Myocardial infarction

This trial is testing the best timing for opening additional blocked arteries in people who have had a severe type of heart attack (STEMI) with multiple blocked vessels. After the main blocked artery is opened, participants are randomly assigned to have the other blockages treate…

This trial investigates whether using a temporary heart pump (microaxial flow pump) right after opening a blocked artery improves survival in people with cardiogenic shock—a life-threatening condition where the heart can't pump enough blood. It also tests whether advanced monitor…

This trial tests whether starting a temporary balloon pump in the aorta before the standard artery-opening procedure (angioplasty) can improve outcomes for people who arrive at the hospital 4 to 12 hours after a major heart attack. Half of the participants will receive the balloo…

This trial tests whether giving empagliflozin before or after a procedure to open a blocked heart artery (primary PCI) reduces heart muscle injury during a heart attack. Adults aged 18-75 of South Asian origin having their first heart attack will be randomly assigned to receive e…

This trial tests whether a virtual world-based cardiac rehabilitation program can improve heart health and participation compared to standard in-person rehab. The program, called Destination Cardiac Rehab, is a 3D interactive telehealth option that patients can use from home. Res…

This study tests whether adding mobile health tools—like smartphone apps, connected scales, blood pressure monitors, and activity trackers—to standard cardiac rehab helps heart patients monitor their health and stick to healthy habits at home. The trial enrolls adults who have ha…

This study tests whether a medicine given as a nose spray before a heart stent procedure can reduce heart muscle injury or heart attack. About 1800 adults scheduled for elective stent placement will receive either the medicine or a placebo spray. Researchers will measure heart da…

This trial tests whether a hybrid cardiac telerehabilitation program — combining in-person sessions, live video workouts, and remote monitoring — can improve adherence to exercise rehab in people with coronary artery disease or stable heart failure. Participants are randomly assi…

This study tests whether a 6-month program delivered through the Telegram messaging app can help people stop smoking after a heart attack. 142 adult smokers who use Telegram will either get the chatbot support or standard advice. The goal is to see if more people quit with the ch…

This trial tests whether adding eccentric cycling—a type of exercise where muscles lengthen under tension—to standard cardiac rehabilitation can improve recovery in people who have had a heart attack. Eccentric exercise may allow higher muscle loads with less cardiovascular deman…

This study tests whether giving high-risk heart attack patients personalized education before they leave the hospital can reduce their chances of being readmitted. The education covers disease management, medication adherence, lifestyle changes, and recognizing warning signs. Res…

This trial tests whether filtering a specific inflammatory protein (C-reactive protein, or CRP) from the blood can improve outcomes in people with cardiogenic shock—a life-threatening condition where the heart cannot pump enough blood—after a heart attack. About 50 participants w…

This trial investigates whether patients with acute coronary syndrome can safely stop taking aspirin soon after a heart stent procedure and continue with only a potent antiplatelet drug (ticagrelor or prasugrel). The standard approach is to take both aspirin and a P2Y12 inhibitor…

This study tests a simple balloon inflation technique to modify blood clots during emergency heart artery opening. 100 heart attack patients will either get the balloon procedure or standard care. The goal is to see if this reduces damage to the heart muscle and improves recovery…

This study tests whether the diabetes drug ertugliflozin, started within 72 hours of a first heart attack, can improve heart function in people with type 2 diabetes. About 476 adults will be randomly assigned to take the drug or receive standard care. Researchers will measure cha…

This study compares two approaches to blood thinning after a heart attack in patients with atrial fibrillation. One group gets two blood thinners (a DOAC plus clopidogrel), while the other gets only one (a DOAC alone). The goal is to see if using just one drug reduces bleeding ri…

This study compares two ways to guide stent placement during emergency treatment for a severe type of heart attack (STEMI). About 2,500 patients will be randomly assigned to receive either standard X-ray guidance or ultrasound guidance (IVUS) during the procedure. The goal is to …

This study looks at 240 adults having a major heart attack (STEMI) when the standard emergency procedure to open the blocked artery is expected to be delayed by over an hour. Half will get a clot-busting drug (tenecteplase) right away, followed by the procedure within 2-24 hours.…

