Shanghai Zhongshan Hospital

This study is for people with a type of advanced liver cancer called intrahepatic cholangiocarcinoma. It tests whether a new evaluation system (TDTP-RECIST) can better guide doctors on when to perform surgery after patients have received initial drug therapy (GOLP regimen). The g…

This study is testing a new approach for treating stomach cancer. After surgery, a blood test will check for tiny traces of leftover cancer. The goal is to see if patients with a clean blood test can safely skip the usual harsh chemotherapy, avoiding its severe side effects, with…

This study is testing a new national program in China designed to improve the quality of care for people hospitalized with heart failure. It will compare hospitals using the new accreditation system against those giving usual care. The goal is to see if the program leads to bette…

This study is testing a two-step treatment for pancreatic cancer that is borderline or locally advanced, meaning it is difficult or impossible to remove with surgery right away. The goal is to see if giving two different combinations of chemotherapy drugs plus an immunotherapy dr…

This study is testing whether a combination of two drugs can help prevent a rare and aggressive type of liver cancer from returning after surgery. About 75 patients who have had their tumor removed but are at medium to high risk of it coming back will receive both an immunotherap…

This study is testing if adding an injectable medication called Treprostinil to a patient's existing oral therapy can improve heart function in people with intermediate-risk pulmonary arterial hypertension (PAH). All 32 participants will receive the injection for 3 months while r…

This study tests whether a 7-day personalized antibiotic treatment works as well as a 14-day treatment for people with stubborn H. pylori stomach infections that didn't clear with previous treatments. Researchers will use stool tests to identify which antibiotics the bacteria are…

This study is testing a new medical device called the FARAPULSE™ system, which uses pulsed field energy to treat a common type of irregular heartbeat called paroxysmal atrial fibrillation. The procedure aims to electrically isolate specific heart veins to prevent faulty electrica…

This study is testing whether adding acupuncture to standard care helps prevent the return of a dangerous irregular heartbeat (atrial fibrillation) after a common heart procedure called catheter ablation. It will involve 120 people who have persistent atrial fibrillation and have…

This study is testing if surgically disrupting a nerve in the tongue can make chemotherapy and immunotherapy work better for people with advanced tongue cancer. About 69 adults will have the nerve procedure, then receive two cycles of drug treatment before their main cancer-remov…

This study aims to see if a newer combination injection (iGlarLixi) works better and is safer than standard insulin treatments for adults in China whose type 2 diabetes is not well controlled on pills alone. About 1,300 participants will be randomly assigned to receive either the…

This study aims to understand why some patients with a specific type of stomach cancer respond well to immunotherapy while others do not. It will enroll 15 Asian patients with this cancer type who are scheduled for surgery after receiving immunotherapy. The goal is to learn what …

This study aims to find the safest and most effective way to treat dangerous swollen veins in the stomach and esophagus, which are caused by high blood pressure in the liver. Researchers will follow over 1,300 patients who receive either a scope-based treatment or other medical/s…

This study is for people whose thymic cancer has spread to the lining of their lungs. It compares two approaches: surgery alone versus surgery followed by a special heated chemotherapy wash applied directly inside the chest. The goal is to see if this heated chemo wash can better…

This study is testing a high-tech brain implant system designed to help people with paralysis in all four limbs (tetraplegia). Ten participants will have electrodes implanted in their brain to read their movement intentions. The system will use these signals to control a robotic …

This study is for people with advanced liver cancer that cannot be removed by surgery right away. First, patients receive a combination of treatments to shrink the tumors. If the tumors shrink enough, the study then compares two options: having surgery to remove what's left or co…

This study is testing whether a drug called sivelestat sodium can help protect the organs of patients who have just had emergency surgery for a torn aorta (type A aortic dissection). Researchers will give the drug or a placebo (inactive substance) through an IV for 3 days after s…

This study aims to see if one of two different drug combinations can help shrink tumors before surgery for people with a specific type of advanced stomach or gastroesophageal cancer. About 30 participants will be randomly assigned to receive either an immunotherapy drug plus chem…

This study is testing if adding the drug pirfenidone to standard treatment can better control Takayasu arteritis, a rare disease that causes scarring and narrowing of blood vessels. Researchers will compare pirfenidone to a placebo in 92 patients already on standard therapy to se…

