Assistance Publique - Hôpitaux De Paris

This study tests a new gene therapy for children with a severe immune disorder called Artemis-SCID, where the body cannot fight infections. Doctors take the child's own blood stem cells, fix the faulty gene in a lab, and put the corrected cells back. The goal is to rebuild a work…

This study is for adults with granulomatosis with polyangiitis (GPA), a rare disease that inflames blood vessels, who haven't improved with usual treatments. Researchers will compare three different drug strategies—adding a standard arthritis drug to rituximab, or using tocilizum…

This study tests a new stem cell transplant method for adults aged 40 to 60 with severe aplastic anemia that has not improved or has returned after standard drug therapy. The approach uses a special drug after transplant to reduce the risk of graft-versus-host disease, a common a…

This study tests whether ruxolitinib, a drug that blocks a specific immune signal (interferon-γ), can help people with inclusion body myositis, a rare muscle disease that causes progressive weakness. About 80 adults aged 45 and older will receive either the drug or a placebo. The…

This study tests a drug called ruxolitinib as the first treatment for children with primary haemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening immune disorder. The goal is to see if ruxolitinib, given with steroids, can help children survive long enough to rec…

This study looks at whether giving iron through a vein (IV) is better than iron pills for treating anemia after a C-section and lowering the risk of postpartum depression. About 2860 women with moderate anemia after delivery will be randomly assigned to one of the two treatments.…

This study compares two weight-loss surgeries for people with severe obesity: the standard Roux-en-Y gastric bypass and a newer, simpler omega gastric bypass with a 150 cm loop. About 368 adults aged 18-65 with a BMI of 40 or higher (or 35-40 with related health issues) will take…

This study looks at whether starting intensive day hospital treatment early for teenagers with anorexia nervosa can improve their recovery and reduce serious events like hospital stays. It involves 164 teens aged 12-18 and their families. The goal is to see if this approach works…

This study looks at 600 ICU patients with sepsis caused by drug-resistant bacteria. It compares giving antibiotics continuously versus intermittently, and using one drug versus a combination. The main goal is to see which approach reduces deaths within 30 days.

This study tests a high-precision radiation treatment called SBRT for people with liver cancer who are waiting for a liver transplant but cannot have standard bridging treatments like radiofrequency ablation or chemoembolization. The goal is to see if SBRT can keep the cancer und…

This study tests whether adding a balloon pump early to relieve pressure on the left ventricle improves outcomes for people in severe cardiogenic shock who are already on a heart-lung machine (VA-ECMO). About 298 adults will be randomly assigned to early preventive unloading or s…

This study compares a 3-day course of intravenous (IV) antibiotics to a 10-day course (3 days IV plus 7 days oral) for treating acute kidney infection in children aged 1 month to 3 years. The goal is to see if the shorter treatment works just as well, while reducing antibiotic re…

This study explores whether using connected inhalers that track medication use, combined with video doctor visits when problems arise, can manage childhood asthma as well as standard in-person care. Fifty children aged 4 to 12 with asthma will take part for 8 months. Half will us…

This study tests whether temporarily stopping the breathing machine (apneic ventilation) in people with severe lung failure on life support (ECMO) helps them recover faster and survive longer. About 280 adults will be randomly assigned to either the pause approach or standard car…

This study tests a drug called baricitinib (a JAK1 inhibitor) in 25 people with large inflammatory hepatocellular adenomas (benign liver tumors). The goal is to see if a short course of the drug can shrink these tumors enough to avoid risky surgery. Participants will have MRI sca…

This study tests whether giving antibiotics before burn surgery lowers the chance of infections afterward. About 506 adults with burns covering 5% to 40% of their body will take part. Half will get antibiotics, half a placebo, and doctors will watch for infections, sepsis, and gr…

This study looks at whether people whose heart failure has improved enough to restore normal pumping function can stop taking beta-blockers without their heart condition returning. About 1,300 adults who previously had weak hearts but now have normal function will either continue…

This study looks at whether heart failure medication alone works as well as medication plus an implantable defibrillator (ICD) for people aged 70 and older with weak hearts. The goal is to see if avoiding the device leads to the same survival rate after 4 years. About 730 partici…

This study tests whether tadalafil, a drug that relaxes blood vessels, can improve exercise ability in people with severe high blood pressure in the lungs caused by COPD. About 200 adults with advanced symptoms will receive either tadalafil or a placebo for 16 weeks. The main goa…

This study tests whether a dietary supplement made from omega-3 fatty acids (called SPM) can reduce blood vessel damage caused by inflammation in people with obesity and high blood pressure. Researchers will give 60 participants either the supplement or a placebo for 12 weeks and…

This study looks at people with colorectal cancer that spread to the liver. After successful liver surgery and initial chemotherapy, half the participants will restart chemotherapy (FOLFIRI) and half will receive no further treatment. The goal is to see if restarting chemo helps …

This study follows 250 people with atrial fibrillation who had a procedure to close a small pouch in the heart (left atrial appendage) to prevent strokes. The goal is to see how well the closure works over 5 years, especially for those who cannot take long-term blood thinners. Re…

This study looks at whether using a CPAP mask along with high-flow oxygen therapy can lower the chance of death in patients with sudden, severe breathing failure. About 1,084 adults in the ICU will be randomly assigned to receive either the combination therapy or high-flow oxygen…

This study is testing whether using chemotherapy alone before surgery works as well as chemotherapy followed by radiation for people with advanced rectal cancer. The goal is to see if the simpler treatment can keep the cancer from coming back for at least 3 years. About 540 adult…

This study tests whether baricitinib, a JAK inhibitor, can help people with dermatomyositis achieve significant improvement without needing steroids. About 62 adults with active disease will receive either baricitinib or a placebo alongside standard care. The goal is to see if ba…

This study tests whether giving a strong chemotherapy combination called FOLFIRINOX before surgery can help remove both the rectal tumor and any liver tumors completely. It includes 550 adults with mid or low rectal cancer that has spread to the liver but can still be surgically …

This study tests whether a combination of two drugs (atezolizumab and bevacizumab) is safe for liver transplant patients whose liver cancer has returned and cannot be treated with surgery or local therapies. About 50 participants will receive the drug combo along with a standardi…

This study tests whether a drug called levosimendan, usually used for heart failure, can help prevent dangerous brain spasms and delayed damage after a type of bleeding stroke (aneurysmal subarachnoid hemorrhage). About 30 adults in intensive care will receive either the drug or …

This study tests whether a medicine called glycerol phenylbutyrate (RAVICTI®) can help people with pyruvate dehydrogenase deficiency, a rare genetic disorder that affects energy production. About 15 children and young adults aged 2 to 25 will take the drug for 6 months while cont…

This early-phase study tests whether injecting specially grown immune cells (HTLP) after a cord blood transplant can help rebuild the immune system more quickly in adults with blood cancers. Ten participants will receive the injection and be monitored for side effects like graft-…

This study tests whether adding newer antibody-based drugs to standard chemotherapy can improve survival and reduce the need for stem cell transplants in adults with acute lymphoblastic leukemia (ALL). About 1,200 patients aged 18–65 with newly diagnosed ALL will be assigned to o…

This study tests whether adding letermovir to the standard drug valganciclovir works better than valganciclovir alone for treating cytomegalovirus (CMV) infections in kidney transplant recipients. About 80 adults who have a CMV infection after their transplant will take either th…

This study tests a blood-filtering device (apheresis) to remove a harmful protein called sFlt-1 and restore a healthy balance in pregnant women with preeclampsia. The goal is to safely prolong pregnancy and reduce the risks of very early delivery. About 100 women with preeclampsi…

This study is testing whether a combination of two steroids (hydrocortisone and fludrocortisone) can reduce death or long-term organ failure in adults with sepsis in the ICU. About 1,800 participants will receive either the steroid combo or a placebo, and researchers will track t…

This study tests whether a special ultrasound device can safely open the blood-brain barrier in children with hard-to-treat brain tumors. The goal is to let chemotherapy reach the tumor more effectively. About 24 children aged 5 to 17 with recurrent malignant brain tumors will re…

This study tests whether a liver transplant after a special type of radiation (SIRT) and chemotherapy can help people with advanced bile duct cancer that cannot be removed by surgery but hasn't spread. About 36 adults aged 18 to 65 in France will receive the treatment and be foll…

