Assistance Publique - Hôpitaux De Paris

This study tests whether an oral medication called dimethyl fumarate (Tecfidera) can safely slow the growth of geographic atrophy, a severe form of age-related macular degeneration that causes vision loss. About 90 adults aged 55–85 with geographic atrophy will take the drug dail…

This study looks at whether heart failure medication alone works as well as medication plus an implantable cardioverter-defibrillator (ICD) for people aged 70 and older. The goal is to see if avoiding the device can still keep patients alive just as long. About 730 participants w…

This study tests whether adding letermovir to the standard drug valganciclovir works better than valganciclovir alone for treating cytomegalovirus (CMV) infections in kidney transplant recipients. About 80 adults who have a CMV infection after their transplant will take either th…

This study tests a JAK1 inhibitor drug (baricitinib) to shrink large inflammatory hepatocellular adenomas (liver tumors) in 25 people. These tumors are rare, often affect young women on birth control, and usually require surgery when larger than 5 cm. The goal is to see if a shor…

This study compares a 3-day intravenous (IV) antibiotic treatment against a standard 10-day course (3 days IV plus 7 days oral) for acute kidney infection in children aged 1 month to 3 years. The goal is to see if the shorter treatment works just as well, reduces antibiotic resis…

This study tests whether levosimendan, a drug used for heart failure, can reduce dangerous brain spasms and delayed damage after a bleeding stroke (aneurysmal subarachnoid hemorrhage). Thirty adults in intensive care will receive either the drug or a placebo. The goal is to see i…

This study aims to find out which sepsis patients benefit most from a combination of two steroids (hydrocortisone and fludrocortisone). About 1,800 adults in intensive care will receive either the steroid combo or a placebo. The main goal is to see if the treatment reduces death …

This study tests a high-precision radiation treatment called SBRT for people with liver cancer who are waiting for a liver transplant and cannot have standard treatments like radiofrequency ablation or chemoembolization. The goal is to see if SBRT can control the tumor and keep p…

This study tests a new gene therapy for people with severe sickle cell disease who do not have a matching bone marrow donor. The treatment uses the patient's own blood stem cells, which are modified in a lab to produce healthy red blood cells and reduce sickling. The goal is to d…

This study looks at 600 ICU patients with sepsis caused by hard-to-treat bacteria. It compares giving antibiotics as a continuous drip versus intermittent doses, and also tests adding a second antibiotic versus using just one. The main goal is to see which approach lowers the cha…

This study looks at whether starting intensive day hospital treatment early for teenagers (ages 12-18) with anorexia nervosa can improve their health and reduce serious events like hospital stays. It compares this approach to standard outpatient care. The study also examines how …

This study is for adults aged 18–65 newly diagnosed with acute lymphoblastic leukemia (ALL). It tests whether adding newer immunotherapy drugs (blinatumomab for B-cell ALL, isatuximab for T-cell ALL) to standard treatment can improve survival and reduce the need for a stem cell t…

This study tests a drug called ruxolitinib as the first treatment for children with primary haemophagocytic lymphohistiocytosis (HLH), a rare and serious immune disorder. The goal is to see if ruxolitinib, given with steroids, can help children survive long enough to receive a st…

This study tests if a drug called letermovir works better than valaciclovir to stop cytomegalovirus (CMV) from passing to the baby during pregnancy. About 46 pregnant women with a CMV-infected fetus will be randomly assigned to one of the two drugs. The goal is to see which drug …

This study looks at whether a simple measurement called GapCO2 can help emergency doctors quickly tell if a patient's shortness of breath is caused by fluid buildup (congestive) or other reasons. About 45 adults with sudden breathing trouble will have their blood gases measured a…

This study tests a new way to diagnose sarcopenia—age-related muscle loss—in people 75 and older. Researchers will use a high-definition muscle sensor to see if it can spot muscle problems earlier than current methods. The goal is to help older adults stay independent and avoid f…

This study tests a software tool called MyCMV that helps doctors interpret blood test results for cytomegalovirus (CMV) infection during pregnancy. CMV is a common virus that can cause hearing loss and developmental problems in babies if the mother gets infected for the first tim…

This study aims to see if a simple blood test from the mother can accurately diagnose single-gene disorders (like sickle cell disease or cystic fibrosis) in the fetus, starting as early as 9 weeks of pregnancy. The test looks at fetal DNA found in the mother's blood, which avoids…

This study checks if a quick bedside test (qLabs®FIB) can accurately measure fibrinogen levels in women with severe postpartum hemorrhage. Fibrinogen is a key protein for blood clotting, and low levels signal danger. The goal is to see if this faster test can replace the standard…

This study tests whether screening for preeclampsia in the first trimester (weeks 11-14 of pregnancy) can reduce serious health problems for mothers and babies. About 14,500 pregnant women will be randomly assigned to receive the screening or standard care. The goal is to see if …

