Could a common supplement protect the failing heart? a major trial puts Alpha-Lipoic acid to the test
NCT ID NCT07725484
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This trial investigates whether a daily dose of alpha-lipoic acid, a vitamin-like antioxidant, can lower the risk of major heart problems in people with chronic heart failure caused by coronary artery disease. Researchers will compare the supplement against a placebo in over 1,500 adults aged 18 to 75 with reduced heart pumping function. The goal is to see if this simple addition to standard care can reduce heart-related deaths, hospitalizations, strokes, and heart attacks over two years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a vitamin-like supplement called alpha-lipoic acid (ALA), taken as a 600 mg daily pill
- What this could lead to
- If it works, this could offer a simple, low-cost add-on treatment to reduce the risk of heart-related death and hospital stays for people with heart failure.
- What could go wrong
- This is a large phase 3 trial, but earlier evidence was exploratory. The supplement may not provide significant benefit over standard care, and any effect may be modest.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Affiliated Hospital of Jining Medical University
Jining, Shandong, 272029, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Affiliated Zhongshan Hospital of Dalian University
Dalian, Liaoning, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fujian provincial hospital
Fuzhou, Fujian, 35000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Guangdong Provincial People's Hospital
Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Luoyang Central Hospital Affiliated to Zhengzhou University
Luoyang, Henan, 471009, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Qilu Hospital of Shandong University
Jinan, Shandong, 250012, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University
Shanghai, Shanghai Municipality, 201700, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Quzhou People's Hospital (Quzhou Affiliated Hospital of Wenzhou Medical University)
Quzhou, Zhejiang, 324000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shanghai East Hospital, Tongji University School of Medicine
Shanghai, Shanghai Municipality, 200120, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital
Shanghai, Shanghai Municipality, 200237, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shanxi Cardiovascular Hospital
Taiyuan, Shanxi, 030024, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Affiliated Hospital of Qingdao University
Qingdao, Shandong, 266000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Dalian Medical University
Dalian, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of USTC (Anhui Provincial Hospital)
Hefei, Anhui, 230001, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, 710061, China
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450052, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, 510080, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Hospital of Shanxi Medical University
Taiyuan, Shanxi, 030001, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Wusong Hospital, Zhongshan Hospital, Fudan University
Shanghai, Shanghai Municipality, 200940, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Zhongda Hospital, Southeast University
Nanjing, Jiangsu, 210009, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Zhongshan Hospital, Fudan University
Shanghai, Shanghai Municipality, 200032, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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