Could a common vitamin tame a rare gut disease?
NCT ID NCT06649825
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether taking vitamin B1 tablets for a year can reduce the size and number of colon polyps in people with familial adenomatous polyposis (FAP), a genetic condition that raises colon cancer risk. Ten adults with FAP who still have their colon will take vitamin B1 twice daily and get colonoscopies every three months to track changes. It's a small, early-stage trial exploring a potential new use for a safe, inexpensive vitamin.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vitamin B1 (thiamine) tablets
What this could lead to
If it works, this could point toward a simple, low-cost way to reduce polyp growth in people with familial adenomatous polyposis, potentially lowering their cancer risk.
What could go wrong
This is a very small, early exploratory study with only 10 people, so results may not apply broadly. It's not yet known if vitamin B1 will have any real effect on polyps.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Shanghai Zhongshan Hospital
Shanghai, Shanghai Municipality, 200032, China