This study tests whether using a connected exercise bike at home, along with standard care, can improve daily activities and walking ability in people with lumbar spinal stenosis. About 302 adults aged 50 and older with confirmed spinal narrowing will be randomly assigned to eith…

This study compares different visual keyboard layouts to see which helps people with complex sensorimotor disabilities type faster and feel less tired. About 12 adults who already use a virtual scanning keyboard will test the layouts. The goal is to improve communication and dail…

This study tests whether metformin, a common diabetes medicine, can improve muscle function in adults with myotonic dystrophy type 1 (Steinert's disease). About 142 non-diabetic participants will receive either metformin or a placebo for 6 months. The main goal is to see if metfo…

This pilot study tests whether a personalized home respiratory exercise program is practical for people with systemic sclerosis (scleroderma) who have early lung disease. Fifteen participants will do one supervised session then follow a 3-month home program. The goal is to see if…

This study tests whether automatic settings on hearing aids help children with hearing loss understand speech better in noisy environments. Twenty children aged 6 to 16 who use a cochlear implant and hearing aid (or two implants) will compare three different hearing aid programs.…

This study is testing whether shiatsu, a type of massage, can improve symptoms like fatigue, pain, and anxiety in people with severe cardiac amyloidosis. 108 participants will receive either targeted shiatsu or a comfort version, and researchers will measure changes in symptoms a…

This study compares two approaches for people newly diagnosed with early Alzheimer's disease: taking the drug donepezil versus using non-drug methods like cognitive stimulation or remediation. Researchers want to see which approach better helps with memory and thinking symptoms a…

This study compares yoga therapy to standard physiotherapy for people with moderate axial spondyloarthritis, a type of arthritis that causes back pain and stiffness. Researchers will measure changes in disease activity, pain, and fatigue over 6 months. The goal is to see if yoga …

This study looks at why some patients with severe lung failure (ARDS) get worse than others. Researchers will analyze blood and lung fluid from 50 ICU patients to find different immune patterns. The goal is to better understand the disease so future treatments can be more persona…

This study looks at whether CAR-T cell therapy, a new immune treatment for blood cancers, can cause early heart problems. Researchers will check heart function with ultrasound before and a few days after treatment in 60 patients. The goal is to find out how often heart issues hap…

This study looks at whether cancer patients do better when they go to the emergency room at their own cancer hospital versus another hospital. Researchers will track 2,000 adults with active cancer or recent remission to see how many days they spend alive and out of the hospital …

This study aims to understand how the brain is different in people with autism, especially in areas related to social thinking. Researchers will use MRI scans and eye-tracking tests to compare brain structure and function between 160 people with autism and healthy volunteers. The…

This study looks at whether 3D models of children's tumors are better than regular 2D scans for planning surgery. About 60 children with pelvic or retroperitoneal tumors will take part. Surgeons and parents will answer questions comparing the two types of images to see if 3D help…

This study compares two types of lung cancer surgery—traditional open surgery (thoracotomy) and newer, less invasive methods (video-assisted or robotic surgery). The goal is to understand why patients who have minimally invasive surgery often have fewer complications and a better…

This study follows 1,200 people from two memory clinics in Paris to see if sleep patterns and other personal factors are linked to different types and stages of dementia. Researchers will track participants for up to 15 years using routine clinic visits. The goal is to find simpl…

This study interviews 90 teens with anorexia, their parents, and healthcare professionals to understand their experiences with psychiatric drugs. The goal is to learn about perceptions and feelings, not to test a new treatment. No medication is given as part of this research.

This study aims to better understand amyotrophic lateral sclerosis (ALS) by growing skin cells from patients in the lab. Researchers will collect skin biopsies and blood samples from 110 adults, including people with ALS, healthy carriers of ALS-related gene mutations, and contro…

This study talks to siblings aged 9 to 18 whose brother or sister is in the pediatric intensive care unit (PICU). Researchers want to understand what these siblings need and how the experience affects their daily life. They will interview each sibling twice: once during the hospi…

This study looks at whether children with multiple sclerosis (MS) can repair myelin, the protective coating around nerves, better than adults. Researchers will use special MRI scans to measure myelin repair in the brain's cortex. The study involves 40 children aged 12-18 with MS …

This study tests whether a short, 10-minute MRI scan (Fast-MRI) can detect early-stage liver cancer better than the standard ultrasound in people with cirrhosis who are at high risk. About 944 participants will be randomly assigned to get either ultrasound alone or ultrasound plu…

This study follows 425 adults with recent psoriatic arthritis (PsA) for up to 10 years to see who develops joint damage and why. Researchers will use X-rays and other data to find early signs of aggressive disease. The goal is to help doctors identify high-risk patients sooner an…

This study tests whether measuring pressure inside the chest can help doctors set breathing machines better for severely obese patients with acute lung injury. About 40 adults with a BMI over 40 and moderate to severe ARDS will take part. Researchers will use a special tube to me…

