Assistance Publique - Hôpitaux De Paris

This study tests a low-dose immune treatment (ILT-101) in 22 children aged 6 to 8 with moderate to severe autism. The children's mothers had an immune condition during pregnancy, which may have affected the child's immune balance. The goal is to see if the treatment can correct t…

This study tests whether a combination of aspirin and folic acid can help people recover from sudden sensorineural hearing loss, a condition where hearing drops sharply over a few days. The researchers believe that improving blood flow to the inner ear may aid recovery. About 142…

This study looks at whether giving the drug rituximab early, when signs of the disease reappear in the blood, can prevent relapses in people with certain types of vasculitis (GPA and MPA). About 70 adults who have been on maintenance rituximab for at least 18 months will be rando…

This study tests biologic drugs for folliculitis decalvans, a rare scalp disease that causes painful pustules and permanent hair loss. Current antibiotics only work about half the time and the condition often returns. The trial will enroll 120 adults who have already tried at lea…

This study tests whether giving a mix of three antibiotics to pregnant women showing signs of very early labour (between 18 and 23 weeks) can help keep the pregnancy going longer and reduce serious health problems or death in newborns. About 350 women will take part. The goal is …

This study tests whether a combination of three drugs (prednisone, azithromycin, and hydroxychloroquine) can slow lung function decline in adults with interstitial lung disease caused by certain gene variants. About 30 participants will receive either the triple therapy or standa…

This study looks at whether giving a clot-busting drug (tenecteplase) before a mechanical clot-removal procedure (thrombectomy) helps people with a large, severe stroke recover better than just the procedure alone. About 486 adults with a large blockage in a major brain artery wi…

This study tests whether adding visits with a nurse, dietitian, and pharmacist to standard follow-up care helps heart attack patients reach their LDL cholesterol goals. About 230 adults who had a recent heart attack will be randomly assigned to usual care or extra team-based supp…

This study tests a drug called obinutuzumab in 30 adults with a rare, serious blood vessel disease (cryoglobulinemia vasculitis) that did not improve with or caused reactions to the standard treatment rituximab. The goal is to see if obinutuzumab can stop disease activity and all…

This early-phase trial tests a new drug called DT-7012 for people with a rare type of skin lymphoma (CTCL) that has not responded to other treatments. The drug is an antibody designed to find and kill cancer cells in the skin and boost the immune system. About 30 adults with adva…

This study tests whether adding extra nursing care—both in the hospital and at home—helps people with tuberculosis complete their full treatment. About 40 adults in Paris will take part. The goal is to see if this support improves treatment completion rates and reduces the number…

This study tests whether transplanting healthy donor stool into the gut can improve liver function in people with primary sclerosing cholangitis (PSC), a rare liver disease often linked to inflammatory bowel disease (IBD). About 72 adults with stable IBD and elevated liver enzyme…

This study tests whether changing the order of steps during a Whipple surgery for pancreatic head cancer can help surgeons remove the tumor more completely and lower the chance of cancer coming back. About 150 adults with operable pancreatic cancer will be randomly assigned to ei…

This study tests whether giving the drug brentuximab vedotin after a stem cell transplant can prevent early relapse in people with advanced cutaneous T-cell lymphoma (CTCL). About 84 adults aged 18-70 with CD30-positive mycosis fungoides who have had at least one prior treatment …

This study tests a drug called teclistamab for people with a severe, fast-worsening lung disease linked to anti-MDA5 antibodies. The disease is often fatal, with only about 25% of patients surviving 90 days without a lung transplant. Teclistamab is a bispecific antibody that help…

This study tests whether giving a lower dose of a drug called cyclophosphamide after a stem cell transplant can reduce side effects while still preventing graft-versus-host disease (GVHD) and cancer relapse. The trial involves 180 adults with blood cancers who are receiving a hal…

This study tests whether frozen stool capsules (fecal transplants) can help children aged 8-17 with ulcerative colitis stay in remission after steroid treatment. The goal is to improve gut bacteria diversity over 6 months. Participants must already be stable on their usual medica…

This study compares temocillin, a targeted antibiotic, to the standard treatment ceftriaxone for gonorrhea infections. About 360 adults with asymptomatic gonorrhea will receive either drug to see if temocillin works just as well while causing less harm to gut bacteria and reducin…

This study looks at whether a single, image-guided radiation implant can control advanced cervical cancer as well as the usual multiple implants. About 400 women from six French hospitals who had this single-implant treatment between 2014 and 2024 will have their medical records …

