New study tests powerful cholesterol drug right after heart attacks
NCT ID NCT04951856
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding evolocumab (Repatha) to standard care helps people who recently had a heart attack reach very low LDL cholesterol levels and avoid death or unplanned heart-related hospital stays. About 2,166 participants with STEMI or NSTEMI will be randomly assigned to evolocumab injections every two weeks or usual care. The trial is active but no longer recruiting, and results are expected to show if this approach is better than standard cholesterol management.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Evolocumab (Repatha), a cholesterol-lowering injection
- What this could lead to
- If it works, this could show that adding evolocumab right after a heart attack helps more people reach very low cholesterol goals and reduces the risk of death or heart-related hospital stays.
- What could go wrong
- This is a phase 4 trial, so the drug is already approved, but it may not prove a clear benefit over standard care. Side effects like injection-site reactions or muscle pain are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
ACTION Group, Institut de Cardiologie, Centre Hospitalier Universitaire Pitié Salpêtrière (APHP), UPMC
Paris, 75013, France
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Other studies related to the condition(s) this trial covers.
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