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This trial tested a gene therapy to fix the faulty gene causing X-linked severe combined immunodeficiency (SCID-X1), a life-threatening condition where boys are born without a working immune system. Five boys who lacked a suitable bone marrow donor received a single treatment wit…

This study tested if draining a tubo-ovarian abscess (a pocket of infection in the female reproductive organs) through a needle guided by ultrasound works as well as keyhole surgery. About 208 women with this condition received antibiotics plus either drainage or laparoscopy. The…

This study tested whether a 14-day course of doxycycline pills works as well as the standard penicillin shot for curing early syphilis. About 200 adults with early-stage syphilis took part. The goal is to offer a reliable oral option, especially when penicillin is in short supply…

This study tested whether giving a stronger or extra dose of the pneumococcal vaccine could improve immune protection in 96 adults with ANCA-associated vasculitis who are taking rituximab. Participants received either the standard vaccine schedule or one of two reinforced schedul…

This study tested a new two-step vaccine approach to protect adults who have had their spleen removed from serious pneumococcal infections. Seventy participants received one shot of a conjugate vaccine followed by a second shot of a polysaccharide vaccine two months later. The go…

This study looked at how well the seasonal and H1N1 flu vaccine works in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were on steroids or other immune-suppressing drugs. Researchers measured antibody levels three weeks after each shot to see if the v…

This study tested the drug adalimumab (Humira) in 34 children with juvenile arthritis who also had active eye inflammation (uveitis) that was not controlled by steroid eye drops and methotrexate. Half received adalimumab and half received a placebo for 2 months. The goal was to s…

This study tracked over 4,200 immunocompromised patients who received monoclonal antibodies to prevent or treat severe COVID-19. Researchers measured how many were hospitalized or died from the virus. The goal was to see if these antibody treatments help protect people whose immu…

This study tested whether turning off the labor drug oxytocin once a woman reaches 6 cm dilation (active labor) could lower the chance of newborn complications. Over 2,400 women with a single, full-term baby in head-down position took part. The goal was to see if this simple chan…

This small pilot study looked at whether the drug pirfenidone is safe and effective for people with a specific type of lung scarring (pulmonary fibrosis) linked to MPO antibodies or vasculitis. Seven adults took the drug for a year. The main goal was to see if their lung function…

This study looked at men with advanced prostate cancer that was no longer controlled by standard hormone therapy. Researchers tested whether increasing the dose of the drug abiraterone could stop the cancer from growing. 94 men participated, and the goal was to see if the higher …

This study looked at whether patients with rheumatoid arthritis, spondyloarthritis, Crohn's disease, or uveitis could safely switch from the original drug Remicade to its lower-cost biosimilar Inflectra. Researchers tracked 262 patients at one hospital to see how many stayed on t…

This study tested a new way to dose the blood thinner enoxaparin in 50 children who had a kidney transplant. The goal was to prevent dangerous blood clots in the new kidney while avoiding bleeding. The method used a computer model to personalize each child's dose, aiming to keep …

This study tested the drug itacitinib in 35 adults with a mild form of hemophagocytic lymphohistiocytosis (HLH), a rare immune condition. The goal was to see if itacitinib could control the disease by day 15. Participants took the drug for at least 7 days, and researchers measure…

This study looked at whether a nurse with advanced training could help people with high blood pressure get it under control. Over 480 adults were included, and the nurse helped them monitor their blood pressure at home and stick to their treatment plan. The goal was to see if thi…

This early-phase study tested a gene therapy for sickle cell disease in 6 patients aged 12-20. Doctors took the patients' own blood stem cells, added a working gene to help produce healthy red blood cells, and infused them back after chemotherapy. The goal was to see if the treat…

This study tested whether placing small amounts of milk under the tongue (sublingual immunotherapy) could help children with cow milk allergy tolerate more milk over time. 51 children aged 5 and older with confirmed IgE-mediated cow milk allergy participated. The goal was to safe…

This study tested the gout medicine allopurinol in 8 people with a rare genetic condition called ADSL deficiency, which causes autism, seizures, and developmental delays. Researchers measured changes in thinking, daily skills, and seizure control over 12 months. The goal was to s…

This study tested a 5-week hospital program combining physical activity, nutrition advice, and education for 128 adults with Prader-Willi syndrome. The goal was to help patients stabilize or lose weight 6 months after leaving the hospital. The program focuses on changing daily ha…

This study looked at people with sudden, dense bleeding inside the eye (vitreous hemorrhage) caused by the vitreous gel pulling away from the retina. It compared having surgery right away versus waiting and monitoring with ultrasound, to see if early surgery lowers the chance of …

This study tested whether giving two seizure-stopping drugs together works better than one drug alone for people having a severe, prolonged seizure (status epilepticus) before they get to the hospital. 203 adults were treated by emergency medical teams. The main goal was to see i…

This study looked at whether adding a probiotic called VSL#3 to standard treatment can improve disease activity and reduce flare-ups in children with juvenile idiopathic arthritis (JIA). Fifty-one children aged 1 to 7 with specific types of JIA took part. The goal was to see if t…

This study tested whether drugs normally used for HIV could help children with Aicardi-Goutières syndrome (AGS), a rare genetic disease that causes severe brain inflammation. Eleven children received reverse transcriptase inhibitors to see if the drugs could lower abnormal immune…

This study tested whether placing a heart-lung machine (ECMO) at the location of a cardiac arrest, rather than waiting until the patient reaches the hospital, could improve survival with good brain function. About 65 adults with refractory cardiac arrest were enrolled. The goal w…

This study compared two treatments for symptomatic uterine fibroids—surgery (myomectomy) and a minimally invasive procedure (uterine artery embolization)—to see which one better helps women get pregnant and have a live birth. It included 9 women aged 18 to 43 with fibroids larger…

This study tested a drug called ustekinumab in 16 adults with Behçet disease, a condition that causes painful mouth sores and eye swelling. The goal was to see if the drug could reduce the number of mouth ulcers and calm eye inflammation over 24 weeks. While not a cure, the treat…

This study tested whether bosentan, a drug used for lung and blood vessel problems, can help protect kidney function in people with scleroderma who develop a sudden kidney crisis. Sixteen adults with scleroderma and kidney crisis took bosentan for 6 months. The goal was to see if…

This study tested whether giving methionine (an amino acid) by mouth or feeding tube is safe and tolerable for children with a severe, inherited lung disease called pulmonary alveolar proteinosis. The disease is caused by a faulty MARS gene that prevents cells from using methioni…

This study tested a surgery done before birth to repair a spinal defect called myelomeningocele (a severe form of spina bifida). The goal was to reduce brain problems and limit nerve damage. 38 pregnant women carrying a fetus with this condition took part. The surgery aims to imp…

This study tested whether a medicine called isosorbide mononitrate, given to help soften the cervix, could reduce the need for C-sections in first-time mothers whose pregnancies went past 41 weeks. Over 1,400 women took part. The goal was to see if this outpatient treatment could…

This study tested two antibiotics, cloxacillin and cefazolin, in 315 adults with bloodstream infections caused by a common staph bacteria (MSSA). The goal was to see if cefazolin works as well as cloxacillin, which is the standard treatment but can have side effects and supply is…

This study tested a new, less invasive way to repair spina bifida before birth. Instead of opening the womb, doctors used a tiny camera and tools through two small cuts. The goal was to see if this approach could safely cover the spinal defect and reduce the need for surgery afte…

This study tested whether baricitinib, a pill that calms the immune system, works better than standard treatment when combined with steroids for children with newly diagnosed juvenile dermatomyositis. Sixteen children aged 3 to 18 took part. The goal was to see if more children i…

This study tested the antiviral drug valacyclovir in 41 pregnant women whose unborn babies were infected with cytomegalovirus (CMV), a leading cause of birth defects. The goal was to see if treating the mother could lower the virus levels in the baby and reduce symptoms at birth.…

This study tested a new ovarian stimulation protocol using degarelix (a drug typically used for prostate cancer) to help breast cancer patients preserve their fertility before chemotherapy. The goal was to keep estrogen levels low while still collecting enough eggs for freezing. …

This study tested whether babies with a rare, permanent form of diabetes caused by specific gene changes could switch from daily insulin injections to an oral pill called glibenclamide. Nineteen infants took part. The goal was to see if the pill could control their blood sugar an…

This study tested whether the drug nintedanib can slow the loss of lung function in people who have had a lung transplant and developed a condition called bronchiolitis obliterans syndrome (BOS). 58 adults who were at least 6 months post-transplant and had early to moderate BOS t…

This study tested whether a drug called rituximab, combined with steroids, works better than the usual treatment for a rare disease called eosinophilic granulomatosis with polyangiitis (EGPA). EGPA causes inflammation in small blood vessels, affecting organs like the lungs and ki…

This study looked at 452 people with kidney cancer that had spread. It compared the standard approach of removing the kidney plus taking the drug sunitinib to just taking sunitinib alone. The main goal was to see which group lived longer. The results help doctors decide if surger…

This study tested a medicine called Revestive® in 25 children aged 2 to 18 with short bowel syndrome who rely on IV nutrition at home. The goal was to see if the drug could help their intestines absorb more nutrients and reduce or eliminate the need for IV support. Researchers me…

This study tested whether a high dose of epoetin alfa, a drug that mimics a natural hormone, could improve brain recovery in people who remained unconscious after a cardiac arrest. 500 adults were randomly assigned to receive either the drug plus standard care or standard care al…

This study tested whether denosumab, a drug given as a shot every 6 months, can improve bone density in people with osteoporosis caused by systemic mastocytosis. 24 adults with the condition took part. The goal was to see if the drug strengthens bones and prevents fractures bette…

This study looked at whether rituximab, a targeted antibody therapy, works better than the standard drug azathioprine for preventing major relapses in people with ANCA-associated vasculitis (inflammation of blood vessels). 117 adults who were already in remission after initial tr…

This study looked at two approaches for managing stage 1 twin-to-twin transfusion syndrome (TTTS), a serious condition where twins share a placenta unevenly. One approach was careful monitoring without immediate surgery, and the other was laser surgery to fix the blood vessel con…

This study looked at a new liquid version of the diabetes drug glibenclamide for children with a rare form of diabetes caused by a gene change. The goal was to see if the liquid is easier for kids to take and works just as well as the pill form. Ten children already on the pill t…

This study tested whether a drug that blocks TNF-alpha, a protein involved in inflammation, can reduce pain from scar tissue that forms after back surgery. 38 adults with ongoing sciatica after a discectomy received the treatment. The goal was to see if the drug could relieve pai…

This study tested a new method to adjust vancomycin doses in 100 children with MRSA infections. The goal was to reach the right drug level in the blood more quickly and safely than with the usual approach. The new method uses a computer model (Bayesian approach) to personalize do…

This study tested a modified surgical technique to improve breathing in 14 children with faciocraniosynostosis, a condition where skull bones fuse too early. The surgery used special devices to gradually reshape the skull and face. The main goal was to see if the new approach cou…

This study tested whether a drug called sodium phenylbutyrate could lower a marker of kidney injury (Lcn2) in the urine of people with chronic kidney disease and proteinuria (excess protein in urine). 26 adults with stable kidney function took part. The goal was to see if the dru…

This study tested the drug topiramate in 18 severely obese children and teens aged 9-17. The goal was to see if it could lower body mass index (BMI) more than a placebo over 9 months. Participants had to have a very high BMI and had not succeeded with other weight-loss efforts.

This study tested three biologic drugs (adalimumab, anakinra, and tocilizumab) against each other in 112 people with non-infectious uveitis that did not improve with standard treatments. The goal was to see which drug best controls eye inflammation and reduces the need for steroi…

This study tested whether rituximab is better than azathioprine at keeping eosinophilic granulomatosis with polyangiitis (EGPA) in remission. 98 adults with newly diagnosed or relapsing EGPA who had already achieved remission took part. The key approach was to compare how long re…

This study tested whether a special blood-filtering treatment (high-permeability hemodialysis) could help people recover faster from shock after a cardiac arrest. The treatment aims to remove harmful inflammatory substances from the blood. The study included 38 comatose ICU patie…

This study tested whether treating inflammation in the male reproductive tract could improve sperm health and fertility. About 200 men with signs of inflammation in their semen received either an anti-inflammatory drug or a placebo. The main goal was to reduce a marker of sperm d…

This study looked at whether taking aspirin twice a day (100 mg each time) works better than once a day to prevent another heart attack, stroke, or urgent heart procedure in people with diabetes who recently had a heart attack or unstable chest pain. About 2,500 participants were…

This study tested a high dose (10 mg/kg/day) of the antifungal drug liposomal amphotericin B (Ambisome) in 40 people with zygomycosis, a rare but serious fungal infection. The goal was to see if this dose could control the infection, measured by complete or partial response after…

This study tested whether using technology for remote check-ins helps obese teenagers lose weight better than standard in-person visits. 91 teens aged 11-17 took part. The main goal was to see if their body mass index (BMI) improved after 15 months.