This study tests a liquid material called SQUIDPERI for a procedure that blocks blood flow to the prostate (prostatic artery embolization) in men with an enlarged prostate. The goal is to see if it works better than standard particles at easing urinary symptoms like frequent or w…

This study compares two strategies for giving the drug etoposide to adults with severe hemophagocytic lymphohistiocytosis (HLH) in the intensive care unit. HLH is a life-threatening overreaction of the immune system that can cause organ failure. The goal is to see if starting eto…

This study tests a drug called secukinumab in 52 people with active, severe Takayasu arteritis, a rare disease that causes inflammation and narrowing of major blood vessels. The goal is to see if secukinumab can help patients stop taking steroids and achieve remission. Participan…

This study tests whether giving one unit of red blood cells to critically ill patients right before removing their breathing tube can prevent them from needing the tube again or dying within a week. It involves 800 adults in intensive care who are at high risk of breathing failur…

This study tests a new combination of three drugs—mezigdomide, carfilzomib, and dexamethasone—in people whose multiple myeloma has returned or stopped responding to prior treatments. The goal is to see if this combo can keep the cancer from growing for as long as possible. About …

This study tests whether anakinra, a drug used for arthritis, can help children with severe heart inflammation (myocarditis) recover heart function faster. About 110 children in intensive care will receive either anakinra or a placebo, in addition to standard care. The main goal …

This study tests a new gene therapy for GM2 gangliosidosis, which includes Tay-Sachs and Sandhoff diseases. Researchers will take blood cells from 6 patients, fix the genetic defect in the lab, and then see if these cells can help brain cells work better. The goal is to show the …

This early study tests whether MRI-guided high-intensity focused ultrasound (HIFU) can safely heat and destroy small brain areas causing seizures in 13 adults with drug-resistant epilepsy. Participants have visible brain lesions that are too risky or deep for traditional surgery.…

This study tests whether eating fiber-rich snacks (with inulin and pectin) for 28 days can help people with alcohol use disorder during withdrawal. The goal is to improve gut health, reduce cravings and anxiety, and support abstinence. Participants will be hospitalized for 7 days…

This study tests whether giving a combination of activated charcoal and polyethylene glycol can lower the amount of poison in the blood of people who have taken a severe overdose of certain drugs and need intensive care. About 200 adults on ventilators will be randomly assigned t…

This study looks at whether a special day hospital program helps people with inflammatory bowel disease (IBD) manage their condition better. About 240 adults with Crohn's disease or ulcerative colitis will take part. In one visit, they get blood tests, a doctor checkup, education…

This study tests a new way to use breathing machines for people with severe lung injury (ARDS). The goal is to use very gentle breaths to avoid further lung damage, while a special life support machine helps with oxygen and carbon dioxide removal. About 290 adults on breathing ma…

This study tests different treatments for sepsis based on each patient's unique traits, like their immune or metabolic profile. It will include 2000 children and adults with sepsis. The goal is to reduce deaths and the need for life-support machines like ventilators or dialysis.

This early-stage study tests whether repeatedly opening the blood-brain barrier with ultrasound is safe and may slow disease progression in people with ALS (Lou Gehrig's disease). About 23 adults will receive 9 ultrasound sessions over 24 weeks. The goal is to see if this approac…

This study tests whether a common steroid drug (prednisolone) can slow the decline in lung function for people with fibrotic hypersensitivity pneumonitis, a lung disease caused by inhaling certain particles. About 120 adults with mild to moderate lung damage will receive either t…

This study tests a new 6-month treatment called BPaLM for people with multidrug-resistant tuberculosis (MDR-TB). It aims to see if this shorter regimen works as well as the standard long treatment that can last over a year. About 55 adults in France will receive BPaLM, and their …

This study tests whether adding bosentan to standard steroid treatment helps people with giant cell arteritis (GCA) stay relapse-free longer and use less steroids. About 40 adults with GCA will receive either bosentan plus steroids or steroids alone for 3 months, then be followed…

This trial tests a gene therapy for FHL3, a rare immune disorder caused by a gene mutation. Instead of a donor stem cell transplant, patients receive their own stem cells that have been corrected with a healthy gene. The goal is to restore immune function while avoiding transplan…

This study tests whether adding corticosteroids to standard antibiotic treatment can reduce joint damage and improve function in adults with septic arthritis, a serious joint infection. About 200 participants will receive either steroids or a placebo alongside antibiotics. The ma…

This study aims to develop an artificial intelligence tool that can analyze photographs of suspicious spots in the mouth to help doctors diagnose oral cancer and precancerous conditions. Researchers will collect thousands of de-identified clinical images and patient data from med…

