Scientists use Mini-Brains to unlock Autism's secrets

NCT ID NCT07494331

Not yet recruiting Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study aims to understand the biological causes of autism by growing tiny 3D brain models called organoids from cells of people with autism. Researchers will compare these organoids to those from siblings without autism to see how genetic differences affect brain cell development. The goal is to uncover the mechanisms behind autism, which could lead to better treatments in the future. The study involves 80 participants, including children with autism, their siblings, and parents.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could reveal how genetic changes lead to autism, pointing toward future treatments.
What could go wrong: This is an early-stage observational study using lab-grown organoids, not a treatment trial. Findings may not directly translate to therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autism spectrum disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTISM SPECTRUM DISORDER (ASD

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Robert Debré Hospital

Paris, 75019, France

Contact Phone: •••-•••-•••• Email: •••••@•••••

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