Blood test may spare gastric cancer patients from unnecessary chemo

NCT ID NCT07257380

Not yet recruiting Disease control Sponsor: Shanghai Zhongshan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a simple blood test that detects tiny traces of cancer DNA can guide treatment decisions after gastric cancer surgery. About 90 patients will have their blood tested after surgery, and those with no detectable cancer DNA may safely skip additional chemotherapy. The goal is to reduce side effects from unnecessary treatment without affecting how long patients stay cancer-free.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: circulating tumor DNA (ctDNA) blood test
What this could lead to: If successful, this approach could spare many gastric cancer patients from unnecessary chemotherapy after surgery, reducing side effects while maintaining survival outcomes.
What could go wrong: This is a small, early-phase feasibility study (90 participants). The ctDNA test may not accurately predict who needs chemo, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastric adenocarcinoma gastroesophageal junction adenocarcinoma Neoplasm, Residual

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRIC / GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA

Contacts and locations

Locations

Zhongshan Hospital, Fudan University

Shanghai, Shanghai Municipality, 200032, China

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