This study aims to see if a shorter, 7-day personalized antibiotic treatment works as well as the standard 14-day course for clearing a common stomach bacteria called H. pylori. Researchers will use a stool test to check which antibiotics the bacteria are resistant to, then assig…

This study is for people with advanced lung cancer who had chemotherapy and immunotherapy before surgery, but cancer cells were still found in their lymph nodes after the operation. It tests whether adding a targeted radiation treatment to the standard immunotherapy drug helps ke…

This study is testing how well a small, plug-like device seals and heals inside the heart to prevent strokes in people with a common irregular heartbeat called atrial fibrillation. Researchers will follow 306 patients for 6 months after the device is implanted, using heart scans …

This study is for adults with advanced liver cancer that cannot be removed by surgery. It compares two different drug combinations, both given alongside a standard procedure called TACE. The goal is to see which combination helps patients live longer and control their cancer bett…

This early-stage study is testing a new type of personalized immune cell therapy called XW-LTH-03 for people with advanced stomach cancer that has spread and no longer responds to standard treatments. Doctors will collect a patient's own immune cells, modify them in a lab to bett…

This study is testing whether an artificial intelligence (AI) system can help doctors make better medication decisions for people with a weakened heart (heart failure). About 1,200 patients from 60 hospitals will be involved. The main goal is to see if using the AI tool leads to …

This study aims to find the better treatment to help control muscle weakness in people with a specific type of myasthenia gravis who need surgery to remove a chest tumor called a thymoma. It will compare a newer drug, efgartigimod, against the standard treatment, intravenous immu…

This study aims to compare four different imaging tracers to see which one best shows prostate cancer tumors on PET/CT scans. Researchers will enroll 9 men with advanced prostate cancer who have already shown positive results on a standard PSMA scan. The study focuses on measurin…

This study is testing whether an injected medication called octreotide microspheres can prevent a serious complication called a pancreatic fistula after surgery to remove part of the pancreas. About 230 patients scheduled for this specific surgery will receive either the real dru…

This study is testing whether a special breathing device called the MetaNeb System can prevent and treat lung collapse in patients recovering from esophageal cancer surgery. Researchers will compare the device to standard care in 178 adults admitted to the ICU after surgery. They…

This study is testing a special eye-tracking device to see if it helps patients in the intensive care unit (ICU) who cannot speak communicate their needs. Researchers will compare the device to standard communication methods to see if it makes communication easier, reduces patien…

This study is testing whether a new eye-tracking computer system can help patients in intensive care who cannot speak communicate their needs more easily. Researchers will compare this high-tech system to traditional low-tech methods like writing boards and hand signals. The goal…

This study is testing if using a special pacemaker set to a faster-than-normal heart rate can help people with right heart failure and a severely leaky tricuspid valve. It will enroll 24 patients who have a slow resting heart rate and need a pacemaker. Researchers will implant th…

This study aims to develop a computer program that can predict which patients with severe lung failure (ARDS) are most likely to die in intensive care after receiving a special positioning treatment. Researchers will analyze past medical records from 377 patients to teach the pro…

This study aims to understand how blood flow in the lungs changes when people hold their breath after inhaling versus after exhaling. Researchers will use a safe, non-invasive imaging technique on 100 healthy volunteers. The goal is to gather basic knowledge that could one day he…

This study aims to understand how often a second heart condition called cardiac amyloidosis occurs in patients with aortic stenosis (a narrowed heart valve). Researchers will observe 143 patients aged 65-85 who are scheduled for a valve replacement procedure. They will compare th…

This nationwide study in China aims to learn more about a specific, hard type of plaque in heart arteries called a calcified nodule, which can cause sudden heart attacks and is difficult to treat. Researchers will use advanced imaging tools during standard heart procedures to see…

This study aims to see if artificial intelligence (AI) can watch video of patients in the Intensive Care Unit (ICU) and spot early warning signs of dangerous events like agitation or accidentally pulling out medical tubes. About 300 patients will have a small, privacy-protected c…

This study aims to understand if tracking a natural gas in a patient's breath (exhaled carbon monoxide) over time can help doctors predict how well a critically ill patient will recover. Researchers will measure this gas daily for up to a week in 220 adult ICU patients and see if…