New injection could save heart muscle after attack
NCT ID NCT07306182
First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times
Summary
This study tests a new medicine called SGC001 in people who have had a serious type of heart attack (anterior STEMI) and are scheduled for a procedure to open blocked arteries. The goal is to see if SGC001 can reduce the size of the heart damage and lower the chance of future heart problems. About 210 participants will receive either the drug or a placebo by IV within 6 hours of their symptoms starting.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- SGC001 injection
- What this could lead to
- If it works, this could lead to a new treatment that limits heart muscle damage and reduces the risk of future heart problems after a heart attack.
- What could go wrong
- This is an early Phase 2 trial with only 210 participants, so results may not apply to everyone. The drug is still experimental and not yet approved anywhere.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 210 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2026
- Expected to finish
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Oct 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 79 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria 1.18-79 years of age (including boundary values), male or female; 2.Anterior wall STEMI: (a) history of persistent chest pain/precordial discomfort (\>30 minutes); (b) upon admission, the ECG must meet the following requirements: i.For male participants \>40 years old, ST-segment elevation ≥2 mm in leads V2 and V3; ii.For male participants ≤40 years old, ST-segment elevation ≥2.5 mm in leads V2 and V3; iii.For female participants, ST-segment elevation ≥1.5 mm in leads V2 and V3; If clinical symptoms of (a) are atypical, then (c) a positive point-of-care troponin test is required. 3.Planned for pPCI treatment; 4.Assessed as being able to complete dosing within 6 hours of the onset of persistent chest pain/precordial discomfort symptoms; 5.The participant or their legal guardian fully understands the objectives, nature, methods, and potential adverse reactions of the study, voluntarily agrees to participate, and has signed the informed consent form (ICF). Exclusion Criteria 1. History of the following cardiac conditions: 1. History of myocardial infarction, coronary revascularization (including percutaneous coronary intervention \[PCI\] and coronary artery bypass grafting \[CABG\], etc.); 2. History of cardiopulmonary resuscitation; 3. History of stroke within 6 months; 4. Presence of severe cardiac structural abnormalities such as aortic dissection, and ventricular aneurysm; 2. Patients who have received thrombolysis; 3. Patients with a life expectancy of less than 1 year; 4. Febrile infection requiring systemic treatment within 2 weeks prior to screening; 5. Concomitant left bundle branch block; 6. Cardiogenic shock or hemodynamic instability; 7. Concomitant severe arrhythmia (including high-degree atrioventricular block, sick sinus syndrome, sustained ventricular tachycardia, etc.) or implanted cardiac pacemaker; 8. Definitive diagnosis of acute heart failure (Killip classification ≥ III; for details on Killip classification, see Appendix); 9. Unable to undergo cardiac magnetic resonance (CMR) imaging according to the study protocol, or known allergy to any radiocontrast agent;
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Shanghai East Hospital
RECRUITINGShanghai, Shanghai Municipality, 200120, China
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Other studies related to the condition(s) this trial covers.
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