This study looks at whether keeping patients with severe lung failure (ARDS) lying on their stomachs for 40 hours at a time, instead of the usual 16 hours, can reduce deaths. About 800 adults on breathing machines will be randomly assigned to one of the two positions. The goal is…

This study tests a new gene therapy called DREAM01 for people with severe sickle cell disease who do not have a matching bone marrow donor. The therapy uses the patient's own blood stem cells, which are modified in a lab to produce healthy hemoglobin and reduce sickling. The goal…

This study tests whether dapagliflozin, a drug already used for diabetes and heart failure, can help the heart heal better after a heart attack. About 450 adults who have had a heart attack and have weak heart pumping will receive either the drug or a placebo for 6 months. The go…

This study tests a surgical technique to prevent severe bleeding after pancreatic surgery. In 150 high-risk patients, surgeons will either wrap the arteries near the pancreas with a piece of the patient's own belly fat (omentoplasty) or leave them uncovered. The goal is to see if…

This study tests whether dapagliflozin, a drug already used for heart and kidney protection, can reduce death and serious heart or kidney problems in patients leaving the intensive care unit (ICU). About 600 adults who needed a breathing machine or blood pressure support in the I…

This study looks at whether adding blood thinners (anticoagulants) to standard steroid treatment helps prevent new blood clots in people with Behçet's syndrome who have deep vein thrombosis (DVT). About 134 adults with Behçet's and a first or repeat DVT will be randomly assigned …

This study looks at 240 adults with septic shock who develop a new, fast heart rhythm problem. It compares three treatment approaches: controlling heart rate with low-dose amiodarone, restoring normal rhythm with high-dose amiodarone or electric shock, or managing risk factors wi…

This study compares two treatments for people with long blockages (15-25 cm) in the main leg artery that cause pain when walking. About 290 adults will be randomly assigned to either bypass surgery or a less invasive endovascular procedure. The goal is to see which treatment keep…

This study tests whether a drug called interferon gamma can help intensive care patients recover from a weakened immune system caused by severe illness or injury. About 170 adults on breathing machines will receive either the drug or a placebo. The main goal is to see if the drug…

This study tests which of two anti-thymocyte globulin drugs (ATG-thymoglobulin vs. ATLG-grafalon) better prevents graft-versus-host disease (GVHD) in adults aged 50-70 with acute myeloid leukemia or myelodysplastic syndrome. Participants receive a stem cell transplant from a matc…

This study tests a new vaccine designed to help the immune system recognize and attack glioblastoma, an aggressive brain cancer. About 35 people who have already had standard surgery and radiation will receive the vaccine. The goal is to see if it is safe and whether it triggers …

This study tests whether giving a low dose of the hormone vasopressin during liver transplant surgery can prevent acute kidney injury, a common and serious complication. About 304 adults scheduled for a liver transplant will receive either vasopressin or the standard drug norepin…

This study tests whether using a non-invasive ventilator (NIV) at home is better than a CPAP machine for people who have both COPD and obstructive sleep apnea and recently survived a severe breathing crisis. About 386 adults will use one of the two machines nightly for a year, an…

This study compares a new device called Endorotor to standard endoscopic techniques for removing dead tissue from the pancreas in people with severe pancreatitis. About 64 adults who need this procedure will be randomly assigned to one of the two methods. The goal is to see if th…

This study tests whether an oral drug called dimethyl fumarate (Tecfidera) can safely slow the growth of geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 90 adults aged 55–85 with geographic atrophy will take the drug for 12 m…

This study tests whether a single dose of rituximab, a drug that calms the immune system, can improve heart function six months after a severe type of heart attack called anterior STEMI. About 372 adults who have had this heart attack will receive either rituximab or a placebo. T…

This study looks at how long it takes for urate crystals to dissolve in the joints of people with gout when uric acid levels are kept very low. Researchers will use ultrasound to monitor crystal disappearance in 250 adults over time. The goal is to find out what factors affect ho…

This study is for people who have had an ischemic stroke (a stroke caused by a blocked blood vessel) and are at high risk for another one. Researchers want to see if adding two medicines—colchicine (usually used for gout) and ticagrelor (a blood thinner)—to standard care can redu…

This study looks at the best way to prevent a second stroke in people aged 60 to 80 who had a stroke linked to a small hole in the heart (PFO). Participants will either get a device to close the hole plus antiplatelet drugs, antiplatelet drugs alone, or oral blood thinners. The g…

This study follows 20 adults with severe, drug-resistant Tourette syndrome who receive deep brain stimulation (DBS) targeting a specific brain region. Researchers will track tic severity, mental health, and quality of life every year for up to 5 years after surgery. The goal is t…

This study looks at whether adding a protein called albumin to the standard IV fluids given during a major cancer surgery (cytoreduction with heated chemotherapy) can lower the risk of complications after the operation. About 140 adults with peritoneal cancer will be randomly ass…

This study tests whether adding a special diet (Crohn's Disease Exclusion Diet) to standard medication helps children with unstable Crohn's disease have fewer flare-ups over a year. About 120 kids aged 6-17 will be randomly assigned to either diet plus medication or medication al…

This study tests a drug called obinutuzumab in 33 adults with a relapsing form of granulomatosis with polyangiitis (GPA, formerly Wegener's). The goal is to see if the drug can stop disease activity and turn off the related antibody. Participants will be followed for 6 months to …

This study tests whether itacitinib is safe and effective for adults with systemic sclerosis, a disease that causes skin thickening and organ damage. About 74 participants with early or active disease will receive the drug or a placebo for one year. The main goal is to see if it …

This study tests whether a new drug combination (obinutuzumab plus mycophenolate mofetil) can control lupus-related kidney inflammation without the need for oral steroids. About 196 people with active lupus nephritis will be randomly assigned to either the standard steroid-based …

This study tests whether using a quick genetic test to choose a milder blood thinner (clopidogrel or aspirin) instead of a stronger one (ticagrelor or prasugrel) can reduce bleeding in people at high risk after a heart attack. About 2,468 participants will be randomly assigned to…

This study compares starting with two oral medications (tadalafil and ambrisentan) versus one medication alone in people newly diagnosed with pulmonary arterial hypertension (PAH) who also have at least two heart-related conditions. The goal is to see if the two-drug approach lea…

This study tests if a medicine called letermovir can stop cytomegalovirus (CMV) in unborn babies better than the current treatment, valaciclovir. Pregnant women who had CMV in the first trimester and whose fetus is infected (confirmed by amniotic fluid test) can join. The goal is…

This study tests whether lowering blood pressure can slow the growth of white matter lesions (small brain changes linked to thinking problems) in older adults aged 60-88 who have memory concerns and high blood pressure. Researchers will compare brain scans from 820 participants o…

This study tests whether colchicine, an anti-inflammatory drug, can reduce heart scarring and prevent serious complications in people with acute myocarditis (heart muscle inflammation). About 300 adults with recent-onset myocarditis will receive either colchicine or a placebo for…

This study tests a new technology (HD-sEMG) that monitors muscle signals to better diagnose sarcopenia—a condition where older adults lose muscle mass and strength. Researchers will enroll 846 people aged 75 and older who are hospitalized and at risk for sarcopenia. The goal is t…

This study is testing whether a simple, 8-item screening tool called the AMSE can help non-specialist doctors accurately identify autism in adults. Currently, people often wait over a year for a diagnosis at expert centers, and many are found not to have autism. The goal is to se…

This study looks at whether the position a person is in during a bladder test (lying down vs. sitting) affects the diagnosis of overactive bladder in people with multiple sclerosis or Parkinson's disease. Researchers will compare results from both positions in 160 adults to see i…

This study tests whether a short, 10-minute MRI (Fast-MRI) is better than standard ultrasound for catching liver cancer early in people with cirrhosis who are at high risk. About 944 participants will be randomly assigned to get either ultrasound alone or both ultrasound and Fast…

This study aims to see if a simple CO2 measurement can help emergency doctors quickly tell whether shortness of breath is caused by fluid buildup (congestive) or other reasons. About 45 adults with sudden breathing trouble will have a small sensor placed on their skin to measure …

This study looks at whether a single trained radiologist can accurately read low-dose CT scans to screen for lung cancer in women, compared to the current standard of two experts reading the same scan. It will enroll about 2,635 women aged 50-74 who are at risk due to heavy smoki…

This study tests a new software tool called MyCMV that helps doctors interpret blood test results for cytomegalovirus (CMV) infection during pregnancy. CMV is a common virus that can cause hearing loss and developmental problems in babies if the mother gets infected while pregnan…

This study aims to develop an artificial intelligence tool that can analyze images and videos from capsule endoscopy—a procedure where you swallow a tiny camera. The goal is to help doctors detect bowel diseases like Crohn's, celiac disease, and tumors more accurately and quickly…

This study looks at whether a small, portable ultrasound device (echOpen) can help doctors diagnose patients faster. About 100 adults in hospitals, clinics, and a health bus in France will take part. Researchers will compare how long diagnosis takes with and without the device.