This study tested whether using a special antiseptic dressing on ECMO tubes can reduce serious infections in critically ill patients. About 270 adults on ECMO for heart or lung failure were randomly assigned to get either the special dressing or a standard one. The goal was to se…

This study tested a device called NEMOST, used with physical therapy, to treat progressive scoliosis in children aged 5 to 15. The goal was to keep the spine straight as the child grows and avoid the need for more surgeries. The study included 20 children and checked if the devic…

This study looked at people with a specific type of brain tumor (anaplastic glioma with 1p/19q codeletion). The goal was to see if using chemotherapy alone could delay the need for radiation therapy, which can cause thinking and memory problems. About 280 patients took part, and …

This study looks at whether giving rituximab for a longer time (46 months) can better prevent relapses of ANCA-associated vasculitis compared to the usual shorter treatment (18 months). About 97 adults who are already in remission after initial rituximab therapy will be randomly …

This study followed 852 people with cystic fibrosis (ages 12 and older) who took the drug Orkambi for one year outside of a clinical trial. Researchers tracked how many stopped treatment, why, and how their lung function, nutrition, and symptoms changed. The goal was to see how t…

This study tested a new way to treat children aged 6 to 18 who have a dead nerve in an immature tooth. The new method uses a material called MTA to help the tooth form a hard barrier, compared to the standard treatment with calcium hydroxide. The goal was to see which method work…

This study looked at whether adding azathioprine to standard corticosteroid treatment could help people with newly diagnosed microscopic polyangiitis, polyarteritis nodosa, or eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) who have no poor prognosis factor…

This study tested a special educational tool for parents of children aged 1 to 6 with type 1 diabetes. The goal was to see if the tool helps improve blood sugar control and prevent dangerous events like low blood sugar or ketosis. The study involved 24 children across French hosp…

This study tested whether triggering the sperm's acrosome reaction (a natural process that releases enzymes to help fertilize an egg) before doing ICSI (a type of IVF) could improve pregnancy outcomes. Researchers enrolled 111 couples undergoing their first ICSI cycle with at lea…

This early-stage study tested a new gene therapy in 2 HIV-positive people with high-risk lymphoma. The therapy involved taking their own stem cells and immune cells, adding a gene to block HIV, and giving them back after chemotherapy. The main goal was to see if the procedure was…

This study tested whether people with rheumatoid arthritis, psoriatic arthritis, or spine arthritis could safely switch from receiving infliximab through an IV infusion at a clinic to giving themselves a simple shot under the skin at home. 22 adults who were already stable on IV …

This study tested whether adding rituximab to standard steroid treatment helps people with a rare disease called microscopic polyangiitis (MPA) achieve remission and stay relapse-free longer. Eight adults with newly active MPA and no poor prognosis signs took part. The goal was t…

This study tested whether giving strong, early treatment to people with severe sepsis or septic shock right in the ambulance could lower the number of deaths. The treatment included early antibiotics and fluids to support blood pressure. The study involved 398 adults and measured…

This study looked at whether a high dose of vitamin D (100,000 IU) is better than a low dose (12,000 IU) for kidney transplant recipients. The goal was to see if it could prevent new diabetes, heart problems, cancer, or death. Over 500 adults who had a kidney transplant 1 to 4 ye…

This study tested a procedure called radiofrequency ablation (using heat) to treat Barrett's esophagus with low-grade dysplasia, a condition where cells in the food pipe look abnormal and may turn into cancer. 125 adults with this condition were randomly assigned to get the heat …

This early-phase study tested whether injecting special immune-building cells (HTLPs) could safely and quickly restore the immune system in 4 children with severe combined immunodeficiency (SCID) after a partially matched stem cell transplant. The goal was to help their bodies ma…

This study tested whether lanreotide, a drug that affects hormone levels, can slow the loss of kidney function in people with autosomal dominant polycystic kidney disease (ADPKD). The trial included 159 adults with moderate kidney decline and compared lanreotide to a placebo over…

This study tested two ways of using liquid nutrition to prevent Crohn's disease from flaring up again in children aged 6 to 18. One group got all their calories from a special liquid diet for one week out of every four (cyclic), while the other group got 25% of their calories fro…

This study tested a new way to treat low-risk prostate cancer using a microwave probe inserted through the rectum. The goal was to see if the procedure could precisely destroy the main tumor while being safe and well-tolerated. Eleven men participated, and the researchers used MR…

This study tested a special filter placed in a large vein to catch blood clots before they reach the lungs. It included 50 people who could not take blood thinners. The goal was to see how often the filter could be successfully placed and removed, and to track any problems.

This study looked at 126 children with juvenile idiopathic arthritis (JIA) to find the best individual dose of the drug etanercept. The goal was to control the disease effectively while minimizing side effects. Researchers measured drug levels in the blood and checked for remissi…

This study looked at whether gently pulling on the umbilical cord (controlled cord traction) after childbirth helps prevent heavy bleeding (postpartum hemorrhage). Over 4,300 women who had a vaginal birth took part. The goal was to see if this technique works better than waiting …

This study tested the drug alemtuzumab as a first treatment for children with hemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening immune disorder. The goal was to see if the drug could keep patients alive long enough to receive a stem cell transplant. The trial …

This study looked at how well the drug Ivacaftor works and how safe it is for people with cystic fibrosis who have a specific genetic change (G551D mutation) in everyday life, not just in a controlled trial. Researchers followed 57 French patients aged 6 and older for one year af…

This study looked back at the medical records of 84 hospitalized adults with severe COVID-19 who received the drug remdesivir. Researchers wanted to see how patients were doing on day 15 of treatment, using a standard scale to measure their progress. The goal was to understand wh…

This study tested whether sending supportive text messages to teenagers with poorly controlled type 1 diabetes could help lower their blood sugar levels. 92 teens aged 12-21 with high HbA1c levels participated. The approach used mobile phone reminders to encourage better diabetes…

This study tested whether famotidine, a common heartburn medicine, can reduce a blood marker linked to painful crises in children with sickle cell disease. Thirty children aged 1 to 17 took the drug for 29 days, and researchers measured changes in P-selectin levels. The goal is t…

This study tested whether the drug baclofen helps people with alcoholism reduce their drinking to safe levels or stop completely over one year. 323 adults who wanted to cut back or quit alcohol took either baclofen or a placebo pill. The goal was to see if more people on baclofen…

This study tested if the antibiotic temocillin works as well as a stronger antibiotic (carbapenem) for treating urinary tract infections caused by resistant bacteria. 29 hospitalized adults took part. The goal was to see if both treatments could clear the infection and symptoms. …

This study tested whether daily washing with a special antiseptic pad (chlorhexidine) reduces skin bacteria better than regular mild soap in children staying in the intensive care unit. 34 children with a central line (a special IV) took part. Researchers measured skin germs befo…

This study tested the drug Humira (adalimumab) in 11 people with Netherton Syndrome, a rare genetic skin condition that causes severe inflammation, itching, and pain. The goal was to see if Humira could reduce skin symptoms by at least 20% after 3 months of treatment, with a 3-mo…

This study looked at two different ways to manage blood sugar in pregnant women with a rare form of diabetes called MODY2. The goal was to find the best way to prevent the baby from growing too large or too small. 46 women took part, and researchers compared starting insulin righ…

This study tested whether miglustat, a drug used for other conditions, can help restore salt and water balance in the lungs of adults with cystic fibrosis who have the most common genetic mutation (F508del). Sixteen participants received miglustat and a placebo at different times…

This study tested whether giving special immune cells (CD4 and CD8 T cells) that target CMV or adenovirus could help control these infections in people who had a stem cell transplant. Sixteen children and adults received the cells, and researchers measured virus levels in the blo…

This study tested if the pill glyburide works as well as insulin shots for treating gestational diabetes (diabetes during pregnancy). Over 900 pregnant women took part. The main goal was to see if babies had fewer problems like being very large, having low blood sugar, or jaundic…

This study looked at 62 children with juvenile idiopathic arthritis whose disease was inactive. Researchers tested whether slowly reducing and then stopping their biologic medication was safe and just as effective as staying on the full dose for 24 weeks. The goal was to lower co…

This study looked at whether using a balloon device early, along with standard medication, can better control heavy bleeding after vaginal birth compared to waiting to use the balloon only if medication fails. About 405 women who had persistent bleeding after initial treatment we…

This study tested whether adding intravenous cyclophosphamide to prednisone can stabilize or improve lung function in people with scleroderma whose lung disease is getting worse. The trial enrolled 40 adults with significant lung volume or gas exchange decline in the past year. T…

This study looked at whether rosuvastatin, a cholesterol-lowering drug, can reduce early signs of artery hardening and prevent heart problems in people with ANCA-associated vasculitis (a type of blood vessel inflammation). 121 adults whose vasculitis was in remission took part. T…

This study tested a new ovarian stimulation protocol for IVF that aims to keep estrogen levels more natural while still producing many eggs. 129 women with good IVF prognosis participated. The goal was to see if this approach leads to more live births compared to the standard met…

This early-phase study tested whether low doses of interleukin-2 (IL-2) can increase regulatory T cells in the blood of women who have had at least five unexplained early miscarriages. The goal was to see if this immune adjustment could help prevent the body from rejecting a preg…

This study tested a new device (Smart-TO) that places a small balloon in the windpipe of unborn babies with congenital diaphragmatic hernia, a condition where the diaphragm has a hole and the lungs don't grow properly. The balloon is later removed using a special MRI technique. T…

This study tested an experimental enzyme therapy called METAZYM in one child with late infantile metachromatic leukodystrophy (MLD) who had already received a stem cell transplant. The goal was to see if the enzyme could slow nerve damage and improve function. The child received …

This study tested whether adding early steroids or SGLT2 inhibitors to standard blood pressure medication can better protect kidney function in people with IgA nephropathy who have severe kidney damage. 62 adults with active disease were randomly assigned to receive either the co…

This study tested whether a drug called bortezomib, given with steroids, plasma exchange, and immunoglobulins, can treat chronic antibody-mediated rejection in kidney transplant recipients. The trial included 60 adults who had a kidney transplant and developed donor-specific anti…

This study looked at 577 women under 45 who had an incomplete miscarriage and wanted to get pregnant again. It compared two surgical treatments—hysteroscopy and standard curettage—to see which one leads to more successful pregnancies later. The goal is to find the safest and most…

This study tested whether giving the drug rituximab only when certain blood markers (ANCA and CD19 cells) appear is as good as giving it on a fixed schedule for keeping ANCA vasculitis in remission. 166 adults with the disease who were already in remission took part. The goal was…

This study looked at how well a glucose tolerance test (drinking a sugary drink) can diagnose acromegaly, a condition where the body makes too much growth hormone. Researchers tested 109 people, some with acromegaly and some without, to see if the test gives consistent results. T…

This study looked at whether a set of blood markers can quickly tell if a person having a stroke has a large blocked artery that needs special treatment. Researchers tested nearly 4,000 adults with stroke symptoms to see if these biomarkers could help paramedics and doctors send …

This study tested whether using an ultrasound to measure the thickness of the womb scar can help women who have had a previous C-section decide whether to attempt a vaginal birth. The goal was to reduce the risk of uterine rupture and other serious complications for both mother a…

This study looked at whether a blood test measuring tiny molecules called microRNAs can spot early signs of organ rejection in heart transplant patients. Researchers tested 461 people who had a heart transplant and compared the blood test results to the standard method, a heart b…

This study tested a new, non-invasive method to find prostate cancer cells in blood or urine samples from 127 men. The goal was to see if this approach could accurately detect cancer before a prostate biopsy. If successful, it could reduce the need for invasive biopsies in the fu…

This study looked at whether a chest CT scan can accurately diagnose when a child has inhaled a foreign object (like a toy piece or food). Researchers compared CT scan results with the standard method, endoscopy (a camera tube), in 311 children aged 6 months to 16 years. The goal…

This study collected CT scan images from over 10,000 adults to find better ways to diagnose COVID-19. Researchers aimed to identify key signs on scans and develop computer programs that can automatically detect the disease. The goal was to improve accuracy and help predict which …

This study tested whether a simple blood test (NIPT) can safely replace the standard invasive test for Down syndrome in pregnant women at higher risk. Over 2,100 women were asked about their preferences and then randomly assigned to receive either the blood test or the usual inva…

This study tested whether a blood test from the mother could accurately detect Down syndrome (trisomy 21) in the baby as early as 11 weeks into pregnancy. Researchers analyzed fetal DNA found in the mother's blood using a high-speed sequencing method. The goal was to see if this …

This study tested whether using MRI to guide prostate biopsies could detect cancer as well as the standard 12-sample systematic biopsy. Researchers enrolled 108 men aged 45-75 with elevated PSA levels. They compared three MRI-targeted samples to the usual systematic approach to s…

This study tested a new kit (MycoGenie) that uses a blood sample to detect a serious fungal infection called invasive aspergillosis in people with blood cancers. The test also checks if the fungus is resistant to common medicines. The study involved 350 adult patients at high ris…

This study looked at whether testing saliva (spit) can find COVID-19 infections just as well as the standard nose swab test. Over 5,000 people of all ages provided both a nose swab and a saliva sample. The goal was to see if saliva testing could make screening easier and more com…

This study looked at whether a non-invasive breathing test called the lung clearance index (LCI) can find early signs of lung disease in young children with cystic fibrosis. 53 children aged 3 to 6 took the test along with standard lung scans and function tests. The goal was to s…

This study tested whether functional MRI can detect placental problems in pregnant women without invasive procedures. Researchers gave 101 pregnant women oxygen while scanning the placenta and fetus to see if the MRI signal changed. The goal was to tell the difference between hea…

This study looked at whether it is possible to diagnose congenital cytomegalovirus (CMV) infection and confirm hearing loss in newborns who failed their newborn hearing screening, all before they turn one month old. Researchers enrolled 235 newborns and measured how many days it …

This study tested a new, non-invasive blood test to diagnose Down syndrome (trisomy 21) during pregnancy. Current screening methods have high false-positive rates, and confirmatory tests like amniocentesis carry a 1-3% risk of miscarriage. The new method analyzes fetal cells from…

This study looked at whether a stool test for a protein called calprotectin can help predict serious gut inflammation in premature babies. Researchers followed 122 infants born at 33 weeks or earlier, collecting stool samples weekly. The goal was to see if this test could help do…

This study looked at whether a blood test called the sFlt-1/PlGF ratio can help doctors make better decisions for pregnant women with suspected preeclampsia before 35 weeks. The goal was to see if using the test improves care for both mother and baby and lowers hospital costs. 84…

This study looked at whether measuring certain proteins (amyloid peptides) in the blood can help diagnose Alzheimer's disease or predict if someone with mild memory problems will develop Alzheimer's. Over 1,000 older adults with either mild cognitive impairment or Alzheimer's too…

This study tested a new imaging technique called Full Field Optical Coherence Tomography (FFOCT) to see if it can accurately detect prostate cancer in biopsy samples. Researchers compared FFOCT results to standard lab analysis in 91 men with elevated PSA levels. The goal was to d…

This study looked at whether adding a CT scan of the legs and pelvis to the usual chest scan helps find more blood clots in women who may have a pulmonary embolism (a clot in the lung) within six weeks after giving birth. 125 women took part. The goal was to see if the extra scan…

This study tested a new, non-invasive tool that measures skin conductance to detect small nerve fiber damage in children undergoing chemotherapy. The goal was to see if this quick test could accurately identify chemotherapy-induced peripheral neuropathy (CIPN) earlier than curren…

This study tested whether a special MRI technique called Arterial Spin Labeling (ASL) can measure brain blood flow to help diagnose autism in children aged 5 to 17. The goal was to replace PET scans, which use radiation, with a safer, non-invasive method. Researchers studied 115 …

This study looked at whether a special ultrasound technique can detect kidney damage in people who have received a kidney transplant. The goal is to find a safer, less invasive way to diagnose chronic kidney disease without needing a needle biopsy. 141 transplant recipients were …

This study tested a new rapid test that uses a vaginal swab to find germs and infection markers that can cause serious infections in newborns. Over 2,500 pregnant women took part. The goal was to see if this test could help doctors prevent infections in babies more effectively.

