Myocardial infarction

This study tests a drug called selatogrel, which people inject themselves at the first sign of a heart attack. The goal is to see if it can prevent death or reduce heart damage. The trial involves 25,000 people who recently had a heart attack and have other risk factors. Particip…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This study tests whether a weekly injection of CagriSema (a combination of two drugs) can reduce the risk of heart attacks, strokes, and other heart-related events in people with established cardiovascular disease. About 7,100 participants will receive either CagriSema or a place…

This trial aimed to test whether umbilical cord stem cells, delivered through a catheter into heart arteries, could safely improve heart function in people with severe heart damage after a major heart attack. It was designed for patients with very weak hearts (ejection fraction b…

This study tests a technique called acute normovolemic hemodilution (ANH) in 2000 high-risk heart surgery patients. Before the heart-lung machine is used, doctors remove some blood and replace it with fluids. The goal is to see if this reduces the number of patients who need a bl…

This study tests whether a drug called anakinra, which reduces inflammation, can help prevent heart failure in people who have just had a heart attack. About 84 participants will receive daily injections of anakinra or a placebo for up to 14 days. The goal is to see if blocking i…

This phase 3 trial tests whether a monthly injection of pelacarsen can reduce major heart problems like heart attacks and strokes in people with high levels of Lp(a), a genetic risk factor. Over 8,000 participants with existing heart disease are being followed for several years. …

This study compares two ways to decide which blocked arteries to stent in heart attack patients who have multiple blockages. One method uses standard X-ray images; the other uses a computer analysis of those images to measure blood flow. About 1,800 patients will be randomly assi…

This study tests a newer drug-coated stent (Resolute Onyx) against an older one (Resolute Integrity) in 550 people with blocked heart arteries in China. The goal is to see if the new stent works better at keeping arteries open after angioplasty. Participants receive one of the tw…

This study tests a special stent coated with a drug called zotarolimus to treat people with blocked heart arteries. The stent is placed during a procedure to open the artery and slowly releases medication to prevent re-blockage. About 591 participants in China are being followed …

This study planned to test whether cooling the body before and after opening a blocked artery could help people having a heart attack. It was designed to include 80 patients at up to 15 hospitals. However, the trial was withdrawn before anyone was enrolled, so we have no informat…

This phase 2 trial tests whether empagliflozin (Jardiance), a diabetes drug, can reduce the 'no-reflow' phenomenon—when blood flow fails to fully restore after angioplasty—in 162 heart attack patients. Participants receive a loading dose before the procedure and daily doses for 3…

This study tests whether adding evolocumab (Repatha) to standard care helps people who recently had a heart attack reach very low LDL cholesterol levels and avoid death or unplanned heart-related hospital stays. About 2,166 participants with STEMI or NSTEMI will be randomly assig…

This study tests whether adding an external support device to vein grafts during heart bypass surgery helps keep them open over time. Researchers will compare patients who receive the support with those who don't, tracking graft function and symptoms like chest pain. The goal is …

This study compares using a manual clot-removal catheter (Export) before standard balloon angioplasty versus angioplasty alone in 300 heart attack patients with completely blocked arteries. The goal is to see if removing the clot first improves blood flow and reduces in-hospital …

This study looks at two ways to treat heart attacks in people aged 75 and older who have several blocked heart arteries. One approach only fixes the artery that caused the heart attack, while the other uses a special test to decide which other blockages to open. The goal is to se…

This study tests a new device called enVast that removes blood clots from heart arteries during a severe heart attack (STEMI). About 148 adults with large clots will either get standard care or standard care plus the enVast device. The goal is to see if the device reduces the siz…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This early-stage study tests a monoclonal antibody called atibuclimab (IC14) in 10 adults who had a severe heart attack (STEMI) and received a stent. The drug is given by IV to see if it can prevent further heart muscle damage and reduce inflammation. Participants are compared to…

This early study tests a new freezing treatment for people who recently had a heart attack or unstable chest pain. The treatment uses a special balloon to freeze high-risk plaque in the heart's arteries that could rupture and cause another heart attack. The goal is to stabilize t…