This study looks at 40 ICU patients on breathing machines to see if the ventilator mode affects how well chest physiotherapy works. The goal is to find out if one mode helps clear mucus and improve lung function better than the other. Results may help doctors choose the best vent…

This study aims to learn more about how the spleen filters blood cells and fights infections. Researchers will study spleens removed from 100 adult patients during surgery. By pumping blood through the spleens in the lab, they hope to understand the spleen's role in diseases like…

This study is looking at how the immune system responds to serious mold infections, like those caused by Aspergillus. The goal is to find out which patients might benefit from adding immunotherapy (drugs that boost the immune system) to standard treatment. Researchers will monito…

This study looks at whether the position a person is in during a bladder test (lying down vs sitting) affects the diagnosis of overactive bladder in people with multiple sclerosis or Parkinson's disease. Researchers will compare results from both positions in 160 patients to see …

This study looks at how the hepatitis B vaccine activates T-cells, a key part of the immune system, in healthy adults. Researchers want to understand why some people have a stronger T-cell response and how that relates to long-term protection. The goal is to improve future vaccin…

This study is testing whether adding MRI scans to standard ultrasound can help doctors better see and diagnose birth defects in unborn babies. About 1500 pregnant women will get a fetal MRI to check if it provides clearer details than ultrasound alone. The goal is to improve how …

This study looks at how anti-infective medicines (like antibiotics) behave in critically ill children. The goal is to understand why drug levels vary so much and to find the right dose for each child. Researchers will collect blood samples and health data from 3,000 children in i…

This study is testing whether measuring a protein called EDN in urine, blood, or esophageal brushings can help monitor eosinophilic esophagitis in children without needing repeated endoscopies. Researchers will collect samples from 60 children undergoing upper GI endoscopy for di…

This study looks at blood samples from 80 children (ages 2–17) recently diagnosed with type 1 diabetes and compares them to healthy children. Researchers want to understand how certain immune cells (called CD4 T cells) stop working properly, leading to the disease. The goal is to…

This study looks at whether certain proteins in the blood can help predict how severe juvenile idiopathic arthritis (JIA) will become. Researchers will measure these markers in 300 teenagers and young adults with JIA and track their joint damage and treatments over time. The goal…

This study explores whether using advanced insulin delivery systems early after a type 1 diabetes diagnosis can protect brain development in children aged 5 to 7. Researchers will compare brain scans and thinking skills among kids using different treatments and those without diab…

This study looks at whether a non-invasive digital cuff can accurately measure blood pressure continuously during carotid artery surgery, instead of the usual invasive arterial catheter. The catheter, while standard, can cause discomfort and complications like infection or blocke…

This study looks at how vasoplegic syndrome—a serious drop in blood pressure after heart surgery—affects the adrenal glands. Researchers will measure stress hormones in 200 adults using advanced lab tests. The goal is to better understand this complication, not to test a new trea…

This study is looking back at the health records of over 1,200 people who survived a rare, life-threatening blood disorder called immune thrombotic thrombocytopenic purpura (iTTP). The goal is to understand their long-term health, especially heart and brain problems, and how diff…

This study looks at whether giving parents feedback from a device called LENA (which counts words and conversations at home) can improve how they support their deaf child's language development after early cochlear implant surgery. About 30 children implanted before 18 months old…

This study looks at people in Paris whose hearts stopped outside the hospital and did not restart with standard CPR. They received a special machine called ECMO that pumps blood for the body while doctors try to restart the heart. Researchers will track how many survive for one y…

This study looks at how slow brain waves during sleep and wakefulness are linked to memory and attention problems in normal aging and early Alzheimer's disease. Researchers will study 90 people: young adults, healthy seniors, and those with early-stage Alzheimer's. They aim to un…

This study investigates whether chronic infections with gut viruses can lead to hepatitis and other liver problems in people with primary or secondary immune deficiencies. Researchers will collect blood, stool, and urine samples from 120 participants to screen for viruses and ana…

This study looks at whether a special health program (PEGASE) helps young children in foster care have better mental and physical health. About 220 children under 3.5 years old will be followed for 2 years. The program provides regular medical and mental health check-ups, and the…

This study tests a new tool called PRECOM that uses brain wave signals to predict whether comatose patients after cardiac arrest will wake up within 3 months. Researchers will enroll 100 adults in French ICUs who remain in a coma 3 days after cardiac arrest. The goal is to see if…

This study follows 900 couples in Paris who tried preimplantation genetic diagnosis (PGD) to avoid passing on severe genetic disorders but did not have a baby from the procedure. Researchers want to learn how many later had a healthy child through other means, and why some couple…

This observational study aims to identify biomarkers in blood and joint fluid that can predict how knee osteoarthritis will progress over time. Researchers will follow 300 participants with knee pain for up to 10 years, collecting samples and tracking symptoms, X-ray changes, and…