New shot may slash cholesterol right after a heart attack

NCT ID NCT07102628

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This study tests whether starting inclisiran early during a hospital stay for a heart attack can lower bad cholesterol more than a placebo, when both are added to standard care. About 300 adults hospitalized for a heart attack will receive either inclisiran or a placebo shot at the start and again 90 days later. The main goal is to see if inclisiran leads to greater cholesterol reduction by day 150.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Inclisiran
What this could lead to: If it works, this could provide a new way to quickly lower bad cholesterol after a heart attack, potentially reducing the risk of future heart problems.
What could go wrong: This is still an early Phase 3 trial with 300 participants, so results may not apply to everyone. Inclisiran may not lower cholesterol enough or could have side effects not yet seen.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute coronary syndrome hyperlipidemia Non-ST Elevated Myocardial Infarction ST-elevation myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE CORONARY SYNDROME

Contacts and locations

Locations

Novartis Investigative Site
RECRUITING

Capital Federal, Buenos Aires, B1406, Argentina
Novartis Investigative Site
RECRUITING

Garran, Australian Capital Territory, 2605, Australia
Novartis Investigative Site
RECRUITING

Clayton, Victoria, 3168, Australia
Novartis Investigative Site
RECRUITING

Edmonton, Alberta, T6G 2B7, Canada
Novartis Investigative Site
RECRUITING

London, Ontario, N6A 5W9, Canada
Novartis Investigative Site
RECRUITING

Newmarket, Ontario, J7Y 2P9, Canada
Novartis Investigative Site
RECRUITING

Montreal, Quebec, H1T 1C8, Canada
Novartis Investigative Site
RECRUITING

Québec, Quebec, G1V 4G5, Canada
Novartis Investigative Site
RECRUITING

Beijing, China, 100037, China
Novartis Investigative Site
RECRUITING

Guangzhou, Guangdong, 510080, China
Novartis Investigative Site
RECRUITING

Luoyang, Henan, 471002, China
Novartis Investigative Site
RECRUITING

Xuzhou, Jiangsu, 221003, China
Novartis Investigative Site
RECRUITING

Nanchang, Jiangxi, 330009, China
Novartis Investigative Site
RECRUITING

Wenzhou, Zhejiang, 325000, China
Novartis Investigative Site
RECRUITING

Beijing, 100191, China
Novartis Investigative Site
RECRUITING

Beijing, 100730, China
Novartis Investigative Site
RECRUITING

Fuzhou, 350001, China
Novartis Investigative Site
RECRUITING

Guangzhou, 510260, China
Novartis Investigative Site
RECRUITING

Guangzhou, 510280, China
Novartis Investigative Site
RECRUITING

Jining, 272011, China
Novartis Investigative Site
RECRUITING

Shanghai, 200032, China
Novartis Investigative Site
RECRUITING

Shanghai, 200120, China
Novartis Investigative Site
RECRUITING

Tianjin, 300052, China
Novartis Investigative Site
RECRUITING

Chambray-lès-Tours, 37170, France
Novartis Investigative Site
RECRUITING

Montpellier, 34295, France
Novartis Investigative Site
RECRUITING

Nantes, 44093, France
Novartis Investigative Site
RECRUITING

Pessac, 33604, France
Novartis Investigative Site
RECRUITING

Poitiers, 86021, France
Novartis Investigative Site
RECRUITING

Leipzig, Saxony, 04289, Germany
Novartis Investigative Site
RECRUITING

Coburg, 96450, Germany
Novartis Investigative Site
RECRUITING

Erfurt, 99089, Germany
Novartis Investigative Site
RECRUITING

Essen, 45147, Germany
Novartis Investigative Site
RECRUITING

Hennigsdorf, 16761, Germany
Novartis Investigative Site
RECRUITING

Kiel, 24105, Germany
Novartis Investigative Site
RECRUITING

Hong Kong, Hong Kong, 999077, Hong Kong
Novartis Investigative Site
RECRUITING

Hong Kong, 999077, Hong Kong
Novartis Investigative Site
RECRUITING

Pécs, Baranya, 7623, Hungary
Novartis Investigative Site
RECRUITING

Debrecen, Hajdu Bihar Megye, 4032, Hungary
Novartis Investigative Site
RECRUITING

Budapest, 1083, Hungary
Novartis Investigative Site
RECRUITING

Budapest, 1134, Hungary
Novartis Investigative Site
RECRUITING

Miskolc, 3526, Hungary
Novartis Investigative Site
RECRUITING

Belagavi, Karnataka, 590010, India
Novartis Investigative Site
RECRUITING

Mumbai, Maharashtra, 400012, India
Novartis Investigative Site
RECRUITING

Nashik, Maharashtra, 422005, India
Novartis Investigative Site
RECRUITING

Bikaner, Rajasthan, 334003, India
Novartis Investigative Site
COMPLETED

Chikushino-shi, Fukuka, 818-8516, Japan
Novartis Investigative Site
ACTIVE_NOT_RECRUITING

Kitakyushu, Fukuoka, 8028555, Japan
Novartis Investigative Site
ACTIVE_NOT_RECRUITING

Kamakura, Kanagawa, 247-8533, Japan
Novartis Investigative Site
WITHDRAWN

Sagamihara, Kanagawa, 252-0375, Japan
Novartis Investigative Site
ACTIVE_NOT_RECRUITING

Bunkyo Ku, Tokyo, 1138431, Japan
Novartis Investigative Site
RECRUITING

Gdansk, 80-214, Poland
Novartis Investigative Site
RECRUITING

Katowice, 40-635, Poland
Novartis Investigative Site
RECRUITING

Krakow, 31 202, Poland
Novartis Investigative Site
RECRUITING

Opole, 45-401, Poland
Novartis Investigative Site
RECRUITING

Seoul, Seoul, 06351, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 07804, South Korea
Novartis Investigative Site
RECRUITING

Santiago Compostela, A Coruna, 15706, Spain
Novartis Investigative Site
RECRUITING

Huelva, Andalusia, 21005, Spain
Novartis Investigative Site
RECRUITING

El Palmar, Murcia, 30120, Spain
Novartis Investigative Site
RECRUITING

Las Palmas GC, 35010, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28034, Spain
Novartis Investigative Site
RECRUITING

Madrid, 28046, Spain
Novartis Investigative Site
RECRUITING

Salamanca, 37007, Spain
Novartis Investigative Site
RECRUITING

Seville, 41013, Spain
Novartis Investigative Site
RECRUITING

Valencia, 46010, Spain
Novartis Investigative Site
RECRUITING

Bern, 3010, Switzerland
Novartis Investigative Site
RECRUITING

Geneva, 1211, Switzerland
Novartis Investigative Site
RECRUITING

Lucerne, 6000, Switzerland

More trials for these conditions

Other studies related to the condition(s) this trial covers.