This study tests whether a special PET scan using a tracer called 82-Rb can accurately tell how aggressive a kidney tumor is. About 50 adults with suspected or confirmed kidney cancer will get the scan before surgery. The goal is to see if the scan can separate low-risk from high…

This study looks at women with PCOS to see if some have a genetic condition called lipodystrophy that causes severe insulin resistance. Researchers will compare insulin and blood sugar levels between women with known genetic lipodystrophy and those with PCOS. The goal is to impro…

This study will test a smartphone app that automatically measures how quickly blood returns to a fingertip after pressing on it. Researchers will compare the app's reading to measurements made by expert doctors. The goal is to see if the app can reliably monitor blood flow in 60 …

This study looks at whether measuring a protein called S100B in the blood can help emergency doctors quickly tell if a person's fainting spell was caused by epilepsy or something else, like a heart problem. About 100 adults who come to the ER after losing consciousness will give …

This study looks at whether a special 4D MRI scan can accurately measure blood flow and pressure in the liver without needing an invasive needle procedure. It will enroll 60 adults with cirrhosis, some with early-stage disease and others needing a shunt (TIPS) for complications. …

This study tests whether a quick, non-invasive liver scan (Fibroscan) can help emergency doctors diagnose acute heart failure in patients with sudden shortness of breath. Researchers will enroll 100 adults in the emergency department to see if liver stiffness measurements can acc…

This study aims to improve how doctors diagnose and manage hyperandrogenism, a condition causing excess male hormones in women. Researchers will use machine learning and metabolomics to better distinguish between common causes like PCOS and rarer genetic conditions. The study wil…

This study aims to improve how doctors classify colon tumors by using artificial intelligence (AI) to analyze CT scans. The AI will be trained to tell early-stage tumors from advanced ones and to detect lymph node involvement, which is key for deciding on treatments like chemothe…

This study evaluates a new rapid test that can detect the dangerous fungus Candida auris in just 15 minutes. Researchers will compare the test's accuracy to standard lab methods using samples from over 550 hospital patients. The goal is to help hospitals quickly identify and cont…

This study tests whether a smartphone app, called ICD-Shield, can help doctors adjust Parkinson's medications to prevent impulse control disorders (like compulsive gambling or shopping). About 528 people with early-stage Parkinson's will be randomly assigned to use the app or rec…

This study looks at whether a personalized prevention plan helps female night shift workers at higher risk for breast cancer stick to healthy changes. Participants get a one-on-one consultation to address risks like smoking, diet, and exercise, then are followed for 5 years. The …

This study tests a new way to help transgender sex workers and their clients get HIV and STI prevention services through a digital teleconsultation program called E-PrevenT. The goal is to reach people who are often left out of prevention programs due to social and economic barri…

This study tests whether using a special breathing device (intrapulmonary percussive ventilation) at home can prevent hospitalizations for children with multiple disabilities. About 146 children aged 1 to 16 will be randomly assigned to either standard chest therapy or the device…

This study tests whether adding low-dose ketamine to standard sedatives helps critically ill patients on breathing machines recover faster and spend more days alive at home. About 640 adults who need unplanned ventilation and sedation will receive either ketamine or a placebo for…

This study tests whether cannabidiol (CBD) can reduce severe self-injuries, like biting or head-banging, in 21 children aged 5-17 with severe neurodevelopmental disorders. Researchers will measure if the frequency of self-harm drops by at least 30% after 63 days of treatment. The…

This study tests if a new carbon-fiber ankle brace helps children with cerebral palsy move better during walking, running, and jumping compared to their usual plastic brace. About 38 children aged 8 to 15 will try both braces to see which one improves propulsion and is more comfo…

This study tests whether bringing airflow back to the nose can reduce shortness of breath in people who breathe through a tracheostomy tube connected to a ventilator. Researchers will compare three simple, non-drug methods: continuous nasal airflow, nasal sprays, and a fan blowin…

This study tests whether personalized text messages sent after in-person rehab sessions can help people with chronic low back pain do more daily activities. One hundred adults with back pain lasting over 3 months will receive either standard rehab or rehab plus automated SMS foll…

This study tests whether several sessions of medical hypnosis can improve quality of life for people with COPD who still feel very short of breath despite standard treatment. About 154 adults with severe dyspnea will either receive five hypnosis sessions or standard phone check-i…

This study tests if a personalized digital coaching program can help people with chronic low back pain do more daily activities. About 330 adults will either get the digital coach or usual care. The goal is to see if the coaching reduces pain and improves function over 4 to 12 mo…

