Assistance Publique - Hôpitaux De Paris

This study tested whether a drug called rituximab works better than standard treatments to bring a rare disease called eosinophilic granulomatosis with polyangiitis (EGPA) under control. EGPA causes inflammation of small blood vessels, leading to organ damage. The trial involved …

This study tested a drug called miglustat in 16 adults with cystic fibrosis who have a specific genetic mutation (F508del). The goal was to see if miglustat could help restore the function of a faulty protein that controls salt and water movement in the lungs. Researchers measure…

This study looked at whether anti-inflammatory medication can improve sperm health in men with infertility caused by inflammation. About 200 men with signs of inflammation in their semen took either the drug or a placebo for 6 months. The goal was to reduce oxidative stress damag…

This study tested whether using a special antiseptic dressing (containing chlorhexidine) on the tubes that connect patients to ECMO life support can reduce serious infections. Researchers compared this to standard dressings in 270 critically ill adults with heart or lung failure.…

This study followed 852 people with cystic fibrosis (age 12 and older) who were taking the drug combination ivacaftor+lumacaftor (Orkambi) for one year. Researchers wanted to see how often patients stopped treatment, why, and how the drug affected lung function and nutrition. The…

This study looked at whether a high dose of vitamin D (100,000 IU) is better than a low dose (12,000 IU) for kidney transplant recipients. The goal was to see if it could lower the risk of new diabetes, heart problems, cancer, or death. Over 500 adults who had a kidney transplant…

This study compared two methods to treat tubo-ovarian abscess (a pocket of infection in the female reproductive organs): draining it through the vagina using ultrasound guidance, or removing it with keyhole surgery (laparoscopy). Both groups also received antibiotics. The goal wa…

This study tested three different biologic drugs (adalimumab, anakinra, and tocilizumab) in 112 people with severe, hard-to-treat eye inflammation called uveitis. The goal was to see which drug works best to reduce eye inflammation and allow patients to lower their steroid use. U…

This study tested whether adding early steroid treatment to standard blood pressure or diabetes medications can better control IgA nephropathy, a kidney disease. 62 adults with severe kidney damage on biopsy were randomly assigned to get either the combination or standard care al…

This study tested whether adding bortezomib to standard treatments (steroids, plasma exchange, and immunoglobulins) can help control chronic antibody-mediated rejection in kidney transplant recipients. 60 adults who had a kidney transplant and developed donor-specific antibodies …

This study looked at 46 pregnant women with a rare form of diabetes called MODY2. It compared two standard care plans: starting insulin right away versus using ultrasound to decide when to start insulin. The goal was to find the best way to keep both mother and baby healthy.

This study tested whether allopurinol, a medicine usually used for gout, can help people with a rare genetic condition called ADSL deficiency. The condition causes autism, seizures, and developmental delays. Eight children and adults took allopurinol for 12 months, and researcher…

This study tested whether rituximab, a targeted antibody therapy, is more effective than the standard drug azathioprine at preventing major relapses in people with ANCA-associated vasculitis (Wegener's granulomatosis or microscopic polyangiitis). 117 adults who had already achiev…

This small pilot study looked at whether the drug pirfenidone is safe and effective for people with a specific type of lung scarring (pulmonary fibrosis) linked to certain antibodies or a related blood vessel condition. Seven adults took the drug for a year, and researchers measu…

This study compared a heat-based treatment (radiofrequency ablation) to regular monitoring for people with Barrett's esophagus and low grade dysplasia, a condition that can lead to cancer. 125 adults with this condition were randomly assigned to either the ablation procedure or c…

This study tested whether a low dose of a protein called IL-2 can increase certain immune cells (Tregs) in women who have had at least 5 unexplained early miscarriages. The goal was to see if this approach could help the body accept a pregnancy instead of rejecting it. 18 women t…

This early-phase study tested whether giving methionine (an amino acid) by mouth or feeding tube is safe for children with a rare, severe lung disease caused by a specific gene mutation. The disease leads to breathing problems and has no cure. Only 3 children took part. The main …

This study tested whether using saliva samples can find COVID-19 infections just as well as the standard nose swab test. Over 5,000 adults and children provided both a saliva sample and a nose swab. The goal was to see if the easier, less uncomfortable saliva test could be used f…

This study tested whether a noninvasive ultrasound device called FibroScan can accurately measure liver scarring (fibrosis) in children. Currently, the only reliable method is a liver biopsy, which involves inserting a needle into the liver. The study included 264 children aged 6…

This study looked at whether measuring certain proteins (amyloid peptides) in the blood can help diagnose Alzheimer's disease or predict if someone with mild memory problems will develop Alzheimer's. Over 1,000 older adults with either mild cognitive impairment or Alzheimer's dis…