This study looked at whether a quick, bedside test (qLabs®FIB) can accurately measure fibrinogen levels in women with severe postpartum hemorrhage. Low fibrinogen is a key warning sign, and getting results faster could help doctors act sooner. The study involved 70 adult women an…

This study looked at whether whole body MRI can accurately diagnose inflammatory myopathies (muscle diseases like myositis). Researchers compared MRI results to muscle biopsy in 139 people suspected of having these conditions. The goal was to see if MRI could be a reliable, less …

This study tested whether a noninvasive device called FibroScan can accurately measure liver scarring (fibrosis) in children, potentially replacing the need for a liver biopsy. Researchers compared FibroScan results with biopsy results in 264 children aged 6 months to 18 years wi…

This study looked at 339 emergency room patients with suspected pneumonia to see if a chest CT scan could improve diagnosis. The goal was to find out if the CT scan changed the doctor's initial diagnosis, and if it led to changes in antibiotic treatment or hospital admission deci…

This study tested whether lung ultrasound can accurately check if a breathing tube is in the right place in children. 79 children who were already intubated and on a ventilator received both an ultrasound and a chest X-ray. The goal was to see if ultrasound could reliably detect …

This study looked at three new ways to diagnose bloodstream infections linked to central venous catheters in 148 critically ill children. The goal was to see if these methods could accurately detect an infection without needing to remove the catheter. The approaches included comp…

This study tested whether giving pregnant women with sickle cell disease oxygen at home every night could prevent painful crises and other serious complications. 178 women took part. The goal was to see if this simple approach reduces hospital stays and protects both mother and b…

This study tested whether warming the fluids given through an IV during a planned C-section can prevent mothers from getting too cold and shivery afterward. 75 healthy pregnant women took part. The results will help improve comfort and recovery after surgery.

This study looked at whether an educational program for pregnant women who are overweight or obese could help prevent their babies from gaining weight too quickly in the first two years of life. The program focused on healthy eating and lifestyle habits. The goal was to reduce th…

This study tested whether a high dose of erythropoietin, a drug that helps produce red blood cells, could prevent long-term brain damage in full-term newborns who suffered oxygen deprivation at birth. All 120 babies in the study received standard cooling therapy, and half also re…

This study looked at whether drinking toddler milk formula helps prevent iron deficiency in 2-year-old children in France. Iron deficiency can harm a child's brain development, thinking, and movement. Researchers studied 830 infants to see how formula use, along with diet and fam…

This study looked at whether testing people for COVID-19 just before a large indoor concert could keep the event from causing new infections. Over 6,600 healthy adults aged 18-45 either attended the concert after a negative test or stayed home. The goal was to see if the concert …

This study tested whether somatostatin works better than octreotide at preventing pancreatic fistula—a serious leak of digestive fluid—after pancreas surgery. Over 650 adults having their pancreas removed or partially removed took part. The goal was to see which drug reduces the …

This study tested two ways to give pneumococcal vaccines to adults with systemic lupus erythematosus (SLE). One group received a prime-boost strategy (conjugate vaccine first, then polysaccharide vaccine six months later), while the other got a placebo followed by the standard po…

This study tested the H1N1 flu vaccine in 439 people with cystic fibrosis to see if it prevents the flu and is safe. Participants included adults, children, pregnant women, and lung transplant recipients. Researchers measured immune response and tracked flu symptoms, using antivi…

This study looked at 160 top-level French athletes in sprinting, rugby 7, and bobsleigh to see if training adapted to each athlete's muscle properties could reduce lower-limb injuries. Researchers used advanced imaging and motion capture to design personalized strength and preven…

This study tested whether giving melatonin, a natural sleep hormone, could prevent delirium (sudden confusion) in elderly patients after surgery for a broken leg. About 357 people aged 70 and older took either melatonin or a placebo pill nightly from before surgery until five day…

This study tested whether nebivolol, a beta-blocker heart drug, could prevent heart failure in 51 boys aged 10-15 with Duchenne muscular dystrophy. Participants had normal heart function at the start and were randomly given either nebivolol or a placebo. The trial found that nebi…

This study tested whether hydroxychloroquine or azithromycin could prevent COVID-19 infection in hospital workers who were regularly exposed to the virus. 122 participants took one of the drugs or a placebo for 40 days. The study found no significant difference in infection rates…

This study looked at whether giving trauma patients a short course of antibiotics soon after injury can prevent ventilator-associated pneumonia (VAP), a common and serious lung infection. Over 2,100 adults on breathing machines were included. The goal was to see if early antibiot…

This study tested whether a low dose of interleukin-2 (IL-2), a protein that helps regulate the immune system, could improve depressive symptoms in people with bipolar disorder. Fourteen participants already on mood stabilizers received the treatment. The goal was to see if it in…

This study tested whether applying heat or cold during childbirth can lessen perineal pain after delivery. 115 women having their first vaginal birth took part. Researchers measured pain levels and healing to see if thermotherapy helps.

This study tested whether a gentle electrical current applied to the head at home could help reduce fatigue in people with multiple sclerosis. Ten adults with MS and long-term fatigue used the device. The goal was to see if this safe, non-invasive approach could ease tiredness an…

This study tested whether applying a Xylocaine (numbing) compress before a trigger finger injection reduces pain during the procedure. 60 adults with trigger finger took part in a double-blind trial where neither they nor the doctor knew who got the numbing compress. The main goa…

This study tested whether injecting steroids directly into the spinal disc can reduce chronic lower back pain caused by inflammation seen on MRI. 137 adults with persistent pain for at least 3 months received the injection. The goal was to see if pain levels dropped below a certa…

This study tested whether a technique called ischemic preconditioning, which is used to protect organs during transplants, could reduce fat tissue damage after breast reconstruction in 18 women who had mastectomies for breast cancer. The approach involves briefly cutting off and …

This study tested a device called ANI that measures pain during surgery in children having scoliosis correction. The goal was to see if using this monitor to guide pain medicine during the operation would lower the amount of morphine needed in the first 24 hours after surgery. 26…

This study tested whether using a PARO robot (a soft, interactive robot seal) could help prevent pain and distress in elderly people with moderate to severe dementia during daily nursing care. Ten participants living in nursing homes were given the robot before or during care to …

This study tested whether mangafodipir, an MRI contrast agent with antioxidant properties, could reduce nerve damage caused by oxaliplatin chemotherapy. Researchers enrolled 23 cancer patients who already had moderate nerve problems from oxaliplatin but needed to continue treatme…

This study tested whether a low dose of IL-2, a protein that helps calm the immune system, could reduce nasal symptoms in people with birch pollen allergy. Twenty-four adults with a history of seasonal hay fever received either the drug or a placebo and were then exposed to birch…

This study looked at whether giving a higher dose of oxytocin (a drug that helps labor progress) could lower the chance of needing a C-section in obese women having their first baby. Over 400 women participated, and doctors did not know which dose each woman received. The goal wa…

This study looked at whether giving a 7-day course of the steroid prednisone to emergency room patients with acute heart failure and high inflammation could reduce their C-reactive protein (CRP) levels. Only 3 people took part, and the main goal was to see how CRP changed from th…

This study looked at 304 children aged 2 to 17 with broken arm or leg bones who came to the emergency room in severe pain. Researchers wanted to see if giving paracetamol (Tylenol) or ibuprofen (Advil) along with morphine worked better than morphine alone. They measured pain leve…

This study looked at whether letting cataract surgery patients eat and drink normally before their procedure could lower their anxiety. 126 adults having their first cataract surgery under numbing eye drops were included. The goal was to see if a non-fasting approach reduces worr…

This small pilot study tested whether therapeutic gardening (horticulture) could reduce pain-related brain activity in 16 adults with chronic low back pain. Participants tried both gardening and handiwork sessions, and researchers used MRI scans to measure changes in a brain regi…

This study tested whether using a small temporary screw (miniscrew) in the jawbone works better than using other teeth as anchors to close gaps after removing two upper premolars. 99 people aged 12 to 50 who needed braces and tooth removal took part. The main goal was to see how …

This study looked at whether 6 weeks of osteopathic medicine (a type of hands-on body treatment) can reduce pain in people with fibromyalgia. 101 adults with long-term fibromyalgia took part. The main goal was to track pain levels weekly using a simple 0-to-100 scale, and also me…

This study tested whether a personalized, standardized rehabilitation program could improve the quality of life for people with systemic sclerosis (a disease that causes skin and joint stiffness). The trial involved 220 adults and compared the rehab program to usual care. The mai…

This study tested a website designed to help family caregivers of people with Alzheimer's disease. The program provided information about the illness, relaxation techniques, and a forum to talk with other caregivers. 49 caregivers took part to see if the program could reduce thei…

This study tested whether having a woman lie on one side (asymmetrical lateral decubitus) during labor can help turn a baby that is facing the wrong way (occipitoposterior position) into a better position for birth. The trial included 326 women in labor. The main goal was to see …

This study looked at whether taking oral corticosteroids for five days helps people with COPD who are having a flare-up. The goal was to see if it reduces the need for emergency doctor visits or hospital stays. The study involved 189 adults aged 40 and older who were treated in g…

This study tested whether adding a drug called droperidol to two standard anti-nausea medicines (ondansetron and dexamethasone) could better prevent vomiting after surgery in children at high risk. A total of 322 children aged 3 to 18 years took part. The main goal was to see if …

This study looked at whether a single antihistamine works as well as antihistamine plus steroids for treating sudden hives in the emergency department. 137 adults with acute hives (with or without mild swelling) took part. The goal was to see if adding steroids is necessary for s…

This study tested lithium as a treatment for social communication problems in children with autism spectrum disorder and Phelan-McDermid syndrome (a rare genetic condition). The goal was to see if lithium could reduce autism symptoms. The study included 22 children under 18. Rese…

This study aimed to find out which patients with severe frozen shoulder (adhesive capsulitis) respond best to a treatment that combines a special shoulder injection (arthrographic distension) with intensive physical therapy. Researchers enrolled 55 adults who had shoulder pain an…

This study tested whether a non-invasive brain stimulation technique called rTMS can reduce core symptoms of schizophrenia, known as first rank symptoms. 31 patients with schizophrenia who still had these symptoms despite medication took part. The study used brain scans to see ho…

This study tested whether resveratrol, a natural substance found in grapes and red wine, can reduce pain in people with knee osteoarthritis. 142 adults with painful knee arthritis took either resveratrol or a placebo pill daily for three months. The main goal was to measure chang…

This study tested whether art and movement workshops could help 8 children and teens with unexplained chronic pain who had been bullied at school. The program combined martial-arts-inspired dance with creating a street-art mural to rebuild confidence and ease pain. Results focuse…

This study tested whether breathing high-flow oxygen can quickly stop dystonic (stiffening) and plegic (paralysis) attacks in children with alternating hemiplegia of childhood, a rare genetic condition. Twenty-four participants used oxygen or a placebo at the start of an attack. …

This study tested a short program that combines education and rehabilitation for people with subacute or chronic low back pain. The goal was to reduce how much back pain limits daily activities. One hundred adults with low back pain lasting at least six weeks took part. The progr…

This study looked at whether using cervical dilators (tools to open the cervix) before medication can shorten labor for women ending a pregnancy in the second trimester. 355 women took part. The goal was to see if more women delivered within 12 hours with dilators compared to med…

This study tested whether a standardized osteopathic treatment works better than a placebo version for people with sub-acute or chronic low back pain. 400 adults aged 18 to 65 took part. The main goal was to see if the treatment improved daily function after 3 months.