This study tests whether guiding a child aged 1 to 3 years to shake a maraca with the arm opposite to the one getting a blood draw can reduce pain. The idea is that active movement distracts the child, making the procedure less painful and reducing the need for restraint. The tri…

This study aims to create and test a self-rehabilitation program that uses everyday activities to help people who have had a stroke more than 6 months ago. About 158 participants will be randomly assigned to either the program or usual care. The goal is to see if this approach ca…

This study tests if methoxyflurane, a painkiller gas that patients breathe in themselves, works as well as morphine for severe chest pain during a heart attack. About 700 adults with a specific type of heart attack (STEMI) will be treated by emergency medical teams. The goal is t…

This study tests whether wearing a custom back brace, along with usual care, can reduce low back pain in adults with degenerative scoliosis (a curved spine). About 130 people aged 40 to 75 with moderate to severe pain will be randomly assigned to get the brace or not. Researchers…

This study tests whether a drug called gamma-hydroxybutyrate (GHB) can improve deep sleep in intensive care patients. Sleep problems are very common in the ICU and can lead to worse outcomes. The trial will involve 24 adults in the ICU who will receive either GHB or a placebo, an…

This study tests whether awake prone positioning (lying on the stomach) can improve breathing in 15 adults with sickle cell disease who are in the intensive care unit for severe acute chest syndrome. The approach aims to improve oxygen levels and reduce breathing effort. The tria…

This study tests whether a smartphone app called MAELA can help people recover better after surgery for digestive cancers. About 555 adults having surgery for colon, pancreas, liver, rectal, stomach, or esophageal cancer will use the app to report symptoms for 90 days after surge…

This study tests a special education program focused on improving self-image for 60 adults with chronic inflammatory rheumatic diseases like rheumatoid arthritis. Participants will attend workshops designed to help them feel better about their bodies and themselves. The goal is t…

This study looks at whether a special education program and a check-in on caregivers' needs can help improve the quality of life for people caring for a loved one with multiple myeloma. About 27 caregivers will take part. The goal is to see if this support helps them feel better …

This study tests a portable device called ActiTENS mini that uses mild electrical pulses to relieve chronic pelvic pain in women with endometriosis. About 208 women will try different stimulation strengths over 9 months to see if it reduces pain and improves quality of life. If i…

This study looks at whether special 'active' sports shoes can help people with severe COPD walk farther during a 6-minute walk test. About 75 adults with advanced COPD will try both the special shoes and their usual shoes, and researchers will compare how far they walk and how br…

This study looks at whether using two OSIA hearing implants (one on each side) helps children with severe outer ear problems hear speech better in noisy places compared to using just one implant. Twelve children aged 7 to 17 who already use a bone conduction device will get impla…

This study tests whether adding movement sonification—turning body movements into sound—to standard therapy can help people with acute stress disorder (ASD) feel more connected to their bodies. About 30 adults who recently experienced a traumatic event will try this approach. The…

This study tests whether tocilizumab, an anti-inflammatory drug, can reduce joint pain and improve daily life in people with a rare form of arthritis called CPPD. About 80 adults whose pain has not improved with standard treatments will receive monthly infusions of either the dru…

This study tests a functional restoration program for people with chronic low back pain who have been unable to work for at least 3 months. The goal is to see if the program helps them return to work, reduces healthcare use, and is cost-effective. 242 participants will be randoml…

This study looks at whether custom-made shoes can improve walking quality in people who have had a stroke and still have trouble walking due to muscle tightness and foot dragging. About 58 adults who had a stroke at least 6 months ago will wear adapted shoes and be tested on how …

This study aims to find out why some pregnant women with severe preeclampsia do not respond to a common blood pressure medication called labetalol. Researchers will follow about 350 women across multiple hospitals, collecting data from routine care without changing their treatmen…

This study looks at whether certain natural chemicals in vaginal fluid can predict if labor induction will work in first-time mothers. Researchers will measure these chemicals in 190 women with full-term pregnancies who are scheduled for induction. The goal is to find a way to be…

This study watches for thinking and memory issues in 90 adults with early-stage, operable lung cancer. Researchers will track complaints like forgetfulness or trouble focusing before, during, and after treatment using simple questionnaires. The goal is to understand when these pr…

This study looks at how personal traits like anxiety, self-esteem, and perfectionism affect the ability to adapt to change in people with alcohol use disorder. About 30 participants will complete a computer task and questionnaires in one 45-minute session. The goal is to better u…

This study checks if a new French questionnaire accurately measures how the look of your smile affects your daily life. Researchers will ask 120 adult dental patients to fill out the survey twice to see if the results are consistent. The goal is to give dentists a reliable way to…

This study looks at how a common virus called CMV changes the immune system in people who have had a kidney transplant. Researchers will compare immune responses in 60 patients, some with and some without CMV infection. The goal is to understand which immune pathways are affected…

This study looks at whether tumor DNA found in blood or belly fluid can help predict if stomach, colon, or pancreatic cancer will spread to the lining of the abdomen (peritoneum). Researchers will follow 300 adults with early-stage cancers who are scheduled for surgery. The goal …

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—just observation and data collection over time.