This study is testing whether daily shakes made from bilberries and oats can lower LDL cholesterol and improve exercise capacity in people who have had a heart attack or have type 2 diabetes. 900 participants will drink either a bilberry shake, an oat shake, a combination shake, …

This study tests whether an implantable heart monitor with remote follow-up can help doctors decide when to prescribe blood thinners to patients who have had a heart attack and developed new atrial fibrillation. The goal is to reduce bleeding complications compared to the standar…

This trial tests whether a procedure called catheter ablation works better than anti-arrhythmic drugs for people with structural heart disease who have had a dangerous fast heart rhythm (ventricular tachycardia). About 162 participants will be randomly assigned to either ablation…

This study follows over 1,000 people who had a heart attack and received a stent. Researchers want to see if a supervised exercise program lasting at least 1.5 months can reduce the risk of future heart problems, stroke, or death. The goal is to find out whether regular, moderate…

This study tests whether using the Impella heart pump during a high-risk stenting procedure helps people with weak hearts and blocked arteries. About 1,250 participants will be randomly assigned to get either Impella-supported stenting or standard care. The goal is to see if the …

This study tests if using a temporary heart pump (Impella CP) for 30 minutes before opening a blocked artery can reduce heart muscle damage in people having a severe heart attack. About 527 adults with a first-time anterior heart attack are enrolled. The goal is to see if this ap…

This study tests a new care model for people who have had a heart attack. It uses digital tools and specially trained pharmacists to help manage health after leaving the hospital. The goal is to reduce the risk of another heart attack or death. The study involves 1,633 adults in …

This study tests whether a web-based program, including activity tracking, blood pressure monitoring, and educational modules, can help people who have had a heart attack avoid future heart problems. About 864 participants will either use the program or receive standard care. Som…

This study tests whether a newer type of blood thinner (DOA) works better than the standard one (VKA) for dissolving dangerous blood clots inside the heart. About 340 adults with such clots will be randomly assigned to one of the two treatments. The goal is to see which drug redu…

This study tracks over 1,300 heart attack patients who received a procedure called percutaneous coronary intervention (PCI), which opens blocked heart arteries. Researchers want to see if PCI reduces major heart problems like death, another heart attack, or the need for more proc…

This study tests whether a blood test can help doctors safely lower the dose of strong blood thinners (P2Y12 inhibitors) in people who recently had a heart attack or stent. The goal is to reduce bleeding complications without raising the risk of another heart attack or stroke. Ab…

This study compares two methods of prescribing high-intensity interval training (HIIT) for people in cardiac rehabilitation. Thirty adults with heart conditions will follow a 12-week exercise program to see which prescription approach improves fitness, heart function, and oxygen …

This study tests whether giving patients capsules containing gut bacteria (called Probacine) before and after heart surgery can reduce gut injury and organ failure. Researchers will enroll 500 adults undergoing cardiovascular surgery. The goal is to see if changing the gut microb…

This study compares two types of drug-coated stents (SYNERGY and BioMatrix NeoFlex) in 160 patients with coronary artery disease. Researchers use a special camera to check how well the stents heal inside the artery at 1 and 3 months after placement. The goal is to see which stent…

This study follows 1,500 patients with multivessel coronary artery disease who were randomly assigned to receive either coronary stenting guided by fractional flow reserve or coronary bypass surgery. Researchers will compare survival, quality of life, and chest pain relief over 1…

This study tests a single injection of zalunfiban given in the ambulance to people having a severe type of heart attack (STEMI). The goal is to see if the drug improves blood flow and reduces complications like death, stroke, or heart failure within 30 days. About 2,463 participa…

This study tests whether giving evolocumab, a powerful cholesterol-lowering drug, very early during a heart attack hospital stay can reduce the chance of another heart attack, stroke, or death. About 6,000 adults hospitalized for a heart attack are randomly assigned to receive ev…

This study aimed to test a gene therapy called VM202RY in people who recently had a heart attack. The treatment was injected directly into the heart muscle to help it heal and improve pumping strength. However, the trial was withdrawn before enrolling any participants, so no data…

