New drug eRapa could slow polyps in inherited colon cancer condition
NCT ID NCT06950385
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests if the drug eRapa can slow disease progression in adults with Familial Adenomatous Polyposis (FAP), a condition that causes many polyps in the gut and raises cancer risk. About 168 participants will take eRapa or a placebo daily every other week. Researchers will track how long it takes for the disease to worsen, using colonoscopies and other checks every 3 to 6 months.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Amsterdam UMC
RECRUITINGAmsterdam, Netherlands
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Benaroya Research Institute at Virginia Mason
RECRUITINGSeattle, Washington, 98101, United States
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City of Hope
RECRUITINGArcadia, California, 91007, United States
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
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Cleveland Clinic Florida
RECRUITINGWeston, Florida, 33331, United States
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Copenhagen University Hospital
RECRUITINGCopenhagen, Denmark
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Dana Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02115, United States
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Department of Surgery, Section of Colon Rectal and Surgery
RECRUITINGSt Louis, Missouri, 63110, United States
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Digestive & Liver Center of Florida
RECRUITINGOrlando, Florida, 32825, United States
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Geisinger Medical Center
RECRUITINGDanville, Pennsylvania, 17822, United States
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Georgetown University
RECRUITINGWashington D.C., District of Columbia, 20057, United States
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Hospital Clínic de Barcelona
RECRUITINGBarcelona, Spain
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Hospital Comarcal de Inca
RECRUITINGInca, Spain
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Hospital General Universitario Gregorio Marañón
RECRUITINGMadrid, Spain
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Hospital La Fe de Valencia
RECRUITINGValencia, Spain
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Hospital Oncologico - Puerto Rico Medical Center
RECRUITINGRio Piedras, 00935, Puerto Rico
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IRCCS Ospedale San Raffaele
RECRUITINGMilan, Italy
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Istituto Nazionale dei Tumori
RECRUITINGMilan, Italy
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Johns Hopkins University
RECRUITINGBaltimore, Maryland, 21205, United States
Contact Email: •••••@•••••
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Ohio State University
RECRUITINGColumbus, Ohio, 43210, United States
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Radboud University Medical Center
RECRUITINGNijmegen, Netherlands
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The University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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University of Chicago
RECRUITINGChicago, Illinois, 60615, United States
Contact Email: •••••@•••••
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University of Kansas Medical Center
RECRUITINGKansas City, Kansas, 66160, United States
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Pittsburgh Medical Center
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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University of Washington - Fred Hutchinson
RECRUITINGSeattle, Washington, 98195, United States
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Universitätsklinikum Bonn
RECRUITINGBonn, Germany
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Yale Cancer Center
RECRUITINGNew Haven, Connecticut, 06520, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can an experimental drug stop polyps from coming back in a rare inherited condition?
- Which scope method spots precancerous polyps best in FAP pouches? a head-to-head trial aims to find out.
- Rapamycin formulation offers hope for rare polyp disorder
- Could a common vitamin tame a rare gut disease?
- New national registry aims to improve care for rare genetic polyposis syndromes
- New surgical approach may improve outcomes for bowel disease patients