This study looks at videos of embryos growing in the lab during IVF. Researchers will use machine learning to find patterns in how embryos divide and develop that predict successful implantation. The goal is to create a tool that helps doctors choose the best embryo for transfer,…

This study looks at the bacteria, fungi, and viruses living on the skin, in the gut, and in the mouth of people with Netherton syndrome, a rare condition that damages the skin barrier and often causes allergies. Researchers will compare these microbes to those in healthy voluntee…

This study looks at people with Enamel Renal Syndrome, a rare genetic condition that causes calcium deposits in the body, leading to kidney and blood vessel problems. Researchers will measure kidney function and test how the body handles calcium, phosphate, water, and acid. The g…

This study looks at whether having a neonatal transport team arrive before or after birth affects survival and brain development in extremely premature babies (23-28 weeks) born at hospitals without a specialized intensive care unit. Researchers will follow about 627 infants acro…

This study looks at whether a computer can figure out what a person is saying by reading their brain signals during awake brain tumor surgery. Twenty adults with brain tumors near language areas will name pictures while their brain activity is recorded. The goal is to see how acc…

This study looks at whether testing stool and urine samples with advanced genetic methods can find hidden germs in people with weakened immune systems (like those on chemotherapy or with HIV). The goal is to see if these non-invasive tests work as well as or better than standard …

This study looks at stored blood samples from 2500 adults newly diagnosed with hepatitis C in France. Researchers want to map the different virus types and unusual subtypes circulating in the country. They also aim to understand why some treatments fail by checking for drug resis…

This study aims to create a 3D model of the bile ducts using MRI and CT scans, along with an AI tool to help doctors guide a camera during a procedure called ERCP. The goal is to improve safety and accuracy. The study will use existing medical images from 100 adult patients who h…

This study looks at whether nerve ultrasound can distinguish between genetic and acquired forms of a rare nerve condition called sensory neuronopathy. Researchers will review existing data from 50 adults to compare nerve size on ultrasound images. The goal is to see if a specific…

This study explores whether testing hospital wastewater can reliably detect multidrug-resistant organisms (superbugs) in patients, potentially replacing uncomfortable rectal swabs. Researchers will compare bacteria and resistance genes found in sewage from a specialized hospital …

This study will test whether a smartphone app called Resilience PRO can help doctors better monitor symptoms and quality of life in 80 adults with IDH-mutated glioma (a type of brain tumor) who are starting a new treatment. Patients will answer weekly questionnaires about their s…

This study aims to develop blood tests that can predict if a person with early-stage liver disease will develop serious complications like liver failure or liver cancer. Researchers will analyze tiny particles in the blood called extracellular vesicles, along with other markers, …

This study will follow 200 adults with pulmonary arterial hypertension who experience a sudden worsening of right heart failure. Researchers will collect medical data to see how many survive or need a lung transplant within 3 and 12 months. The goal is to identify better ways to …

This study looks at how the drug sildenafil is processed in the bodies of full-term newborns who have suffered brain injury from lack of oxygen at birth. All babies will receive standard cooling therapy. The goal is to find the right dose for a future larger trial that will test …

This study aims to develop a new bedside 3D ultrasound method to better predict developmental problems in very premature infants (born before 30 weeks). Researchers will scan the brains of 360 babies and track their development up to age 2. The goal is to find early brain markers…

This study will analyze blood and tissue samples from 500 adults with rare inflammatory disorders called systemic histiocytoses. The goal is to find new biological markers that can help doctors better diagnose, classify, and monitor these diseases without invasive procedures. Res…

This study looks at how a new type of heart ablation (pulsed-field ablation) changes the heart's structure in people with atrial fibrillation. Researchers will use MRI scans before and 4 months after the procedure to measure scarring and function. About 39 adults with persistent …

This study looks at data from 562 people who had a liver transplant for liver cancer (hepatocellular carcinoma). The goal is to create a better scoring system that considers tumor shrinkage before transplant, how the tumor behaves over time, and certain cell features. This could …

