungs using a belt that sends weak electrical currents and small injections of salt water. One hundred healthy adults will hold their breath at two different lung volumes while the device creates a map of blood flow. The…

This study is looking at a specific type of hard plaque in heart arteries called a calcified nodule, which can cause sudden heart attacks and is hard to treat. Researchers will use special cameras inside the arteries to see these plaques in detail and track how patients do over t…