This study tested whether wearing a daily weighted brace on the unaffected ankle helps people who have had a stroke walk farther. 42 participants who had a stroke more than 3 months ago and could walk a little without help were split into two groups: one wore a weighted brace, th…

This study explored whether art therapy can help people recover language after a stroke that damaged the left side of the brain. Fifteen stroke survivors with moderate to severe language problems took part. The goal was to see if activating the right brain through visual arts cou…

This study tested whether a self-hypnosis smartphone app could reduce attention problems and anxiety in 49 children aged 7–12 with ADHD, who were already taking medication. Children used the app 5 days a week for 6 weeks, and parents and kids filled out questionnaires to track ch…

This study looked at whether injecting botulinum toxin A (like Botox) into a groin muscle can help athletes with long-lasting groin pain that hasn't gotten better with other treatments. Twenty adults with chronic athletic pubalgia received one injection, and researchers tracked t…

This study tested whether a single injection of botulinum toxin A (like Botox) into the thumb joint, along with wearing a splint, can reduce pain from base-of-thumb osteoarthritis. Sixty adults with moderate to severe thumb pain took part. The main goal was to see if pain decreas…

This study tested whether a jaw-widening surgery helps adults with obstructive sleep apnea feel better day-to-day. Nine patients filled out quality-of-life questionnaires before surgery and again 3 months and 1 year after. The goal was to see if the surgery improved their sleep, …

This study tested whether a numbing gel (ropivacaine) can reduce severe pain during bath and dressing changes for children and young adults (up to age 21) with epidermolysis bullosa, a condition causing fragile skin. Ten participants applied the gel before dressing changes over f…

This study looked at whether 14 months of specialized medical follow-up and individual care can help people who say they are sensitive to electromagnetic fields. 79 adults took part, and researchers measured changes in symptoms, sensitivity, and quality of life using self-report …

This study tested a group program that teaches and supports family caregivers whose parent has moved into a nursing home. The goal was to reduce feelings of anxiety and depression that often come with this life change. 73 caregivers took part, and the program aimed to lower their…

This study tested whether a personalized home exercise program is practical for people with systemic sclerosis (scleroderma) who have early lung disease. Fifteen participants did one supervised session and then followed a 3-month home exercise plan. The goal was to see if patient…

This study looked at whether adding a sedative medicine (midazolam) under the tongue to standard oral morphine can reduce pain more effectively in children with arm fractures. Sixty children aged 5 to 16 were randomly assigned to receive either morphine plus midazolam or morphine…

This study tested whether using virtual reality to guide children into a hypnotic state could reduce their pain and anxiety during a sickle cell crisis. Twelve children aged 6 and older participated. Researchers measured pain scores before and after a virtual reality session. The…

This study tested a short therapy program for mothers who developed PTSD after a traumatic pregnancy or childbirth. The therapy, called Interaction Guidance Therapy, uses video feedback to help mothers bond with their babies. Researchers measured whether it improved maternal sens…

This study looked at whether adding relaxation sessions at home could help people with cystic fibrosis who have long-term pain. Thirteen patients received standard medical and psychological care plus guided relaxation exercises. The goal was to see if this combined approach could…

This study looked at how well supportive and palliative care works for infants under 1 year old with spinal muscular atrophy (SMA) type 1, a severe muscle-weakening disease. Researchers measured the use of oxygen therapy and breathing machines, and also interviewed parents about …

This study looked at whether having a therapy dog present during dental visits could help anxious autistic children feel calmer and complete their treatment. Fifty children aged 6 to 17 with autism and high dental anxiety took part. The goal was to see if two sessions with a dog …

This study looked at whether a personalized, multidisciplinary day-hospital program could improve quality of life for people with persistent symptoms after COVID-19. 80 adults with long COVID symptoms like fatigue, shortness of breath, or brain fog were assigned to either the pro…

This study tested a virtual reality device to see if it could reduce pain in adults with chronic low back pain that didn't respond to medication. 122 participants used the VR system, which creates a 3D environment with changing colors. The main goal was to measure pain levels aft…

This study tested whether inhaling tranexamic acid or terlipressin can quickly stop mild to severe coughing up blood (hemoptysis) without side effects. 315 adults were randomly assigned to receive one of the two drugs or a placebo. The goal was to see if these treatments could co…

This study tested a special stent with a magnetic end in 67 children with urinary tract problems or kidney transplants. The goal was to see if the stent could be removed in a clinic without general anesthesia, making the process easier and less scary for kids. The approach worked…

This study tested a device that sends mild electrical pulses to the ear to stimulate the vagus nerve, aiming to reduce pain and inflammation in people with erosive hand osteoarthritis, a painful and hard-to-treat arthritis. 148 adults with this condition used either the active de…

This study tested whether a 1.5-day program combining education and exercise is feasible for people with low back pain that hasn't improved with first treatments. 23 adults with subacute or chronic low back pain took part. The program aimed to reduce pain and fear of movement, an…

This study tested whether using near-infrared light to make veins visible helps doctors successfully draw blood or start an IV on the first try in children with hard-to-see veins. 163 children in the hospital or emergency room took part. The goal was to see if the light reduces t…

This study tested whether rituximab, a drug used for certain cancers and autoimmune diseases, can reduce joint pain and swelling in people with scleroderma (systemic sclerosis) who have arthritis. 22 participants with active arthritis took the drug. The main goal was to see if it…

This study looked at whether a program of education and exercises before total knee replacement surgery helps people recover function more quickly. 262 adults with knee osteoarthritis took part. The program aimed to improve the ability to get out of bed, walk, and climb stairs sh…

This study looked at whether listening to music during cataract surgery can help reduce anxiety and prevent spikes in blood pressure. 313 adults having the surgery under numbing eye drops took part. Researchers measured blood pressure and asked patients about their anxiety before…

This study looked at whether multi-family therapy (therapy with several families together) can help teenagers who refuse to go to school because of anxiety. 74 teens aged 12-18 who had been out of school for at least 2 weeks took part. The researchers measured anxiety and school …

This study tested whether hypnosis can help reduce pain during an ultrasound-guided liver biopsy. 70 adults were randomly assigned to receive either hypnosis or standard supportive care during the procedure. The main goal was to see if those who got hypnosis reported less pain.

This study tested a non-invasive brain stimulation technique called TMS in 20 young adults with autism. The goal was to see if stimulating a specific brain area could improve how they look at faces and interact socially. Participants received 10 daily sessions, and researchers me…

This study tested whether sitting cross-legged during epidural placement helps laboring women. It involved 457 women in France. The goal was to see if this position leads to successful placement on the first try without needing to adjust the needle.

This study tested whether cannabidiol (CBD) can reduce severe itching in 10 children with hereditary epidermolysis bullosa, a rare genetic condition causing fragile skin and painful blisters. The children took oral CBD three times daily for one month, and researchers measured cha…

This study looked at the types of fungi living on the head and neck skin of 30 adults with eczema (atopic dermatitis) compared to healthy volunteers. The goal was to understand if differences in the fungal community are linked to eczema in these areas. Researchers used advanced l…

This study looked at 400 couples to understand how diet, lifestyle habits like smoking and exercise, and genetics influence fertility. Researchers compared fertile and infertile couples to find nutritional factors that may help or hinder conception. No treatment was given; the go…

This study looked at over 3,000 women in France whose labor was started artificially (induced). Researchers compared different methods like medication or a small balloon to see which worked best and were safest for mothers and babies. The goal was to learn which methods are most …

This study looked at blood clots from 380 people who had a heart attack or sudden cardiac death. Researchers wanted to see if the age and makeup of the clot could explain why some people die suddenly while others survive. They compared clots from sudden death victims, heart attac…

This study looked at 150 children with severe hearing loss to find how many have a specific genetic condition called DFNB9. The goal was to better understand this form of deafness by checking children's hearing and doing genetic tests. The results will help doctors know more abou…

This study tested whether a special MRI technique can measure lung scarring (fibrosis) in people with scleroderma. 24 adults with scleroderma had MRI scans of their lungs while breathing in and out. The goal was to see if MRI could provide a safe, radiation-free way to track lung…

This study looked at 72 adults with high blood pressure to see if how well the kidneys concentrate urine is related to artery stiffness. Researchers measured urine concentration and used a simple test to check artery health. The goal was to better understand the connections betwe…

This study looked for genetic differences that might make some children and teens more prone to severe cavities. Researchers compared 390 participants—young patients with at least three active cavities and cavity-free young adults—to find mutations in genes linked to enamel struc…

This study looked at how the drug letermovir passes from a pregnant woman to her fetus during the second trimester. Seven women who were already scheduled to end their pregnancy for other reasons took part. The goal was to measure drug levels in fetal blood and amniotic fluid to …

This study followed 50 children who received one or two cochlear implants to see how their brain's response to sound relates to their speech and language skills after 3 years. Researchers measured brain waves and speech recognition to better understand how well the implants are w…

This completed study looked at how neutrophils (a type of white blood cell) behave in people with granulomatosis with polyangiitis, a rare blood vessel inflammation disease. Researchers compared blood samples from 93 patients and healthy donors to find proteins that could help pr…

This study looked at whether teenagers with restrictive eating disorders (like anorexia or ARFID) have different sensory experiences compared to healthy teens. Researchers used a questionnaire to measure sensory over- or under-reactivity in 29 adolescents. The goal was to better …

This study aims to establish normal blood tryptase levels for children from birth to age 18. Researchers will use leftover blood samples from 402 children already having routine blood tests during surgery. Knowing these normal ranges could help doctors diagnose mast cell diseases…

This study looked back at 91 children who had surgery to remove a malignant bone tumor from their leg and then had the bone rebuilt using one of three techniques: induced membrane, vascularized fibula, or fibula plus a bone graft. The goal was to compare how well each method help…

This study looked at 126 children and young adults (up to age 25) with serious, non-progressive brain conditions like cerebral palsy or traumatic brain injury. Researchers wanted to understand the best time to introduce a pediatric palliative care team. They reviewed medical reco…

This study followed 25 women with MRKH syndrome, a condition where the uterus and vagina are underdeveloped, to see how their quality of life changed 8 to 10 years after an earlier study. Participants completed surveys about their well-being and social and professional life. The …

This completed study looked at 472 pregnant women to find out what factors might make them refuse to join a clinical trial on early screening for pre-eclampsia. Researchers also asked women who agreed or declined to explain their reasons. The goal is to improve how future studies…

This study looked at whether measuring a blood marker called procalcitonin can help doctors decide when to stop antibiotics in newborns with late-onset sepsis. Over 500 infants were included to see if this approach reduces antibiotic use without increasing infection return or dea…

This study looked at different programs hospitals use to make sure antibiotics are prescribed correctly. Researchers studied 27 French hospitals to see which programs work best and are most cost-effective. The goal is to help hospitals choose the best ways to fight antibiotic res…

This study followed over 1,400 pregnant women with endometriosis to see how the disease affects pregnancy outcomes like preterm birth and other complications. Researchers compared different types of endometriosis to better understand risks. The goal was to provide clearer informa…

This study followed 601 adults who survived a cardiac arrest outside the hospital. Researchers wanted to learn how many survive long-term and how their quality of life and daily functioning are affected. The goal is to better understand what helps people recover and live well aft…

This study examined 33 preterm babies born before 30 weeks to mothers with preeclampsia. Researchers measured certain proteins in the mother's blood, umbilical cord blood, and amniotic fluid to see if they were linked to a lung condition called bronchopulmonary dysplasia (BPD). T…

This study looked at 116 people who had a cardiac arrest outside the hospital and were treated with a special heart-lung machine (ECMO). The goal was to see how well their heart function recovered over time. Researchers measured the heart's pumping ability at 28 days and again at…

This study looked at whether sending text message reminders to people over 50 who had a minor fracture could help them get a bone density test within 6 months. The goal was to improve screening for osteoporosis, a condition that weakens bones. The study involved 97 participants a…

This study looked at nearly 1,000 children who had both a tumor and a developmental problem (like a birth defect or learning delay) before age 18. The goal was to find new genetic syndromes that make kids more likely to get cancer. Researchers collected information from across Fr…

This study aimed to better understand a rare bowel disease called intestinal epithelial dysplasia (tufting enteropathy) by looking at the genes and physical traits of affected children. Researchers studied 41 children, ages 0 to 15, who were being evaluated for an intestinal tran…

This study looked at the gut bacteria and bile acids of 80 people—some with coronary artery disease and some healthy. Researchers wanted to see if differences in these gut-related substances might be linked to heart disease. The study was observational, meaning it only measured a…

This study looked at whether certain gene variations (ABCB1) make it harder for the brain to clear a protein called amyloid beta, which is linked to Alzheimer's disease. Researchers compared 510 people with and without Alzheimer's to see if these gene changes are more common in t…

This study looked at whether functional MRI (fMRI) can help doctors diagnose Auditory Processing Disorder (APD) in children aged 7 to 18. APD makes it hard for kids to understand sounds even though their ears work normally. Researchers compared brain scans of children with APD, c…

This study talked to 27 children (ages 6 and up) who have a parent with cystic fibrosis. Through interviews and small group discussions led by a psychologist, researchers aimed to understand their feelings, worries, and needs. The goal is to use this information to create better …

This study looked at how the antifungal medicine caspofungin is processed in the bodies of adults with serious burns. The goal was to find the best dose, since burns can change how drugs work. Only 2 people took part, so the results are very limited.

This study looked at mental health and thinking problems in 20 adults with Behçet's disease, a rare condition that causes inflammation in blood vessels. Researchers used questionnaires to measure anxiety, depression, tiredness, and quality of life. The goal was to better understa…

This study looked at medical records of 168 people with a rare type of digestive cancer called well-differentiated grade 3 neuroendocrine tumors. The goal was to compare how well different chemotherapy treatments work and to learn more about how the disease progresses. No new tre…

This study looked at 60 adults who were resuscitated after a cardiac arrest outside the hospital. Researchers analyzed the activity of all genes in their blood to see if it could predict how well their brain would recover 60 days later. The goal was to find early clues about neur…

This study looked back at 40 children who needed a heart-lung machine (ECMO) to survive. Researchers wanted to understand what brain problems they had and what raised the risk. They also checked how the children were doing one year later. This study does not test a new treatment—…

This study looked at how trouble controlling body temperature affects sleep in people with hypohidrotic ectodermal dysplasia (HED), a rare condition that limits sweating. Researchers compared sleep quality, body temperature, and melatonin levels in 22 HED patients and healthy vol…

This study followed 35 men with spinal cord injuries for 18 months to see how their sperm quality changes over time. Researchers looked at factors like bladder infections and inflammation that might harm sperm. The goal is to find ways to preserve fertility and reduce the need fo…

This study looked at tissue samples from 45 children under 8 who had surgery for a rare lung condition called CCAM. The goal was to find genetic and molecular changes that might cause the malformation. Researchers analyzed gene activity and protein patterns to better understand t…

This study looked at how epilepsy medicines behave in children aged 0 to 18. Researchers used data from 753 kids to build computer models that predict drug levels based on factors like age, weight, and genetics. The goal is to help doctors give the right dose to each child, reduc…

This study looks at children born very early who received either hydrocortisone or a placebo in the PREMILOC trial. Now aged 7 to 13, researchers measure their blood vessel stiffness and blood pressure to see if the drug had any lasting effects. The goal is to understand long-ter…

This study looked at 1,701 first-time mothers to see if a more relaxed approach to the pushing phase of labor is as safe as the usual intensive method. The researchers compared newborn health and delivery outcomes between the two approaches. The goal was to find out if a less int…

This study looked at how well patients and doctors understand each other after an emergency room visit. Over 1,800 adults from 14 hospitals took part. Doctors and patients each filled out a questionnaire separately, and their answers were compared to see if they agreed on key poi…

This study followed 530 working-age adults (18-70) who were hospitalized with COVID-19 to see how disability changes over time. Researchers measured physical and mental impairments, activity limits, and social participation using standard checklists at 12 and 36 months after leav…

This study looked at 225 adults with a rare, inherited form of kidney disease to find the genetic causes. Participants had chronic kidney failure and often had a family history of gout. Researchers tested for known gene mutations and searched for new ones in families without a cl…

This study looked at how hemodialysis changes the electrical properties of skin and muscle in 18 adults on chronic dialysis. Researchers measured these changes to better understand fluid shifts during treatment. The goal was to gather knowledge, not to test a new treatment.

