Could a single dose of rituximab help hearts heal after a massive attack?
NCT ID NCT05211401
First seen Jun 26, 2026 · Last updated Aug 13, 2026 · Updated 3 times
Summary
This study tests whether a single dose of rituximab, a drug that calms the immune system, can help the heart pump better six months after a severe type of heart attack called an anterior STEMI. About 372 adults who have just had such an attack will receive either rituximab or a placebo. The main goal is to see if the drug improves the heart's pumping strength, measured by MRI.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- rituximab
- What this could lead to
- If it works, this could point toward a new treatment to help the heart recover better after a major heart attack.
- What could go wrong
- This is an early phase 2 trial, so results are uncertain. Rituximab is an immune-suppressing drug, which carries risks like increased infection. The benefit may be small or absent.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cardiology department, Hôpital Bichat, AP-HP
RECRUITINGParis, 75018, France
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