This study tested whether giving a high dose of erythropoietin, a hormone that boosts red blood cell production, can improve survival and prevent long-term brain damage in full-term newborns who suffered oxygen deprivation at birth. All 120 babies also received standard cooling t…

This study aimed to see if the drugs azithromycin and hydroxychloroquine could prevent hospital workers from catching COVID-19. About 122 workers who tested negative for the virus were given either one of the drugs or a placebo for 40 days. The main goal was to see if fewer peopl…

This study looked at whether giving antibiotics early to trauma patients on breathing machines can prevent ventilator-associated pneumonia (VAP). Researchers analyzed data from 2,143 adults admitted for severe trauma who needed a ventilator. The goal was to see if this approach r…

This study tested whether adding a sedative (midazolam) to standard pain medicine (morphine) helps children with arm fractures feel less pain. Sixty children aged 5 to 16 took part. One group got morphine plus midazolam, the other got morphine plus a placebo. Researchers measured…

This study looked at 304 children aged 2 to 17 who came to the emergency room with a broken arm or leg bone. Researchers wanted to see if giving paracetamol (Tylenol) and/or ibuprofen (Advil) along with morphine would relieve pain better than morphine alone. The goal was to find …

This study tested whether a self-hypnosis smartphone app could reduce attention problems and anxiety in children with ADHD who were already taking medication. 49 children aged 7 to 12 used the app for 6 weeks alongside their usual treatment. The goal was to see if the app provide…

This study tested whether a single antihistamine works as well as an antihistamine plus a corticosteroid for treating acute hives in the emergency department. 137 adults with hives (with or without mild swelling) took part. The main goal was to see if symptoms improved over 7 day…

This study tested whether a special pain monitor (called ANI) used during scoliosis surgery in children could help doctors give just the right amount of pain medicine, reducing the need for morphine after surgery. About 260 children took part. The goal was to see if using the mon…

This study looked at whether listening to music during cataract surgery can reduce anxiety and prevent spikes in blood pressure. Over 300 adults having the procedure under numbing eye drops took part. Researchers measured blood pressure and asked patients about their anxiety befo…

This study tested whether having a woman lie on one side (asymmetrical lateral decubitus) during labor can help turn a baby that is facing the wrong way (occipitoposterior position) into the correct position. The trial involved 326 women in labor. The goal was to see if this simp…

This study looked at whether using cervical dilators (tools to open the cervix) before starting labor medication can shorten the time to delivery in second-trimester pregnancy terminations. 355 women participated. The main goal was to see if more women delivered within 12 hours w…

This study examined blood samples from 57 people who received stem cell transplants for blood cancers. Researchers looked at specific immune cells to see if they could predict a serious complication called graft-versus-host disease, where donor cells attack the patient's body. Th…

This study looked at whether it is possible to run diabetes education workshops for inmates in a Paris jail. Researchers enrolled 22 men with type 1 or type 2 diabetes to see how many would attend at least two workshops. The goal was to understand if such programs can work in a p…

This study looked at whether certain immune system markers (autoantibodies) are linked to how pulmonary arterial hypertension (PAH) progresses. Researchers examined blood samples from 629 adults with different types of PAH, including those with HIV, congenital heart defects, and …

This study looked at 20 infants with severe bronchiolitis (a serious lung infection) to compare two types of breathing support: CPAP and NiPPV. The goal was to see which one reduces the effort of breathing more effectively. Researchers measured breathing effort using a special tu…

This study looked at why people with myotonic dystrophy type 1 (DM1) have a much higher risk of dangerous blood clots in the legs or lungs. Researchers tested blood clotting in 130 participants, including people with DM1, people with a history of clots, and healthy volunteers. Th…

This study looked at whether a small blood transfusion in healthy volunteers causes measurable changes in blood cells and particles. Researchers analyzed blood samples before and after transfusion to find markers that could identify this type of doping. 28 healthy male volunteers…

This study tested whether a special ultrasound technique (M-mode) can help doctors confirm that an epidural catheter is correctly placed in women during labor. About 100 women having vaginal delivery with epidural pain relief took part. The goal was to see if ultrasound could red…

This study looked for simpler ways to measure how many insulin-producing cells are left in people with type 1 diabetes. Instead of a long, 3-hour meal test, researchers checked if immune cells in the blood or urine tests could give the same information. 156 children and adults wi…

This study tested a French version of a questionnaire that measures how chronic sinusitis affects children's quality of life. It involved 89 children aged 2 to 12, some with sinusitis and some without. The goal was to make sure the translated questionnaire works as well as the or…

This pilot study tested whether a combination of two drugs (G-CSF and plerixafor) could safely collect enough stem cells from the blood of children with Fanconi anemia for future gene therapy. Four patients aged 2 to 17 took part. The main goal was to see if the stem cell collect…

This study followed 60 heart transplant patients for one year to see if the level of a harmless virus called TTV in their blood could predict when they might get an infection or reject the new heart. Researchers measured TTV levels monthly and compared them to actual infections a…

This study looked at how the heart rhythm medicine amiodarone behaves in children aged 0 to 18. Researchers measured drug levels in the blood to understand the right dose for kids. The goal was to improve treatment safety and effectiveness, not to test a new drug.