This study aims to see if a special MRI scan called CEST can accurately tell apart radiation damage from tumor growth in people with lung cancer that has spread to the brain. About 60 adults who have had radiation therapy for brain metastases and show new changes on follow-up MRI…

This study is testing a new, safer blood test for pregnant women to diagnose genetic disorders like sickle cell disease and cystic fibrosis in their unborn babies. The test uses a small sample of the mother's blood, avoiding the miscarriage risk of traditional invasive procedures…

This study looks at whether a simple nose swab or mouth rinse can accurately diagnose pneumocystis pneumonia, a serious lung infection, in 240 adults with weakened immune systems. Currently, diagnosis often requires a more invasive procedure called a bronchoscopy. If successful, …

This study is testing a new, fast thinking test using building blocks to find a condition called minimal hepatic encephalopathy (MHE) in people with liver problems. MHE can cause subtle memory and attention issues that are hard to diagnose. The study will compare this new test wi…

This study aims to see if a new blood test can better predict whether a fever in babies under 3 months old is caused by a serious bacterial infection or a virus. Currently, many babies get admitted to the hospital for antibiotics just in case, even though most fevers are viral. T…

This study tests a new medical device called PrediMAP to see if it can accurately predict whether a pregnant woman in preterm labor will give birth within 7 days. Researchers will enroll 3,600 women visiting the emergency room with signs of preterm labor. If successful, the devic…

This study aims to see how well low-dose chest CT scans can detect lung cancer in people at high risk. Researchers will screen 20,000 adults aged 50-74 who are current or former heavy smokers. The goal is to find cancer early, when treatment may work better.

This study tests three different schedules of the meningococcal B vaccine in 84 adults aged 18 to 75 who have had their spleen removed. People without a spleen are at higher risk for serious infections. The goal is to find which vaccine strategy produces the strongest immune resp…

This study tests whether giving a short, targeted dose of radiation before pancreatic surgery can prevent a serious complication called pancreatic fistula, where digestive fluid leaks from the pancreas. About 50 adults who are overweight and have a narrow pancreatic duct will rec…

This study looks at whether smokers aged 50-74 are more likely to get a low-dose CT scan for lung cancer when their family doctor recommends it. Researchers will track how many people complete the scan within one year. The goal is to catch lung cancer early in high-risk smokers.

This study tests whether a simple screening test in early pregnancy (11-14 weeks) can predict preeclampsia, a dangerous condition causing high blood pressure. Researchers will compare outcomes for 14,500 pregnant women who receive the screening versus those who don't. The goal is…

This study looks at whether children aged 8-13 with early onset anorexia nervosa can do just as well with a shorter hospital stay followed by day treatment (going home at night) compared to staying in the hospital full-time. The goal is to see if this approach is as effective for…

This study looks at people with stomach cancer who need part of their stomach removed. It compares two ways to reconnect the digestive tract—Billroth II and Roux-en-Y—to see which one leads to a better quality of life after surgery. About 250 adults will be randomly assigned to o…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce tobacco cravings in 100 adults who smoke daily. Participants receive either real or fake tDCS sessions alongside standard support. The goal is to see if this gentle, side-effect-free method…

This study compares two sedatives—dexmedetomidine and midazolam—in very preterm infants (born before 32 weeks) who need a breathing tube. The goal is to see if dexmedetomidine helps them come off the ventilator faster, reducing lung damage. About 380 babies will take part across …

This study compares different visual keyboard layouts to see which helps people with complex sensorimotor disabilities type faster and feel less tired. Twelve adults who already use a virtual scanning keyboard will test each layout. The goal is to improve communication and daily …

This study compares yoga therapy to standard physiotherapy for people with moderate axial spondyloarthritis, a type of arthritis that causes pain and stiffness in the spine and pelvis. Researchers want to see if yoga can improve physical symptoms like pain and fatigue, as well as…

This study tests whether regular yoga practice can improve quality of life and well-being in adults with stable chronic heart failure. Researchers will measure changes in physical and mental health using standard questionnaires. The goal is to see if adding yoga to standard care …

This study tests whether using a smartphone app for follow-up after a gynecological emergency is as good as or better than coming back to the hospital. About 200 women aged 18-60 with conditions like infections, early pregnancy issues, or severe nausea will either use the app or …

This study tests whether adding cannabidiol (CBD) to standard alcohol detox treatment helps people with severe alcohol use disorder stay sober longer. About 210 adults will receive either CBD or a placebo for 11 days during a hospital stay. Researchers will check if participants …

This study looks at whether cancer patients who have a blood clot in the lung (pulmonary embolism) can be treated safely at home instead of staying in the hospital. About 824 adults with active cancer and a stable blood clot will be randomly assigned to go home within 24 hours or…

This study compares two different materials used in multifocal lenses for cataract surgery. 40 people will receive one type of lens in each eye. The goal is to see which lens provides better contrast sensitivity (ability to see differences in light and dark) 3 months after surger…

This study tests whether the drug fampridine can improve walking and daily function in people with a rare genetic balance disorder called SCA27B. About 70 adults with this condition will receive either fampridine or a placebo for 3 months. The goal is to see if the drug reduces m…

This study compares two nasal sprays (fentanyl and ketamine) to a standard oral painkiller (morphine) for children aged 2-17 with moderate to severe pain from a broken arm or leg. The goal is to see which approach provides faster and better pain relief in the emergency room. 300 …

This study looks at whether using walking sticks can help people with a forward-leaning spine walk longer distances. Thirty-five adults aged 50 and older who have trouble walking will try using walking sticks for three months. Researchers will measure how far they can walk in six…

This study looks at whether a cochlear implant can improve hearing in children aged 4 to 6 who have severe hearing loss in one ear or uneven hearing between ears. The implant sends sound signals directly to the hearing nerve, potentially helping kids understand speech better in n…

This study tests whether balance exercises done with eyes closed or with distorted vision can improve walking stability in people with chronic nerve damage. 40 adults with walking problems due to nerve disease will do 20 rehab sessions, either with normal vision or with vision bl…

This study tests if a new automatic setting on Sky hearing aids helps children with hearing loss understand speech better in noisy places. Twenty children aged 6 to 16 who use a cochlear implant and/or hearing aid will compare three different hearing aid settings. The goal is to …

This phase 3 study tests whether metformin, a standard diabetes medication, can improve muscle function in people with myotonic dystrophy type 1 (Steinert's disease). About 142 non-diabetic adults aged 18-70 who can still walk will receive either metformin or a placebo for 6 mont…

This study compares two types of catheter ablation for people with paroxysmal atrial fibrillation (a type of irregular heartbeat). The goal is to see if a newer method called pulse field ablation preserves heart muscle function better than the standard cryoablation. Eighty adults…

This study tests whether workshops and exchange groups can improve quality of life for people who had their larynx removed due to cancer. About 50 participants who had surgery in the last four years will join group sessions. Researchers will compare their well-being before and af…

This study tests if using a connected exercise bike at home, along with usual care, helps people with lumbar spinal stenosis do daily activities more easily. About 302 adults aged 50 and older with this back condition will take part. The main goal is to see if cycling improves th…

This study tests whether a connected scale can help monitor people with lymphoma or multiple myeloma who are receiving chemotherapy. Thirty patients will weigh themselves daily for about 7 weeks, and their data will be sent to their medical team. If weight or heart rate changes u…

This study tests a special cinnamon-scented dressing designed to reduce bad smells from chronic, infected, or cancerous wounds. The goal is to see if it improves patients' quality of life by making the odor less bothersome. About 98 adults with smelly wounds will be randomly assi…