This study looks at a special stent (a small mesh tube) coated with a drug called sirolimus, used to open blocked heart arteries. Researchers will follow 300 adults who received this stent during a standard heart procedure to see how safe and effective it is over 5 years. The mai…

This study tests a drug called pelacarsen in people who recently had a heart attack and have high levels of Lp(a), a type of fat in the blood that raises heart risk. The goal is to see if the drug can safely lower Lp(a) levels and improve heart health. About 240 adults in the US …

This study tests whether a new wire-free imaging method called μFR can help doctors decide which blocked heart arteries need stents after a heart attack. About 350 patients with multiple blocked arteries will be randomly assigned to standard care or μFR-guided treatment. The goal…

This study tests a new use of low-intensity focused ultrasound (LIFU) to calm nerve signals that can trigger dangerous heart rhythms after a heart attack. About 100 adults who recently had a severe heart attack will receive either real or fake ultrasound sessions during and for a…

This study tests a drug called NL005 in people who have had a severe type of heart attack (STEMI) and undergone emergency artery-opening treatment. The goal is to see if NL005 can reduce permanent heart muscle damage. Participants will receive either NL005 or a placebo daily for …

This study tests whether drinking a specially designed milk every day for a year can reduce the chance of stents narrowing again and prevent further heart problems in people who have had a first heart attack. About 140 adults who recently had a stent placed will be randomly assig…

This study tests whether removing blood clots from heart arteries during emergency treatment can improve long-term heart health. About 6,760 adults having a severe heart attack will be randomly assigned to get standard care or standard care plus clot removal. Researchers will tra…

This study tests a new radiation treatment for people with a life-threatening fast heart rhythm called ventricular tachycardia that hasn't been helped by medication or prior procedures. About 24 adults with an implanted defibrillator will receive a single, targeted dose of radiat…

This trial tests a hybrid exercise program (HyBEST) for people with coronary artery disease. It combines supervised sessions at a center with home workouts using a wearable tracker. The goal is to see if this approach improves exercise capacity, body composition, and quality of l…

This study involves 8,100 adults who had a heart attack and received a stent. It compares different approved blood-thinning strategies to see which one best prevents another heart attack, stroke, or death while also reducing serious bleeding. Participants will either receive a sh…

This study tests whether routinely placing a small tube in the leg artery (distal perfusion catheter) is better than waiting until a problem arises in patients on mechanical heart pumps. About 500 adults with severe heart failure or shock will be randomly assigned to one of the t…

This study tests whether inserting a heart pump (IABP) early, before severe shock develops, can reduce deaths in patients who develop a hole in the heart after a heart attack. The trial will enroll 100 patients across 5 centers, randomly assigning half to receive the pump within …

This study tracks 1,200 people with coronary artery disease who receive a drug-coated balloon instead of a metal stent during angioplasty. The goal is to see if this approach reduces heart-related deaths, heart attacks, and the need for repeat procedures. Researchers hope to conf…

This study tests a new treatment called MiSaver, made from umbilical cord blood cells, for people who recently had a heart attack. The goal is to see if it safely helps the heart pump better and reduces future heart problems. About 102 participants will either receive the cell tr…

This study tests whether the drug nicorandil can improve blood flow in the heart's tiny vessels after a heart attack. About 170 patients having emergency angioplasty will receive either nicorandil or a placebo directly into their heart artery. The goal is to see if nicorandil red…

This study tests whether a smartwatch, combined with artificial intelligence, can help monitor heart attack patients during their recovery at home. About 1,050 participants will either use the smartwatch with AI, a smartwatch without AI, or receive standard care. The goal is to s…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study compares two blood thinners, bivalirudin and heparin, used during a heart procedure called PCI in people with acute coronary syndrome who are at high risk of bleeding. About 5,270 participants will be randomly assigned to receive one of the two drugs. The goal is to se…

This early-phase trial tests a new treatment for people in shock after a severe heart attack. The therapy uses specially engineered immune cells (CAR-DC) to target a protein found in heart scar tissue, aiming to calm the immune response. The study will enroll 18 patients and prim…

This study looks at two ways to treat people with a type of heart attack (NSTE-ACS) who have multiple blocked arteries. One group gets all blockages fixed during the same emergency procedure, while the other group fixes the main blockage first and the others later. The goal is to…