This study used powerful MRI scans to track how a rare brain disease called metachromatic leukodystrophy (MLD) damages white matter in children aged 1 to 6. Researchers studied 29 children recently diagnosed with MLD to better understand the disease's progression. The goal was to…

This study looked at whether functional MRI (fMRI) can help diagnose Auditory Processing Disorder (APD), a condition that makes it hard for children to understand sounds despite normal hearing. Researchers compared brain scans of 45 children aged 7 to 18—some with APD, some suspe…

This study looked at how rare diseases affect oral health and quality of life. Researchers interviewed 28 patients (ages 6 and up) at Necker Hospital in Paris. The goal was to understand their experiences and challenges with dental care, not to test a new treatment.

This study looked at what makes intensive care and pediatric nurses feel overworked. Researchers surveyed 484 nurses to measure their workload based on mental demands, physical effort, time pressure, and frustration. The goal was to identify factors related to the care unit, staf…

This study looked at how faithfully 227 adults with precapillary pulmonary hypertension take their diuretics (water pills). Researchers used questionnaires and pharmacy records to measure adherence and find out why some people miss doses. The goal was to understand the problem an…

This study aims to better understand insulin allergy, a rare but serious condition in people with diabetes who need insulin to live. Researchers will test a new way to diagnose the allergy and look at the genetic and immune system factors involved. The study includes 55 adults wi…

This study examined 33 preterm babies born before 30 weeks to mothers with preeclampsia, a pregnancy complication. Researchers measured certain proteins in the mother's blood, umbilical cord blood, and amniotic fluid to see if they were linked to a lung condition called bronchopu…

This study tested whether 3D ultrasound can measure kidney and tumor volumes as accurately as CT or MRI scans. Researchers enrolled 53 adults with chronic kidney disease or kidney tumors. The goal is to see if a safer, radiation-free method can be used for monitoring.

This study involved 70 people with rheumatoid arthritis to see how virtual doctor visits influence care. Researchers tracked whether these visits led to in-person appointments, hospital stays, or changes in medication. The goal was to learn how to better use telemedicine for mana…

This study reviewed medical records of 70 children under 18 who had a stroke and received clot-busting treatments (medication or a procedure to remove the clot). Researchers measured how quickly treatment was given and whether any bleeding complications occurred. The goal was to …

This study tested whether having a pharmacist review medications before cancer treatment starts can prevent drug-related problems, like harmful interactions. Researchers observed 440 adults with solid tumors who were about to begin chemotherapy, immunotherapy, or oral targeted th…

This study looked at blood neutrophils (a type of immune cell) in 47 adults with cystic fibrosis to see how chronic infection and certain treatments affect these cells. Researchers compared cells from patients with those from healthy blood donors. The goal was to learn more about…

This study looked at how two different COVID-19 booster vaccines affect immune cells in the lymph nodes of 12 adults who had already received at least three doses of an mRNA COVID-19 vaccine. Researchers used a needle to take a small sample from lymph nodes a few weeks after the …

This study examined how the steroid betamethasone passes from a pregnant woman to her unborn baby and whether that affects the baby's risk of developing a serious lung condition called hyaline membrane disease. Researchers enrolled 127 pregnant women who received the steroid to p…

This study looked at 20 adults with Behçet's disease to understand how the condition affects mental health and thinking. Researchers used questionnaires to measure anxiety, depression, fatigue, and quality of life. The goal was to gather information, not to test a treatment.

This study looked at whether a test using cells from the nose can predict how well the drug Orkambi works for people with cystic fibrosis. Researchers collected nasal cells from 91 participants before treatment and measured how the drug improved cell function. They then compared …

This study looked at how the pressure used to help patients with Acute Respiratory Distress Syndrome (ARDS) breathe affects the right side of the heart. Researchers measured lung and heart pressures in 50 adults and children to see if high pressure leads to heart failure. The goa…

This completed study looked at how certain immune cells called neutrophils behave in people with granulomatosis with polyangiitis (GPA), a rare disease that causes blood vessel inflammation. Researchers compared blood samples from 93 participants—including GPA patients, patients …

This study looked at the psychological experiences of children aged 10 to 16 who were born with one missing ear (ear aplasia) and chose to have reconstructive surgery. Researchers used personality tests and questionnaires to understand the children's emotions, body image, and qua…

This study looked at blood levels of a specific immune marker (IgG4) for cow's milk and egg in 135 children, both with and without allergies. The goal was to understand how these levels change with age and whether they can show if a child has outgrown their allergy. Researchers a…