This study tests whether a comprehensive approach—combining pain medication, physical therapy, psychological support, and social help—can reduce pain and disability in people with sudden low back pain. About 782 adults aged 18 to 55 will take part in French emergency departments.…

This study tests whether one or two Botox injections into the thumb joint, combined with a custom splint, can reduce pain from base-of-thumb osteoarthritis for up to 6 months. About 120 adults with moderate to severe thumb pain will be randomly assigned to receive Botox, a mix of…

This study tests whether immersive virtual reality (VR) can reduce persistent shortness of breath in people with ALS who already use a breathing machine (non-invasive ventilation). Researchers will compare VR sessions to music therapy in 35 adults. The goal is to find a drug-free…

This study tests whether adding a single dose of ketamine to the antidepressant venlafaxine can relieve severe depression faster than venlafaxine alone. 60 hospitalized adults with major depression will receive either ketamine or a placebo alongside their regular treatment. The g…

This study compares two approaches for people newly diagnosed with early-stage Alzheimer's disease: taking the medication donepezil versus using non-drug cognitive therapy (like brain exercises). Researchers want to see which approach better slows down memory and thinking decline…

This study tests a new 3D calendar tool designed to help people with mild to moderate Alzheimer's disease better understand what day, month, or season it is. Twenty participants will use the tool during their hospital stay to see if it improves their time orientation. The goal is…

This study looks at whether shiatsu, a type of Japanese bodywork, can improve symptoms and quality of life in people with cardiac amyloidosis, a serious heart condition. Researchers will compare targeted shiatsu to comfort-focused shiatsu and no shiatsu in 108 adults. They will m…

This study tests whether a blood test that measures donor DNA can help doctors decide when a kidney biopsy is truly needed after a transplant. About 500 kidney transplant recipients will be randomly assigned to standard care or to have their doctors receive this blood test result…

This study follows 3,000 adults with cirrhosis or who have had a liver transplant at a French hospital. Researchers will track survival and complications like bleeding or infections to learn how to improve patient care. The goal is to collect data and samples to better understand…

This study aims to understand how teenagers with post-traumatic stress disorder (PTSD) experience psychotherapy. Researchers will interview 65 teens, their parents, and therapists to learn what helps them change and heal. The goal is to improve therapy for young people by listeni…

This study aims to better understand movement in infants with spinal muscular atrophy (SMA) by observing them in a bath. Water reduces the pull of gravity, which may help reveal subtle movements that are hard to see on a dry exam table. Researchers will use small motion sensors t…

This study looks at whether people with a low-risk staph bloodstream infection (based on the VIRSTA score) can safely skip a heart ultrasound. About 700 adults will be randomly assigned to either get the ultrasound or not. The goal is to see if skipping it leads to similar rates …

This study enrolls 80 people with advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs) who are scheduled for peptide receptor radionuclide therapy (PRRT). Researchers will collect PET-MRI scans, genetic profiles, and other data before, during, and after treatment. The…

This study involves 50 adults with lung cancer whose disease has worsened while on immunotherapy. Researchers will take a new tumor sample (rebiopsy) to study why the treatment stopped working. The goal is to better understand resistance mechanisms, not to provide a direct treatm…

This study follows people who survived a cardiac arrest and received ultra-rapid cooling treatment in a previous study. Researchers will check their health and survival status over 5 years through phone interviews and medical records. The goal is to understand the long-term effec…

This study is for people with certain immune deficiencies (primary or secondary) who may be at risk for chronic liver problems. Researchers want to see if a long-term infection with an enteric (gut) virus is linked to liver damage or digestive issues. Participants will give extra…

This study looks at how the natural bacteria in your lungs (the microbiome) might influence how well antibiotics work for pneumonia. Researchers will follow 300 adults with pneumonia, taking samples from the mouth, rectum, and lungs over 90 days. The goal is to see if certain bac…

This study collects blood, spinal fluid, and brain tissue from 400 people with severe seizures (status epilepticus) or epilepsy linked to brain inflammation (dysimmune encephalitis), plus control patients. Researchers aim to find antibodies and markers of nerve cell death that co…

This study looks at whether a non-invasive digital cuff can accurately measure blood pressure during carotid artery surgery, instead of the usual arterial catheter inserted into an artery. The catheter can cause discomfort and complications like infection or blocked blood flow. R…

This study looks at how the brain and lungs interact in adults with severe breathing problems who are getting high-flow oxygen through a nasal tube. Researchers will use brain wave tests (EEG) and light-based brain scans (NIRS) to measure brain activity before and after starting …

This study follows 800 people who carry a PRSS1 gene mutation, which can cause hereditary pancreatitis. Researchers will track how the disease progresses over time and how often pancreatic cancer develops. The goal is to better understand the natural history of this condition and…

This study aims to map gene activity in the placenta at two key points in pregnancy: the first trimester and at childbirth. Researchers will analyze small tissue samples from 100 pregnant women to understand how placental cells change over time. The goal is to learn more about no…

This study aims to find immune system markers that can predict how well a cancer patient responds to radiotherapy. Researchers will analyze blood samples from 40 adults who have already completed radiotherapy without major side effects. The goal is to personalize future cancer tr…

This study looks at sleep problems in people with Parkinson's disease and those with a sleep disorder called REM sleep behavior disorder (iRBD). Researchers will compare sleep quality among these groups and healthy volunteers using overnight sleep tests. The goal is to better und…

This study looks at how losing a lot of weight after bariatric surgery affects the spine in obese patients. Researchers will measure changes in low back pain, spine alignment, and spinal fat over one year. About 80 adults who qualify for weight-loss surgery will take part. The go…

This study looks at whether severe hearing loss in adults aged 45 to 64 is linked to mild cognitive impairment (MCI). Researchers will compare memory, attention, and thinking skills between 180 people with severe hearing loss and those with normal hearing. The goal is to understa…

This study is building a registry of 450 adults with tic disorders to understand how tic severity affects quality of life differently in men versus women. Researchers will track changes in tics over time using standard questionnaires. The goal is to gather information, not to tes…

This study aims to find the best doses of anti-infective medicines for hospitalized patients, especially those with sepsis. Researchers will use mathematical models to understand how the body processes these drugs and how to personalize dosing. The study involves 60 adults at Coc…

This study looks at whether a new 3D ultrasound method can measure heart muscle stiffness in people with a leaky mitral valve (mitral regurgitation). The goal is to see if these measurements match findings from MRI scans that show scarring in the heart. About 40 adults with diffe…

This study looks at how certain brain waves, called slow waves, change with age and in early Alzheimer's disease. Researchers want to see if these waves are linked to memory problems and trouble paying attention during the day. They will study 90 people: young adults, healthy old…

This study follows 5300 women aged 18-42 with endometriosis or adenomyosis to see if these conditions get worse over time. Researchers will track pain, bleeding, fertility, and use imaging to monitor changes. They also want to understand the immune system and gut bacteria's role …

This study looks for new markers in the blood to better track a rare immune disease called Activated PI3K Delta Syndrome (APDS). Researchers will collect blood samples from 14 patients before and during treatment with a targeted drug. The goal is to find better ways to measure di…

This study looks at 400 women aged 29-37 who are freezing their eggs for non-medical reasons. Researchers use vaginal ultrasound to check for endometriosis and adenomyosis, and compare the results with symptoms, anxiety, depression, and quality of life. The goal is to understand …

This study is testing a special camera (Mueller polarimetric colposcopy) to see if it can measure changes in the cervix during pregnancy. The goal is to find patterns that could help predict if a baby will be born early (preterm). Researchers will study 683 pregnant women, both w…

This study looks at whether CAR-T cell therapy, a new immune treatment for blood cancers, can cause early heart problems. About 60 adults who just received CAR-T cells will get heart ultrasounds before and a few days after treatment. The goal is to measure how often heart functio…

This study aims to understand why the body sometimes rejects a kidney transplant despite treatment. Researchers will study B cells (a type of immune cell) from 45 adult kidney transplant patients who are having a biopsy or graft removal. By analyzing these cells and their antibod…

This study is looking for a way to predict which pregnant women with high blood pressure will develop pre-eclampsia, a more serious condition. Researchers will measure tiny particles in the urine of 110 pregnant women to see if these particles can serve as an early warning sign. …