This study tests if a special balloon pump placed in a heart vein (coronary sinus) can reduce heart muscle damage when used alongside standard angioplasty in people having a major heart attack (STEMI). About 177 adults aged 18-80 with moderate heart pumping weakness will be rando…

This study tests whether giving a powerful cholesterol-lowering drug (recaticimab) early after a heart attack can safely reduce future heart problems. About 2,442 adults who recently had a heart attack will receive the drug or standard care. The goal is to see if this approach lo…

This study tests whether using a smartwatch combined with artificial intelligence can improve recovery for people who have had a heart attack. 200 adults aged 18-75 who recently had a heart attack and a stent placed will wear a smartwatch that tracks health data. The AI analyzes …

This study tests a smartphone-based rehab program for young and middle-aged people (18-60) who had a heart attack. The program uses an app to guide exercise, diet, medication, and stress management, with support from a team of heart doctors, nurses, nutritionists, and psychologis…

This study tests whether starting the drug tafolecimab (a PCSK9 inhibitor) just before emergency angioplasty can lower the chance of major heart problems over the next year in people having a heart attack. About 1,160 adults will either get the drug plus standard care or standard…

This study tests whether a short course of the antibiotic rifaximin can improve how well the blood thinner ticagrelor works in people who have had a heart attack. The idea is that unhealthy gut bacteria may interfere with the drug, and clearing them out could help prevent future …

This study tests whether adding the blood thinner rivaroxaban to standard aspirin and clopidogrel can improve sluggish blood flow in heart attack patients who just had a stent placed. About 60 adults will receive either the triple therapy or standard dual therapy for one month. R…

This study will test whether adding a special breathing exercise (inspiratory muscle training) to standard cardiac rehab helps heart patients recover better. About 80 adults who have been hospitalized for a heart condition will take part. The main goal is to see if the training i…

This study tests if gently cooling the body (to 33-34°C) during emergency heart procedures can limit heart damage in people having a severe heart attack complicated by shock. All 44 participants will receive standard care with a heart-lung machine, and half will also be cooled fo…

This study tests whether digital health tools can help people recover safely at home after a heart attack. Researchers will compare two types of follow-up care: education alone versus education plus extra support like symptom tracking and virtual appointments. The goal is to redu…

This large study will test whether adding Shexiang Baoxin Pill (Muskardia) to standard treatment helps people who have had a heart attack. About 9,588 participants will receive either standard care alone or standard care plus the pill for 12 months. The goal is to see if the pill…

This study looks at whether a 12-week cardiac rehabilitation program—including supervised exercise, education, and lifestyle advice—can improve heart function and quality of life in people who have had a heart attack treated with stenting. One hundred participants will be randoml…

This trial compares two blood-test strategies for diagnosing heart attacks in people with chest pain: the standard approach of testing at arrival and again 3 hours later, versus an accelerated approach testing at arrival and again after just 1 hour. The goal is to see whether the…

This trial tests whether a smartphone app called Antshrike, paired with a smartwatch, can predict heart attacks or strokes within 3-4 days in people at high risk. Participants aged 40 to 79 with existing heart disease or elevated risk will wear the smartwatch for 18 months while …

This study looks at whether a simple blood test done in the ambulance can safely rule out a heart attack in people with chest pain. Many patients are taken to the hospital even though they are not having a heart attack. The test uses a portable device to measure a heart protein c…

This study aims to create a risk prediction model for acute myocardial infarction (heart attack) using artificial intelligence and wearable devices. Researchers will enroll 3,000 high-risk patients in the Beijing area and collect data from ECGs and other sources. The goal is to e…

This study will develop and test an artificial intelligence (AI) model to predict the risk of a heart attack within 6 months in people who have already had one. Researchers will combine different types of patient data to create a more accurate risk score. The goal is to identify …

This study is testing a new tool called UFR, which uses ultrasound images to measure blockages in heart arteries during a heart attack. Currently, the most accurate method requires patients to return 30 days later for a second invasive procedure. The study will enroll 200 heart a…

