Can a simple gas during heart surgery protect your kidneys?

NCT ID NCT07544147

Not yet recruiting Prevention Sponsor: Shanghai Zhongshan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving inhaled nitric oxide during heart surgery can prevent acute kidney injury (AKI) in high-risk patients. AKI is a common and serious complication after heart surgery with no approved prevention. The trial will include 330 adults undergoing elective heart surgery with a heart-lung machine. Participants will receive either nitric oxide gas or a placebo through their breathing circuit during surgery, and kidney function will be monitored for 90 days after.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Inhaled nitric oxide
What this could lead to: If it works, this could provide a simple, drug-free way to prevent kidney damage after heart surgery, reducing hospital stays and long-term complications.
What could go wrong: This is an early-stage trial with no prior proof of effectiveness. The treatment is only given during surgery, and results may not apply to all patients or surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute kidney injury prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC SURGERY ASSOCIATED - ACUTE KIDNEY INJURY CARDIAC SURGERY WITH CARDIOPULMONARY BYPASS

Contacts and locations

Locations

Zhongshan Hospital, Fudan University

Shanghai, Shanghai Municipality, 200032, China

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