This study looks at CT scans of the heart from 22,000 people who had chest pain. Researchers want to see if certain features of plaque (fatty deposits) in the heart arteries can help predict who will later have a heart attack, stroke, or die from heart disease. The goal is to imp…

This study tests a new PET heart scan that uses 100 times less radiation than current methods. Researchers will scan 200 adults with known or suspected heart artery disease to see if the ultra-low dose still produces clear images. The goal is to make heart imaging safer while kee…

This study is testing whether a special heart scan (dynamic SPECT) can accurately detect remaining blockages in heart arteries after a heart attack, compared to the current standard invasive procedure (FFR). Sixty adults with multiple blocked arteries will receive both tests one …

This study enrolls 800 patients having heart attacks to test an artificial intelligence model that reads standard 12-lead ECGs. The AI aims to detect which artery is blocked and how severely blood flow is reduced, at the moment of a heart catheterization. If accurate, this could …

This study compares two blood test schedules for diagnosing heart attacks in the emergency room: the standard 3-hour test and a newer 1-hour test. Over 64,000 adults with chest pain will be enrolled to see if the faster test is just as safe and accurate. If it works, patients cou…

This large observational study involving 150,000 people tests whether artificial intelligence can predict new heart attacks by analyzing electrocardiogram (ECG) images. The AI model, called AMIdECG, looks at past ECG data that was considered normal to see if it can forecast a fut…

This study explores whether a simple, non-invasive leg movement test can measure blood vessel health in older adults. Researchers will use ultrasound to track blood flow changes after a passive leg movement, comparing young healthy people and older patients undergoing heart tests…

This study tests a new way to classify heart attacks based on whether a coronary artery is fully blocked (occlusion) or not, instead of the traditional ST-elevation vs non-ST-elevation method. Researchers will compare outcomes in 6,000 patients to see if the new approach leads to…

This large Phase 3 study tests whether inclisiran, a twice-yearly injection, can prevent major heart problems like heart attacks, strokes, and heart-related death in people at high risk who have not yet had such an event. Over 14,000 participants are receiving either inclisiran o…

This study compares two ways to prevent heart attacks in people at risk: a CT scan of the heart arteries versus the usual risk score method. About 6,139 adults aged 40-70 with risk factors like high blood pressure, diabetes, or smoking are involved. The goal is to see if the CT-g…

This large study tested whether taking daily vitamin D3 and omega-3 (fish oil) supplements can lower the risk of developing cancer, heart disease, or stroke. Over 25,000 healthy older adults (men 50+, women 55+) took the supplements or placebos for about 5 years. The goal is to s…

This study tests a nurse-led education program designed to help women in cardiac rehab address sexual concerns after a heart event. Sixty-six women will be randomly assigned to either the program or usual care. The goal is to see if the program improves sexual function, mood, and…

This study tests whether adding blood flow restriction (BFR) to standard resistance training helps heart rehab patients get stronger and healthier. Twenty adults with stable heart disease will do exercises with and without a special cuff that limits blood flow to the arms and leg…

This study tests whether a virtual world-based cardiac rehabilitation program is feasible for heart patients. Five participants will attend 24 online sessions over 8 weeks, including video visits with exercise physiologists and nurse coaches, plus group education. The goal is to …

This study tests whether a nerve block given before heart surgery can reduce pain and the need for opioid painkillers afterward. About 150 adults having heart surgery will receive either a long-acting or standard form of the numbing drug bupivacaine via ultrasound-guided injectio…

This study tests a short program that helps heart patients and their families explore what gives life meaning during cardiac rehab. About 80 people in Denmark will try one of three formats: one-on-one, with a relative, or in a group. The goal is to see if this approach can reduce…

This study is building a large gene bank by collecting blood samples and health information from nearly 10,000 people who have had heart catheterization or cardiac CT scans. The goal is to identify genetic and other factors that contribute to coronary artery disease. Participants…

This observational study tracks 5,000 people taking common blood thinners (like rivaroxaban or apixaban) or antiplatelet drugs (like aspirin). Researchers regularly measure drug levels in the blood to see how they relate to clots or bleeding events. The goal is to find the best d…