This study followed 512 children born to parents with type 1 diabetes to see if early immune system changes and other factors could predict who might develop the disease. Researchers looked at blood markers, gut bacteria, and family environment. The goal was to better understand …

This study tested a new set of guidelines to help doctors decide when babies under 2 years old with minor head injuries really need a CT scan. Over 8,800 children took part across multiple hospitals. The goal was to see if the rule could safely reduce the number of scans, avoidin…

This study reviewed the medical records of 980 children who had surgery to repair a hole in their eardrum. The goal was to see how well the eardrum healed and how much hearing improved after the operation. Researchers looked at exams and hearing tests done 9 to 18 months after su…

This study looked at how often brainstem problems occur in COVID-19 patients who are on breathing machines and deeply sedated in the ICU. Researchers checked for nerve issues using a special scale. The goal was to learn more about the virus's effects on the brain, not to test a t…

This study tested an artificial intelligence system that helps doctors decide when and how much fluid to give during high-risk abdominal surgery. The goal was to see if using this tool could reduce serious complications like kidney injury, infections, or heart problems within 30 …

This study looked at 36 children with neuromuscular scoliosis (a spine curve caused by muscle or nerve problems) who had a special surgery that doesn't fuse the bones. Researchers used ultrasound to measure how stiff the spine's discs and muscles became over time. The goal was to…

This study looked at how often early blood clots form after placing a central venous catheter (a special IV) in children in the intensive care unit. Researchers used ultrasound to check for clots in 81 children. The goal was to better understand how common these clots are and wha…

This study looked at the experiences of 50 family caregivers of people with systemic sclerosis (scleroderma), a rare and serious disease. Researchers wanted to understand how caregiving affects caregivers' physical, mental, and social health. The goal is to use this information t…

This study looked at 25 children and adults with FOXP1 syndrome, a rare genetic condition that affects development. Researchers used detailed interviews and questionnaires to measure symptoms like hyperactivity, anxiety, autism traits, and unusual sensory experiences. The goal wa…

This study looked at how doctors, nurses, and physiotherapists in community health teams experienced the COVID-19 epidemic. Researchers interviewed 62 healthcare workers to understand how the outbreak affected their work, personal life, and the challenges they faced. The goal was…

This study looked at how hard children with heart failure work to breathe and how well they sleep. Researchers tested whether using a CPAP mask (a device that pushes air into the lungs) during wakefulness could make breathing easier and improve heart function. The study involved …

This study looked at how endometriosis affects egg development and quality. Researchers analyzed fluid from around the eggs and cells from the egg's support layer in 16 women. The goal was to find clues that could explain infertility in women with endometriosis.

This study looked at 99 women with primary immune deficiency who had been or tried to become pregnant. Researchers tracked infections and pregnancy outcomes to better understand how to manage these patients. The goal was to gather information to help doctors provide better care, …

This study reviewed medical records of 70 children under 18 who had a stroke and received treatments like clot-busting drugs or mechanical clot removal. Researchers measured how quickly treatment was given and whether complications like bleeding occurred. The goal was to understa…

This study tested whether the Montreal Cognitive Assessment (MoCA), a short screening tool, can reliably detect cognitive (thinking) problems in adults with sickle cell anemia. Researchers compared MoCA results with a full set of detailed neuropsychological tests in 65 participan…

This study looked at 146 children already taking steroid medications (prednisone, prednisolone, methylprednisolone, or hydrocortisone) to understand why drug levels vary so much between individuals. Researchers measured how the body processes the drug and checked for genetic diff…

This study looked at how a specific type of spinal surgery (from the upper back down to the pelvis) changes the way children with scoliosis walk. Six children under 18 who could walk or stroll were followed for 6 months after surgery. Researchers measured walking quality, enduran…

This study tested whether using a checklist could lower the number of surgeries canceled at the last minute. Over 4,000 patients scheduled for same-day surgery took part. The main goal was to see if the checklist helped reduce cancellations and improve how the surgery unit runs.

This study looked at how the heart medication amiodarone behaves in children aged 0 to 18 with heart rhythm problems. Researchers measured drug levels in the blood to understand dosing and safety. The goal is to find the best dose for kids, since there is no standard yet. 57 chil…

This study looked at whether using physical restraints (like wrist straps) less often in the ICU could shorten the time patients on breathing machines experience delirium (confusion). Over 400 adults from six hospitals were randomly assigned to either routine restraint use or res…

This study looked for special molecules in vaginal fluid that might show if a pregnant woman is about to go into labor early. Researchers studied 238 women to find clues that could help doctors predict and manage preterm birth. The goal is to develop a simple test to improve care…

This study looked at whether changing how prescriptions are written (like using words instead of numbers) helps people over 75 make fewer errors when organizing their daily pills. 64 hospitalized older adults with mild or no memory problems were asked to fill pillboxes using diff…

This study looked at 73 families with a child born with an isolated diaphragmatic hernia (a hole in the muscle that helps breathing). Researchers used advanced genetic testing to search for new or inherited gene changes that might cause the condition. The goal was to better under…

This study tracked 120 children with asthma to see how they used emergency inhalers at home during asthma attacks. Parents used a smart inhaler and a mobile app to report symptoms and treatments. The goal was to gather real-world data to create better, more practical asthma actio…

This study looked at how often heart iron buildup happens in people with thalassemia, sickle cell disease, or myelodysplasia who receive many blood transfusions. Researchers used MRI scans to measure iron in the heart and liver. The goal was to understand the problem better, not …

This study looked at 98 girls with RETT syndrome to understand why they often develop weak bones at a young age. Researchers checked bone density, looked for risk factors like diet and medication, and measured proteins linked to bone health. The goal was to find clues that could …

This study looked at whether a special training course on doctor-patient relationships can help 4th-year medical students keep or improve their empathy and emotional skills. Over 400 students took part, and the researchers measured changes using questionnaires and simulated patie…

This study looked at rhabdoid tumors at the single-cell level to understand why they differ from child to child and resist treatment. Researchers analyzed tumor samples from 15 children to identify different cell types and potential targets for new therapies. The goal was to gath…

This study looked at 240 people with ciliopathies—rare genetic disorders that often lead to kidney failure. Researchers analyzed genes and proteins from patient cells to find patterns that could predict how the disease will progress. The goal is to create a test that helps doctor…

This study analyzed data from 249 adults with blood cancers like lymphoma and leukemia who received immunotherapy. The goal was to find markers that could predict how well a patient would respond to treatment and whether they would experience severe side effects. By identifying t…

This study asked 307 children with asthma, their parents, and their doctors to rank what they want most from daily asthma treatment—like preventing attacks or making medicine easier to take. The goal was to understand everyone's priorities so future computer programs can help man…

This study aimed to find risk factors for osteoporosis in people with cystic fibrosis. Researchers took blood samples to study monocytes, which can turn into osteoclasts—cells that break down bone. They also tested how CFTR modulators affect these bone cells. The study included 2…

This study looked at whether listeria infection during pregnancy or shortly after birth can cause long-term brain problems in children. Researchers compared 53 children who had listeria with a control group, testing their thinking, movement, and behavior. The goal was to understa…

This early-phase study tested whether a single injection of plerixafor could safely and effectively mobilize stem cells for collection in 3 adults with severe sickle cell disease who lacked a matched sibling donor. The goal was to see if enough stem cells could be gathered for a …

This study looked at whether showing patients a short video, along with the usual written information, helps them understand what will happen during a medical test like a scan or a tube insertion. About 97 adults with infectious diseases took part. The goal was to see if the vide…

This study tested a new way to create 3D models of the head and neck area in young children (ages 1 to 5) who have tumors or birth defects. The models show where important nerves are located, which could help surgeons plan operations more carefully. Seven children participated, a…

This study followed teenagers who were born very small (very low birthweight) to see how their lungs developed. Researchers measured their breathing and compared it to full-term babies. The goal was to understand long-term respiratory health in this group.

This study looked at whether certain immune system markers (autoantibodies) are linked to how pulmonary arterial hypertension (PAH) progresses. Researchers tested blood samples from 629 adults with different types of PAH, including those with HIV, congenital heart defects, and co…

This study looked at why children with hereditary epidermolysis bullosa (a rare condition causing fragile skin and painful blisters) often do not take prescribed opioid painkillers before baths and bandage changes. Researchers interviewed 10 children and their parents to understa…

This study surveyed 257 adults with sickle cell disease to find out how many use strong painkillers (opioids) or cannabis for pain at home. Researchers wanted to measure how common opioid addiction is in this group. The goal is to better understand the problem so doctors can offe…

This study looked at whether gently pressing on the front of the chest can improve how air and blood move in the lungs of people with severe acute respiratory distress syndrome (ARDS). Twenty adults on breathing machines took part. Researchers used special imaging to measure lung…

This study tested whether 3D ultrasound can accurately measure kidney and tumor volumes compared to standard CT or MRI scans. 53 adults with chronic kidney disease or kidney tumors participated. Researchers compared 3D ultrasound measurements to those from contrast-enhanced CT or…

This study used a special MRI technique to look at the spinal cord in 40 adults with cervical spondylosis, a type of arthritis in the neck. The goal was to see if changes in the spinal cord relate to symptoms like muscle weakness or numbness. Participants had an MRI and physical …

This study looked at whether a simple urine test could predict kidney scarring (fibrosis) after a kidney transplant, instead of using a needle biopsy. Researchers measured certain genetic markers in the urine of 300 kidney transplant recipients over the first year after surgery. …

This study tested whether training emergency room staff could reduce the number of IV catheters placed but never used. Over 500 patients were observed before and after the training. The goal was to lower patient risks like bruising or infection and save time and money.

This study looked at 20 children with a rare lung condition called pulmonary alveolar proteinosis (PAP) caused by changes in the MARS gene. Researchers wanted to understand if the lung cleaning cells (macrophages) are not working properly. They grew these cells in a lab from bloo…

This completed study looked at 526 pregnant women in France to find out what factors make them more likely to refuse joining a randomized clinical trial about pregnancy and childbirth. Researchers collected information on age, education, medical history, and how the study was exp…

This study looked at how attention and daydreaming influence obsessive thoughts in people with Obsessive Compulsive Disorder (OCD). Researchers compared 80 participants—some with OCD and some without—to see if obsessions change depending on how much the mind wanders. The goal was…

This study looked back at medical records of 2,740 adults with type 2 diabetes who were admitted to the ICU for septic shock, a life-threatening infection. Researchers wanted to see if those who were already taking metformin (a standard diabetes pill) before getting sick had a lo…

This study looked at how HIV medications behave in 65 children from birth to 18 years old. Researchers used blood samples and computer models to understand how factors like weight, age, and other medicines affect drug levels. The goal was to help doctors choose the right dose for…

This study examined the reasons why people with Parkinson's disease end up in the hospital after visiting the emergency room. Researchers looked at data from over 2,500 patients to understand what health problems lead to their hospitalization. The goal was to learn more about the…

This study looked at whether women with primary immunodeficiencies (weakened immune systems) face a higher risk of serious infections, like epidural abscess or meningitis, after receiving epidural or spinal anesthesia during childbirth. Researchers followed 30 women from a nation…

This study looked at 21 children and young adults with Moyamoya disease, a rare brain vessel condition that causes strokes. Even after surgery, many still have headaches and other symptoms. Researchers used questionnaires to measure anxiety, depression, and family relationships, …

This study looked at 57 adults with mild or no COVID-19 symptoms to understand how their immune system responds to the virus. Researchers measured immune markers and how quickly the virus cleared from the body. The goal was to learn why some people fight off the infection easily,…

This study looked at how many children of hospital workers had antibodies against the virus that causes COVID-19. Researchers tested blood and saliva samples from 563 family members to see if a parent's infection status affected the child's risk. The goal was to better understand…

This study examined the immune systems of 29 full-term newborns whose mothers took anti-integrase HIV drugs during pregnancy, comparing them to babies exposed to other HIV medications. The goal was to see if the type of drug affects the diversity of immune cells at birth. The fin…

This study involved 422 pregnant women who developed a fever during labor. Researchers wanted to find out how often fever is caused by an infection in the mother or baby, and what factors predict that. By analyzing medical data from three hospitals, the goal is to help doctors de…

This study followed 85 adults who survived severe COVID-19 and needed a breathing machine in the ICU. Researchers tracked their thinking, movement, and emotional health as they moved from hospital to home. The goal was to better understand the challenges these patients face durin…

This study looked at whether a special type of scan (PET/CT) can help doctors see if treatment for a serious fungal lung infection is working earlier than usual. It involved 51 adults with blood cancer and invasive pulmonary aspergillosis. The goal was to see if the scan results …

This study looked at specific immune cells in the esophagus of children with eosinophilic esophagitis (EoE) compared to healthy children. Researchers counted these cells and also studied the microbiome. The goal was to better understand the disease, not to test a treatment. 35 ch…

This study looked at how a specific layer of the eye (the pigment epithelium) works in people with neurofibromatosis type 1. Researchers used special eye tests to measure electrical signals and took detailed images of the back of the eye. The goal was to understand if certain bri…

This study measured how well children with hearing aids or cochlear implants hear in everyday situations. Researchers used a special questionnaire called PEACH with 130 children aged 2 to 10. The goal was to compare hearing quality between different types of devices and find ways…

This study tracked severe Group A Strep infections in 269 children admitted to a Paris hospital from 2018 to 2023. Researchers compared infection rates before, during, and after COVID-19 restrictions like mask-wearing and lockdowns. The goal was to understand how these measures i…

This study looked at whether an exercise test can be used to monitor treatment in 27 people with rhabdomyolysis (severe muscle breakdown) caused by inherited metabolic diseases. Researchers measured heart function and oxygen use during exercise to see if these tests could track d…

This study looked at children with mild, delayed allergic reactions to betalactam antibiotics (like amoxicillin). Researchers compared a short (1-4 day) versus a longer (5-8 day) oral drug challenge to see if the longer test increased the growth of resistant bacteria in the gut. …

This study looked at how phenelzine, a monoamine oxidase inhibitor, affects immune cells in 51 adults with COVID-19. Researchers measured changes in T cells and monocytes to understand immune activation. The goal was to gather knowledge, not to treat or cure the disease.