This trial tests whether a structured oral hydration plan—drinking at least 1,500 mL of fluid within 12 hours around the procedure—can reduce the risk of contrast-induced acute kidney injury (CI-AKI) in patients with ST-elevation myocardial infarction (STEMI) undergoing primary P…

This study tests whether adding cilostazol, a drug that improves blood flow, to standard aspirin or clopidogrel therapy can prevent another stroke or heart attack in people who have recently had a stroke or mini-stroke. About 2,000 participants will take either cilostazol or a pl…

This study tests a 13-week remote stress recovery program for people who had a heart attack before age 55 and still feel distressed. The program includes online sessions with a therapist, a workbook, and videos. The goal is to see if a larger trial is possible by checking how man…

This study looks at whether 12 virtual health coaching sessions over 16 weeks can help people with heart disease (like heart failure or a heart attack) improve their health, reduce stress, and lower the chance of going back to the hospital. About 70 adults will take part, and the…

This study tests if combining arm and leg cycling exercise is better than leg cycling alone for improving fitness and quality of life in people who have had a heart attack. Forty medically stable adults aged 40-70 will exercise three times a week for six weeks. Researchers will m…

This early study tests whether a special gel, injected into the heart during a procedure to open blocked arteries, can safely reduce injury in people having their first major heart attack. Twenty participants will be randomly assigned to get the gel plus standard care or standard…

This study tests whether a combination of a motivational phone call for patients and reminders for their doctors can increase attendance at cardiac rehabilitation after a type 2 heart attack. Researchers will compare 60 adults who receive this extra support to those who get usual…

This study will compare two types of aerobic exercise—interval training and continuous training—in 48 people with stable coronary artery disease. Participants will exercise twice a week for 8 weeks as part of a cardiac rehab program. Researchers will measure heart efficiency, exe…

This study looks at whether listening to music can help lower anxiety and improve sleep in people who have had a heart attack and are spending their first night in a special heart unit. About 64 adults will take part. They will listen to music and then use eye masks and earplugs …

This phase 3 trial will compare methoxyflurane (Penthrox®), a painkiller gas patients inhale themselves, against standard morphine injections for chest pain during a heart attack. About 700 adults with a specific type of heart attack (STEMI) will be enrolled in pre-hospital setti…

This study looks at two simple methods to help local anesthesia work better for children aged 6-12 with a condition called Molar-Incisor Hypomineralization (MIH), which makes teeth sensitive and hard to numb. Researchers will apply either silver diamine fluoride or a cold pack to…

This study tests whether a home-based cardiac rehabilitation program can improve quality of life and health behaviors in heart patients living in low-resource settings in Pakistan. The program includes diet advice, exercise suggestions, medication reminders, and counseling, deliv…

This study investigates whether insulin resistance, measured by the TyG index, is linked to the no-reflow phenomenon—where blood flow fails to restore properly—after primary PCI (stenting) for heart attacks in people with type 2 diabetes. Researchers will also examine how insulin…

This study follows 600 older adults (age 60+) who have had a heart attack to see if aging-related markers in their blood and body can predict future heart problems or death. Researchers collect medical data, blood samples, and heart scans over at least two years. The goal is to b…

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study will follow 400 people who had a heart attack and have moderately reduced heart function (ejection fraction 35-50%). Participants will get a small implantable heart monitor to track their heart rhythm for up to 5 years. The goal is to identify markers that could predic…

This study aims to see if wearable foot-pods (like Stryd) and breathing frequency monitors can accurately measure exercise intensity in people who have had a heart attack in the past 6 months. 24 participants will perform walking tests on flat ground and a treadmill while their o…

This study looks at whether Guanxinning tablets can help repair tiny blood vessels in the heart after a heart attack. About 70 people who have had a severe heart attack will take the tablets or a placebo for 6 months. The main goal is to see if the tablets reduce bleeding in the …

This study investigates whether a condition called clonal hematopoiesis of indeterminate potential (CHIP), which is an age-related change in blood cells, is linked to more severe heart damage in people who have had a major heart attack (STEMI). Researchers will test blood samples…

This study will create a digital twin of the heart for 1,000 people who have had a heart attack. The goal is to see if this computer model can better predict who is at risk for sudden cardiac death compared to the current standard method. Participants will undergo a cardiac CT sc…

