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Which scope method spots precancerous polyps best in FAP pouches? a head-to-head trial aims to find out.

NCT ID NCT07726771

Recruiting now Knowledge-focused Sponsor: London North West Healthcare NHS Trust Source: ClinicalTrials.gov ↗

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial compares two ways of inspecting the ileo-anal pouch during routine surveillance in adults with familial adenomatous polyposis (FAP): dye-based chromoendoscopy (spraying a blue dye) versus virtual chromoendoscopy (using special light filters). The goal is to see which technique detects more clinically relevant adenomas (polyps larger than 5 mm). Fifty participants will be randomly assigned to one method during their scheduled pouchoscopy. The results could help standardize surveillance practices for people with FAP.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Chromoendoscopy (dye spray with indigo carmine or virtual with narrow-band imaging)
What this could lead to
If one technique proves better at spotting precancerous polyps, it could become the standard for surveillance in people with FAP and a pouch, potentially catching problems earlier.
What could go wrong
This is a small, early-stage comparison with 50 participants, and the two methods may turn out to be equally effective. The study cannot show whether better detection actually prevents cancer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Adenomatous Polyposis Coli classic familial adenomatous polyposis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FAMILIAL ADENOMATOUS POLYPOSIS (FAP) POUCHES, ILEOANAL

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • St Mark's Hospital Polyposis Registry (St Mark's Centre for Familial Intestinal Cancer)

    RECRUITING

    London, London, N10 7NS, United Kingdom

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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