This study observed 5000 cataract surgery patients to see if using a special handpiece (Active Sentry) makes the procedure safer. The handpiece helps control pressure inside the eye during surgery, which may reduce the amount of energy needed and lower the risk of complications. …

This study followed 46 obese men who had weight-loss surgery (gastric banding, bypass, or sleeve gastrectomy). Researchers checked their sperm quality and other health factors before and after surgery to see if losing weight improved fertility. The goal was to understand how bari…

This study followed 14 people who called a special crisis hotline after terrorist attacks in Paris, London, Barcelona, and Strasbourg. Researchers wanted to see how their symptoms of post-traumatic stress and depression changed over time and what kind of help they sought. The goa…

This study looked at whether giving a small, fast fluid injection (mini-bolus) can help predict if a child with septic shock will benefit from more fluids. It included 11 children on breathing machines in intensive care. The goal was to find a simple way to guide fluid treatment …

This study looked at 54 children with severe asthma to better understand the different types of the disease. Researchers analyzed immune cells, lung tissue, and microbes from samples taken during a routine bronchoscopy. The goal was to identify patterns that could lead to more pe…

This study looked at how the HIV drug tenofovir passes from mother to baby through the placenta. Researchers used a lab model with placentas from 369 healthy pregnant women to measure drug levels and gene activity. The goal was to understand what affects drug transfer, not to tre…

This study looked at how cystinosis affects muscles, breathing, and swallowing in 20 adults and teens aged 16 and older. Participants had tests like walking, muscle strength, and sleep assessments over a year. The goal was to better understand the disease's progression, not to te…

This study looked at how families experience being told their child has craniosynostosis, a condition where skull bones fuse too early. Researchers surveyed and interviewed 574 parents and older children to understand the emotional impact and improve the process. The goal is to m…

This study looked at 45 pregnant women having planned C-sections to see if a simple finger sensor (measuring perfusion index) could predict dangerous drops in blood pressure after spinal anesthesia. The goal was to find an easy, non-invasive way to identify high-risk patients so …

This study looked at 70 patients who had a stem cell transplant for blood cancer. The goal was to understand how the complement system, a part of the immune system, is linked to a serious side effect called graft-versus-host disease (GvHD). By analyzing blood samples, researchers…

This study examined 20 children under 18 who were in intensive care with heart inflammation (myocarditis) and possible COVID-19. Researchers aimed to describe the symptoms and lab results, and to figure out whether the virus directly damages the heart or if the body's own immune …

This study looked at 45 people with patellofemoral pain syndrome (front knee pain) to see if different types of the condition have unique movement problems. Researchers used a non-invasive device to measure how the thigh and shin bones rotate during walking. The goal was to bette…

This study involved 39 adults and children with six types of autoinflammatory diseases (such as FMF and Still's disease). Researchers conducted interviews to understand how these conditions affect daily life and well-being. The goal was to create a questionnaire that doctors can …

This study looked at tumor samples from 44 children with a rare and aggressive cancer called rhabdoid tumor. Researchers used advanced protein analysis to understand differences between tumors, hoping to identify new targets for future treatments. No experimental therapy was give…

This study looked at 142 children aged 5-6 to see if their mothers' vitamin D levels early in pregnancy were linked to how well their lungs worked. Researchers measured airway resistance, a sign of breathing difficulty, and compared kids whose mothers had low vitamin D (<20 ng/ml…

This study followed 80 people newly diagnosed with Cushing's disease to see how the condition affects the heart, bones, metabolism, and quality of life over three years. Researchers checked for complications before treatment and every year after, especially after pituitary surger…

This study looked at whether alendronate, a common osteoporosis medication, affects how well the jawbone heals after a tooth extraction in postmenopausal women. Researchers compared bone healing in 66 women who took the drug and those who did not. The goal was to see if the medic…

This study looked at 20 infants with severe bronchiolitis (a serious lung infection) to compare two types of breathing support: CPAP and NiPPV. The goal was to see which method reduces the effort of breathing more effectively. Researchers measured breathing effort using a special…

This study follows 179 children aged 4 to 16 who were born from twin pregnancies complicated by twin-to-twin transfusion syndrome (TTTS). Researchers want to see if the condition during pregnancy affects heart, kidney, and metabolic health later in childhood. No new treatments ar…

This study looked at 204 adults with hemophagocytic syndrome, a rare condition where the immune system becomes overactive and damages the body. Researchers checked blood markers and symptoms to better understand what causes the disease in adults. No new treatment was tested; the …

This study tested a new questionnaire called ORALQUEST, designed for parents of children aged 9 months to 6 years who have feeding or eating disorders. The tool looks at four areas: behavior, mouth motor skills, sensory sensitivity, and family environment. Researchers worked with…

This study looked at whether giving parents a simple information leaflet about fever before seeing a doctor in the pediatric emergency room helps them better understand how to manage their child's fever. 220 parents of children with fever took part. The goal was to see if the lea…

This study aimed to understand why people with Lowe syndrome experience unusual bleeding. Researchers tested the function of platelets (blood cells that help clotting) in 30 patients with Lowe syndrome. The goal was to confirm and characterize platelet problems, which could lead …

This study looked at whether a simple 6-minute walk test can help predict how long people with cystic fibrosis will survive without needing a lung transplant. Researchers followed 291 adults with cystic fibrosis and measured how far they could walk and how their oxygen levels cha…

This study looked at how much taxi drivers are exposed to tiny air pollution particles (ultrafine particles and black carbon) inside their cabs during a workday. Researchers measured the air in the taxi and tested drivers' breathing before and after their shift. The goal was to s…

This study looked at whether low vitamin D levels in the first trimester of pregnancy are linked to developing preeclampsia later on. Researchers measured vitamin D in over 3,000 pregnant women in France and compared those who developed preeclampsia with those who did not. The go…

This study looked at whether measuring a hormone called pancreatic polypeptide can help doctors tell the difference between type 1 diabetes and type 3c diabetes (diabetes caused by pancreas damage). Thirty-six adults with either type 1 or type 3c diabetes had their pancreatic pol…

This study looked at how the lining of blood vessels (endothelium) might be involved in stroke-like episodes in people with Congenital Disorders of Glycosylation (CDG). Researchers measured how leaky the blood vessel lining was and checked proteins that help control blood clottin…

This study tested whether analyzing a patient's DNA and RNA can help doctors choose the right targeted therapy for hard-to-classify inflammatory diseases affecting multiple organs. 32 adults with such conditions were enrolled. The goal was to see if molecular mapping could predic…

This study looked back at 84 cases of sacrococcygeal teratoma, a rare tumor near the tailbone in fetuses and infants. Researchers wanted to find clues that predict how the tumor will behave, whether it will come back, or cause long-term problems like bowel or bladder issues. The …

This study measured levels of two related proteins, IGF-I and IGFBP-3, in the blood of 693 older adults. Researchers compared people with Alzheimer's disease, those with mild memory problems, and healthy older adults to see if these protein levels relate to thinking and memory. T…

This study looked at 57 people who had a stem cell transplant for blood cancer. Researchers measured certain immune cells in the blood to see if they could predict a serious side effect called graft-versus-host disease (GVHD). The goal was to find patterns that could help doctors…

This pilot study looked at 13 adults with shoulder pain (subacromial pain syndrome) to see if their arm movement speed changed after a 4-session rehab program. Researchers used a 3D motion tool to measure speed and smoothness during arm raises. They also checked if changes in spe…

This study looked at how a baby's gut bacteria and immune system might help a dangerous type of Group B Strep (GBS) grow. Researchers tested 151 pregnant women for GBS in vaginal and fecal samples. The goal was to understand why some newborns get severe infections, not to test a …

This study measured eye dominance, an angle called lambda, and how eyes align in 76 healthy adults. The goal was to see if these measurements are connected. Understanding these links could help doctors plan eye surgeries and exams better.

This study looked at whether a 15-second pause in breathing (called an end-expiratory occlusion test) can predict if giving fluids will help infants under 2 years old who are in shock and on a breathing machine. Ten infants in intensive care were included. The goal was to see if …

This study looked at 501 adults with severe liver disease (decompensated cirrhosis) who were on the national transplant waiting list. The goal was to create new mathematical models that better predict who is at highest risk of dying while waiting for a liver. By combining known a…

This study looked at how patients with advanced cancer respond to being offered a conversation about their future care preferences. Researchers invited 71 patients to discuss their wishes and tracked who took part. The goal was to learn more about what helps patients feel ready t…

This study followed 60 heart transplant recipients for one year to see if the amount of a harmless virus called TTV in their blood could predict infections or organ rejection. Researchers measured TTV levels monthly and compared them to actual complications. The goal is to find a…

This study compared two types of imaging—ultra-low-dose CT and lung MRI—to see how well they show lung damage in adults with cystic fibrosis. 185 adults took part, and researchers checked if MRI could give similar results to the standard low-dose CT. The goal is to find a way to …

This study looked at 156 people with type 1 diabetes to see if measuring immune cells that attack insulin-making cells could be a simpler way to track how many of those cells remain. Currently, doctors use a long meal test to check insulin production, but it's not very sensitive.…

This study tested a new evaluation plan for a program that teaches parents how to care for children who need nutrition through a tube at home. Eleven parents took part to see if the evaluation helped them learn better. The goal was to improve the education program for future fami…

This study looked at whether giving healthy volunteers a small amount of their own stored blood (200 ml) causes detectable changes in blood cells and particles. Researchers analyzed blood samples before and after transfusion to find markers that could reveal this type of doping i…

This study looked at whether a special type of PET scan can help doctors decide the best treatment for a rare fungal infection in the liver and spleen. It involved 100 adults with blood cancer or those who had a stem cell transplant. The goal was to see if the scan could track ho…

This study looked at how children aged 10 to 16 with a missing outer ear (ear aplasia) feel about their condition and how reconstructive surgery affects their emotions and thinking. Researchers used interviews and psychological tests to understand their mental state before and af…

This study looked at how well a muscle relaxant called atracurium works for inserting a breathing tube when doctors wait exactly three minutes after giving the drug. It involved 100 adult women having planned gynecological surgery under general anesthesia. The goal was to see if …

This study looked at whether having a well-organized emergency system helps more people survive severe injuries. Researchers compared death rates within 28 days for over 2,000 patients treated in structured versus non-structured systems. The goal was to see if a coordinated appro…

This study looked at 50 adults having thyroid or parathyroid surgery to see if a muscle relaxant called rocuronium wears off quickly enough to allow nerve monitoring during the operation. Doctors used the drug to make intubation easier, then checked if the nerves recovered in tim…

This study looked at immune cells (T cells, NK cells, and macrophages) inside melanoma tumors from 217 patients. The goal was to understand how these cells affect the body's ability to fight the cancer and how chemotherapy might change them. It was an observational study, not a t…

This study looked at 60 babies who had heart surgery for a condition called transposition of the great vessels before 6 months of age. Researchers measured how often severe sensory integration disorders (problems processing sights, sounds, and touch) occurred one week after surge…

This study checked if a French translation of a quality-of-life questionnaire for children with chronic sinusitis works correctly. Researchers asked 89 children (ages 2-12) and their parents to fill out the survey twice, two weeks apart. The goal was to make sure the French versi…

This study looked at two important eye measurements, called angle kappa and angle alpha, in 70 healthy adults. The goal was to see how these angles relate to each other, which could help doctors plan eye surgeries and exams more accurately. Participants had their eyes photographe…

This study looked at 237 women having IVF to see if using frozen embryos instead of fresh ones leads to more live births. The idea is that freezing embryos may give the womb a better chance to accept them. The main goal was to compare live birth rates between the two methods.

This study looked at how blood clots in people with liver cirrhosis, a condition that can cause dangerous bleeding. Researchers used a special machine called T-TAS to measure clotting in blood samples from 60 patients. They also tested whether tiny artificial particles that act l…

This study followed 100 adults who had brain lesions from a serious heart infection (infectious endocarditis). Researchers used MRI scans and thinking tests to see how these brain spots changed over time and if they affected memory or daily life. The goal was to understand the lo…

This study looked at how a specific, more dangerous type of Group B Strep bacteria (called ST17) spreads in newborns' digestive systems. Researchers followed nearly 950 mothers and their babies to see if this strain sticks around longer than other types. The goal was to better un…

This study tested French versions of three questionnaires (PEACH, SSQ-C, SSQ-P) in 101 children and teens with and without deafness. The goal was to see if these tools can reliably measure hearing performance and quality of life in French-speaking kids. The results will help doct…

This study looked at how blood clotting works in 57 people with congenital disorder of glycosylation (CDG), a rare genetic condition. Researchers used a special test to measure clotting balance, without giving any treatment. The goal was to better understand the clotting problems…

This study looked at 558 children and adults with congenital hypothyroidism (a thyroid condition present at birth) to find genetic causes. Researchers compared patients' genes with their medical and imaging results to better understand why the condition occurs and what other heal…

This study looked at how many infertile women have migraines and how those headaches change during IVF treatment. Researchers followed 137 women aged 18-40 at a fertility center. The goal was to understand the link between hormone changes from IVF and migraine attacks.