This study is for people aged 70 and older with early-stage lung cancer who are scheduled for surgery. Researchers want to see if markers of aging (like changes in DNA and cell health) can help predict who will have complications or need unplanned hospital stays. The goal is to u…

This study looks at how medicines move from a mother to her baby through the placenta. Researchers will test placentas after birth from 2,000 healthy pregnant women. The goal is to learn which drugs reach the baby and in what amounts, helping doctors prescribe safer medications d…

This study looks at how limiting eating to an 8-hour window each day (time-restricted feeding) affects the immune system of women with severe obesity. Researchers will compare two groups of women with obesity—one following the 8-hour eating schedule and one eating normally—and al…

This study is testing whether adding MRI scans to standard ultrasound can help doctors better detect and understand birth defects in unborn babies. About 1500 pregnant women will receive advanced fetal MRI exams. The goal is to see if MRI provides clearer, more useful information…

This study looks at how gut bacteria influence the energy use of immune cells in healthy adults and people with inflammatory bowel disease (IBD). Healthy volunteers will take a short course of antibiotics to change their gut bacteria, while IBD patients will be tested once. Resea…

This study looks at how anti-infective drugs (like antibiotics) work in critically ill children. The goal is to find the best doses for each child to improve treatment and reduce risks. Researchers will collect blood samples and health data from 3000 children to understand how th…

This study looks at how often young children (ages 1 to 6) with inherited metabolic diseases develop eating disorders when they are on special diets. Researchers will use a feeding scale to measure eating problems in 200 children. The goal is to understand the link between these …

This study will follow 1,000 children and teens with rare epilepsies (like West syndrome and Dravet syndrome) for several years. Researchers want to see how different treatments affect seizure control and thinking or behavior problems. The goal is to gather real-world information…

This study follows 840 adults who had a heart attack outside the hospital and received ECMO, a machine that pumps blood for the heart and lungs. The goal is to see how many survive for one year and how well their brains recover. Researchers want to learn if this emergency treatme…

This study looks at people with a rare condition causing very low folate in brain fluid, which may be due to a problem with the choroid plexus—a part of the brain that helps filter fluids. Researchers will use brain scans and blood/spinal fluid tests to find signs of this dysfunc…

This study follows 140 people who were first hospitalized for early-onset anorexia nervosa as teens, checking in 4 to 9 years later. Researchers will measure their quality of life, eating habits, and physical health to understand long-term recovery patterns. The goal is to identi…

This study looks at how well people with frontotemporal dementia or Alzheimer's disease can recognize emotions in others and how aware they are of their own performance. Researchers will ask 34 participants (ages 50-80) to complete computer tasks and confidence ratings. The goal …

This study explores whether a specific gut bacterium, Akkermansia muciniphila, can serve as a marker to predict how well men with advanced prostate cancer respond to a common hormone therapy (abiraterone acetate). Researchers will measure the levels of this bacterium in stool sam…

This study aims to find better ways to detect acute mesenteric ischemia, a condition where blood flow to the intestine is blocked, causing severe pain and damage. Researchers will analyze blood samples and CT scans from 556 adults with sudden abdominal pain to identify early biom…

This study follows 800 adults with IgA nephropathy, a kidney disease, to see how well current treatments work in everyday medical practice. Researchers want to understand why some patients still have protein in their urine or worsening kidney function despite standard care. The g…

This study aims to better understand why some patients with ARDS (a severe lung condition) get very sick while others recover. Researchers will collect blood and lung fluid from 50 ICU patients to study their immune cells and inflammation patterns. The goal is to identify differe…

This study tests a new MRI method called eASL to measure blood flow in the brains of 50 children with artery disease (like moyamoya or sickle cell). Standard ASL may miss slow flow in diseased arteries, but eASL uses multiple timing delays to get a more accurate picture. The goal…

This study looks at how bladder filling sensations are linked to overactive bladder (OAB) severity in people with multiple sclerosis (MS). Researchers will measure bladder sensitivity during a standard test called urodynamics. The goal is to better understand bladder symptoms in …

This study reviews medical records from over 1,200 people with immune thrombotic thrombocytopenic purpura (iTTP), a rare and life-threatening blood disorder. The goal is to understand long-term health problems, such as heart disease and thinking issues, that survivors face. By an…

This study looks at how vasoplegic syndrome (a condition causing dangerously low blood pressure after heart surgery) affects the adrenal glands. Researchers will measure steroid levels in 200 adults undergoing scheduled heart surgery. The goal is to better understand adrenal func…

This study tests a virtual reality (VR) game to measure hand-eye coordination in children aged 7 to 17 with and without chronic balance (vestibular) disorders. Researchers want to see if the VR tasks are reliable and fun for kids, and how balance problems affect coordination. The…

This study looks at how antibiotic-resistant bacteria move between people and their pet dogs. Researchers will follow 525 dog owners and their dogs for three months, collecting samples to track the bacteria. The goal is to create a list of priorities to prevent the spread of thes…

This study aims to find biological markers in the skin and blood that can predict how well people with chronic inflammatory skin diseases (like psoriasis, eczema, and lupus) will respond to treatments. Researchers will follow 830 adults over one year to see which markers are link…

This study aims to see if newer lab techniques can better detect the germs causing serious eye infections like endophthalmitis and corneal abscesses. Researchers will compare standard culture methods with advanced genetic tests (metagenomics and multiplex PCR) on samples from 153…

This study looks at how small fiber neuropathy (nerve damage causing pain, burning, and numbness) impacts the quality of life and medical costs for people with Sjögren's syndrome. Researchers will follow 100 adults with Sjögren's to measure their symptoms, daily functioning, and …

This study tests a new questionnaire that measures how well patients stick to a bowel management technique called transanal irrigation. The method helps people with bowel movement or leakage problems, but many stop using it over time. Researchers will enroll 100 adults who have u…

This study looks at how the hepatitis B vaccine activates special immune cells called T cells in healthy adults. Researchers want to know how many people develop these T cells after vaccination and how they help maintain long-term protection. The goal is to better understand why …

This study looks at whether cancer patients do better when they go to an emergency room at their own cancer hospital versus a regular hospital. Researchers will track 2,000 adults with active cancer or recent remission to see how many days they spend alive and out of the hospital…

This study checks if French versions of two short questionnaires can accurately screen for anxiety, depression, and PTSD in adults. Researchers will enroll 90 people to see how well these tools work in everyday medical settings. The goal is to give doctors simple, reliable ways t…

This study aims to learn more about a condition called posterior staphyloma, where the back of the eye bulges out, in people with severe nearsightedness (high myopia). Researchers will collect eye images and blood samples from 200 adults in France, the Netherlands, and Spain to l…

This study looks at whether a special health program (PEGASE) helps children under 5 who are in child protective services. About 220 children will be followed for 2 years to see if their mental and physical health gets better. The goal is to find out if this program should be use…

This study looks at how often serious heart rhythm problems happen in people who need a special machine (ECMO) to help their heart pump blood. Researchers will track 600 adults on ECMO for severe shock to see how common these rhythm issues are and how they affect recovery. The go…

This study tests a new tool called PRECOM that uses brain wave signals to predict whether coma patients after cardiac arrest will wake up within three months. Researchers will enroll 100 adults in French ICUs and compare the tool's predictions to actual outcomes. The goal is to i…

This study looks for substances in the blood that might be linked to fatigue in people with low platelet counts (thrombocytopenia). Researchers think a protein called BDNF, which is stored in platelets, could play a role. They will measure BDNF levels in 280 patients and healthy …

This study looks at whether low oxygen levels during sleep after hip fracture surgery are linked to delirium (sudden confusion) in patients over 70. Researchers will monitor 70 participants in the hospital to see if nighttime hypoxia increases the risk of complications like infec…

This study is following 670 adults with vasculitis, a rare blood vessel disease, to learn more about how the disease shows up, how it is treated, and what health problems may arise over time. Researchers will collect medical data during regular doctor visits but will not test any…

This study looks at why some people with liver cirrhosis develop blood clots in the portal vein (a major liver blood vessel). Researchers will compare blood samples taken from a neck vein and the portal vein during a routine procedure (TIPS) in 45 adults. The goal is to understan…

This study is testing whether a sleep breathing test done at home can help doctors check and adjust nighttime breathing machines for people with neuromuscular diseases. The goal is to see if the home test works well and gives useful information to improve machine settings. About …