This study compares 108 children with Denys-Drash syndrome who had a kidney transplant to similar children without the syndrome. The goal is to see if the syndrome increases the risk of a type of cancer called post-transplant lymphoproliferative disorder. Researchers will review …

This study tests whether a personalized computer model, called a 'digital twin,' can predict which patients with high blood pressure will respond to a procedure called renal denervation. The procedure reduces overactive kidney nerves, but not everyone benefits. Researchers will e…

This study tests whether a smartphone app can help people with rheumatoid arthritis, spondyloarthritis, or psoriatic arthritis learn how to safely use their anti-rheumatic drugs. About 144 adults will either use the app or receive standard care with a website. The goal is to see …

This study will follow 45,000 university students in France for three years to understand how financial and social hardships (like housing, isolation, and money worries) affect their mental health and whether they seek help. Researchers hope to identify key factors that can be ta…

This study will follow 5,000 adults with immune system problems to see if they also have hidden blood cell mutations (clonal hematopoiesis), including the rare VEXAS syndrome. Researchers aim to track how often these immune issues appear with blood disorders. No new treatments ar…

This study follows 30 women aged 18-80 who are getting an artificial urinary sphincter to treat severe urine leakage. Researchers want to see if the surgery changes their sexual quality of life. Participants will answer questionnaires 6 and 12 months after the procedure. The goal…

This study watches brain activity (EEG) in 330 people during routine anesthesia or sedation—including children with autism, adults over 70, and patients having digestive endoscopy. Researchers aim to link brain wave patterns to drug levels and patient responses, without changing …

This study aims to see if a simple, markerless motion capture system using only 4 cameras can accurately measure how children walk. Researchers will study 125 healthy volunteers aged 6 to 17. If successful, this could make gait analysis easier and more widely available for childr…

This study looks at how severe infections (sepsis) change the immune system's inner workings. Researchers will follow 290 adults, including sepsis patients, other critically ill patients, and healthy volunteers, to map changes in immune cell activity over time. The goal is to bet…

This study looks at whether a common, non-invasive jaundice test (using a light meter on the skin) is accurate for newborns with different skin colors. Darker skin may interfere with the device. Researchers will compare the skin test results with blood tests in 510 babies to see …

This study follows 412 people who survived severe acute kidney injury in the intensive care unit. Researchers want to see if two blood markers, galectin-3 and CD146, can predict future heart attacks, strokes, heart failure, chronic dialysis, or death. The goal is to better identi…

This study looks at whether special hearing tests can help doctors program cochlear implants more accurately for adults with severe hearing loss. Instead of relying only on what patients say feels comfortable, researchers will use electrical measurements from the ear to guide set…

This study tests whether body-worn sensors can help doctors better adjust medication for people with Parkinson's disease who have motor fluctuations. 218 participants will wear sensors at home to track movement, and doctors will use that data to optimize therapy. The goal is to r…

This study will look back at medical records of 60 people treated for a rare brain infection called cerebral nocardiosis. Researchers want to see how brain lesions change on MRI or CT scans over time and whether those changes relate to how well patients recover. The goal is to be…

This study looks at tooth pulp tissue from 1,200 adults to understand inflammation at a molecular level. Researchers will analyze genes and proteins in samples collected during routine dental procedures. The goal is to improve how dentists diagnose pulp inflammation and decide on…

This study looks at how living kidney donors feel about receiving a symbolic award, like a commemorative medal, after their donation. Researchers will interview 15 donors to understand their motivations and whether such recognition improves their experience. The goal is to find r…

This study looks at how safe surgery is for a rare condition called functional popliteal artery entrapment, which causes leg pain in young athletes during exercise. Researchers will track 138 adults who have the surgery to see how many need to return to the hospital within 30 day…

This study looks at blood immune cells in 10 adults with a rare genetic skin disease called NIPAL4 ichthyosis. Researchers want to understand why three patients with this disease also developed a rare lymphoma (Sezary syndrome). By describing the normal immune cell pattern in pat…

This study looks at whether a newer, gentler heart procedure called pulse-field ablation (PFA) can reverse harmful changes in the heart's upper chambers caused by atrial fibrillation. Researchers will compare CT scans taken before and 3 months after the procedure in 200 adults. T…

This study looks back at heart MRI scans from 5,000 adults who had acute myocarditis (heart muscle inflammation). The goal is to find patterns that predict serious outcomes like death or heart failure. No new treatments are tested; instead, researchers hope to improve how doctors…