This study tested a new breathing aid called continuous anterior chest compression (CACC) in 20 adults with severe lung injury (ARDS). Researchers compared CACC to the standard prone (face-down) position to see if it improved lung function. The goal was to gather data on safety a…

This study looked at whether it's possible to teach diabetes self-care to inmates in a Paris prison. Twenty-two men with type 1 or type 2 diabetes were invited to take part in educational workshops. The main goal was to see how many would attend at least two sessions, and to chec…

This study looked at 119 children who had platinum-based chemotherapy for certain cancers. Researchers wanted to find out if certain genes make some kids more likely to develop hearing loss from the treatment. By analyzing DNA from saliva samples, they hope to identify high-risk …

This study looked at whether explaining the potential harms of chemotherapy—including how it can worsen life-threatening conditions—helps patients with incurable stage IV lung cancer avoid unnecessary chemo near the end of life. 123 patients were randomly assigned to receive eith…

This study looked at 90 adults with Marfan syndrome to see how dural ectasia (a widening of the spinal sac) affects their symptoms and daily life. Researchers compared those with dural ectasia to those without, focusing on back pain, headaches, and activity limits. The goal was t…

This study looked at 145 people who had an allergic or non-allergic reaction during surgery. Researchers wanted to find out which signs, like skin changes or heart rate, could tell the difference between a true allergy and a non-allergic reaction. The goal is to help doctors trea…

This study looked at whether heart rate patterns and pupil reactions can objectively measure anxiety in patients before day surgery. 71 adults scheduled for day-case surgery were monitored before and during a small procedure (cannulation). The goal was to see if these simple, non…

This study tested a French version of a questionnaire that helps children describe dizziness and balance problems. Researchers worked with 85 children aged 7 to 17, including those with dizziness and healthy controls. The goal was to make sure the translated questionnaire is accu…

This study tested whether a special high-flow nose tube (HFNO) keeps oxygen levels better than a standard facemask during anesthesia in children under 11. It involved 44 kids having surgery that required a fast-acting anesthesia. The goal was to see which method prevents oxygen d…

This study tested a new ultrasound technique called ultrasound localization microscopy (ULM) to see very small arteries in the brain. Researchers used it on 24 people who had a stroke or Moya Moya disease. The goal was to see if ULM could find more tiny arteries than standard MRI…

This study followed 206 very premature babies (born before 32 weeks) to see how early nutrition, including mother's milk, healthy fats, and iron, relates to their brain development. Researchers measured development using a standard questionnaire. The goal was to understand which …

This study looked back at the records of 203 adults hospitalized with pneumonia caused by Haemophilus influenzae bacteria. The goal was to find out why some patients had a repeat infection soon after treatment and what factors made the illness more severe. Researchers hope these …

This study looks at how growth hormone treatment affects the quality of life of short children once they reach their final adult height. Researchers will ask 36 teens and young adults, along with their parents, to fill out questionnaires about physical, emotional, and social well…

This study looked at scalp ringworm, a common fungal infection in children, across 11 French hospitals. Researchers collected samples from 701 patients to identify which fungi were causing the infections and whether they were resistant to common antifungal drugs. The goal was to …

This study looked at 47 people with a rare condition called Idiopathic CD4 Lymphocytopenia (ICL), where the body has too few CD4 immune cells, making them prone to serious infections. Researchers aimed to confirm diagnoses and describe patients' immune profiles and health over ti…

This study looked at how faithfully people with active lupus take their medication, especially hydroxychloroquine. Researchers measured drug levels in the blood of 307 patients across multiple countries. The goal was to understand how common it is for patients to skip doses, whic…

This study looked at whether the seasonal flu vaccine works as well in people with sarcoidosis, an inflammatory disease, as it does in healthy people. Researchers enrolled 190 adults aged 18-65 with sarcoidosis and a control group of healthy volunteers. They measured immune respo…

This study looked at how physical therapy and rehabilitation departments function by interviewing 63 people, including doctors, nurses, and patients. The goal was to find ways to improve communication and patient care. No new treatments or drugs were tested—just gathering ideas t…

This study looked at how the steroid drug prednisone is processed by the body in 114 adults taking it for at least 3 months. Researchers measured drug levels in the blood and linked them to side effects like bone loss and infections. The goal was to better understand how the drug…

This study looked at what makes intensive care and pediatric nurses feel their workload is high. Researchers surveyed 484 nurses to measure mental demands, physical effort, time pressure, and frustration. The goal is to understand these factors to help improve working conditions …

This study looked at whether the measles vaccine virus can be found in the breast milk of women who received the MMR vaccine shortly after giving birth. Fourteen breastfeeding mothers with no immunity to measles or rubella were vaccinated, and their milk was tested over two weeks…

This study tested blood and urine samples from 100 adults who filed a police complaint for suspected chemical submission (being secretly given drugs). Researchers compared lab results with medical exams to find out how many cases were confirmed and which substances were used. The…

This study tested a simple method to see if giving extra fluids would help patients on breathing machines who are in shock. Doctors used a short increase in breathing machine pressure (PEEP test) to predict fluid needs. The goal was to avoid unnecessary fluids. The study involved…

This study collected blood, stomach, liver, intestine, and fat tissue samples from 360 severely obese adults undergoing bariatric surgery. The goal was to better understand how obesity and surgery change the body, especially the digestive system. Researchers hope this knowledge w…

This study looked at how often kidney hypodysplasia (a condition where kidneys are smaller and don't work as well) runs in families. Researchers collected DNA from 342 children aged 3 months to 18 years to find genes that might cause the condition. The goal was to understand inhe…

This study looked at 15 people with severe haemophilia B who were taking a medicine called eftrenonacog-alfa (a recombinant factor IX). The goal was to see how well different lab tests measure the level of clotting factor in their blood. Researchers also checked how the medicine …

This study looked at a personalized way to reduce steroid doses in people with lupus. 72 patients were followed for 3 months to see how their bodies processed the drug. The goal was to learn how to safely lower steroid use without causing flare-ups.

This study looked at how two different COVID-19 booster vaccines affect immune cells in the lymph nodes. Researchers used a needle to take samples from the lymph nodes of 12 adults who had already received at least three doses of an mRNA COVID-19 vaccine. The goal was to understa…

This study tested whether M-mode ultrasound can accurately confirm the placement of an epidural catheter in women in labor. Researchers enrolled 100 women receiving epidural pain relief during vaginal delivery. They used ultrasound to visualize the catheter and compared it to sta…

This study looked at how certain immune cells (antigen-presenting cells) behave in people with sepsis, a life-threatening response to infection. Researchers collected extra blood samples from 119 participants, including sepsis patients, critically ill patients without sepsis, and…

This study looked at the DNA of Staphylococcus epidermidis bacteria from 320 patients to find genetic markers that separate harmless strains from those that cause serious infections. The goal is to help doctors decide when antibiotics are truly needed. No new treatment was tested…

This study followed 72 children who were diagnosed before birth with a missing or abnormal corpus callosum, the bundle of nerves connecting the brain's two halves. Researchers tested their thinking, movement, and behavior at age 3 to understand how they develop. The goal was to g…

This study looked at 57 people with Currarino syndrome, a rare condition that can cause a tumor near the tailbone. Researchers used yearly MRI scans and blood tests to track the tumor and look for genetic links. The goal was to better understand who is at risk and why, not to tes…

This study looked at blood neutrophils (a type of immune cell) in 47 adults with cystic fibrosis. Researchers wanted to see how these cells behave differently in people with chronic infections or on certain treatments. The goal was to learn more about the disease, not to test a n…

This study looked at 116 overweight or moderately obese adults who had a procedure called endoscopic sleeve gastroplasty to help them lose weight. The goal was to find out why some people lose more weight than others after the procedure. Researchers checked blood samples and medi…

This study looked at 82 pregnant women whose babies were growing slowly in the womb (intrauterine growth restriction). Researchers used a special brain MRI to see if differences in brain water movement could tell which babies would have serious problems after birth. The goal was …

This study looked back at 224 patients with tubulointerstitial nephritis (TIN), a common cause of kidney failure. Researchers reviewed kidney biopsies to better understand the causes, treatments, and long-term outcomes. The goal is to improve how doctors diagnose and care for peo…

This study looked at how often low blood sugar (hypoglycemia) happens in children aged 6 months to 6 years with congenital adrenal insufficiency, a condition where the body doesn't make enough cortisol. Even with standard treatment, these children may have dangerously low blood s…

This study looked at how a marker of inflammation called C-reactive protein (CRP) changes in the blood of 35 people having emergency angioplasty for a heart attack. Researchers took blood samples before the procedure and at several time points after, up to 30 days. The goal was t…

This study collected blood samples from 236 pregnant women with and without preeclampsia. The goal was to test a new treatment that filters a harmful protein called sFlt-1 from the blood. Researchers measured levels of sFlt-1 and another protein, PlGF, to understand how they chan…

This study looked at 60 teens ages 12 to 18 to see if those with Avoidant and Restrictive Food Intake Disorder (ARFID) had more feeding problems before age 4 compared to healthy teens. Researchers used questionnaires to check early feeding history, growth, and sensory sensitiviti…

This study looked at nearly 9,000 twin births to find the safest way to deliver twins. Researchers compared different delivery methods and tracked serious health problems in the second twin. The goal was to help doctors choose the best approach for each birth.

This study looked at whether two common pain relievers, ibuprofen and ketoprofen, enter breastmilk in significant amounts. Researchers measured drug levels in milk from 35 breastfeeding women who had been taking one of these medicines for more than 24 hours. The goal was to help …

This study looked at children with pharyngitis (sore throat) to find out why some develop serious complications like abscesses or severe neck infections. Researchers compared 289 children hospitalized for these complications with those who had simple pharyngitis. The goal was to …

This study tested a smartphone app called Predigraft that helps kidney transplant patients and their doctors monitor the health of the new kidney from home. The app predicts how long the kidney might last and lets patients send in test results and vital signs. The goal was to see…

This study looked at what influences daily physical activity in 80 adults with cystic fibrosis, focusing on factors outside the lungs like nutrition, diabetes, bone health, and mood. Participants wore an activity monitor for a week and completed questionnaires. The goal was to id…

This study aimed to find specific molecules made by cells from the chorionic membranes (the 'water bag' around the baby) that might signal when preterm labor starts. Researchers collected samples from 24 healthy pregnant women after full-term delivery to measure proteins released…

This study looked at 51 adults with cardiac amyloidosis, a rare heart condition, to find out how many also have problems with smell and taste. Researchers used simple tests to measure these senses. The goal was to see if smell or taste loss could help doctors catch the disease ea…

This study looked at why people with myotonic dystrophy type 1 (DM1) have a much higher risk of dangerous blood clots in the legs or lungs. Researchers tested blood clotting in 130 participants, including people with DM1, those with a history of clots, and healthy volunteers. The…

This study looked at 175 premature babies to see if high iron levels in their blood during the first month of life are linked to a serious eye condition called retinopathy of prematurity (ROP). Researchers measured iron-related markers and tracked which babies developed ROP. The …

This study followed 708 adults with early inflammatory back pain for up to 5 years. Researchers collected data to better understand how the disease progresses, what predicts joint damage, and how to improve diagnosis. The goal was to gather knowledge, not to test a new treatment.

This study looked at 674 pregnant women at high risk for placenta accreta, a condition where the placenta grows too deeply into the womb. Researchers wanted to find out which factors, like how the condition is diagnosed and managed, affect the mother's health. The study also meas…

This study tracked 19 teens and young adults with cystic fibrosis to see how starting the drug ORKAMBI changed their anxiety, depression, quality of life, and how well they stuck to their treatments. Researchers compared those taking ORKAMBI to a similar group not on the drug. Th…

This study looked at 27 children in intensive care who needed medicine to raise their blood pressure or treat shock. Researchers used ultrasound and light sensors to measure blood flow and oxygen levels in the brain during treatment. The goal was to understand how the brain respo…

This study tested whether artificial intelligence (AI) can help doctors better predict how diabetic retinopathy (an eye disease from diabetes) will progress. Over 3,000 adults with diabetes were followed for about 2 years. The goal was to create a smarter system that uses eye ima…

This study looked at 22 deaf infants under 10 months old to find out why some show early signs of neurodevelopmental disorders like autism. Researchers filmed the babies during checkups and used a special scoring system to rate their social and motor skills. The goal was to ident…

This study looked at how a steroid called betamethasone, given to pregnant women to help their babies' lungs, moves from mother to baby. Researchers wanted to see if the amount that reaches the baby affects the risk or severity of hyaline membrane disease, a serious breathing pro…

This study looked at 120 teenagers aged 10 to 15 who had heart surgery for birth defects when they were younger. Researchers checked their blood and urine to see how many had chronic kidney disease. They also looked back at medical records to find possible causes during or after …

This study looked at how well the antibiotic ertapenem reaches prostate tissue after a single dose given before surgery. Twenty men with an enlarged prostate (BPH) who needed surgery took part. The goal was to see if enough antibiotic gets into the prostate to help prevent infect…

This study followed 912 men and women over 60 in France who were hospitalized for a severe bone fracture caused by a minor fall. Researchers tracked how many had another severe fracture or died within 2 and 5 years. The goal was to better understand the long-term risks after such…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This study aimed to create a reference range for normal placental blood flow using MRI. 135 women undergoing pregnancy termination for fetal reasons participated. The goal was to establish what healthy placental perfusion looks like, which can help doctors better understand and d…

This study tested whether having a clinical pharmacist review medications before cancer treatment starts can prevent drug-related problems, especially dangerous drug interactions. Researchers observed 440 adults with solid tumors who were about to begin chemotherapy, immunotherap…

This study looked at how 15 teenagers with anorexia nervosa experienced being prescribed antidepressants. Researchers interviewed them to understand their feelings about the medication and its effects. The goal was to gather insights, not to test a new treatment.