This study looks at how parents can help their deaf child's language development after early cochlear implant surgery. Researchers will use a special recorder called LENA to measure conversations at home. Then, speech therapists will guide parents based on that data. The goal is …

This study compares 3D models of children's pelvic and retroperitoneal tumors to standard 2D scans to see if they help surgeons plan better. About 60 children and their surgeons will answer questions about the images. The goal is to improve surgical precision, not to test a new t…

This study looks at how sleep-disordered breathing (like snoring or pauses in breathing during sleep) relates to thinking skills, mood, and behavior in children and young adults aged 1 to 20. Researchers will use sleep tests and questionnaires to see if there is a link. No treatm…

This study uses advanced MRI scans to measure how well the brains of children with multiple sclerosis (MS) can repair myelin, the protective coating around nerve cells. Researchers will compare these repair levels with thinking and memory test scores. The goal is to understand if…

This study is testing a new cell therapy in the lab for people with Merkel cell carcinoma, a rare skin cancer linked to a virus. Researchers will take immune cells from 15 patients and try to train them to attack the cancer in a test tube. The goal is to see if this approach work…

This study looks at whether a rapid test that checks for three common respiratory viruses (COVID-19, flu, and RSV) can help doctors prescribe fewer antibiotics for infections that are likely viral. About 2,000 people with fever or cold symptoms will take part. The goal is to see …

This study is looking at whether a blood test that detects tumor DNA can help doctors better predict if Hodgkin lymphoma will come back in children and young adults. About 400 participants under 25 will give blood samples before, during, and after treatment. The goal is to see if…

This study looks at how different speech therapy methods affect language development in 60 children with severe hearing loss who received cochlear implants before age 2. Researchers will compare two therapy styles and track language skills over time. The goal is to find out which…

This study aims to find genetic differences that make some cancer patients more likely to develop a rare but life-threatening heart inflammation (myocarditis) from immune checkpoint inhibitors. Researchers will compare the DNA of 100 patients who had this side effect with 400 who…

This study looks at people with a mechanical heart valve who hear a clicking noise from it. Researchers want to know if remembering information given before surgery about this noise affects their quality of life afterward. About 180 participants will answer questionnaires over th…

This study is looking at how well robotic surgery works in both children and adults. Researchers want to see if it is safe, efficient, and worth the cost compared to other methods. The study will track complications, pain, and quality of life in 16,000 people who need surgery.

This study looks at DNA methylation patterns (chemical marks on DNA) in tissue from fetuses and children with rare genetic diseases. Researchers aim to create a reference map of these patterns using samples from amniotic fluid, lung tissue, and blood. The goal is to improve diagn…

This study aims to define normal scores on tests for spatial neglect, a common attention problem after stroke. Researchers will test 210 healthy French-speaking volunteers aged 20 to 89. The results will help doctors better diagnose spatial neglect in stroke patients by knowing w…

This study aims to validate a new serious game test called REALSoCog that detects social thinking and behavior problems in people with Alzheimer's, Lewy body dementia, or frontotemporal degeneration. Researchers will enroll 120 patients and their caregivers to see how well the te…

This study tests whether healthcare workers with minimal training can measure blood flow in critically ill patients as accurately as experts, using an AI-guided ultrasound tool. About 100 ICU patients who need fluids will be enrolled. The goal is to see if AI can make this import…

This study follows 425 adults with recent psoriatic arthritis (PsA) for up to 10 years to see how many develop joint damage and why. Researchers will use X-rays and other data to find factors like genetics or environment that lead to worse outcomes. The goal is to help doctors id…

This study talks to siblings aged 9 to 18 whose brother or sister is in the pediatric intensive care unit (PICU). Researchers want to learn about the siblings' needs and how this experience affects their daily life. They will interview each sibling twice: once during the hospital…

This study aims to understand why blood vessels become leaky during severe inflammation (SIRS), a condition common in sepsis and shock. Researchers will measure certain proteins in the blood and lung fluid of 180 ICU patients and see how they relate to fluid balance and organ fun…

This study looks at how to measure airway opening pressure in children with acute respiratory distress syndrome (ARDS) who are on breathing machines. The goal is to see if two measurement methods are practical and can help doctors personalize ventilation. About 50 children over a…

This study monitors immune function in 200 intensive care patients after severe trauma, high-risk surgery, or respiratory distress. Researchers use a simple, automated blood test to measure interferon-gamma production, a key immune marker. The goal is to identify when patients be…

This study aims to measure how hard children with conditions like neuromuscular diseases, lung problems, or scoliosis work to breathe. Researchers will use a thin tube placed in the esophagus to track breathing effort in up to 550 children. The goal is to better understand breath…

This study aims to better understand how the spleen filters abnormal blood cells and fights infections. Researchers will use spleens removed from 100 patients during surgery to study the organ's role in diseases like malaria and other blood disorders. The goal is to learn more ab…

This study looks at how the immune system and inflammation affect recovery in 540 adults admitted to intensive care. Researchers will collect extra blood samples to measure immune cells and inflammatory proteins. The goal is to build models that predict survival and infections af…

This study looks at how immune cells called macrophages behave in people with certain rare brain diseases (X-ALD, MLD, and ALSP). Researchers will collect one blood sample from 100 participants during a regular check-up. The goal is to learn if these immune cells play a role in h…

This study looks at how standard ICU treatments, like giving fluids or drugs to support blood pressure, affect blood flow in the small vessels near the skin. Researchers will monitor 180 patients with acute circulatory failure to see how quickly these treatments improve blood flo…

This study aims to identify biological markers in blood and joint fluid that can predict how knee osteoarthritis will progress over time. Researchers will follow 300 participants with knee pain for up to 10 years, collecting samples during routine joint fluid removal or injection…

This study looks at how children with Angelman syndrome (a rare genetic disorder causing severe developmental delays) pay attention to social cues. Researchers will use eye-tracking technology to measure where children look when watching social scenes. The goal is to find a relia…

This study observes 50 young adults with chronic inflammatory rheumatic diseases to see which type of transition program helps them manage their own care better. Some participants received a special education workshop plus a joint pediatric-adult doctor visit, while others had on…

This study is for people with early-stage hormone receptor-positive, HER2-negative breast cancer. It uses a test called EndoPredict to measure the risk of the cancer coming back over 10 years. The goal is to see if the test can help doctors decide who can safely skip chemotherapy…

This study is tracking 130 adults with hypophosphatasia, a rare bone disorder, to learn how the disease is diagnosed and how it affects people over time. Researchers hope to find ways to reduce the long delay between first symptoms and diagnosis. The study does not test any new t…

This study follows 200 children aged 3 to 17 with growth hormone deficiency who are starting treatment with either daily or long-acting growth hormone. Researchers will measure body mass index, muscle mass, and fat mass over three years to understand how these treatments affect b…

This study looks at whether measuring a natural ear reflex (the stapedial reflex) can help doctors set the right loudness levels in cochlear implants for children aged 8-17. Currently, children must describe how loud sounds feel, which can be hard. The reflex test may offer a fas…

This study follows 900 couples in Paris who tried preimplantation genetic diagnosis (PGD) during IVF but did not have a baby from it. Researchers want to learn how many later had a healthy child through other means and why some couples stop trying. The goal is to better support f…

This study looks back at the medical records of 150 patients who died in intensive care between 2018 and 2022 after being treated for a joint prosthesis infection. Researchers want to understand what these patients had in common, how they were treated, and what led to their outco…

This study looks at how blood pressure changes affect blood flow to the brain in adults in the intensive care unit (ICU). Researchers will use non-invasive tools like ultrasound and brain wave monitors to measure brain activity and oxygen levels. The goal is to find safe blood pr…

This study follows 50 children and young adults (ages 6 months to 21 years) with Dravet syndrome caused by an SCN1A gene mutation. Researchers will measure changes in thinking, movement, and daily skills over 4 years using standard tests. The goal is to better understand how the …

This study takes small skin samples from people with ALS, healthy carriers of ALS-related gene changes, and volunteers without the disease. The skin cells are grown in the lab to see how they behave under stress. The goal is to better understand what goes wrong in ALS at the cell…

This study aims to learn how well heart scans (MRI, ultrasound, PET) can detect and predict outcomes in people with suspected or known inflammatory heart diseases. Researchers will follow 5,000 adults for one year to see how often heart involvement is confirmed and how it affects…