This study tests a new way to find unstable plaques in the heart arteries of people who come to the emergency room with chest pain but are not having a heart attack. Researchers use a simple calcium scan to group patients by risk, then follow up with special PET scans to see if p…

This study looks at 90 people who recently had a heart attack and have other artery narrowings that may or may not be dangerous. Researchers will use two types of scans—optical coherence tomography (OCT) and magnetic resonance angiography (MRA)—to see if they can tell which narro…

This study tracks 120 adults with heart disease and at least two other long-term illnesses to see how often dangerous drug interactions happen. Researchers check medications, including over-the-counter and herbal products, and follow participants for a year. The goal is to unders…

This study looks at how blood flow in the feet changes during a 12-week heart and blood vessel rehab program for people with narrowed arteries. Researchers will track 80 adults with conditions like peripheral artery disease or coronary artery disease. The goal is to better unders…

This study analyzes data from over 377,000 people who had a heart attack and were prescribed blood thinners (clopidogrel, ticagrelor, or prasugrel) in Germany and the United States between 2011 and 2024. Researchers aim to describe how often each drug is used and how much it cost…

This study looks at whether a special heart MRI, done within a week of a heart attack, can help doctors better predict a patient's future health. Researchers will follow 2,000 adults for years to track serious heart events like another attack or heart failure. The goal is to lear…

This study tracks over 1,700 heart patients who had hip or knee replacement surgery. Researchers want to see how often bleeding or blood clots happen in the months after surgery. The goal is to find better ways to prevent these complications.

This study looks at whether a new screening system can help doctors find heart complications early in high-risk patients after noncardiac surgery. Researchers will track 900 patients to see how well the screening works in practice and what it costs. The goal is to gather informat…

This international registry is collecting information from 2000 people who have had spontaneous coronary artery dissection (SCAD), a rare cause of heart attacks. Researchers will track participants' health over time to better understand the condition and develop best practices fo…

This study is a large international registry that will collect data from up to 130,000 people who have had a heart attack or unstable chest pain. Researchers will track treatments, outcomes, and safety to understand what works best in real-world care. No new drugs or devices are …

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study looks at 2,000 people who had a heart attack to see if checking the stiffness of their blood vessels one month later can help predict future heart failure, another heart attack, or bleeding. Researchers will track participants for several years to identify which measur…

This study looks at how doctors treat people having a severe heart attack complicated by cardiogenic shock, where the heart can't pump enough blood. Researchers will track 124 patients at 20 U.S. hospitals to see how decisions about using mechanical heart support devices affect s…

This study is a large registry that collects medical data and tissue samples from 30,000 people with heart disease and healthy volunteers. Researchers will analyze this information to better understand risk factors, treatments, and outcomes for various heart conditions. The goal …

This study is observing 2,000 people who have had a heart attack to collect detailed medical information, images, and blood samples. Researchers will use this data to better understand different types of heart attacks and find new ways to predict and prevent future heart problems…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …

This study looks at 450 people who had a heart attack but no major blockages in their heart arteries (called MINOCA). Using advanced imaging, researchers aim to find the real cause, such as plaque disruption or artery tears. Participants are followed every 6 months for up to 10 y…

This study tests whether a smartphone app that analyzes your voice can spot signs of depression and anxiety in people recovering from a heart attack. About 200 adults in cardiac rehab will use the app alongside their usual care. The goal is to see if voice analysis can help impro…

This study follows 1,599 people who had a first heart attack to see how their hearts remodel over time. Researchers want to link these changes to later heart failure. Participants are from several Minnesota counties and will be monitored for heart failure and death. No new drug o…

This study looks at whether artificial intelligence can improve predictions of serious heart events in people with chest pain. Researchers will analyze stress echocardiogram results and routine medical data from about 2,281 adults. No extra visits or tests are needed for particip…

This study follows about 3,000 adults in Port-au-Prince, Haiti, to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other heart problems. Researchers will track participants for about…

This study involves 240 people who had a severe heart attack (STEMI) and received emergency treatment to open blocked arteries (PCI). Researchers want to find out if certain blood markers (OxPLs) can help predict the risk of future heart problems. They will use this information t…

