Could a simple inhaled gas replace morphine for heart attack pain?
NCT ID NCT07445737
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 3 trial will compare methoxyflurane (Penthrox®), a painkiller gas patients inhale themselves, against standard morphine injections for chest pain during a heart attack. About 700 adults with a specific type of heart attack (STEMI) will be enrolled in pre-hospital settings. The goal is to see if methoxyflurane is at least as good as morphine at relieving pain within 30 minutes, with fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Methoxyflurane (Penthrox®) inhaled gas
- What this could lead to
- If it works, this could offer a faster, easier-to-use pain relief option for heart attack patients without needing an IV line.
- What could go wrong
- This is a non-inferiority trial, so it may only show methoxyflurane is not worse than morphine, not necessarily better. It has not started recruiting yet, and results may not apply to all heart attack patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hôpital Avicenne
Bobigny, 93000, France
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