This study looks at how well patients with inherited metabolic diseases stick to their daily oral medications. Researchers will survey 200 patients and their parents to measure adherence and knowledge about the disease. The goal is to see if a special education workshop could hel…

This study follows 150 adults with cirrhosis who are waiting for a liver transplant. Researchers will measure sexual function before and one year after transplant using questionnaires, hormone tests, and brain scans. The goal is to understand how transplant and anti-rejection dru…

This study looks at how women with a severe form of congenital adrenal hyperplasia (classic 21-hydroxylase deficiency) become pregnant and what happens during their pregnancies. Researchers will collect information from medical records and phone interviews with 200 adult women. T…

This study aims to understand how people with multiple sclerosis (MS) experience their care pathway, which can often feel like a confusing maze. Researchers will interview 57 participants, including MS patients, their carers, and healthcare professionals, to identify what works w…

This study is for adults with advanced liver cancer who are starting a common immunotherapy combination (Atezolizumab and Bevacizumab). Researchers want to see if levels of a protein called Glypican-3 in the blood can help predict how well the treatment works. About 240 participa…

This study follows 1,200 people from two memory clinics in Paris to see if sleep patterns and other personal factors are linked to different types and stages of dementia. Researchers will track participants for up to 15 years using routine clinic visits. The goal is to find simpl…

This study looks at 200 children and teens (ages 7-20) with psychosis to see if they fall into different groups based on their symptoms and development. Researchers will use interviews, brain scans, and genetic tests to understand these groups. The goal is to find out if these gr…

This study looks at whether treating severe gum disease can lower inflammation in the arteries of people who recently had a heart attack. About 210 participants will either receive specialized gum treatment or standard dental care. Researchers will use PET scans to measure change…

This study looks at how losing all your teeth and getting dentures affects your sense of taste, touch in the mouth, and food likes. Researchers will compare 40 people who have worn dentures for at least a year with 40 people who still have their natural teeth. The goal is to unde…

This study examines whether using advanced automated insulin pumps soon after diagnosis can protect brain growth and thinking skills in children aged 5-7 with type 1 diabetes. Researchers will compare brain scans and cognitive tests over 18 months between children using standard …

This study follows 500 adults who received a stem cell transplant at least 10 years ago to see if iron buildup in the body raises the risk of liver problems. Researchers will use blood tests and a special liver scan (FibroScan) to check for damage. The goal is to understand wheth…

This study aims to observe a specific behavior called behavioral sensitization in people addicted to crack-cocaine. Researchers will track the movement and sleep patterns of 20 participants over 3 weeks using a wearable device called an actimeter. The goal is to see how crack use…

This study looks at 180 people who had a benign thyroid nodule treated with radiofrequency heat ablation three years ago. Researchers want to see how the nodule looks on ultrasound and under a microscope to create a new guide for spotting cancer in treated nodules. The goal is to…

This study looks at how viruses change the environment around tumors in people with lymphoma, lung cancer, or anal cancer. Researchers will analyze blood and tumor samples from 254 patients to understand why some cancers resist treatment. The goal is to find new ways to make anti…

This study looks at why a numbing injection in the thigh (adductor canal block) works so well for knee surgery pain. Researchers think the medicine may spread to the sciatic nerve, but they want to measure how often this happens. About 70 adults having knee surgery will be tested…

This study is testing a new set of tasks to measure social cognition—how we understand emotions, read social cues, and interpret others' intentions—in children aged 8 to 16 with autism, ADHD, or other neurodevelopmental disorders. Researchers want to see if these tasks can reveal…

This study looks at people with autoinflammatory diseases or AA amyloidosis who have genetic changes that are hard to interpret. Researchers want to understand if these changes actually cause the disease. The goal is to improve diagnosis and knowledge, not to test a new treatment…

This study looks at how reliable automated tools are for measuring the amount of lung scarring (interstitial lung disease) on CT scans. Researchers will repeat CT scans and use different software to see if the measurements are consistent. The goal is to improve accuracy in tracki…

This study is testing whether measuring a protein called EDN in urine, blood, or esophageal brushings can help monitor eosinophilic esophagitis in children without needing repeated endoscopies. Researchers will compare these noninvasive markers with biopsy results in 60 children …

This study looks at whether stopping surgical dressings on the first day after abdominal surgery is as safe as keeping them on for about a week. About 1,288 adults having planned abdominal surgery will be randomly assigned to early or late dressing removal. The main goal is to se…

This study looks at whether private medical practices can safely perform direct oral challenges to check for mild, delayed allergic reactions to beta-lactam antibiotics (like amoxicillin) in children. About 200 kids aged 0-17 will be tested, and researchers will track how many ha…

This study looks at 1,400 adults with acute alcoholic hepatitis, a severe liver condition linked to heavy drinking. Researchers will use hospital data to find better ways to predict patient outcomes, such as survival and infection risk. The goal is to help doctors tailor treatmen…

This study uses brain scans (MRI) and eye-tracking to understand how the brain works differently in people with autism. Researchers will compare up to 160 participants, including those with autism and healthy volunteers, to find links between brain structure and social thinking. …

This study looks at fetal cells that remain in a mother's blood after pregnancy to see if they help heal skin ulcers. Researchers will compare women with and without ulcers to find which receptors on these cells are active. The goal is to gather basic knowledge that could lead to…

This study looks at whether serotonin, a chemical in the body, plays a role in oculocutaneous albinism, a condition that affects skin, hair, and eye color. Researchers will measure serotonin levels in 160 children with and without albinism to see if there are differences. The goa…

This study is observing 20 adults with serious mold infections (like Aspergillus) to understand how their immune system responds. Researchers will measure specific immune cells to identify patients who might benefit from adding immunotherapy to standard treatment. The goal is to …

This study follows 700 people hospitalized with infective endocarditis, a severe heart infection that can be fatal. Researchers will track outcomes like death and stroke to find better ways to manage the disease. No new treatment is being tested; the goal is to gather real-world …

This study looks at children aged 9 to 15 who were hospitalized after a serious suicide attempt. Researchers want to understand what psychiatric or developmental conditions these children may have, using detailed interviews and questionnaires. The goal is to better identify and h…

This study collects leftover blood, urine, and other samples from 800 hospitalized adults to create a biobank. The samples will help researchers develop and test rapid diagnostic tools for emerging infectious diseases and chemical or biological threats. No extra procedures are ne…

This study looks at why some people with severe burns get serious fungal infections while others don't. Researchers will follow 327 adult burn patients to understand how their immune system responds to fungi. The goal is to find clues that could help prevent or treat these infect…

This study looks at heart rhythm in women with premature ovarian insufficiency (early menopause) and whether hormone replacement therapy affects it. Researchers will compare 120 women with the condition to healthy volunteers. The goal is to understand if these women have a higher…

This study is testing two questionnaires to better understand and measure breathing difficulty (dyspnea) in children aged 6 to 17. Researchers want to see if these tools can help doctors assess symptoms more accurately in kids with acute or chronic lung conditions. The goal is to…

This study is for 244 people with mild Alzheimer's or early memory problems. Researchers want to check if new blood tests can show why some people's brains resist the disease better than others. Participants will have memory tests and brain scans to help find these clues.

