Shanghai Zhongshan Hospital

This study looks at whether taking vitamin B1 for one year can reduce the size and number of colon polyps in people with familial adenomatous polyposis (FAP), a genetic condition that raises colon cancer risk. Ten adults with FAP will take oral vitamin B1 and have colonoscopies e…

This study tests two drugs, candonilimab and LM-302, in people with advanced biliary tract cancer that has not responded to standard chemotherapy and immunotherapy. The goal is to see if the combination can shrink tumors or slow the disease. About 78 adults with a specific protei…

This early-stage study tests whether a person's own pancreatic cells can be turned into insulin-making cells and transplanted under the belly skin to control diabetes. 24 adults with type 2 diabetes who need insulin shots will take part. The goal is to see if this approach is saf…

This phase 2 study tests whether adding a new antibody (HLX22) to standard treatment (trastuzumab plus chemotherapy) can shrink tumors better in people with HER2-positive pancreatic cancer that has spread. About 45 adults who have not had prior treatment for metastatic disease wi…

This early-phase study tests a new treatment for people with advanced liver cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (CAR-T cells) designed to target a protein called IL1RAP on cancer cells. Only 3 participants are …

This study tests whether giving a combination of immunotherapy (Toripalimab), a targeted drug (lenvatinib), and chemotherapy (GEMOX) before surgery can improve outcomes for people with a high-risk type of bile duct cancer. About 178 participants will be randomly assigned to recei…

This study is gathering medical data, images, and blood samples from 2,000 people who have had a heart attack. Researchers want to learn more about the disease and find new ways to predict and prevent future heart problems. The goal is to improve personalized diagnosis and treatm…