Could a shorter course of blood thinners be safer after a heart attack?

NCT ID NCT05491200

Recruiting now Disease control Sponsor: Research Maatschap Cardiologen Rotterdam Zuid Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study looks at people who have had a severe type of heart attack called STEMI. It compares a shorter course (about one month) of two blood thinners followed by just one drug (prasugrel) for a year, versus the standard one-year regimen of two blood thinners. The goal is to see if the shorter approach reduces bleeding complications while still preventing another heart attack or stroke. Some participants also receive either OCT-guided or angiography-guided stent placement to see which imaging method leads to better outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: prasugrel
What this could lead to: If successful, this could allow heart attack patients to take blood thinners for a shorter time, reducing bleeding risk while still preventing clots.
What could go wrong: This is a single trial with 1656 participants; results may not apply to all patients. Shorter therapy could increase the risk of heart attack or stroke in some individuals.

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Conditions

The condition(s) this trial relates to.

ST-elevation myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DUAL ANTIPLATELET THERAPY ST ELEVATED MYOCARDIAL INFARCTION

Contacts and locations

Locations

AZ Delta
RECRUITING

Roeselare, Belgium
AZ St.Jan
RECRUITING

Bruges, Belgium
Albert Schweitzer ziekenhuis
RECRUITING

Dordrecht, Netherlands
Amphia Ziekenhuis
RECRUITING

Breda, 4818 CK, Netherlands
Asklepios Klinik Bad Oldesloe
RECRUITING

Bad Oldesloe, Germany
Catherina ziekenhuis
RECRUITING

Eindhoven, Netherlands
Centro Cardiologico Monzino IRCCS
RECRUITING

Milan, Italy
Charles University Hospital
NOT_YET_RECRUITING

Prague, Czechia
Erasmus Medical Center
RECRUITING

Rotterdam, Netherlands
FN BRNO
RECRUITING

Brno, Czechia
Haga hospital
RECRUITING

The Hague, Netherlands
Imelda Bonheiden
RECRUITING

Bonheiden, Belgium
Institute for CVD Dedinje
RECRUITING

Belgrade, Serbia
Institute for CVD Vojvodine
RECRUITING

Kamenitz, Serbia
Maasstadziekenhuis
RECRUITING

Rotterdam, Netherlands
Masaryk Hospital Usti nad Labem -
RECRUITING

Hradec Králové, Czechia
Ospedale Papa Giovanni XXIII
RECRUITING

Bergamo, Italy
RadboudUMC
RECRUITING

Nijmegen, Netherlands
Segeberger Kliniken
RECRUITING

Bad Segeberg, Germany
UZ Leuven
RECRUITING

Leuven, Belgium
University Federico II
RECRUITING

Naples, Italy
University Gemelli
RECRUITING

Roma, Italy
University San Martino
RECRUITING

Genova, Italy
University clinical center of Serbia
RECRUITING

Belgrade, Serbia
University hospital Dresden
RECRUITING

Dresden, Germany
University of Ferrara
RECRUITING

Ferrara, Italy
ZOL Genk
RECRUITING

Genk, Belgium

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