This study looked back at medical records of 50 children (ages 1 month to 18 years) who were on breathing machines for over 72 hours in intensive care. The goal was to see if adding inhaled gases could lower the amount of sedative and pain medicines needed. The researchers checke…

This study checks if men who had a treated urethritis infection still have signs of long-term inflammation and cell damage in their genital tract. Researchers measured a protein called elastase and markers of oxidative stress in semen 6 and 12 months after treatment. They compare…

This study looked at whether a passive leg raising test (lifting the legs while lying down) can predict low blood pressure after spinal anesthesia for planned C-sections. 64 women participated. The goal was to see if this simple test could help doctors know who might need extra m…

This study looked at whether a special teaching program could help children aged 8 to 12 with IgE-mediated food allergies feel better about their daily lives. It also checked if the program helped their families. The study involved 46 children and measured quality of life using a…

This study looked at 55 adults with diabetes to better understand insulin allergy, a rare but serious condition where the body reacts against insulin. The goal was to create a reliable way to diagnose the allergy and explore why it happens. Researchers tested skin reactions and s…

This study measured emotional problems like post-traumatic stress, anxiety, and depression in 62 parents whose children were in the ICU for severe injuries. Researchers used questionnaires to check parents' mental health 3 to 6 months after the ICU stay. The goal was to understan…

This study followed 574 adults hospitalized with end-stage liver disease to see if alcoholic patients face unfair barriers to getting on the national liver transplant waiting list. Researchers tracked who was registered for a transplant and compared it to their doctors' opinions.…

This study followed 436 pregnant women whose babies were found to have a lung malformation on ultrasound. The goal was to identify signs during pregnancy that could predict whether the baby would have breathing difficulties right after birth. By better understanding these rare co…

This study aimed to find the genes that cause Chiari type I malformation, a condition where part of the brain pushes into the spinal canal. Researchers took blood samples from 40 people with the condition and their family members to look for shared genetic mutations. The goal was…

This study looked back at 46 women who had a procedure called uterine artery embolization to treat fibroids or other uterine issues. The goal was to see how often women later had a baby and what pregnancy complications occurred. Researchers reviewed medical records from one hospi…

This study interviewed 25 health professionals who treat teens and young adults with long-lasting muscle or bone pain that is not caused by cancer. The goal was to learn how these experts figure out what is causing the pain, since there is no standard test. The results will help …

This study looked at how well telemedicine works for people with rheumatoid arthritis. Researchers tracked whether virtual visits led to in-person appointments, hospital stays, or changes in medication. The goal was to see if remote care can effectively manage the disease without…

This study tested a new self-administered questionnaire designed to measure shortness of breath and its impact on daily life in people with chronic respiratory diseases like COPD, pulmonary fibrosis, and cystic fibrosis. Researchers enrolled 199 adults to check if the tool is rel…

This study followed 133 people with PPNAD (a rare adrenal gland disorder) or Carney Complex (a related genetic condition) for three years. The goal was to better understand the symptoms and genetic causes of these diseases, not to test a new treatment. Participants had yearly che…

This study tested a technique called ischemic preconditioning (IPC) in 81 adults having major liver surgery. The idea was that a brief pause in blood flow before the main surgery might protect the liver from damage. The study measured liver enzyme levels the day after surgery to …

This study compared two ways of giving information to young women (ages 18-40) newly diagnosed with breast cancer about preserving their fertility before starting cancer treatment. One group received standard face-to-face advice, while the other used an online decision-support to…

This early-stage study tested whether a combination of two drugs (G-CSF and plerixafor) could safely collect enough blood stem cells from children with Fanconi anemia for a future gene therapy. Only 4 patients took part. The main goal was to see if the cell collection was possibl…

This study looked at 575 adults in intensive care for a severe kidney infection called acute obstructive pyelonephritis. Researchers aimed to find which factors are linked to worse outcomes, such as death or lasting kidney damage. The goal is to better understand and predict pati…

This study looked at whether offering counselling to family members right after a loved one's sudden death helps their mental health. Over 600 relatives were offered support by the emergency medical team. Researchers then checked for signs of depression, anxiety, and post-traumat…

This study looked at blood levels of a specific immune marker (IgG4) for cow's milk and egg in 135 children, both with and without allergies. The goal was to understand how these levels change with age and whether they can tell apart children who are still allergic from those who…

This study looked at 55 adults with acute respiratory failure to understand how breathing difficulty, lung ventilation, and diaphragm function relate to the need for a breathing tube. Researchers used observations and ultrasound to measure these factors. The goal was to identify …

This study looked at 98 new mothers who received a blood patch to treat severe headaches caused by a spinal fluid leak during labor. Researchers wanted to see if certain factors, like how the patch was done or the mother's health history, were linked to headaches that lasted 1 to…

This study used powerful MRI scans to track how a rare genetic disease called metachromatic leukodystrophy (MLD) damages the brain's white matter in young children. Researchers studied 29 children aged 1 to 6 years with MLD, along with a control group, to better understand how th…

This study looked at how often depression and anxiety occur in teenagers with cystic fibrosis (ages 14-17) and their parents. Researchers used simple screening questionnaires during regular clinic visits to measure mental health symptoms. The goal was to find out how common these…

This study looked at how closely 227 adults with precapillary pulmonary hypertension follow their prescribed diuretic (water pill) regimen. Researchers used questionnaires and pharmacy records to measure adherence and identify reasons for missed doses. The goal is to understand n…

This study looked at how the pressure used in mechanical ventilators affects the right side of the heart in people with acute respiratory distress syndrome (ARDS). Researchers measured lung pressure and heart function in 50 adults and children. The goal was to find out if high lu…

This study looked at how well 60 adults with type 2 diabetes could follow a Mediterranean diet for 12 months. Researchers wanted to see what makes it hard or easy to stick with this healthy eating plan. The goal is to find ways to help more people with diabetes adopt this diet.

This study looked at whether ultrasound can help doctors decide which children on breathing machines need extra fluids. Only about half of these children respond to fluids, and too much fluid can be harmful. The researchers tested ultrasound methods used in adults to see if they …

This study used a non-invasive brain stimulation technique called rTMS to investigate how a specific brain region (the superior temporal sulcus) is involved in social perception. Researchers measured how people with autism and healthy controls looked at social scenes and recogniz…

This study looked at how fourth-year medical students learn to communicate with patients during a required training course. The training included role play, simulated doctor visits, and group discussions. Researchers interviewed students and teachers and reviewed written assignme…

This study looked at whether a low salt and low sugar diet can reduce common side effects of corticosteroid treatment, like weight gain, high blood pressure, and diabetes. It involved 50 adults with autoimmune diseases or asthma who were prescribed high-dose steroids for at least…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study looked at over 2,100 people with listeriosis, a serious foodborne infection that can cause blood infections, brain infections, and pregnancy complications. Researchers collected data to find out which clinical, biological, and genetic factors make someone more likely t…

This study looked at a specific enzyme called IL4I1 in the blood and tissues of 127 people with cutaneous melanoma. Researchers wanted to see if this enzyme helps predict how fast the disease progresses and whether it plays a role in resistance to immunotherapy and targeted thera…

This study looked back at 72 children treated over 20 years for a rare kidney cancer (Wilms tumor) that had spread into the large vein carrying blood to the heart. The goal was to find the best surgical approaches to improve survival and reduce complications. No new treatments we…

This study looked at whether a special clinic with nurse visits could help people with rheumatoid arthritis better manage related health problems like heart disease, infections, and osteoporosis. It also tested a program that teaches patients to score their own arthritis activity…

This study looked at how well the flu vaccine works and how safe it is in 228 adults with inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis. Researchers compared people taking immunosuppressive drugs to those not taking them. The goal was to see if t…

This study looked at how salt and other ions move through the cells lining the airways in people with idiopathic bronchiectasis (enlarged airways of unknown cause). Researchers measured these movements using a simple test during a routine bronchoscopy in 42 patients aged 2 to 20.…

This study tested a more accurate method to measure kidney function in 90 critically ill ICU patients whose kidneys were working overtime. The standard creatinine clearance test can be misleading in these patients, so researchers compared it with the iohexol plasma clearance tech…

This study tested a social robot named ARI in a day hospital for older adults. The robot was designed to inform, guide, and entertain patients, families, and staff. Researchers measured how acceptable and easy to use the robot was for 115 participants, including patients aged 60 …

This study looked at 170 men from couples struggling with infertility. Researchers checked if metabolic syndrome (a cluster of conditions like high blood pressure, high blood sugar, and unhealthy cholesterol) is linked to lower sperm counts. The goal was to understand the connect…

This study looked at the overall health and sexual well-being of 138 women with Rokitansky syndrome, a condition where the vagina is underdeveloped. Participants had either surgery or used dilators to create a vagina. The goal was to see how these treatments affect quality of lif…

This study looked at whether a test using cells from the nose can predict if the drug Orkambi® will improve lung function in people with cystic fibrosis. Researchers collected nasal cells from 91 participants before they started Orkambi® and measured how well the drug fixed the c…

This study measured normal nasalance scores in 131 French-speaking children aged 8-10 using a non-invasive device called a nasometer. The goal was to create a reference for doctors to better diagnose velopharyngeal dysfunction, often seen in children with cleft palate. Participan…

This study looked at whether a special training program for nurses and nursing assistants could reduce their stress and anxiety when caring for children with hereditary epidermolysis bullosa (a rare condition causing very fragile skin). Nineteen caregivers at a French hospital to…

This study looked at whether patients can effectively give themselves extra oxygen before surgery by holding the mask themselves, a concept called self-preoxygenation. It involved 110 adults having scheduled surgery with general anesthesia. The main goal was to see how many patie…

This study tested whether a serious game (an educational video game) helps children aged 10 to 17 with newly diagnosed type 1 diabetes learn how to manage their condition. 78 kids participated, and researchers measured their knowledge with a 50-question quiz and tracked blood sug…

This study tested over 1,000 children and their parents for COVID-19 antibodies to find out how many had been infected. Researchers also checked for active virus in nose, saliva, and stool samples. The goal was to better understand infection rates and immune responses in families…

This study looked at immune cells from 138 people with Wegener's granulomatosis, a rare disease causing inflammation of blood vessels. Researchers measured levels of a protein called DAP12 in different immune cells to understand how the disease works. No new treatment was tested;…

This study looked at whether smoking or using nicotine products changes the risk of getting COVID-19. It included over 600 healthcare workers who were tested for the virus. Researchers sent a questionnaire to learn about their tobacco and nicotine use. The goal was to see if ther…

This study talked to 52 adults with cystic fibrosis (and some of their spouses) to learn what they think and feel about becoming parents. Through small group discussions and one-on-one interviews led by a psychologist, researchers collected their hopes, worries, and needs. The go…

This study looked at whether a structured program to check for other health problems (like high blood pressure or diabetes) and a nurse-led self-management course could improve outcomes for people with axial spondyloarthritis. Over 500 adults took part. The goal was to see if the…

This study looked at 166 people with unexplained bleeding to find out how often tiny defects in platelet dense granules (the parts that help blood clot) are the cause. Researchers used special tests to measure the number, content, and release of these granules. The goal was to be…

This study looked at 254 babies born with cytomegalovirus (CMV) infection to find early signs that predict hearing or brain problems at age 1. Researchers checked clinical exams, brain scans, and blood tests shortly after birth. The goal is to create a scoring system to identify …

This study followed 58 children with sickle cell disease from birth to find early warning signs of a life-threatening spleen problem called acute splenic sequestration. Researchers checked blood samples, cell properties, and genetic markers to identify which children are most at …

This study aimed to create a standard set of questions to measure how systemic sclerosis (scleroderma) affects patients' lives. Researchers worked with 100 patients and experts to identify the most important areas to track. The goal was to develop a tool that can be used in clini…

This study looked at how rare diseases impact oral health and quality of life. Researchers interviewed 28 patients aged 6 and older at Necker Hospital in Paris. The goal was to understand their experiences and identify barriers to dental care, not to test a treatment.

This study looked at nearly 6,000 ICU patients with severe kidney injury to see if a scoring tool called UNDERSCORE can predict when dialysis can be safely stopped. The goal was to avoid restarting dialysis or early death within 7 days. Researchers used existing hospital data to …

This study looked at 90 adults having major liver surgery to compare two fluid management approaches: a restrictive method that limits fluids, and an individualized method tailored to each patient. The goal was to see which approach leads to better outcomes, such as less blood lo…

This study tested whether a special thermal camera could automatically detect breathing distress in patients on breathing machines. The camera measures heart rate, breathing rate, and facial expressions to spot signs of suffocation without needing a nurse to watch constantly. The…

This study examined tissue samples from 226 people with early-stage melanoma to see if dormant or stem-like cancer cells were present in the healthy skin around their tumors. Researchers then tracked whether the presence of these hidden cells was linked to survival and cancer ret…

This study looked at the extra costs that families of people with Duchenne muscular dystrophy (DMD) in France have to pay out of their own pockets. It included 28 patients of any age who had been diagnosed for at least six months. The researchers measured things like uninsured me…

This study tested a new MRI technique that lets doctors see children's lungs without using radiation or injected dye. 72 kids aged 6-16 had both a standard CT scan and the new MRI. The goal was to see if the MRI could provide clear images of the lungs, potentially offering a safe…

This study tested whether a rapid test (FilmArray) that identifies the cause of hospital-acquired pneumonia in about an hour, combined with advice from antibiotic experts, could improve patient care. 116 adults with pneumonia caught in the hospital took part. The goal was to see …

This study followed 150 people with nephronophthisis, a rare genetic kidney disease, to see how it progresses over many years. Researchers tracked kidney function and damage to other organs. The goal was to better understand the disease and help doctors anticipate complications. …

This study created a registry to collect medical information from 868 people with Anti-Phospholipid Syndrome (APS) and/or Systemic Lupus Erythematosus (SLE). The goal was to gather data on these conditions, not to test a new treatment. Participants were adults diagnosed with APS …

This study looked at how the antibiotic ceftazidime works in critically ill children with severe burns. Because burns change how the body processes medicine, the usual dose might not be enough. Researchers took blood samples from 3 children to measure drug levels and see how well…

This study looked for rare, single-gene causes of insulin-dependent diabetes in 127 participants. Researchers examined patients' genes, medical histories, and family members to identify new forms of diabetes. The goal was to better understand these genetic subtypes, not to test a…

This study followed 349 adults with myelodysplastic syndromes (MDS), a bone marrow disorder that raises the risk of leukemia. Researchers used DNA testing to find gene changes and see how they affected survival and treatment response. The goal was to better understand the disease…

This study reviewed medical records of 152 infants with rare solid tumors in the chest, belly, or pelvis. The goal was to see how well prenatal scans and exams matched the final diagnosis after birth. Researchers also looked at the range of conditions linked to these tumors. No n…

This study looked at 56 children with cystic fibrosis, aged 6 to 18, to compare four non-invasive methods for measuring liver scarring (fibrosis). The methods tested were FibroTest, Fibroscan, ShearWave elastography, and magnetic resonance elastography. The goal was to see which …