This study looks at whether a quick, point-of-care blood test for heart damage can give results faster than standard lab tests for people with chest pain in the emergency room. Researchers will compare the time it takes to get test results and how long patients stay in the ER. Th…

This study is testing a new AI-powered decision support system designed to help doctors diagnose and treat acute myocardial infarction (heart attack) more quickly and effectively. The system aims to address common delays in care, such as slow diagnosis in clinics and low complian…

This study looks at how being in a hospital intensive care unit (ICU) after heart surgery affects your body's natural sleep-wake cycle. Researchers will track sleep patterns and thinking ability in 15 adults to see if disrupted rhythms slow down recovery. The goal is to understan…

This study followed over 6,800 adults from different racial and ethnic backgrounds to understand how heart disease develops over time. Participants were healthy at the start and were monitored for risk factors and heart-related events like heart attacks and strokes. The goal is t…

This study aimed to see if using a special pad along with a standard closure device could help patients get out of bed sooner after a heart catheterization. It was planned for adults having the procedure through the groin. However, the study was withdrawn before any participants …

This study is collecting information from 500 people who had a first heart attack and received a cardiac MRI. The goal is to see if MRI images of the heart can help predict who will have future heart problems like heart failure or need a heart transplant. Researchers are looking …

This study uses a special PET/MRI scan with an investigational tracer called [18F]DPA-714 to see if a heart attack leads to inflammation in the brain. Researchers will compare 6 people who recently had a heart attack with a control group. The goal is to better understand the link…

This study tests whether offering heart patients extra support—like a $50 incentive, text messages, case management, and coaching—helps more of them attend cardiac rehabilitation, a program that only 30% of eligible patients currently use. Researchers will also try different ways…

This study looks at three ways to treat severely hardened heart arteries before placing a stent: using sound waves (lithotripsy), a high-pressure balloon, or a tiny rotating device (orbital atherectomy). The goal is to see how each method affects the small blood vessels in the he…

This study reviews medical records of about 1520 adults who had a heart attack or stroke and visited a clinic in Belarus between 2019 and 2022. Researchers aim to identify common risk factors and see if patients meet target health goals. The study does not test any new treatment …

This registry follows 75 pregnant women with heart disease to better understand the risks and outcomes for both mother and baby. Researchers will track health data for one year and check vital status at five years. The goal is to fill knowledge gaps and improve future care for th…

This study follows 347 heart surgery patients to understand why some develop swallowing problems (dysphagia). Researchers will use special camera tests to watch how patients swallow and look for risk factors. The goal is to create simple tools that doctors can use at the bedside …

This study follows over 5,700 people with coronary artery disease and mild heart damage to see if blood tests and ECGs can better predict who is at risk for sudden cardiac death. The goal is to find inexpensive markers that could help doctors decide who needs a defibrillator. Par…

This study looks at whether a common diabetes medicine (SGLT2 inhibitor) can help prevent future heart problems in people with type 2 diabetes who have had a heart attack. Researchers will compare health records of 200,000 adults in Korea who took either an SGLT2 inhibitor or ano…

This study is following 10,000 adults who are having a heart MRI for medical reasons. Researchers want to see if the MRI results can help predict who will have heart problems in the future, like heart attacks or heart failure. The goal is to better understand how MRI scans can gu…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. The study was withdrawn before enrolling …

This study was designed to test a new catheter that takes two types of pictures inside heart arteries at the same time—using sound and light. The goal was to see if this hybrid approach is safer and better at identifying fatty plaques that could cause heart attacks compared to st…

This study looks at whether giving people a personalized genetic risk score for coronary artery disease helps doctors make better decisions about prevention. About 1,000 adults with moderate heart risk will be randomly assigned to receive their risk score or not. Researchers will…

This study looks at 15 people who had a heart attack but whose arteries were not blocked. Researchers use two types of imaging—one inside the artery and one MRI of the heart—to find hidden plaque or damage that might explain the attack. The goal is to better understand these puzz…

This study was designed to see if helping heart patients with social problems like food, housing, and mental health could keep them out of the hospital. The researchers planned to screen patients and connect them to community resources. However, the study was withdrawn before enr…