This study explores whether ultrasound images of the diaphragm can reliably estimate a key measure of breathing drive (P0.1) in ICU patients. The standard test works well for intubated patients but fails with non-invasive ventilation or high-flow oxygen. Researchers will compare …

This study looks at 43 adults in intensive care with septic shock who already have a special heart catheter (Swan-Ganz IQ). It compares a new continuous method that analyzes heart pressure waves to the standard method (thermodilution) for measuring how well the heart pumps blood.…

This study looks at whether a blood test that measures tiny bits of tumor DNA floating in the bloodstream can be used instead of painful bone marrow biopsies to track how well treatment is working in children with acute lymphoblastic leukemia (ALL). About 205 children and teens w…

This study will take small pieces of diaphragm muscle from 10 women having surgery for endometriosis and grow the muscle cells in a lab. Researchers will compare these diaphragm cells to arm muscle cells to find unique features. The goal is to create a better tool for studying di…

This study follows 300 adults with a genetic condition that causes very high cholesterol (familial hypercholesterolemia) to see how their heart artery blockages change over 5 years. Participants will have a special CT scan to measure plaque buildup. The goal is to understand the …

This study will compare the costs and benefits of a new, non-invasive blood test that screens for many genetic disorders in unborn babies, versus current methods that often require invasive procedures like amniocentesis. Researchers will enroll 300 couples in France who are alrea…

This study will follow 400 people receiving a stem cell transplant to learn why some develop serious heart issues like heart attacks, irregular heartbeat, or heart failure. Researchers will use heart scans, blood tests, and other monitoring to find early warning signs. The goal i…

This study will follow 1,500 people with lupus or other autoimmune diseases to see if advanced heart scans can predict heart attacks, strokes, or other heart problems. Participants will have one of three types of heart imaging. The goal is to learn if these scans can help doctors…

This study looks for early signs of ADHD in children aged 3 to 5, before the official diagnosis age of 6. Researchers will use eye-tracking and balance tests to find differences between 30 children at risk for ADHD and 30 healthy children. The goal is to create better tools for e…

This study looks at how 36 young people (ages 12-25) with somatic symptom disorder—where physical symptoms like pain or fatigue have no clear medical cause—move through the healthcare system before getting specialized help. Researchers will interview participants and their parent…

This study looks at how well antiviral drugs work for people with weakened immune systems who get COVID-19. Researchers will review medical records of 300 patients in France who were treated with nirmatrelvir/ritonavir or remdesivir between June 2023 and April 2024. The goal is t…

This study will use artificial intelligence to analyze sleep recordings from 1,500 adults with chronic insomnia and/or epilepsy. The goal is to see if AI can accurately identify sleep stages and patterns, which could help doctors diagnose these conditions more easily. No new trea…

This study aims to find out which people with major depression (unipolar or bipolar) respond best to light therapy. Researchers will measure sleep, mood, and biological rhythms before and after treatment in 173 adults. The goal is to identify biomarkers that predict a positive re…

This study looks at how male hormones (androgens) might influence the immune system around glioblastoma, an aggressive brain cancer that is more common and deadly in men. Researchers will analyze tumor and blood samples from 40 newly diagnosed patients aged 18 to 55. The goal is …

This study will follow 4500 adults with Crohn's disease or ulcerative colitis to find biological clues that predict how the disease will progress or lead to complications. Researchers will analyze gut bacteria from stool and tissue samples. The goal is to better understand the di…

This study aims to understand why some cancer patients develop nerve or brain problems after receiving immunotherapy drugs called immune checkpoint inhibitors. Researchers will analyze spinal fluid and blood from 160 adult patients to find immune cells and antibodies that may mis…

This study tests whether a mobile app called EPIDAY can accurately predict the daily risk of epileptic seizures. Researchers will ask 50 adults with focal epilepsy to report their symptoms each day, and machine learning will analyze the data to forecast seizure likelihood. The go…

This study looks at whether certain gut bacteria help the remaining intestine absorb nutrients better after surgery for short bowel syndrome. Researchers will follow 15 adults who are having surgery to reconnect their small intestine and colon. They will measure how well the inte…

This study looks at how the antibiotic cefazolin spreads in the chest of children after heart surgery. Ten children under 6 years old will have a tiny probe placed in their chest to measure antibiotic levels. The goal is to learn how to give the right dose to prevent infections.

