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Which scope method spots precancerous polyps best in FAP pouches? a head-to-head trial aims to find out.

NCT ID NCT07726771

Knowledge-focused Sponsor: London North West Healthcare NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial compares two ways of inspecting the ileo-anal pouch during routine surveillance in adults with familial adenomatous polyposis (FAP): dye-based chromoendoscopy (spraying a blue dye) versus virtual chromoendoscopy (using special light filters). The goal is to see which technique detects more clinically relevant adenomas (polyps larger than 5 mm). Fifty participants will be randomly assigned to one method during their scheduled pouchoscopy. The results could help standardize surveillance practices for people with FAP.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Chromoendoscopy (dye spray with indigo carmine or virtual with narrow-band imaging)
What this could lead to
If one technique proves better at spotting precancerous polyps, it could become the standard for surveillance in people with FAP and a pouch, potentially catching problems earlier.
What could go wrong
This is a small, early-stage comparison with 50 participants, and the two methods may turn out to be equally effective. The study cannot show whether better detection actually prevents cancer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jul 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: ALL of the following: 1. Diagnosis of FAP i.e., at least one of following: * Genetic diagnosis: proven APC germline mutation OR * Clinical diagnosis: \>100 colorectal adenomas in combination with a positive family history of FAP 2. Have an ileal-pouch anal anastomosis (IPAA), either after primary proctocolectomy or secondary proctectomy after initial colectomy and ileorectal or ileosigmoidal anastomosis (IRA/ISA) 3. Age ≥ 18 years Exclusion Criteria: ANY of the following 1. Diagnosis of FAP i.e., at least one of following: * Genetic diagnosis: proven APC germline mutation OR * Clinical diagnosis: \>100 colorectal adenomas in combination with a positive family history of FAP 2. Have an ileal-pouch anal anastomosis (IPAA), either after primary proctocolectomy or secondary proctectomy after initial colectomy and ileorectal or ileosigmoidal anastomosis (IRA/ISA) 3. Age ≥ 18 years

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Conditions

The condition(s) this trial relates to.

Adenomatous Polyposis Coli classic familial adenomatous polyposis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Familial adenomatous polyposis (FAP) Pouches, ileoanal

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • St Mark's Hospital Polyposis Registry (St Mark's Centre for Familial Intestinal Cancer)

    RECRUITING

    London, London, N10 7NS, United Kingdom

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