This study looked at 21 children and young adults (ages 7-25) who had surgery for Moyamoya disease, a rare brain vessel condition. Researchers used questionnaires and interviews to measure anxiety, depression, and family relationships, aiming to understand why some patients still…

This study measured how well children with hearing aids or cochlear implants hear in everyday situations. Researchers used a special questionnaire called PEACH to ask parents about their child's hearing in quiet and noisy places. The goal was to understand how different types of …

This study tested a personalized method for safely lowering steroid doses in people with lupus. Researchers monitored 72 patients over three months to see how their bodies processed the medication. The goal was to find the best way to reduce steroids while keeping the disease und…

This study checked if men who had a treated urethritis infection develop long-term inflammation in their genital tract. Researchers measured a marker called elastase in semen 6 and 12 months after treatment, and also looked for signs of oxidative stress. They compared 113 men who…

This study interviewed 25 healthcare professionals to learn how they diagnose and manage chronic (non-cancer) muscle and joint pain in French adolescents and young adults. The goal is to use their experiences to build the first multidimensional scale that helps doctors more accur…

This study looked at 674 pregnant women at high risk for placenta accreta (a condition where the placenta grows too deeply into the womb). Researchers wanted to find out which factors—like how the condition was diagnosed or the type of care received—affect the mother's health. Th…

This study looked back at 91 children who had surgery to remove a bone tumor from their leg and then had the bone rebuilt using one of three methods: the induced membrane technique, a vascularized fibula graft, or a fibula graft plus a donor bone. The goal was to see which method…

This study followed over 1,400 pregnant women with endometriosis to see how the disease affects pregnancy. Researchers looked at risks like early birth, pregnancy loss, and other complications based on the type of endometriosis. The goal is to help doctors better monitor and care…

This study looked at 142 children aged 5 to 6 to see if their mothers' vitamin D levels during early pregnancy affected their breathing. Researchers measured airway resistance, a sign of lung health, and compared children whose mothers had low vitamin D to those with higher level…

This study aimed to better understand a rare bowel disease called intestinal epithelial dysplasia (tufting enteropathy) by looking at the genes and physical traits of affected children. Researchers studied 41 children aged 0 to 15 who were being evaluated for an intestinal transp…

This study looked at whether a 15-second pause in a breathing machine (end-expiratory occlusion) can help doctors decide if infants in shock need more fluids. Ten infants under 2 years old on ventilators in intensive care were included. Researchers measured heart function before,…

This study tested whether using a checklist could lower the number of same-day or day-before cancellations for planned outpatient surgeries. Over 4,000 adults and children took part. The goal was to see if better organization could help surgeries happen as scheduled.

This study looked at whether explaining the life-threatening risks of chemotherapy at diagnosis helps patients with incurable stage IV lung cancer avoid aggressive treatment at the end of life. 123 patients were randomly assigned to receive either standard information or a more h…

This study looked at whether an exercise test can be used to monitor treatment in people with a rare inherited disease that causes sudden muscle breakdown (rhabdomyolysis). Researchers measured heart function and oxygen use during exercise in 27 patients. The goal was to find bet…

This study followed 6 children under 18 with scoliosis who had spinal surgery that included fixing the pelvis with screws. Researchers measured changes in walking ability and quality of life 6 months after surgery using gait analysis, a 6-minute walk test, and a questionnaire. Th…

This study looked at 116 people who had a cardiac arrest outside the hospital and were treated with a special heart-lung machine called ECMO. The goal was to see how well their heart pumped blood 28 days and 90 days later. Researchers measured heart function using ultrasound to u…

This study looked at how much of the antibiotic ertapenem gets into prostate tissue after a single dose given before surgery. Twenty men with an enlarged prostate who needed surgery took part. The goal was simply to measure the drug's concentration in the prostate, not to treat o…

This study looked at the types of fungi living on the head and neck skin of 30 adults with eczema (atopic dermatitis) compared to healthy volunteers. The goal was to understand if differences in the fungal community are linked to eczema in these areas. Researchers used lab tests …

This study followed 912 men and women over 60 in France who were hospitalized for a severe bone fracture caused by a minor fall. Researchers tracked how many had another severe fracture or died within 2 and 5 years. The goal was to better understand long-term outcomes, not to tes…

This study examined 145 patients who had allergic-like reactions during surgery. Researchers wanted to find specific signs—like skin changes, heart rate, and blood pressure—that could help doctors quickly tell the difference between true allergic reactions and non-allergic ones. …

This study followed 99 women with primary immune deficiency who had been pregnant or tried to become pregnant. Researchers tracked infections during and after pregnancy, as well as pregnancy outcomes like miscarriage and live birth. The goal was to better understand how to monito…