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New imaging technique could save lives after heart attacks

NCT ID NCT05818475

Ongoing Disease control Sponsor: University Hospital of Ferrara Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two ways to decide which blocked arteries to stent in heart attack patients who have multiple blockages. One method uses standard X-ray images; the other uses a computer analysis of those images to measure blood flow. About 1,800 patients will be randomly assigned to one approach. The goal is to see if the computer-guided method reduces deaths, heart attacks, strokes, or the need for repeat procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
angiography-derived fractional flow reserve (FFR) imaging
What this could lead to
If successful, this could lead to a more precise way to decide which blockages need stenting, potentially reducing deaths, heart attacks, and strokes in heart attack patients.
What could go wrong
This is a large trial, but the new method may not prove better than standard visual assessment. There is also a risk of kidney injury or bleeding from the procedure itself.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder myocardial infarction ST-elevation myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYOCARDIAL INFARCTION

Contacts and locations

Locations

  • AORN Sant'Anna e San Sebastiano

    Caserta, Italy

  • ASST Papa Giovanni XXIII

    Bergamo, Italy

  • AUSL Bologna Ospedale Maggiore

    Bologna, BO, 40133, Italy

  • AUSL Piacenza

    Piacenza, PC, Italy

  • AUSL Romagna Ospedale degli Infermi Rimini

    Rimini, RN, Italy

  • AUSL Romagna Santa Maria delle Croci Ravenna

    Ravenna, Italy

  • Arcispedale Santa Maria Nuova di Reggio Emilia

    Reggio Emilia, RE, 42123, Italy

  • Azienda Ospedaliero Universitaria Integrata di Verona

    Verona, VR, Italy

  • Azienda Ospedaliero Universitaria Mater Domini

    Catanzaro, Italy, Italy

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, Italy

  • Azienda Ospedaliero Universitaria di Ferrara

    Ferrara, FE, 44124, Italy

  • Azienda Ospedaliero Universitaria di Parma

    Parma, PR, Italy

  • NICVD Karachi

    Karachi, Pakistan

  • Ospedale Annunziata

    Cosenza, Italy, 87100, Italy

  • Ospedale Civile di Baggiovara

    Baggiovara, MO, Italy

  • Ospedale Maggiore della Carità Novara

    Novara, Italy

  • Ospedale Mater Salutis Legnago

    Legnago, VR, Italy

  • Ospedale Santa Maria Goretti

    Latina, Italy

  • Ospedale Santa Maria della Misericordia Rovigo

    Rovigo, RO, Italy

  • Ospedale dell'Angelo Mestre

    Mestre, VE, 30100, Italy

  • Ospedale di Bolzano

    Bolzano, Italy, 39100, Italy

  • Policlinico Casilino

    Roma, Italy

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