Assistance Publique - Hôpitaux De Paris

This study tests whether a lower dose of a chemotherapy drug (cyclophosphamide) given after a half-matched stem cell transplant can help people with blood cancers live longer without severe complications. About 180 adults will be randomly assigned to receive either the standard d…

This study looks at whether a special one-day hospital visit can help people with Crohn's disease or ulcerative colitis better manage their illness. The program includes blood tests, a doctor visit, education from a nurse, and extra services like diet advice or fatigue help. Rese…

This study tests a surgical method for functional popliteal artery entrapment syndrome, a rare condition where leg muscles compress an artery during exercise, causing pain. Researchers will review 70 patients who had surgery between 2015 and 2025. The goal is to see if cutting pa…

This early-phase trial tests a new antibody drug, DT-7012, in 30 adults with advanced cutaneous T-cell lymphoma (CTCL) that has not responded to at least two prior treatments. The drug aims to kill cancer cells by targeting a protein called CCR8 found on tumor cells. The main goa…

This study tests whether extra nursing care, both in the hospital and at home, can help people with tuberculosis stick with their treatment. About 40 adults will receive this support to see if it improves treatment completion and reduces the number of patients lost to follow-up. …

This study tests whether giving brentuximab vedotin (a targeted drug) right after a stem cell transplant can prevent early relapse in people with advanced cutaneous T-cell lymphoma (CTCL). About 84 adults with CD30-positive mycosis fungoides who have already tried at least one sy…

This study looks at people newly diagnosed with pulmonary arterial hypertension (PAH) who also have at least two heart-related conditions. It compares starting treatment with two oral drugs (tadalafil and ambrisentan) versus just one drug. The goal is to see if the combination he…

This study evaluates a new rapid test that can detect Candida auris, a drug-resistant fungus that causes severe infections in hospitals, in about 15 minutes. Researchers will compare the test's accuracy to standard lab methods using samples from 554 patients. No extra samples are…

This study will collect photos of mouth lesions from 5,000 patients to train an artificial intelligence (AI) system to detect oral cancer and precancerous conditions. The goal is to help doctors identify dangerous lesions earlier and more accurately. Participants are adults seen …

This study aims to improve how doctors diagnose and manage hyperandrogenism, a hormone condition causing excess male-pattern hair growth, acne, and infertility in women. Researchers will use machine learning and metabolomics (detailed analysis of body chemicals) to better disting…

This study tests whether adding movement sonification—turning body movements into sounds—to standard talk therapy can help people with acute stress disorder (ASD). ASD can cause feelings of disconnection from your own body after a traumatic event. The study will include 30 adults…

This study looks at whether awake prone positioning (lying on your stomach while awake) can improve breathing in adults with sickle cell disease who are in the intensive care unit for acute chest syndrome. The approach aims to improve oxygen levels and reduce the need for a breat…

This study looks at whether a functional restoration program (a type of rehab) is worth the cost for people with long-term low back pain who are unable to work. Researchers will compare the program to usual care in 242 adults, measuring quality of life, healthcare use, and return…

This study tests a portable device called ActiTENS mini that uses mild electrical pulses to relieve chronic pelvic pain in women with endometriosis. About 208 women will use the device daily for 30 minutes over three 3-month periods, comparing different stimulation strengths. The…

This study looks at how a person's genes influence their response to the heart drug mavacamten, used for obstructive hypertrophic cardiomyopathy. Researchers will collect DNA samples from 300 patients to see why some respond better than others. The goal is to make treatment safer…

This study tests a smartphone app that automatically measures capillary refill time—how quickly blood returns after pressing a finger—in 60 adult ICU patients. The app analyzes a short video of the finger to give a reading, which will be compared to measurements by expert clinici…

This study watches for memory, attention, and concentration problems in 90 adults with early-stage, operable lung cancer. Researchers will track when these issues start, how bad they get, and how long they last. They will also look at how mood, fatigue, and social factors might p…

This study will test new lab methods to better diagnose inflammatory and non-inflammatory bone and joint diseases. Researchers will collect joint fluid and tissue from 50 adults who need joint aspiration or replacement. They will use both standard and advanced techniques to find …

This study looks at whether objective measurements like eSRT, eABR, and eCAP can help doctors program cochlear implants more precisely. Currently, tuning relies on the patient's subjective feedback, which can be difficult. Researchers will enroll 60 adults with severe-to-profound…

This study will gather information from 100 people in France with SITRAME syndrome, a rare autoinflammatory disease that causes repeated skin rashes and fever. Researchers will track patients' symptoms, treatments, and health outcomes over time. The goal is to better understand t…

This study looks at whether giving doctors antibiotic sensitivity results in 4-6 hours (instead of the usual 18-24 hours) helps them choose a better antibiotic for ICU patients with Gram-negative bloodstream infections. About 200 adults will take part. The goal is to see if faste…

This study aims to grow diaphragm muscle cells in the lab from tissue removed during surgery for endometriosis. Researchers will compare these cells to arm muscle cells to find unique features of the diaphragm. This tool may help develop new therapies for severe neuromuscular dis…