Assistance Publique - Hôpitaux De Paris

This study tested a special stem cell transplant for children with combined immunodeficiency, a condition where the immune system doesn't work properly. The approach removed certain naive cells from the donor's stem cells to try to prevent graft-versus-host disease, a serious com…

This study tested whether setting a patient's blood pressure target based on kidney ultrasound readings could prevent acute kidney injury in people with septic shock. Researchers enrolled 27 adults with septic shock and compared personalized blood pressure management to standard …

This study tested whether doing an early endoscopic ultrasound and removing any gallstones from the bile duct could help people with severe pancreatitis caused by gallstones. The trial planned to enroll many patients but was stopped early after only 27 participants. The main goal…

This study looked at whether a daily inhaled medicine (fluticasone and salmeterol) could improve lung function in children aged 6–17 who had a stem cell transplant and showed early signs of lung decline. The goal was to prevent a serious lung condition called bronchiolitis oblite…

This study aimed to create and validate a screening tool for auditory processing disorder (APD) in children aged 7 to 13. The tool combined a parent/teacher questionnaire with a short set of hearing tests. The goal was to see if it could accurately identify children who need a fu…

This study looked at whether people at high risk for colorectal cancer prefer a CT scan (virtual colonoscopy) or a traditional colonoscopy to find advanced adenomas, which are precancerous growths. The study enrolled 39 adults aged 18 to 80 with a personal or family history of co…

This study tested whether giving two medications together (oxytocin and misoprostol) could prevent severe bleeding after vaginal birth better than oxytocin alone. It involved over 1,700 women giving birth between 36 and 42 weeks. The trial was stopped early, so results are limite…

This study looked at whether a breathing machine (non-invasive ventilation) could prevent acute chest syndrome, a severe lung problem, in children with sickle cell disease who are in the hospital for a pain crisis. The usual prevention method is spirometry, which requires the chi…

This pilot study looked at whether an interactive storyteller called LUNII could lower anxiety in children aged 4 to 6 with cleft lip and palate before their bone graft surgery. The goal was to see if using the device before the operation would also reduce pain and shorten hospit…

This study looked at whether adding clorazepate to standard treatment can ease migraine attacks in adults visiting the emergency room. It included 323 people with moderate to severe migraine. The trial was terminated before completion, so results are limited.

This study aimed to measure the immune response to the COVID-19 vaccine in 78 adults with autoimmune or inflammatory diseases who take immunosuppressants or biologics. Researchers wanted to see if these medications reduce the vaccine's effectiveness. The study was terminated earl…

This study aimed to understand what happens in the mind during sleep by using sound cues in people who sleepwalk. Researchers wanted to see if they could trigger and measure mental processes in real time. The study was terminated early, so results are limited.

This study looked at whether a specific gene (PDE4) affects how well children with asthma respond to the rescue inhaler salbutamol. Researchers planned to compare lung function changes before and after the medication in 99 children aged 6 to 18. The study was terminated early, so…

This study aimed to check if women with thrombophilia (a condition that makes blood clot easily) have differences in how their blood vessels work, which might raise their risk for heart problems. Researchers planned to compare blood vessel function in healthy women and those with…

This study aimed to understand how age impacts the severity of infections, cancers, heart disease, and fractures in people with rheumatoid arthritis. Researchers planned to compare patients over 65 with younger adults. The study was terminated early, so results are limited.

This study aimed to understand how growth hormone treatment affects growth and metabolism in short children who were born small for gestational age. Researchers planned to compare two different ways of giving the hormone and look at genetic factors. Only 10 children were enrolled…

This study looked at whether a special device (Vigi'Fall®) can detect falls in people over 75 living alone and speed up emergency help. Researchers planned to include 200 participants but stopped early with only 33 enrolled. The goal was to compare health outcomes like death and …

This study looked at whether immunosuppressive medications used for rheumatoid arthritis or spondyloarthritis change how the body handles a COVID-19 infection. Researchers compared 150 patients on these drugs with infected family members not on such treatments. The goal was to me…

This study looked at whether people with both rheumatoid arthritis and type 2 diabetes have a more severe diabetes course than those with osteoarthritis and diabetes. Researchers tracked 176 adults to see how quickly diabetes treatments were added. The study was stopped early, so…

This study aimed to track four bone-related substances in the blood and urine of people with multiple myeloma who were receiving intravenous bisphosphonates (bone-strengthening drugs). The goal was to see how these markers changed over 12 months. Only 3 patients were enrolled bef…

This study looked at why a common numbing shot for knee surgery works so well. Doctors used ultrasound to see if the medicine spreads to nerves behind the knee. The goal was to measure how often this spread happens in 30 adults having knee surgery. The study was stopped early, bu…

This study aimed to see if certain immune cells in the blood could predict whether patients with advanced liver cancer would respond to a combination of immunotherapy drugs (Atezolizumab and Bevacizumab). Researchers planned to measure these cells before and after treatment in ab…

This study aimed to find the best level of a drug called mycophenolate mofetil (MMF) in the blood to improve skin tightness and lung function in people with systemic sclerosis. Only 2 people joined before the study was stopped early. The research was designed to see if measuring …

This study looked at whether an online video simulator could help surgeons learn a specific type of prostate cancer surgery (laparoscopic radical prostatectomy). It involved 29 surgeons who were new to the procedure. The study was stopped early, so results are limited.

This study looked at whether the timing of surgery to remove burned skin affects survival and recovery in severely burned adults. Researchers planned to study 470 patients in burn units, but the study was stopped early. The goal was to find the best time for surgery to improve ou…