This study will follow 1,800 people who had a stent placed in their heart arteries using a special camera (OCT). Researchers want to see if new measurements from routine angiograms can better predict future heart problems like heart attacks or chest pain. The goal is to improve h…

This study will follow 6000 people with heart disease or recent heart attacks for years. Researchers will collect blood, urine, and stool samples, plus medical data, to build a huge database. They hope artificial intelligence can find new ways to predict, diagnose, and treat hear…

This study will enroll 1,000 patients in China who have a heart attack complicated by cardiogenic shock, a life-threatening condition. Researchers will test a new team-based care system and create a risk model tailored to Chinese patients. The goal is to reduce deaths and improve…

This observational study will enroll 20,000 Korean adults who have had a heart attack (acute myocardial infarction). Researchers will collect detailed data from hospitals nationwide to understand what factors affect long-term outcomes. The goal is to create better risk prediction…

This study develops and tests an AI system that reads de-identified patient admission notes to classify four types of coronary syndromes, including heart attacks and angina. The tool is designed to protect patient privacy while helping doctors diagnose more accurately and quickly…

This study is testing a new algorithm that helps paramedics decide if a patient with chest pain is having a heart attack. About 304 patients will get a quick blood test in the ambulance, and researchers will track their outcomes for 90 days. The goal is to fine-tune the algorithm…

This study uses a large Korean health database to see if developing insomnia after a heart attack (treated with stents or bypass surgery) is linked to worse long-term outcomes like death, another heart attack, or stroke. Researchers will compare patients who take insomnia medicat…

This study will use data from over 10,000 people to create a risk prediction model for coronary artery disease. Researchers will combine heart imaging scans (like CT angiograms) with blood markers (like cholesterol) to better identify who is at high risk for heart attacks or othe…

This study will track 320 people in Hong Kong who have a heart attack complicated by cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will collect data on standard treatments, including the use of a heart pump called Impella, to…

This study looks at whether heart attack patients get to the hospital just as fast when a non-doctor team (like firefighters or paramedics) does the ECG compared to a doctor-staffed team. Researchers will review records of 350 adults who called emergency services in France betwee…

This observational study will enroll 135 adults who had a severe type of heart attack (STEMI) and were treated with angioplasty. Researchers will use a special ultrasound technique to measure left atrium strain within 48 hours of admission. The goal is to see if this measurement …

This study will develop an artificial intelligence model that combines heart MRI scans and patient data to predict long-term risks after a heart attack. Researchers will enroll 800 patients who have had a severe type of heart attack (STEMI) and undergone emergency artery-opening …

This study will develop a new AI-powered model to predict major heart problems after a heart attack. Researchers will analyze data from over 1,500 patients who had a heart attack and received a stent. The goal is to create a more accurate tool than current methods to identify pat…

This study tests whether using very low radiation doses combined with special software can produce clear images of the heart's arteries. About 50 adults scheduled for a standard heart angiogram will have extra images taken with the new low-radiation method. The goal is to see if …

This study looks at whether a score called CALLY, calculated from routine blood tests, can help predict short-term problems like heart failure or death in people having emergency treatment for a heart attack. Researchers will follow 140 patients for 30 days after their procedure.…

This study will follow 500 people having a major heart attack (STEMI) to see how the time from symptom onset to balloon treatment affects electrical signals on their ECG and their risk of complications. Researchers will track heart rhythm problems and major events like death or a…

This study looks at whether the bacteria in your gut can affect how your heart heals after a heart attack procedure called PCI. Researchers will measure a substance called TMAO, made by gut bacteria, in 144 patients. The goal is to see if TMAO levels are linked to changes in hear…

This study aims to create a risk prediction tool for ischemic stroke in people who have had a heart attack but do not have atrial fibrillation. Researchers will analyze the medical records of 4,000 past patients to see if common hospital data can accurately predict stroke risk du…

This study will enroll 1,000 people with diabetes who are having an emergency procedure to open a blocked artery after a severe heart attack (STEMI). Researchers want to see if certain blood markers of inflammation and clotting can predict complications like heart failure, abnorm…