This study will test whether new lab techniques can help doctors better diagnose hard-to-identify bone and joint diseases. Researchers will collect joint fluid and tissue from 50 adults undergoing routine procedures and analyze them with both standard and advanced methods. The go…

This study aims to better understand what affects fertility in women with Polycystic Ovary Syndrome (PCOS), a common hormone disorder. Researchers will follow about 473 women, including those with PCOS and a healthy comparison group, to see how they conceive and what treatments t…

This study looks at how a person's genes affect their response to the heart drug mavacamten for obstructive hypertrophic cardiomyopathy. Researchers will collect DNA samples from 300 patients to see which genetic types respond best. The goal is to improve dosing safety and effect…

This study will combine medical and genetic information from 2000 children with acute myeloid leukemia (AML) into one large database. The goal is to find hidden patterns that can predict which children are at high risk of relapse. No new treatments are tested; instead, researcher…

This study looks at a new way to program cochlear implants in children aged 0 to 7 years. Normally, programming relies on the child's response, which can be hard to get. The study will test if measuring a reflex in the ear (eSRT) is a reliable and practical method. If successful,…

This study aims to understand how a less invasive stomach procedure called endoscopic sleeve gastroplasty changes digestion, hormones, and gut bacteria compared to traditional weight-loss surgery. Researchers will follow 40 adults with obesity to measure stomach emptying and othe…

This study looks at whether giving doctors rapid (4-6 hour) lab reports on which antibiotics work best against bacteria in the blood helps them choose the right treatment faster. The standard method takes 18-24 hours. The study involves 200 ICU patients with Gram-negative bloodst…

This study aims to identify biological markers and disrupted pathways in the blood and urine of adults with Congenital Central Hypoventilation Syndrome (CCHS), a rare condition that affects breathing. Researchers will compare samples from 40 CCHS patients and healthy volunteers t…

This study aims to translate the COMFORTneo pain assessment tool, originally developed in Dutch, into French. Researchers will work with 50 healthcare professionals from neonatal units in Paris to ensure the translated version is accurate and easy to understand. The goal is to pr…

This study aims to understand the biological causes of autism by creating mini-organs (organoids) from cells of people with autism. Researchers will compare these organoids to those from siblings without autism to find differences in brain cell development. The goal is to discove…

This study aims to understand why children with ulcerative colitis (UC) are more likely to get C. difficile infections. Researchers will compare bile acid profiles and gut bacteria in 80 children: those with active UC and C. diff, those with active UC alone, those in remission, a…

This study looks at how air moves in the lungs of brain-injured patients when doctors are removing their breathing tube. Using a special imaging belt (electrical impedance tomography), researchers will track changes in lung ventilation patterns. The goal is to find patterns that …

This study follows 1,000 patients with rare, life-threatening skin infections treated through a special care network in Paris. Researchers will track survival, long-term health, and quality of life to see what factors lead to better outcomes. No new treatment is being tested; the…

This study looks at children with neuroblastic tumors in the lower chest area who had surgery between 2005 and 2024. It compares those who had a special X-ray before surgery to find a key spinal artery versus those who did not. The goal is to see if this imaging reduces the risk …

This study looks at why some women have repeated failed embryo implants or miscarriages. Researchers will compare uterine tissue and blood samples from 100 women with and without these issues. The goal is to find immune or bacterial differences that might explain these fertility …

This study will gather information from 100 people in France with SITRAME syndrome, a rare disease that causes repeated episodes of skin rash and fever. Researchers will look at patient characteristics, treatments, and outcomes to better understand the disease. The goal is to cre…

This study aims to learn more about a condition called multilocus imprinting disorder (MLID), where multiple genes are abnormally turned on or off. Researchers will test a new technique to detect these changes in 96 people with known imprinting disorders and compare them to healt…

This study watches how the lungs work during surgery in 34 adults under general anesthesia. It uses special monitors to measure lung pressure and air distribution during a routine breathing technique called alveolar recruitment. The goal is to see if these monitors can help docto…

This study creates a registry of 5,000 adults with hypertrophic cardiomyopathy (thick heart muscle) to see if heart MRI scans can better predict who is at risk of dying. Researchers will use the scans to build a new scoring system. The goal is to improve how doctors assess risk f…

This study aims to understand what it's like for patients, their families, and healthcare workers dealing with a prosthetic joint infection. Researchers will interview about 63 people to learn about their challenges and needs. The goal is to use this information to create a teach…

This study looks at how surgery for a rare brain tumor called craniopharyngioma may change what foods people prefer, especially high-fat and sugary items. Researchers will compare food choices of 346 adults who had this surgery with two other groups. The goal is to understand why…

This study looks at whether the way a donor liver is removed affects how well patients do after a liver transplant. Researchers will follow about 1,810 adults in France getting their first liver transplant. The goal is to see if certain methods lead to fewer artery or bile duct p…