Could a shorter course of blood thinners be safer after a heart attack?
NCT ID NCT05491200
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study looks at people who have had a severe type of heart attack called STEMI. It compares a shorter course (about one month) of two blood thinners followed by just one drug (prasugrel) for a year, versus the standard one-year regimen of two blood thinners. The goal is to see if the shorter approach reduces bleeding complications while still preventing another heart attack or stroke. Some participants also receive either OCT-guided or angiography-guided stent placement to see which imaging method leads to better outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
prasugrel
What this could lead to
If successful, this could allow heart attack patients to take blood thinners for a shorter time, reducing bleeding risk while still preventing clots.
What could go wrong
This is a single trial with 1656 participants; results may not apply to all patients. Shorter therapy could increase the risk of heart attack or stroke in some individuals.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AZ Delta
RECRUITINGRoeselare, Belgium
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AZ St.Jan
RECRUITINGBruges, Belgium
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Albert Schweitzer ziekenhuis
RECRUITINGDordrecht, Netherlands
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Amphia Ziekenhuis
RECRUITINGBreda, 4818 CK, Netherlands
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Asklepios Klinik Bad Oldesloe
RECRUITINGBad Oldesloe, Germany
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Catherina ziekenhuis
RECRUITINGEindhoven, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centro Cardiologico Monzino IRCCS
RECRUITINGMilan, Italy
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Charles University Hospital
NOT_YET_RECRUITINGPrague, Czechia
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Erasmus Medical Center
RECRUITINGRotterdam, Netherlands
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FN BRNO
RECRUITINGBrno, Czechia
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Haga hospital
RECRUITINGThe Hague, Netherlands
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Imelda Bonheiden
RECRUITINGBonheiden, Belgium
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Institute for CVD Dedinje
RECRUITINGBelgrade, Serbia
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Institute for CVD Vojvodine
RECRUITINGKamenitz, Serbia
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Maasstadziekenhuis
RECRUITINGRotterdam, Netherlands
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Masaryk Hospital Usti nad Labem -
RECRUITINGHradec Králové, Czechia
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Ospedale Papa Giovanni XXIII
RECRUITINGBergamo, Italy
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RadboudUMC
RECRUITINGNijmegen, Netherlands
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Segeberger Kliniken
RECRUITINGBad Segeberg, Germany
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UZ Leuven
RECRUITINGLeuven, Belgium
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University Federico II
RECRUITINGNaples, Italy
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University Gemelli
RECRUITINGRoma, Italy
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University San Martino
RECRUITINGGenova, Italy
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University clinical center of Serbia
RECRUITINGBelgrade, Serbia
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University hospital Dresden
RECRUITINGDresden, Germany
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University of Ferrara
RECRUITINGFerrara, Italy
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ZOL Genk
RECRUITINGGenk, Belgium
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