Could a common vitamin tame a rare gut disease?
NCT ID NCT06649825
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether taking vitamin B1 tablets for a year can reduce the size and number of colon polyps in people with familial adenomatous polyposis (FAP), a genetic condition that raises colon cancer risk. Ten adults with FAP who still have their colon will take vitamin B1 twice daily and get colonoscopies every three months to track changes. It's a small, early-stage trial exploring a potential new use for a safe, inexpensive vitamin.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Vitamin B1 (thiamine) tablets
- What this could lead to
- If it works, this could point toward a simple, low-cost way to reduce polyp growth in people with familial adenomatous polyposis, potentially lowering their cancer risk.
- What could go wrong
- This is a very small, early exploratory study with only 10 people, so results may not apply broadly. It's not yet known if vitamin B1 will have any real effect on polyps.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Shanghai Zhongshan Hospital
Shanghai, Shanghai Municipality, 200032, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Which scope method spots precancerous polyps best in FAP pouches? a head-to-head trial aims to find out.
- Rapamycin formulation offers hope for rare polyp disorder
- New national registry aims to improve care for rare genetic polyposis syndromes
- New surgical approach may improve outcomes for bowel disease patients
- New drug eRapa could slow polyps in inherited colon cancer condition