New study tests combo of low-dose drug and lifestyle to stop weight regain
NCT ID NCT07517042
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a low dose of the weight-loss drug mazdutide, an intensive lifestyle program, or both can help people with obesity maintain weight loss for a year after initially losing weight with a higher drug dose. About 420 adults with a BMI between 28 and 45 will take part. The goal is to find a safe and effective long-term strategy for weight maintenance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mazdutide (a weight-loss drug given as a weekly injection)
What this could lead to
If successful, this could show a practical way to maintain weight loss long-term using a lower drug dose, lifestyle changes, or both, reducing the need for high-dose medication.
What could go wrong
This is an early-stage study with no phase designation, and it only looks at weight maintenance over one year. The low drug dose may not be enough for everyone, and lifestyle changes can be hard to stick with.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Fujian Provincial Hospital, Affiliated to Fuzhou University
RECRUITINGFuzhou, Fujian, 350000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Huadong Hospital, Fudan University
RECRUITINGShanghai, Shanghai Municipality, 200000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Nanjing First Hospital, Nanjing Medical University
RECRUITINGNanjing, Jiangsu, 210000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Renji Hospital, Shanghai Jiao Tong University School of Medicine
RECRUITINGShanghai, Shanghai Municipality, 200000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Shanghai Tenth People's Hospital, School of Medicine, Tongji University
RECRUITINGShanghai, Shanghai Municipality, 200000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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The Affiliated Hospital of Southwest Medical University
RECRUITINGLuzhou, Sichuan, 646000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University
RECRUITINGSuzhou, Jiangsu, 215000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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The First Affiliated Hospital of Wenzhou Medical University
RECRUITINGWenzhou, Zhejiang, 325000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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The First Affiliated Hospital of Xiamen University
RECRUITINGXiamen, Fujian, 361003, China
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Affiliated Hospital of Chongqing Medical University
RECRUITINGChongqing, Chongqing Municipality, 400000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Zhejiang Provincial People's Hospital
RECRUITINGHangzhou, Zhejiang, 310000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Zhongnan Hospital of Wuhan University
RECRUITINGWuhan, Hubei, 430000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Zhongshan Hospital, Fudan University
RECRUITINGShanghai, Shanghai Municipality, 200030, China
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••