This study aims to find out why some people lose more weight than others after a minimally invasive stomach-shrinking procedure called endoscopic sleeve gastroplasty. Researchers will follow 205 obese adults for 12 months, measuring weight, blood markers, and gut bacteria changes…

This study looks at blood samples from 80 children (ages 2-17) recently diagnosed with type 1 diabetes and healthy controls. Researchers want to understand how certain immune cells (called CD4 T cells) stop working properly and attack the pancreas. The goal is to gather knowledge…

This study looks at whether a device called Mostcare® can help doctors know when critically ill children need more fluids. It involves 100 children aged 0-10 who are in the intensive care unit after surgery or severe injury. The device uses blood pressure readings to estimate flu…

This study looks at whether using a standardized checklist (AnesList) when anesthesiologists hand over patient care in the operating room can reduce serious problems like death, major complications, or return to the hospital within a month after major surgery. About 1,120 adults …

This study follows 1600 advanced practice nurses (APNs) and students in France to understand how they set up their roles and work with other healthcare providers. Researchers will use surveys and interviews over several years. The goal is to learn what helps or hinders APNs in pr…

This study looks at whether a swallowed capsule with a tiny camera can help find early signs of small bowel cancer in people with Lynch syndrome, a genetic condition that raises the risk for several cancers. Researchers will review medical records of 400 patients who had this cap…

This study follows 643 children who were born before 32 weeks of pregnancy. Their mothers received either a full or half dose of betamethasone (a steroid) before birth to help the babies' lungs. Now at age 5, researchers are testing the children's thinking and learning skills to …

This study looks at how different types of lung cancer surgery affect a person's posture and breathing. Researchers want to understand why less invasive surgeries (using small cuts and cameras) might lead to fewer complications and a better quality of life compared to traditional…

This study looks at whether delivering humidified air through the nose can improve brain activity and lung function in sedated patients who are on a breathing tube. Researchers will measure brain waves and oxygen levels in 22 adults with severe respiratory failure. The goal is to…

This study looks at whether an enzyme called glucocerebrosidase is less active in people with Lewy body dementia. If so, it might mean that treatments already used for a related disease (Gaucher disease) could help. The study will compare enzyme activity in 236 people with and wi…

This study follows 600 people with birdshot chorioretinopathy, a rare inflammatory eye disease, to better understand how it affects vision and quality of life. Researchers will use eye exams, imaging, and genetic tests to identify different forms of the disease and find genes tha…

This study aims to bring new molecular markers into routine care for patients with rare adrenal cancers. Researchers will check if these markers can be delivered within 3 months after surgery and if they provide useful information to guide treatment. About 450 adults with adrenal…

This study aims to see if covering the cost of vaccines through France's national health insurance leads to more people getting vaccinated. Researchers will compare vaccination rates before and after funding is provided for pneumococcal and pertussis vaccines in outpatient clinic…

This study follows 434 children with congenital lung malformations to see whether having surgery or just monitoring affects parents' anxiety and children's breathing health. Researchers will measure parent anxiety levels when children are 6-9 years old and track respiratory infec…

This study looks at how the brain handles negative beliefs in people with treatment-resistant depression. Researchers will use brain scans (fMRI) to see how beliefs change before and after a single dose of ketamine. The goal is to understand why some depressed patients hold onto …

This study surveys 200 adult women with primary immune deficiency diseases to see if using IUDs, tampons, or menstrual cups leads to infections. Doctors often advise against these products due to infection risk, but there is little data. The goal is to gather real-world informati…

This study looks at whether children and young adults (ages 12-20) with osteogenesis imperfecta (brittle bone disease) have problems with hearing and balance. Researchers will use hearing tests, balance tests, and scans to find links between the genetic type of the disease and th…

This study looks at 40 intensive care patients on breathing machines who need chest physiotherapy to clear mucus and improve lung function. Researchers will compare two common ventilator settings to see which one helps the lungs expand more during the therapy. The goal is to find…

This study uses a special PET-MRI scan with a tracer called [18F]-DPA-714 to detect brain inflammation in people with multiple sclerosis (MS). Researchers want to see how inflammation in brain lesions relates to worsening disability. About 41 adults with active MS will be scanned…

This study enrolls 700 women aged 18–50 who have had three or more early miscarriages or repeated failed embryo transfers. Researchers will collect medical history, tests, and biological samples to better understand what causes these losses. No new treatment is given; the goal is…

This study aims to understand how the immune system causes bone destruction in gum disease (periodontitis) and implant-related gum disease (peri-implantitis). Researchers will collect samples like plaque, saliva, and gum fluid from 219 adults with severe gum disease and compare t…

This study aims to collect detailed information from 180 people with Susac syndrome, a rare condition affecting the brain, hearing, and vision. Researchers will track symptoms, medical history, and test results to better understand what causes the disease and how it progresses. N…

This study looks at how blood flows in the brains of children who have been on ECMO, a machine that helps the heart and lungs. Researchers want to compare two ways of handling the neck artery after ECMO is removed: repairing it or tying it off. The goal is to understand which met…

This study looks at 200 severely burned adults in intensive care to see if giving albumin (a protein in blood) during the first day affects their risk of death, kidney failure, or lung injury. Researchers will observe patients and collect data, but won't assign treatments. The go…

This study aims to create a tool to assess how well people understand tone of voice (prosody) after a right-sided stroke. Over half of right stroke survivors have communication issues, but current tests are limited. Researchers will use a computer task with the word "really" to m…

This study looks at whether a special physiotherapy assessment (called EPIC) can predict if a patient in the intensive care unit will have trouble after their breathing tube is removed. About 330 adults who have been on a ventilator for more than 48 hours will be checked before t…

This study tests a personalized way to set breathing machines for severely obese patients with a serious lung condition called ARDS. Researchers will use a special tube to measure pressure inside the chest and adjust machine settings accordingly. The goal is to see if this approa…

This study follows 480 children up to age 6 to see if taking nifedipine (a blood pressure drug) during pregnancy affects their brain development. The children's mothers had early rupture of membranes and were part of an earlier trial. Researchers will check for conditions like ce…

This study looks at the overall health of 2000 medical residents working in several Paris hospitals. It checks their physical and mental health, sexual health, and how well they manage chronic conditions. The goal is to find out how many residents have issues like anxiety, depres…

This study looks at 80 adults with multiple sclerosis who had special brain scans 8 or more years ago. Researchers will use new MRI and PET scans to see if certain brain changes can predict how disability will progress over time. The goal is to find better ways to measure and und…

This study looks at how medical care affects the quality of life of 100 pregnant women living with HIV. Researchers will ask women to fill out questionnaires about their feelings and experiences during pregnancy and one year after giving birth. The goal is to improve care and sup…

This study looks at whether playing a patient's own name spoken by a familiar voice (like a family member) can trigger stronger brain responses than an unfamiliar voice. Researchers will test 114 ICU patients with disorders of consciousness after cardiac arrest, stroke, or head t…

This study tests whether a bedside bone biopsy done by a diabetes doctor works as well as the usual surgical or radiology-guided biopsy for people with diabetic foot infections. About 320 adults with diabetes and a foot ulcer suspected of bone infection will take part. The goal i…

This study looks at specific immune cells called neutrophils in the blood of people with lung cancer. Researchers want to see if certain types of these cells are linked to how the cancer grows and whether it responds to treatment. About 100 patients and healthy volunteers will gi…

This study looks at how multi-family therapy works for teenagers with anorexia nervosa. Researchers will interview teens, parents, and siblings who took part in group therapy sessions to understand what helps. The goal is to learn more about the therapy process, not to test a new…

This study aims to find out if certain proteins in the blood can predict how severe juvenile idiopathic arthritis (JIA) will become in children and teens. Researchers will measure these markers in 300 participants aged 16 and older and track their joint damage and treatments over…

This study looks at a new way to monitor kidney transplant health by measuring kidney-specific DNA in the blood. Researchers will test 30 adults with end-stage kidney disease before and after their transplant surgery. The goal is to tell the difference between DNA from the patien…

This study interviews 90 participants—teens with anorexia nervosa, their parents, and healthcare professionals—to understand their personal experiences with psychotropic medications. The goal is to gather insights through open-ended conversations, not to test a treatment. Finding…

This study looks at how certain immune cells (monocytes and macrophages) behave in sarcoidosis and tuberculosis. Researchers will compare blood and tissue samples from 100 adults to find patterns that explain why these cells stay overactive in sarcoidosis. The goal is to better u…

This study investigates whether patients with disorders of consciousness (like coma or minimally conscious state) can form, store, and recall memories. Researchers will use EEG and skin sensors to detect brain and body responses to memory tasks, without requiring any communicatio…

This study looks at infections that happen after surgery to remove esophageal cancer. Researchers will review medical records of 350 adults who had this surgery in France between 2017 and 2024. The goal is to find out how common these infections are, what causes them, and how the…

This study looks at the link between gut bacteria and mental health symptoms like anxiety and depression in people with anorexia nervosa. Researchers will compare 120 participants (patients with severe anorexia and healthy volunteers) to see if changes in gut bacteria, intestinal…

This study uses a one-time survey to learn about the eye and body symptoms of people with congenital aniridia, a rare genetic condition that affects the iris. Researchers want to see how much patients understand about their own disease. About 100 patients of all ages will take pa…